Reviewed, UniProtKB/Swiss-Prot O75884 (RBBP9_HUMAN)

Names and origin

Protein names

Recommended name:
    Retinoblastoma-binding protein 9
      Short name=RBBP-9
Alternative name(s):
    Retinoblastoma-binding protein 10
      Short name=RBBP-10
    B5T overexpressed gene protein
      Short name=Bog protein

Gene names

Name:	RBBP9
Synonyms:	BOG, RBBP10

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	186 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta1 through interaction with retinoblastoma and the subsequent displacement of E2F-1.
Subcellular location	Cytoplasm. Nucleus.
Tissue specificity	Widely expressed. Expressed at higher levels in tumor tissues than in normal tissues.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing
PTM	Phosphoprotein
Technical term	3D-structure
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O75884-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O75884-2)

The sequence of this isoform differs from the canonical sequence as follows:
     152-186: RLETKLHKFTDCGHFQNTEFHELITVVKSLLKVPA → SWTPNCTNSLTVVTFRTQSSMN

Notes: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 186	186	Retinoblastoma-binding protein 9		PRO_0000097180
Regions
	Region	56 – 70	15	Retinoblastoma protein binding Potential
Amino acid modifications
	Modified residue	49	1	Phosphothreonine; by CK2 Potential
	Modified residue	135	1	Phosphoserine; by CK2 Potential
Natural variations
	Alternative sequence	152 – 186	35	RLETK…LKVPA → SWTPNCTNSLTVVTFRTQSS MN in isoform 2.		VSP_004374
Experimental info
	Mutagenesis	63	1	L → Q: Loss of retinoblastoma protein binding
	Sequence conflict	2	1	A → V in AAC63498. Ref.1
	Sequence conflict	13 – 14	2	NG → KI in AAC63498. Ref.1
	Sequence conflict	18	1	V → E in AAC63498. Ref.1
	Sequence conflict	93 – 94	2	IV → LI in AAC63498. Ref.1
	Sequence conflict	102 – 103	2	DL → EF in AAC63498. Ref.1
	Sequence conflict	115	1	T → S in AAC63498. Ref.1
	Sequence conflict	129	1	Y → H in AAC63498. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified September 26, 2001. Version 2. Checksum: F645E159DCB759BF	FASTA	186	21,000
	10 20 30 40 50 60 MASPSKAVIV PGNGGGDVTT HGWYGWVKKE LEKIPGFQCL AKNMPDPITA RESIWLPFME 70 80 90 100 110 120 TELHCDEKTI IIGHSSGAIA AMRYAETHRV YAIVLVSAYT SDLGDENERA SGYFTRPWQW 130 140 150 160 170 180 EKIKANCPYI VQFGSTDDPF LPWKEQQEVA DRLETKLHKF TDCGHFQNTE FHELITVVKS LLKVPA
	Isoform 2 [UniParc]. Checksum: 4BA65444A2BD291D		173	19,394
	10 20 30 40 50 60 MASPSKAVIV PGNGGGDVTT HGWYGWVKKE LEKIPGFQCL AKNMPDPITA RESIWLPFME 70 80 90 100 110 120 TELHCDEKTI IIGHSSGAIA AMRYAETHRV YAIVLVSAYT SDLGDENERA SGYFTRPWQW 130 140 150 160 170 EKIKANCPYI VQFGSTDDPF LPWKEQQEVA DSWTPNCTNS LTVVTFRTQS SMN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability." Woitach J.T., Zhang M., Niu C.-H., Thorgeirsson S.S. Nat. Genet. 19:371-374(1998) [PubMed: 9697699] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), MUTAGENESIS OF LEU-63.
[2]	"Cloning and expression of a novel retinoblastoma binding protein cDNA, RBBP10." Chen J.-Z., Yang Q.-S., Wang S., Meng X.-F., Ying K., Xie Y., Mao Y.-M. Biochem. Genet. 40:273-282(2002) [PubMed: 12296629] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION. Tissue: Fetal brain.
[3]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 1).
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Skin.

Cross-references

Sequence databases

EMBLGenBankDDBJ

AF039564 mRNA. Translation: AAC63498.1.
AF237576 mRNA. Translation: AAL83721.1.
AL121893 Genomic DNA. Translation: CAC11112.1.
BC015938 mRNA. Translation: AAH15938.1.

RefSeq

NP_006597.2.

UniGene

Hs.69330

3D structure databases

PDBMSD

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2QS9	X-ray	1.72	A/B	1-186	[»]

ModBase

Search...

Proteomic databases

PeptideAtlas

O75884.

Genome annotation databases

Ensembl

ENSG00000089050. Homo sapiens. [Contig view]

GeneID

10741.

KEGG

hsa:10741.

Organism-specific databases

H-InvDB

HIX0015668.
HIX0043236.

HGNC

HGNC:9892. RBBP9.

HPA

HPA015830.

MIM

602908. gene.

PharmGKB

PA34256.

GenAtlas

Search...

GeneCards

Search...

Phylogenomic databases

HOGENOM

O75884.

HOVERGEN

O75884.

Gene expression databases

ArrayExpress

O75884.

CleanEx

HS_RBBP9.

GermOnline

ENSG00000089050. Homo sapiens.

Family and domain databases

InterPro

IPR010662. DUF1234.
[Graphical view]

Pfam

PF06821. DUF1234. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

40785.

SOURCE

Search...

Entry information

Entry name

RBBP9_HUMAN

Accession

Primary (citable) accession number: O75884
Secondary accession number(s): Q9H1D8

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	September 26, 2001
Last modified:	November 4, 2008
This is version 67 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)