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Protein

Attractin

Gene

ATRN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system (By similarity).By similarity1 Publication

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB-KW
  • receptor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Inflammatory response

Keywords - Ligandi

Lectin

Enzyme and pathway databases

BioCyciZFISH:ENSG00000088812-MONOMER.
SIGNORiO75882.

Names & Taxonomyi

Protein namesi
Recommended name:
Attractin
Alternative name(s):
DPPT-L
Mahogany homolog
Gene namesi
Name:ATRN
Synonyms:KIAA0548, MGCA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:885. ATRN.

Subcellular locationi

Isoform 1 :
Isoform 2 :
Isoform 3 :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini84 – 1279ExtracellularSequence analysisAdd BLAST1196
Transmembranei1280 – 1300HelicalSequence analysisAdd BLAST21
Topological domaini1301 – 1429CytoplasmicSequence analysisAdd BLAST129

GO - Cellular componenti

  • cytoplasm Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi8455.
OpenTargetsiENSG00000088812.
PharmGKBiPA25178.

Polymorphism and mutation databases

BioMutaiATRN.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
PropeptideiPRO_000039477129 – 831 PublicationAdd BLAST55
ChainiPRO_000000748384 – 1429AttractinAdd BLAST1346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi101 ↔ 111By similarity
Disulfide bondi105 ↔ 118By similarity
Disulfide bondi120 ↔ 129By similarity
Glycosylationi213N-linked (GlcNAc...)Sequence analysis1
Glycosylationi237N-linked (GlcNAc...)Sequence analysis1
Glycosylationi242N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi250 ↔ 260By similarity
Glycosylationi253N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi254 ↔ 271By similarity
Glycosylationi264N-linked (GlcNAc...)2 Publications1
Disulfide bondi273 ↔ 282By similarity
Glycosylationi300N-linked (GlcNAc...) (complex)2 Publications1
Glycosylationi325N-linked (GlcNAc...)Sequence analysis1
Glycosylationi362N-linked (GlcNAc...)Sequence analysis1
Glycosylationi383N-linked (GlcNAc...) (complex)3 Publications1
Glycosylationi416N-linked (GlcNAc...)2 Publications1
Glycosylationi428N-linked (GlcNAc...)1 Publication1
Glycosylationi575N-linked (GlcNAc...)1 Publication1
Glycosylationi623N-linked (GlcNAc...)1 Publication1
Glycosylationi731N-linked (GlcNAc...) (complex)2 Publications1
Disulfide bondi816 ↔ 918By similarity
Glycosylationi863N-linked (GlcNAc...)Sequence analysis1
Glycosylationi914N-linked (GlcNAc...)Sequence analysis1
Glycosylationi923N-linked (GlcNAc...)Sequence analysis1
Glycosylationi986N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1043N-linked (GlcNAc...)1 Publication1
Glycosylationi1054N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1063 ↔ 1071By similarity
Disulfide bondi1065 ↔ 1077By similarity
Glycosylationi1073N-linked (GlcNAc...) (complex)1 Publication1
Disulfide bondi1080 ↔ 1089By similarity
Glycosylationi1082N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1092 ↔ 1106By similarity
Disulfide bondi1127 ↔ 1137By similarity
Disulfide bondi1140 ↔ 1155By similarity
Glycosylationi1198N-linked (GlcNAc...)1 Publication1
Glycosylationi1206N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1250N-linked (GlcNAc...)1 Publication1
Glycosylationi1259N-linked (GlcNAc...)1 Publication1

Post-translational modificationi

Heavily glycosylated.6 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiO75882.
MaxQBiO75882.
PaxDbiO75882.
PeptideAtlasiO75882.
PRIDEiO75882.

PTM databases

iPTMnetiO75882.
PhosphoSitePlusiO75882.
SwissPalmiO75882.
UniCarbKBiO75882.

Expressioni

Tissue specificityi

Isoform 2 is detected in plasma (at protein level). Expressed and secreted by activated T-lymphocytes. Expressed at low to moderate levels in peripheral blood leukocytes, spleen, lymph node, tonsil, bone marrow and fetal liver. At very low levels found in thymus. Isoform 2 is the major isoform in peripheral blood leukocytes.2 Publications

Inductioni

Activation of peripheral blood leukocytes with phytohemagglutinin induces strong expression of the membrane isoform followed by the release of the secreted isoform.

Gene expression databases

BgeeiENSG00000088812.
GenevisibleiO75882. HS.

Organism-specific databases

HPAiHPA008853.

Interactioni

Subunit structurei

Monomer and homotrimer.1 Publication

Protein-protein interaction databases

BioGridi114033. 7 interactors.
IntActiO75882. 7 interactors.
STRINGi9606.ENSP00000262919.

Structurei

3D structure databases

ProteinModelPortaliO75882.
SMRiO75882.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini101 – 129EGF-likePROSITE-ProRule annotationAdd BLAST29
Domaini132 – 248CUBPROSITE-ProRule annotationAdd BLAST117
Repeati352 – 402Kelch 1Add BLAST51
Repeati404 – 451Kelch 2Add BLAST48
Repeati461 – 508Kelch 3Add BLAST48
Repeati513 – 564Kelch 4Add BLAST52
Repeati566 – 624Kelch 5Add BLAST59
Repeati625 – 671Kelch 6Add BLAST47
Domaini703 – 748PSI 1Add BLAST46
Domaini755 – 794PSI 2Add BLAST40
Domaini795 – 919C-type lectinPROSITE-ProRule annotationAdd BLAST125
Domaini932 – 983PSI 3Add BLAST52
Domaini986 – 1061PSI 4Add BLAST76
Domaini1063 – 1108Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST46
Domaini1109 – 1157Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi43 – 77Leu-richAdd BLAST35

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation
Contains 1 CUB domain.PROSITE-ProRule annotation
Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated
Contains 2 laminin EGF-like domains.PROSITE-ProRule annotation
Contains 4 PSI domains.Curated

Keywords - Domaini

EGF-like domain, Kelch repeat, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1388. Eukaryota.
ENOG410XRW4. LUCA.
GeneTreeiENSGT00390000001118.
HOVERGENiHBG004312.
InParanoidiO75882.
OMAiDTGSSQC.
OrthoDBiEOG091G03A0.
PhylomeDBiO75882.
TreeFamiTF321873.

Family and domain databases

CDDicd00041. CUB. 1 hit.
Gene3Di2.120.10.80. 1 hit.
2.60.120.290. 1 hit.
3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
IPR000859. CUB_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR011043. Gal_Oxase/kelch_b-propeller.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR002049. Laminin_EGF.
IPR002165. Plexin_repeat.
IPR016201. PSI.
[Graphical view]
PfamiPF00431. CUB. 1 hit.
PF01344. Kelch_1. 2 hits.
PF00059. Lectin_C. 1 hit.
PF01437. PSI. 2 hits.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
SM00042. CUB. 1 hit.
SM00181. EGF. 2 hits.
SM00180. EGF_Lam. 2 hits.
SM00423. PSI. 5 hits.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
SSF50965. SSF50965. 1 hit.
SSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
PS01180. CUB. 1 hit.
PS00022. EGF_1. 3 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS01248. EGF_LAM_1. 1 hit.
PS50027. EGF_LAM_2. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75882-1) [UniParc]FASTAAdd to basket
Also known as: Membrane

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVAAAAATEA RLRRRTAATA ALAGRSGGPH WDWDVTRAGR PGLGAGLRLP
60 70 80 90 100
RLLSPPLRPR LLLLLLLLSP PLLLLLLPCE AEAAAAAAAV SGSAAAEAKE
110 120 130 140 150
CDRPCVNGGR CNPGTGQCVC PAGWVGEQCQ HCGGRFRLTG SSGFVTDGPG
160 170 180 190 200
NYKYKTKCTW LIEGQPNRIM RLRFNHFATE CSWDHLYVYD GDSIYAPLVA
210 220 230 240 250
AFSGLIVPER DGNETVPEVV ATSGYALLHF FSDAAYNLTG FNITYSFDMC
260 270 280 290 300
PNNCSGRGEC KISNSSDTVE CECSENWKGE ACDIPHCTDN CGFPHRGICN
310 320 330 340 350
SSDVRGCSCF SDWQGPGCSV PVPANQSFWT REEYSNLKLP RASHKAVVNG
360 370 380 390 400
NIMWVVGGYM FNHSDYNMVL AYDLASREWL PLNRSVNNVV VRYGHSLALY
410 420 430 440 450
KDKIYMYGGK IDSTGNVTNE LRVFHIHNES WVLLTPKAKE QYAVVGHSAH
460 470 480 490 500
IVTLKNGRVV MLVIFGHCPL YGYISNVQEY DLDKNTWSIL HTQGALVQGG
510 520 530 540 550
YGHSSVYDHR TRALYVHGGY KAFSANKYRL ADDLYRYDVD TQMWTILKDS
560 570 580 590 600
RFFRYLHTAV IVSGTMLVFG GNTHNDTSMS HGAKCFSSDF MAYDIACDRW
610 620 630 640 650
SVLPRPDLHH DVNRFGHSAV LHNSTMYVFG GFNSLLLSDI LVFTSEQCDA
660 670 680 690 700
HRSEAACLAA GPGIRCVWNT GSSQCISWAL ATDEQEEKLK SECFSKRTLD
710 720 730 740 750
HDRCDQHTDC YSCTANTNDC HWCNDHCVPR NHSCSEGQIS IFRYENCPKD
760 770 780 790 800
NPMYYCNKKT SCRSCALDQN CQWEPRNQEC IALPENICGI GWHLVGNSCL
810 820 830 840 850
KITTAKENYD NAKLFCRNHN ALLASLTTQK KVEFVLKQLR IMQSSQSMSK
860 870 880 890 900
LTLTPWVGLR KINVSYWCWE DMSPFTNSLL QWMPSEPSDA GFCGILSEPS
910 920 930 940 950
TRGLKAATCI NPLNGSVCER PANHSAKQCR TPCALRTACG DCTSGSSECM
960 970 980 990 1000
WCSNMKQCVD SNAYVASFPF GQCMEWYTMS TCPPENCSGY CTCSHCLEQP
1010 1020 1030 1040 1050
GCGWCTDPSN TGKGKCIEGS YKGPVKMPSQ APTGNFYPQP LLNSSMCLED
1060 1070 1080 1090 1100
SRYNWSFIHC PACQCNGHSK CINQSICEKC ENLTTGKHCE TCISGFYGDP
1110 1120 1130 1140 1150
TNGGKCQPCK CNGHASLCNT NTGKCFCTTK GVKGDECQLC EVENRYQGNP
1160 1170 1180 1190 1200
LRGTCYYTLL IDYQFTFSLS QEDDRYYTAI NFVATPDEQN RDLDMFINAS
1210 1220 1230 1240 1250
KNFNLNITWA ASFSAGTQAG EEMPVVSKTN IKEYKDSFSN EKFDFRNHPN
1260 1270 1280 1290 1300
ITFFVYVSNF TWPIKIQIAF SQHSNFMDLV QFFVTFFSCF LSLLLVAAVV
1310 1320 1330 1340 1350
WKIKQSCWAS RRREQLLREM QQMASRPFAS VNVALETDEE PPDLIGGSIK
1360 1370 1380 1390 1400
TVPKPIALEP CFGNKAAVLS VFVRLPRGLG GIPPPGQSGL AVASALVDIS
1410 1420
QQMPIVYKEK SGAVRNRKQQ PPAQPGTCI
Length:1,429
Mass (Da):158,537
Last modified:April 27, 2001 - v2
Checksum:i9F206A319B7E3DD8
GO
Isoform 2 (identifier: O75882-2) [UniParc]FASTAAdd to basket
Also known as: Secreted

The sequence of this isoform differs from the canonical sequence as follows:
     1268-1429: IAFSQHSNFM...QPPAQPGTCI → VQTEQ

Show »
Length:1,272
Mass (Da):141,429
Checksum:iB2DD527761F6FCEE
GO
Isoform 3 (identifier: O75882-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-104: Missing.
     1268-1429: IAFSQHSNFM...QPPAQPGTCI → VQTEQ

Note: No experimental confirmation available.
Show »
Length:1,198
Mass (Da):133,702
Checksum:i29173E6048FE995E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69S → P in AAD03057 (Ref. 2) Curated1
Sequence conflicti267D → E in AAD03057 (Ref. 2) Curated1
Sequence conflicti413S → P in AAD03057 (Ref. 2) Curated1
Sequence conflicti620V → A in BAF85699 (PubMed:14702039).Curated1
Sequence conflicti704C → G AA sequence (PubMed:7539799).Curated1
Sequence conflicti1172E → K in AAF72881 (PubMed:10811918).Curated1
Sequence conflicti1172E → K in AAF72882 (PubMed:10811918).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048967303D → A.Corresponds to variant rs6107308dbSNPEnsembl.1
Natural variantiVAR_048968426I → T.Corresponds to variant rs17782078dbSNPEnsembl.1
Natural variantiVAR_0489691152R → K.Corresponds to variant rs3886999dbSNPEnsembl.1
Natural variantiVAR_0489701226V → I.Corresponds to variant rs12329487dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00137231 – 104Missing in isoform 3. CuratedAdd BLAST74
Alternative sequenceiVSP_0013751268 – 1429IAFSQ…PGTCI → VQTEQ in isoform 2 and isoform 3. 3 PublicationsAdd BLAST162

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF218915
, AF218889, AF218890, AF218891, AF218892, AF218893, AF218894, AF218895, AF218896, AF218897, AF218898, AF218899, AF218900, AF218901, AF218902, AF218903, AF218904, AF218905, AF218906, AF218907, AF218908, AF218909, AF218911, AF218912, AF218913, AF218914 Genomic DNA. Translation: AAF72881.1.
AF218910
, AF218889, AF218890, AF218891, AF218892, AF218893, AF218894, AF218895, AF218896, AF218897, AF218898, AF218899, AF218900, AF218901, AF218902, AF218903, AF218904, AF218905, AF218906, AF218907, AF218908, AF218909 Genomic DNA. Translation: AAF72882.1.
AF106861 mRNA. Translation: AAD03057.1.
AK293010 mRNA. Translation: BAF85699.1.
AL109805, AL132773, AL353193 Genomic DNA. Translation: CAI21876.1.
AL109805, AL132773, AL353193 Genomic DNA. Translation: CAI21878.1.
AL132773, AL109805, AL353193 Genomic DNA. Translation: CAI22614.1.
AL132773, AL109805, AL353193 Genomic DNA. Translation: CAI22616.1.
AL353193, AL109805, AL132773 Genomic DNA. Translation: CAH70471.1.
AL353193, AL109805, AL132773 Genomic DNA. Translation: CAH70472.1.
BC101705 mRNA. Translation: AAI01706.1.
AB011120 mRNA. Translation: BAA25474.1.
CCDSiCCDS13053.1. [O75882-1]
CCDS13054.1. [O75882-2]
RefSeqiNP_001193976.1. NM_001207047.2.
NP_001310261.1. NM_001323332.1.
NP_647537.1. NM_139321.2. [O75882-1]
NP_647538.1. NM_139322.3. [O75882-2]
UniGeneiHs.276252.

Genome annotation databases

EnsembliENST00000262919; ENSP00000262919; ENSG00000088812. [O75882-1]
ENST00000446916; ENSP00000416587; ENSG00000088812. [O75882-2]
GeneIDi8455.
KEGGihsa:8455.
UCSCiuc002wil.3. human. [O75882-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Attractin-2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF218915
, AF218889, AF218890, AF218891, AF218892, AF218893, AF218894, AF218895, AF218896, AF218897, AF218898, AF218899, AF218900, AF218901, AF218902, AF218903, AF218904, AF218905, AF218906, AF218907, AF218908, AF218909, AF218911, AF218912, AF218913, AF218914 Genomic DNA. Translation: AAF72881.1.
AF218910
, AF218889, AF218890, AF218891, AF218892, AF218893, AF218894, AF218895, AF218896, AF218897, AF218898, AF218899, AF218900, AF218901, AF218902, AF218903, AF218904, AF218905, AF218906, AF218907, AF218908, AF218909 Genomic DNA. Translation: AAF72882.1.
AF106861 mRNA. Translation: AAD03057.1.
AK293010 mRNA. Translation: BAF85699.1.
AL109805, AL132773, AL353193 Genomic DNA. Translation: CAI21876.1.
AL109805, AL132773, AL353193 Genomic DNA. Translation: CAI21878.1.
AL132773, AL109805, AL353193 Genomic DNA. Translation: CAI22614.1.
AL132773, AL109805, AL353193 Genomic DNA. Translation: CAI22616.1.
AL353193, AL109805, AL132773 Genomic DNA. Translation: CAH70471.1.
AL353193, AL109805, AL132773 Genomic DNA. Translation: CAH70472.1.
BC101705 mRNA. Translation: AAI01706.1.
AB011120 mRNA. Translation: BAA25474.1.
CCDSiCCDS13053.1. [O75882-1]
CCDS13054.1. [O75882-2]
RefSeqiNP_001193976.1. NM_001207047.2.
NP_001310261.1. NM_001323332.1.
NP_647537.1. NM_139321.2. [O75882-1]
NP_647538.1. NM_139322.3. [O75882-2]
UniGeneiHs.276252.

3D structure databases

ProteinModelPortaliO75882.
SMRiO75882.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114033. 7 interactors.
IntActiO75882. 7 interactors.
STRINGi9606.ENSP00000262919.

PTM databases

iPTMnetiO75882.
PhosphoSitePlusiO75882.
SwissPalmiO75882.
UniCarbKBiO75882.

Polymorphism and mutation databases

BioMutaiATRN.

Proteomic databases

EPDiO75882.
MaxQBiO75882.
PaxDbiO75882.
PeptideAtlasiO75882.
PRIDEiO75882.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262919; ENSP00000262919; ENSG00000088812. [O75882-1]
ENST00000446916; ENSP00000416587; ENSG00000088812. [O75882-2]
GeneIDi8455.
KEGGihsa:8455.
UCSCiuc002wil.3. human. [O75882-1]

Organism-specific databases

CTDi8455.
DisGeNETi8455.
GeneCardsiATRN.
HGNCiHGNC:885. ATRN.
HPAiHPA008853.
MIMi603130. gene.
neXtProtiNX_O75882.
OpenTargetsiENSG00000088812.
PharmGKBiPA25178.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1388. Eukaryota.
ENOG410XRW4. LUCA.
GeneTreeiENSGT00390000001118.
HOVERGENiHBG004312.
InParanoidiO75882.
OMAiDTGSSQC.
OrthoDBiEOG091G03A0.
PhylomeDBiO75882.
TreeFamiTF321873.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000088812-MONOMER.
SIGNORiO75882.

Miscellaneous databases

ChiTaRSiATRN. human.
GeneWikiiATRN.
GenomeRNAii8455.
PROiO75882.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000088812.
GenevisibleiO75882. HS.

Family and domain databases

CDDicd00041. CUB. 1 hit.
Gene3Di2.120.10.80. 1 hit.
2.60.120.290. 1 hit.
3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
IPR000859. CUB_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR011043. Gal_Oxase/kelch_b-propeller.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR002049. Laminin_EGF.
IPR002165. Plexin_repeat.
IPR016201. PSI.
[Graphical view]
PfamiPF00431. CUB. 1 hit.
PF01344. Kelch_1. 2 hits.
PF00059. Lectin_C. 1 hit.
PF01437. PSI. 2 hits.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
SM00042. CUB. 1 hit.
SM00181. EGF. 2 hits.
SM00180. EGF_Lam. 2 hits.
SM00423. PSI. 5 hits.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
SSF50965. SSF50965. 1 hit.
SSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
PS01180. CUB. 1 hit.
PS00022. EGF_1. 3 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS01248. EGF_LAM_1. 1 hit.
PS50027. EGF_LAM_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATRN_HUMAN
AccessioniPrimary (citable) accession number: O75882
Secondary accession number(s): A8KAE5
, O60295, O95414, Q3MIT3, Q5TDA2, Q5TDA4, Q5VYW3, Q9NTQ3, Q9NTQ4, Q9NU01, Q9NZ57, Q9NZ58, Q9UC75, Q9UDF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: November 30, 2016
This is version 166 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was originally (PubMed:7539799 and PubMed:9736737) thought to have dipeptidase activity but it was shown later to lack that activity.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.