Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O75886

- STAM2_HUMAN

UniProt

O75886 - STAM2_HUMAN

Protein

Signal transducing adapter molecule 2

Gene

STAM2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 140 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. endosomal transport Source: Reactome
    2. epidermal growth factor receptor signaling pathway Source: Reactome
    3. intracellular protein transport Source: InterPro
    4. membrane organization Source: Reactome
    5. negative regulation of epidermal growth factor receptor signaling pathway Source: Reactome

    Keywords - Biological processi

    Protein transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_12484. EGFR downregulation.
    REACT_27258. Endosomal Sorting Complex Required For Transport (ESCRT).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Signal transducing adapter molecule 2
    Short name:
    STAM-2
    Alternative name(s):
    Hrs-binding protein
    Gene namesi
    Name:STAM2
    Synonyms:HBP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:11358. STAM2.

    Subcellular locationi

    Cytoplasm By similarity. Early endosome membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: LIFEdb
    2. cytosol Source: Reactome
    3. early endosome membrane Source: UniProtKB-SubCell
    4. intracellular membrane-bounded organelle Source: HPA
    5. nucleus Source: HPA

    Keywords - Cellular componenti

    Cytoplasm, Endosome, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36180.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 525525Signal transducing adapter molecule 2PRO_0000190147Add
    BLAST

    Post-translational modificationi

    Phosphorylated in response to IL-2, GM-CSF, EGF and PDGF.

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO75886.
    PaxDbiO75886.
    PRIDEiO75886.

    PTM databases

    PhosphoSiteiO75886.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed.1 Publication

    Gene expression databases

    BgeeiO75886.
    CleanExiHS_STAM2.
    GenevestigatoriO75886.

    Organism-specific databases

    HPAiHPA035528.
    HPA035529.

    Interactioni

    Subunit structurei

    Component of the ESCRT-0 complex composed of STAM or STAM2 and HGS. Part of a complex at least composed of HSG, STAM2 and EPS15. Interacts with JAK2 and JAK3. Interacts with ubiquitinated proteins and the deubiquitinating enzyme USP8/UBPY By similarity. Interacts (via the via the PxVxL motif) with CBX5; the interaction is direct. Interacts with VPS37C. Interacts with ubiquitin; the interaction is direct.By similarity4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    LCP2Q130943EBI-373258,EBI-346946
    RIN1Q136714EBI-373258,EBI-366017
    STAMBPO956303EBI-373258,EBI-396676

    Protein-protein interaction databases

    BioGridi115548. 41 interactions.
    IntActiO75886. 17 interactions.
    MINTiMINT-145850.
    STRINGi9606.ENSP00000263904.

    Structurei

    Secondary structure

    1
    525
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi10 – 167
    Helixi26 – 3813
    Beta strandi39 – 413
    Helixi42 – 5413
    Helixi59 – 7517
    Helixi78 – 847
    Helixi87 – 9812
    Helixi103 – 11917
    Turni120 – 1223
    Turni124 – 1263
    Helixi127 – 13711
    Turni138 – 1403
    Beta strandi205 – 2117
    Beta strandi217 – 2193
    Beta strandi228 – 2336
    Beta strandi237 – 2448
    Beta strandi247 – 2515
    Helixi253 – 2553
    Beta strandi256 – 2583

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1X2QNMR-A195-269[»]
    1X5BNMR-A1-150[»]
    2L0TNMR-B1-150[»]
    ProteinModelPortaliO75886.
    SMRiO75886. Positions 1-150, 196-367.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO75886.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini16 – 144129VHSPROSITE-ProRule annotationAdd
    BLAST
    Repeati165 – 18420UIMAdd
    BLAST
    Domaini202 – 26160SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini360 – 37718ITAMAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni219 – 2202Interaction with USP8By similarity
    Regioni334 – 36835Interaction with HGSBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi54 – 6714PxVxL motifAdd
    BLAST

    Domaini

    The VHS and UIM domains mediate the interaction with ubiquitinated proteins.
    The SH3 domain mediates the interaction with USP8.
    Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain.

    Sequence similaritiesi

    Belongs to the STAM family.Curated
    Contains 1 ITAM domain.Curated
    Contains 1 SH3 domain.PROSITE-ProRule annotation
    Contains 1 UIM (ubiquitin-interacting motif) repeat.PROSITE-ProRule annotation
    Contains 1 VHS domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3 domain

    Phylogenomic databases

    eggNOGiNOG309509.
    HOGENOMiHOG000231952.
    HOVERGENiHBG053175.
    InParanoidiO75886.
    KOiK04705.
    OMAiHYPPASS.
    OrthoDBiEOG7353WJ.
    PhylomeDBiO75886.
    TreeFamiTF315007.

    Family and domain databases

    Gene3Di1.25.40.90. 1 hit.
    InterProiIPR008942. ENTH_VHS.
    IPR001452. SH3_domain.
    IPR003903. Ubiquitin-int_motif.
    IPR002014. VHS.
    IPR018205. VHS_subgr.
    [Graphical view]
    PfamiPF00018. SH3_1. 1 hit.
    PF02809. UIM. 1 hit.
    PF00790. VHS. 1 hit.
    [Graphical view]
    PRINTSiPR00452. SH3DOMAIN.
    SMARTiSM00326. SH3. 1 hit.
    SM00726. UIM. 1 hit.
    SM00288. VHS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48464. SSF48464. 1 hit.
    SSF50044. SSF50044. 1 hit.
    PROSITEiPS50002. SH3. 1 hit.
    PS50330. UIM. 1 hit.
    PS50179. VHS. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O75886-1) [UniParc]FASTAAdd to Basket

    Also known as: STAM2A

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPLFTANPFE QDVEKATNEY NTTEDWSLIM DICDKVGSTP NGAKDCLKAI    50
    MKRVNHKVPH VALQALTLLG ACVANCGKIF HLEVCSRDFA TEVRAVIKNK 100
    AHPKVCEKLK SLMVEWSEEF QKDPQFSLIS ATIKSMKEEG ITFPPAGSQT 150
    VSAAAKNGTS SNKNKEDEDI AKAIELSLQE QKQQHTETKS LYPSSEIQLN 200
    NKVARKVRAL YDFEAVEDNE LTFKHGEIII VLDDSDANWW KGENHRGIGL 250
    FPSNFVTTNL NIETEAAAVD KLNVIDDDVE EIKKSEPEPV YIDEDKMDRA 300
    LQVLQSIDPT DSKPDSQDLL DLEDICQQMG PMIDEKLEEI DRKHSELSEL 350
    NVKVLEALEL YNKLVNEAPV YSVYSKLHPP AHYPPASSGV PMQTYPVQSH 400
    GGNYMGQSIH QVTVAQSYSL GPDQIGPLRS LPPNVNSSVT AQPAQTSYLS 450
    TGQDTVSNPT YMNQNSNLQS ATGTTAYTQQ MGMSVDMSSY QNTTSNLPQL 500
    AGFPVTVPAH PVAQQHTNYH QQPLL 525
    Length:525
    Mass (Da):58,164
    Last modified:November 1, 1998 - v1
    Checksum:i408D484544DD9403
    GO
    Isoform 2 (identifier: O75886-2) [UniParc]FASTAAdd to Basket

    Also known as: STAM2B

    The sequence of this isoform differs from the canonical sequence as follows:
         343-525: Missing.

    Show »
    Length:342
    Mass (Da):38,370
    Checksum:iE54540C48B6CD1B3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti81 – 833HLE → RLG in CAB63735. (PubMed:11230166)Curated
    Sequence conflicti254 – 2541N → D in CAB63735. (PubMed:11230166)Curated
    Sequence conflicti266 – 2661A → V in CAB63735. (PubMed:11230166)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei343 – 525183Missing in isoform 2. 1 PublicationVSP_014848Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF042273 mRNA. Translation: AAC63963.1.
    AF042274 mRNA. Translation: AAC63964.1.
    AL133600 mRNA. Translation: CAB63735.1.
    AK292265 mRNA. Translation: BAF84954.1.
    AK292847 mRNA. Translation: BAF85536.1.
    AC079790 Genomic DNA. Translation: AAY14712.1.
    CH471058 Genomic DNA. Translation: EAX11490.1.
    CH471058 Genomic DNA. Translation: EAX11492.1.
    BC028740 mRNA. Translation: AAH28740.1.
    CCDSiCCDS2196.1. [O75886-1]
    PIRiT43437.
    RefSeqiNP_005834.4. NM_005843.4. [O75886-1]
    UniGeneiHs.17200.

    Genome annotation databases

    EnsembliENST00000263904; ENSP00000263904; ENSG00000115145. [O75886-1]
    GeneIDi10254.
    KEGGihsa:10254.
    UCSCiuc002tyc.4. human. [O75886-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF042273 mRNA. Translation: AAC63963.1 .
    AF042274 mRNA. Translation: AAC63964.1 .
    AL133600 mRNA. Translation: CAB63735.1 .
    AK292265 mRNA. Translation: BAF84954.1 .
    AK292847 mRNA. Translation: BAF85536.1 .
    AC079790 Genomic DNA. Translation: AAY14712.1 .
    CH471058 Genomic DNA. Translation: EAX11490.1 .
    CH471058 Genomic DNA. Translation: EAX11492.1 .
    BC028740 mRNA. Translation: AAH28740.1 .
    CCDSi CCDS2196.1. [O75886-1 ]
    PIRi T43437.
    RefSeqi NP_005834.4. NM_005843.4. [O75886-1 ]
    UniGenei Hs.17200.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1X2Q NMR - A 195-269 [» ]
    1X5B NMR - A 1-150 [» ]
    2L0T NMR - B 1-150 [» ]
    ProteinModelPortali O75886.
    SMRi O75886. Positions 1-150, 196-367.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115548. 41 interactions.
    IntActi O75886. 17 interactions.
    MINTi MINT-145850.
    STRINGi 9606.ENSP00000263904.

    PTM databases

    PhosphoSitei O75886.

    Proteomic databases

    MaxQBi O75886.
    PaxDbi O75886.
    PRIDEi O75886.

    Protocols and materials databases

    DNASUi 10254.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000263904 ; ENSP00000263904 ; ENSG00000115145 . [O75886-1 ]
    GeneIDi 10254.
    KEGGi hsa:10254.
    UCSCi uc002tyc.4. human. [O75886-1 ]

    Organism-specific databases

    CTDi 10254.
    GeneCardsi GC02M152939.
    HGNCi HGNC:11358. STAM2.
    HPAi HPA035528.
    HPA035529.
    MIMi 606244. gene.
    neXtProti NX_O75886.
    PharmGKBi PA36180.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG309509.
    HOGENOMi HOG000231952.
    HOVERGENi HBG053175.
    InParanoidi O75886.
    KOi K04705.
    OMAi HYPPASS.
    OrthoDBi EOG7353WJ.
    PhylomeDBi O75886.
    TreeFami TF315007.

    Enzyme and pathway databases

    Reactomei REACT_12484. EGFR downregulation.
    REACT_27258. Endosomal Sorting Complex Required For Transport (ESCRT).

    Miscellaneous databases

    EvolutionaryTracei O75886.
    GeneWikii STAM2.
    GenomeRNAii 10254.
    NextBioi 38856.
    PROi O75886.
    SOURCEi Search...

    Gene expression databases

    Bgeei O75886.
    CleanExi HS_STAM2.
    Genevestigatori O75886.

    Family and domain databases

    Gene3Di 1.25.40.90. 1 hit.
    InterProi IPR008942. ENTH_VHS.
    IPR001452. SH3_domain.
    IPR003903. Ubiquitin-int_motif.
    IPR002014. VHS.
    IPR018205. VHS_subgr.
    [Graphical view ]
    Pfami PF00018. SH3_1. 1 hit.
    PF02809. UIM. 1 hit.
    PF00790. VHS. 1 hit.
    [Graphical view ]
    PRINTSi PR00452. SH3DOMAIN.
    SMARTi SM00326. SH3. 1 hit.
    SM00726. UIM. 1 hit.
    SM00288. VHS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48464. SSF48464. 1 hit.
    SSF50044. SSF50044. 1 hit.
    PROSITEi PS50002. SH3. 1 hit.
    PS50330. UIM. 1 hit.
    PS50179. VHS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, INTERACTION WITH JAK2 AND JAK3.
      Tissue: Fetal brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis and Trachea.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    7. "STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes."
      Bache K.G., Raiborg C., Mehlum A., Stenmark H.
      J. Biol. Chem. 278:12513-12521(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HGS AND UBIQUITIN, IDENTIFICATION IN A COMPLEX WITH HSG AND EPS15, SUBCELLULAR LOCATION.
    8. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
      Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C.
      Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    9. "The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain."
      Lechner M.S., Schultz D.C., Negorev D., Maul G.G., Rauscher F.J. III
      Biochem. Biophys. Res. Commun. 331:929-937(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CBX5.
    10. "Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding."
      Eastman S.W., Martin-Serrano J., Chung W., Zang T., Bieniasz P.D.
      J. Biol. Chem. 280:628-636(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH VPS37C.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "The solution structure of the VHS and SH3 domains of human signal transducing adaptor molecule 2."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2005) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 1-269.

    Entry informationi

    Entry nameiSTAM2_HUMAN
    AccessioniPrimary (citable) accession number: O75886
    Secondary accession number(s): A8K8A0
    , D3DPA1, Q7LDQ0, Q9UF58
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 140 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3