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O75882

- ATRN_HUMAN

UniProt

O75882 - ATRN_HUMAN

Protein

Attractin

Gene

ATRN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 145 (01 Oct 2014)
      Sequence version 2 (27 Apr 2001)
      Previous versions | rss
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    Functioni

    Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti By similarity. Has a critical role in normal myelination in the central nervous system By similarity.By similarity

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. receptor activity Source: ProtInc

    GO - Biological processi

    1. cerebellum development Source: Ensembl
    2. inflammatory response Source: UniProtKB-KW
    3. myelination Source: Ensembl
    4. pigmentation Source: Ensembl
    5. regulation of multicellular organism growth Source: Ensembl
    6. response to oxidative stress Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Inflammatory response

    Keywords - Ligandi

    Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Attractin
    Alternative name(s):
    DPPT-L
    Mahogany homolog
    Gene namesi
    Name:ATRN
    Synonyms:KIAA0548, MGCA
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:885. ATRN.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. extracellular space Source: UniProt
    3. extracellular vesicular exosome Source: UniProt
    4. integral component of plasma membrane Source: ProtInc
    5. plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25178.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Sequence AnalysisAdd
    BLAST
    Propeptidei29 – 83551 PublicationPRO_0000394771Add
    BLAST
    Chaini84 – 14291346AttractinPRO_0000007483Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi101 ↔ 111By similarity
    Disulfide bondi105 ↔ 118By similarity
    Disulfide bondi120 ↔ 129By similarity
    Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi237 – 2371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi242 – 2421N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi250 ↔ 260By similarity
    Glycosylationi253 – 2531N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi254 ↔ 271By similarity
    Glycosylationi264 – 2641N-linked (GlcNAc...)2 Publications
    Disulfide bondi273 ↔ 282By similarity
    Glycosylationi300 – 3001N-linked (GlcNAc...) (complex)2 Publications
    Glycosylationi325 – 3251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi362 – 3621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi383 – 3831N-linked (GlcNAc...) (complex)3 Publications
    Glycosylationi416 – 4161N-linked (GlcNAc...)2 Publications
    Glycosylationi428 – 4281N-linked (GlcNAc...)1 Publication
    Glycosylationi575 – 5751N-linked (GlcNAc...)1 Publication
    Glycosylationi623 – 6231N-linked (GlcNAc...)1 Publication
    Glycosylationi731 – 7311N-linked (GlcNAc...) (complex)2 Publications
    Disulfide bondi816 ↔ 918By similarity
    Glycosylationi863 – 8631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi914 – 9141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi923 – 9231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi986 – 9861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1043 – 10431N-linked (GlcNAc...)1 Publication
    Glycosylationi1054 – 10541N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1063 ↔ 1071By similarity
    Disulfide bondi1065 ↔ 1077By similarity
    Glycosylationi1073 – 10731N-linked (GlcNAc...) (complex)1 Publication
    Disulfide bondi1080 ↔ 1089By similarity
    Glycosylationi1082 – 10821N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1092 ↔ 1106By similarity
    Disulfide bondi1127 ↔ 1137By similarity
    Disulfide bondi1140 ↔ 1155By similarity
    Glycosylationi1198 – 11981N-linked (GlcNAc...)1 Publication
    Glycosylationi1206 – 12061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1250 – 12501N-linked (GlcNAc...)1 Publication
    Glycosylationi1259 – 12591N-linked (GlcNAc...)1 Publication

    Post-translational modificationi

    Heavily glycosylated.6 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiO75882.
    PaxDbiO75882.
    PRIDEiO75882.

    PTM databases

    PhosphoSiteiO75882.

    Expressioni

    Tissue specificityi

    Isoform 2 is detected in plasma (at protein level). Expressed and secreted by activated T-lymphocytes. Expressed at low to moderate levels in peripheral blood leukocytes, spleen, lymph node, tonsil, bone marrow and fetal liver. At very low levels found in thymus. Isoform 2 is the major isoform in peripheral blood leukocytes.2 Publications

    Inductioni

    Activation of peripheral blood leukocytes with phytohemagglutinin induces strong expression of the membrane isoform followed by the release of the secreted isoform.

    Gene expression databases

    BgeeiO75882.
    GenevestigatoriO75882.

    Organism-specific databases

    HPAiHPA008853.

    Interactioni

    Subunit structurei

    Monomer and homotrimer.1 Publication

    Protein-protein interaction databases

    BioGridi114033. 6 interactions.
    IntActiO75882. 6 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliO75882.
    SMRiO75882. Positions 101-322, 791-921, 1063-1151.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini84 – 12791196ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1301 – 1429129CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1280 – 130021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini101 – 12929EGF-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini132 – 248117CUBPROSITE-ProRule annotationAdd
    BLAST
    Repeati352 – 40251Kelch 1Add
    BLAST
    Repeati404 – 45148Kelch 2Add
    BLAST
    Repeati461 – 50848Kelch 3Add
    BLAST
    Repeati513 – 56452Kelch 4Add
    BLAST
    Repeati566 – 62459Kelch 5Add
    BLAST
    Repeati625 – 67147Kelch 6Add
    BLAST
    Domaini703 – 74846PSI 1Add
    BLAST
    Domaini755 – 79440PSI 2Add
    BLAST
    Domaini795 – 919125C-type lectinPROSITE-ProRule annotationAdd
    BLAST
    Domaini932 – 98352PSI 3Add
    BLAST
    Domaini986 – 106176PSI 4Add
    BLAST
    Domaini1063 – 110846Laminin EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1109 – 115749Laminin EGF-like 2PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi43 – 7735Leu-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C-type lectin domain.PROSITE-ProRule annotation
    Contains 1 CUB domain.PROSITE-ProRule annotation
    Contains 1 EGF-like domain.PROSITE-ProRule annotation
    Contains 6 Kelch repeats.Curated
    Contains 2 laminin EGF-like domains.PROSITE-ProRule annotation
    Contains 4 PSI domains.Curated

    Keywords - Domaini

    EGF-like domain, Kelch repeat, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG242225.
    HOVERGENiHBG004312.
    InParanoidiO75882.
    OMAiNPLKGTC.
    OrthoDBiEOG7D59MM.
    PhylomeDBiO75882.
    TreeFamiTF321873.

    Family and domain databases

    Gene3Di2.120.10.80. 1 hit.
    2.60.120.290. 1 hit.
    3.10.100.10. 1 hit.
    InterProiIPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    IPR000859. CUB_dom.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR002049. EGF_laminin.
    IPR011043. Gal_Oxase/kelch_b-propeller.
    IPR015915. Kelch-typ_b-propeller.
    IPR006652. Kelch_1.
    IPR016201. Plexin-like_fold.
    IPR002165. Plexin_repeat.
    [Graphical view]
    PfamiPF00431. CUB. 1 hit.
    PF01344. Kelch_1. 1 hit.
    PF00059. Lectin_C. 1 hit.
    PF01437. PSI. 1 hit.
    [Graphical view]
    SMARTiSM00034. CLECT. 1 hit.
    SM00042. CUB. 1 hit.
    SM00181. EGF. 2 hits.
    SM00180. EGF_Lam. 1 hit.
    SM00423. PSI. 5 hits.
    [Graphical view]
    SUPFAMiSSF49854. SSF49854. 1 hit.
    SSF50965. SSF50965. 1 hit.
    SSF56436. SSF56436. 1 hit.
    PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
    PS01180. CUB. 1 hit.
    PS00022. EGF_1. 3 hits.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 2 hits.
    PS01248. EGF_LAM_1. 1 hit.
    PS50027. EGF_LAM_2. 3 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O75882-1) [UniParc]FASTAAdd to Basket

    Also known as: Membrane

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVAAAAATEA RLRRRTAATA ALAGRSGGPH WDWDVTRAGR PGLGAGLRLP     50
    RLLSPPLRPR LLLLLLLLSP PLLLLLLPCE AEAAAAAAAV SGSAAAEAKE 100
    CDRPCVNGGR CNPGTGQCVC PAGWVGEQCQ HCGGRFRLTG SSGFVTDGPG 150
    NYKYKTKCTW LIEGQPNRIM RLRFNHFATE CSWDHLYVYD GDSIYAPLVA 200
    AFSGLIVPER DGNETVPEVV ATSGYALLHF FSDAAYNLTG FNITYSFDMC 250
    PNNCSGRGEC KISNSSDTVE CECSENWKGE ACDIPHCTDN CGFPHRGICN 300
    SSDVRGCSCF SDWQGPGCSV PVPANQSFWT REEYSNLKLP RASHKAVVNG 350
    NIMWVVGGYM FNHSDYNMVL AYDLASREWL PLNRSVNNVV VRYGHSLALY 400
    KDKIYMYGGK IDSTGNVTNE LRVFHIHNES WVLLTPKAKE QYAVVGHSAH 450
    IVTLKNGRVV MLVIFGHCPL YGYISNVQEY DLDKNTWSIL HTQGALVQGG 500
    YGHSSVYDHR TRALYVHGGY KAFSANKYRL ADDLYRYDVD TQMWTILKDS 550
    RFFRYLHTAV IVSGTMLVFG GNTHNDTSMS HGAKCFSSDF MAYDIACDRW 600
    SVLPRPDLHH DVNRFGHSAV LHNSTMYVFG GFNSLLLSDI LVFTSEQCDA 650
    HRSEAACLAA GPGIRCVWNT GSSQCISWAL ATDEQEEKLK SECFSKRTLD 700
    HDRCDQHTDC YSCTANTNDC HWCNDHCVPR NHSCSEGQIS IFRYENCPKD 750
    NPMYYCNKKT SCRSCALDQN CQWEPRNQEC IALPENICGI GWHLVGNSCL 800
    KITTAKENYD NAKLFCRNHN ALLASLTTQK KVEFVLKQLR IMQSSQSMSK 850
    LTLTPWVGLR KINVSYWCWE DMSPFTNSLL QWMPSEPSDA GFCGILSEPS 900
    TRGLKAATCI NPLNGSVCER PANHSAKQCR TPCALRTACG DCTSGSSECM 950
    WCSNMKQCVD SNAYVASFPF GQCMEWYTMS TCPPENCSGY CTCSHCLEQP 1000
    GCGWCTDPSN TGKGKCIEGS YKGPVKMPSQ APTGNFYPQP LLNSSMCLED 1050
    SRYNWSFIHC PACQCNGHSK CINQSICEKC ENLTTGKHCE TCISGFYGDP 1100
    TNGGKCQPCK CNGHASLCNT NTGKCFCTTK GVKGDECQLC EVENRYQGNP 1150
    LRGTCYYTLL IDYQFTFSLS QEDDRYYTAI NFVATPDEQN RDLDMFINAS 1200
    KNFNLNITWA ASFSAGTQAG EEMPVVSKTN IKEYKDSFSN EKFDFRNHPN 1250
    ITFFVYVSNF TWPIKIQIAF SQHSNFMDLV QFFVTFFSCF LSLLLVAAVV 1300
    WKIKQSCWAS RRREQLLREM QQMASRPFAS VNVALETDEE PPDLIGGSIK 1350
    TVPKPIALEP CFGNKAAVLS VFVRLPRGLG GIPPPGQSGL AVASALVDIS 1400
    QQMPIVYKEK SGAVRNRKQQ PPAQPGTCI 1429
    Length:1,429
    Mass (Da):158,537
    Last modified:April 27, 2001 - v2
    Checksum:i9F206A319B7E3DD8
    GO
    Isoform 2 (identifier: O75882-2) [UniParc]FASTAAdd to Basket

    Also known as: Secreted

    The sequence of this isoform differs from the canonical sequence as follows:
         1268-1429: IAFSQHSNFM...QPPAQPGTCI → VQTEQ

    Show »
    Length:1,272
    Mass (Da):141,429
    Checksum:iB2DD527761F6FCEE
    GO
    Isoform 3 (identifier: O75882-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         31-104: Missing.
         1268-1429: IAFSQHSNFM...QPPAQPGTCI → VQTEQ

    Note: No experimental confirmation available.

    Show »
    Length:1,198
    Mass (Da):133,702
    Checksum:i29173E6048FE995E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti69 – 691S → P in AAD03057. 1 PublicationCurated
    Sequence conflicti267 – 2671D → E in AAD03057. 1 PublicationCurated
    Sequence conflicti413 – 4131S → P in AAD03057. 1 PublicationCurated
    Sequence conflicti620 – 6201V → A in BAF85699. (PubMed:14702039)Curated
    Sequence conflicti704 – 7041C → G AA sequence (PubMed:7539799)Curated
    Sequence conflicti1172 – 11721E → K in AAF72881. (PubMed:10811918)Curated
    Sequence conflicti1172 – 11721E → K in AAF72882. (PubMed:10811918)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti303 – 3031D → A.
    Corresponds to variant rs6107308 [ dbSNP | Ensembl ].
    VAR_048967
    Natural varianti426 – 4261I → T.
    Corresponds to variant rs17782078 [ dbSNP | Ensembl ].
    VAR_048968
    Natural varianti1152 – 11521R → K.
    Corresponds to variant rs3886999 [ dbSNP | Ensembl ].
    VAR_048969
    Natural varianti1226 – 12261V → I.
    Corresponds to variant rs12329487 [ dbSNP | Ensembl ].
    VAR_048970

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei31 – 10474Missing in isoform 3. CuratedVSP_001372Add
    BLAST
    Alternative sequencei1268 – 1429162IAFSQ…PGTCI → VQTEQ in isoform 2 and isoform 3. 3 PublicationsVSP_001375Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF218915
    , AF218889, AF218890, AF218891, AF218892, AF218893, AF218894, AF218895, AF218896, AF218897, AF218898, AF218899, AF218900, AF218901, AF218902, AF218903, AF218904, AF218905, AF218906, AF218907, AF218908, AF218909, AF218911, AF218912, AF218913, AF218914 Genomic DNA. Translation: AAF72881.1.
    AF218910
    , AF218889, AF218890, AF218891, AF218892, AF218893, AF218894, AF218895, AF218896, AF218897, AF218898, AF218899, AF218900, AF218901, AF218902, AF218903, AF218904, AF218905, AF218906, AF218907, AF218908, AF218909 Genomic DNA. Translation: AAF72882.1.
    AF106861 mRNA. Translation: AAD03057.1.
    AK293010 mRNA. Translation: BAF85699.1.
    AL109805, AL132773, AL353193 Genomic DNA. Translation: CAI21876.1.
    AL109805, AL132773, AL353193 Genomic DNA. Translation: CAI21878.1.
    AL132773, AL109805, AL353193 Genomic DNA. Translation: CAI22614.1.
    AL132773, AL109805, AL353193 Genomic DNA. Translation: CAI22616.1.
    AL353193, AL109805, AL132773 Genomic DNA. Translation: CAH70471.1.
    AL353193, AL109805, AL132773 Genomic DNA. Translation: CAH70472.1.
    BC101705 mRNA. Translation: AAI01706.1.
    AB011120 mRNA. Translation: BAA25474.1.
    CCDSiCCDS13053.1. [O75882-1]
    CCDS13054.1. [O75882-2]
    RefSeqiNP_001193976.1. NM_001207047.1.
    NP_647537.1. NM_139321.2. [O75882-1]
    NP_647538.1. NM_139322.2. [O75882-2]
    UniGeneiHs.276252.

    Genome annotation databases

    EnsembliENST00000262919; ENSP00000262919; ENSG00000088812. [O75882-1]
    ENST00000446916; ENSP00000416587; ENSG00000088812. [O75882-2]
    GeneIDi8455.
    KEGGihsa:8455.
    UCSCiuc002wil.2. human. [O75882-2]
    uc002wim.2. human. [O75882-1]
    uc021vzz.1. human. [O75882-3]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - Glycan Binding

    Attractin-2

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF218915
    , AF218889 , AF218890 , AF218891 , AF218892 , AF218893 , AF218894 , AF218895 , AF218896 , AF218897 , AF218898 , AF218899 , AF218900 , AF218901 , AF218902 , AF218903 , AF218904 , AF218905 , AF218906 , AF218907 , AF218908 , AF218909 , AF218911 , AF218912 , AF218913 , AF218914 Genomic DNA. Translation: AAF72881.1 .
    AF218910
    , AF218889 , AF218890 , AF218891 , AF218892 , AF218893 , AF218894 , AF218895 , AF218896 , AF218897 , AF218898 , AF218899 , AF218900 , AF218901 , AF218902 , AF218903 , AF218904 , AF218905 , AF218906 , AF218907 , AF218908 , AF218909 Genomic DNA. Translation: AAF72882.1 .
    AF106861 mRNA. Translation: AAD03057.1 .
    AK293010 mRNA. Translation: BAF85699.1 .
    AL109805 , AL132773 , AL353193 Genomic DNA. Translation: CAI21876.1 .
    AL109805 , AL132773 , AL353193 Genomic DNA. Translation: CAI21878.1 .
    AL132773 , AL109805 , AL353193 Genomic DNA. Translation: CAI22614.1 .
    AL132773 , AL109805 , AL353193 Genomic DNA. Translation: CAI22616.1 .
    AL353193 , AL109805 , AL132773 Genomic DNA. Translation: CAH70471.1 .
    AL353193 , AL109805 , AL132773 Genomic DNA. Translation: CAH70472.1 .
    BC101705 mRNA. Translation: AAI01706.1 .
    AB011120 mRNA. Translation: BAA25474.1 .
    CCDSi CCDS13053.1. [O75882-1 ]
    CCDS13054.1. [O75882-2 ]
    RefSeqi NP_001193976.1. NM_001207047.1.
    NP_647537.1. NM_139321.2. [O75882-1 ]
    NP_647538.1. NM_139322.2. [O75882-2 ]
    UniGenei Hs.276252.

    3D structure databases

    ProteinModelPortali O75882.
    SMRi O75882. Positions 101-322, 791-921, 1063-1151.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114033. 6 interactions.
    IntActi O75882. 6 interactions.

    PTM databases

    PhosphoSitei O75882.

    Proteomic databases

    MaxQBi O75882.
    PaxDbi O75882.
    PRIDEi O75882.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262919 ; ENSP00000262919 ; ENSG00000088812 . [O75882-1 ]
    ENST00000446916 ; ENSP00000416587 ; ENSG00000088812 . [O75882-2 ]
    GeneIDi 8455.
    KEGGi hsa:8455.
    UCSCi uc002wil.2. human. [O75882-2 ]
    uc002wim.2. human. [O75882-1 ]
    uc021vzz.1. human. [O75882-3 ]

    Organism-specific databases

    CTDi 8455.
    GeneCardsi GC20P003451.
    HGNCi HGNC:885. ATRN.
    HPAi HPA008853.
    MIMi 603130. gene.
    neXtProti NX_O75882.
    PharmGKBi PA25178.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG242225.
    HOVERGENi HBG004312.
    InParanoidi O75882.
    OMAi NPLKGTC.
    OrthoDBi EOG7D59MM.
    PhylomeDBi O75882.
    TreeFami TF321873.

    Miscellaneous databases

    ChiTaRSi ATRN. human.
    GeneWikii ATRN.
    GenomeRNAii 8455.
    NextBioi 31642.
    PROi O75882.
    SOURCEi Search...

    Gene expression databases

    Bgeei O75882.
    Genevestigatori O75882.

    Family and domain databases

    Gene3Di 2.120.10.80. 1 hit.
    2.60.120.290. 1 hit.
    3.10.100.10. 1 hit.
    InterProi IPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    IPR000859. CUB_dom.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR002049. EGF_laminin.
    IPR011043. Gal_Oxase/kelch_b-propeller.
    IPR015915. Kelch-typ_b-propeller.
    IPR006652. Kelch_1.
    IPR016201. Plexin-like_fold.
    IPR002165. Plexin_repeat.
    [Graphical view ]
    Pfami PF00431. CUB. 1 hit.
    PF01344. Kelch_1. 1 hit.
    PF00059. Lectin_C. 1 hit.
    PF01437. PSI. 1 hit.
    [Graphical view ]
    SMARTi SM00034. CLECT. 1 hit.
    SM00042. CUB. 1 hit.
    SM00181. EGF. 2 hits.
    SM00180. EGF_Lam. 1 hit.
    SM00423. PSI. 5 hits.
    [Graphical view ]
    SUPFAMi SSF49854. SSF49854. 1 hit.
    SSF50965. SSF50965. 1 hit.
    SSF56436. SSF56436. 1 hit.
    PROSITEi PS50041. C_TYPE_LECTIN_2. 1 hit.
    PS01180. CUB. 1 hit.
    PS00022. EGF_1. 3 hits.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 2 hits.
    PS01248. EGF_LAM_1. 1 hit.
    PS50027. EGF_LAM_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Secreted and membrane attractin result from alternative splicing of the human ATRN gene."
      Tang W., Gunn T.M., McLaughlin D.F., Barsh G.S., Schlossman S.F., Duke-Cohan J.S.
      Proc. Natl. Acad. Sci. U.S.A. 97:6025-6030(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
    2. "Cloning of cDNA for attractin-2, identical with that of attractin except for a GC-rich 222 bp 5' insertion."
      Duke-Cohan J.S., Gu J., Freeman G.J., Schlossman S.F.
      Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Trachea.
    4. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    6. "A novel form of dipeptidylpeptidase IV found in human serum. Isolation, characterization, and comparison with T lymphocyte membrane dipeptidylpeptidase IV (CD26)."
      Duke-Cohan J.S., Morimoto C., Rocker J.A., Schlossman S.F.
      J. Biol. Chem. 270:14107-14114(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 138-153; 537-548 AND 704-723 (ISOFORMS 1/2/3), SUBCELLULAR LOCATION, GLYCOSYLATION, SUBUNIT.
      Tissue: Serum.
    7. "Attractin (DPPT-L), a member of the CUB family of cell adhesion and guidance proteins, is secreted by activated human T lymphocytes and modulates immune cell interactions."
      Duke-Cohan J.S., Gu J., McLaughlin D.F., Xu Y., Freeman G.J., Schlossman S.F.
      Proc. Natl. Acad. Sci. U.S.A. 95:11336-11341(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 138-153; 280-285; 355-376; 378-394; 405-411; 513-521; 538-547; 705-722; 735-755; 818-829; 851-860; 1145-1152; 1203-1213; 1243-1246 AND 1255-1272 (ISOFORM 2), FUNCTION, SUBCELLULAR LOCATION.
    8. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 978-1429 (ISOFORM 1).
      Tissue: Brain.
    9. Cited for: PROTEIN SEQUENCE OF N-TERMINUS, TISSUE SPECIFICITY, GLYCOSYLATION, IDENTIFICATION BY MASS SPECTROMETRY.
    10. "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
      Bunkenborg J., Pilch B.J., Podtelejnikov A.V., Wisniewski J.R.
      Proteomics 4:454-465(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-264; ASN-383 AND ASN-731.
      Tissue: Plasma.
    11. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-264; ASN-300; ASN-383; ASN-416; ASN-428; ASN-575; ASN-623; ASN-1043; ASN-1198; ASN-1250 AND ASN-1259.
      Tissue: Plasma.
    12. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-416.
      Tissue: Liver.
    13. Cited for: GLYCOSYLATION AT ASN-300; ASN-383; ASN-731 AND ASN-1073.

    Entry informationi

    Entry nameiATRN_HUMAN
    AccessioniPrimary (citable) accession number: O75882
    Secondary accession number(s): A8KAE5
    , O60295, O95414, Q3MIT3, Q5TDA2, Q5TDA4, Q5VYW3, Q9NTQ3, Q9NTQ4, Q9NU01, Q9NZ57, Q9NZ58, Q9UC75, Q9UDF5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: April 27, 2001
    Last modified: October 1, 2014
    This is version 145 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3