Reviewed, UniProtKB/Swiss-Prot O75882 (ATRN_HUMAN)

Names and origin

Protein names

Recommended name:
    Attractin
Alternative name(s):
    Mahogany homolog
    DPPT-L

Gene names

Name:	ATRN
Synonyms:	KIAA0548, MGCA

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1429 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti By similarity. Has a critical role in normal myelination in the central nervous system By similarity.
Subcellular location	Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Isoform 3: Secreted.
Tissue specificity	Expressed and secreted by activated T lymphocytes. Expressed at low to moderate levels in peripheral blood leukocytes, spleen, lymph node, tonsil, bone marrow and fetal liver. At very low levels found in thymus. Isoform 2 is the major isoform in peripheral blood leukocytes. Ref.1
Induction	Activation of peripheral blood leukocytes with phytohemagglutinin induces strong expression of the membrane isoform followed by the release of the secreted isoform.
Sequence similarities	Contains 1 C-type lectin domain. Contains 1 CUB domain. Contains 1 EGF-like domain. Contains 6 Kelch repeats. Contains 2 laminin EGF-like domains.

Ontologies

Keywords
Biological process	Inflammatory response
Cellular component	Cell membrane Membrane Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	EGF-like domain Kelch repeat Laminin EGF-like domain Repeat Signal Transmembrane
Ligand	Lectin
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	inflammatory response Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular space Ref.7 Traceable author statement. Source: ProtInc integral to plasma membrane Traceable author statement. Source: ProtInc
Molecular function	receptor activity Traceable author statement. Source: ProtInc sugar binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O75882-1)

Also known as: Membrane;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O75882-2)

Also known as: Secreted;

The sequence of this isoform differs from the canonical sequence as follows:
     1268-1429: IAFSQHSNFM...QPPAQPGTCI → VQTEQ

Isoform 3 (identifier: O75882-3)

The sequence of this isoform differs from the canonical sequence as follows:
     31-104: Missing.
     1268-1429: IAFSQHSNFM...QPPAQPGTCI → VQTEQ

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 15	15	Potential
	Chain	16 – 1429	1414	Attractin		PRO_0000007483
Regions
	Topological domain	16 – 1279	1264	Extracellular Potential
	Transmembrane	1280 – 1300	21	Potential
	Topological domain	1301 – 1429	129	Cytoplasmic Potential
	Domain	101 – 129	29	EGF-like
	Domain	132 – 248	117	CUB
	Repeat	352 – 402	51	Kelch 1
	Repeat	404 – 451	48	Kelch 2
	Repeat	461 – 508	48	Kelch 3
	Repeat	513 – 564	52	Kelch 4
	Repeat	566 – 624	59	Kelch 5
	Repeat	625 – 671	47	Kelch 6
	Domain	795 – 919	125	C-type lectin
	Domain	1063 – 1108	46	Laminin EGF-like 1
	Domain	1109 – 1157	49	Laminin EGF-like 2
	Compositional bias	43 – 77	35	Leu-rich
	Compositional bias	81 – 89	9	Poly-Ala
Amino acid modifications
	Glycosylation	213	1	N-linked (GlcNAc...) Potential
	Glycosylation	237	1	N-linked (GlcNAc...) Potential
	Glycosylation	242	1	N-linked (GlcNAc...) Potential
	Glycosylation	253	1	N-linked (GlcNAc...) Potential
	Glycosylation	264	1	N-linked (GlcNAc...) Ref.9 Ref.10
	Glycosylation	300	1	N-linked (GlcNAc...) Ref.10
	Glycosylation	325	1	N-linked (GlcNAc...) Potential
	Glycosylation	362	1	N-linked (GlcNAc...) Potential
	Glycosylation	383	1	N-linked (GlcNAc...) Ref.9 Ref.10
	Glycosylation	416	1	N-linked (GlcNAc...) Ref.10 Ref.11
	Glycosylation	428	1	N-linked (GlcNAc...) Ref.10
	Glycosylation	575	1	N-linked (GlcNAc...) Ref.10
	Glycosylation	623	1	N-linked (GlcNAc...) Ref.10
	Glycosylation	731	1	N-linked (GlcNAc...) Ref.9
	Glycosylation	863	1	N-linked (GlcNAc...) Potential
	Glycosylation	914	1	N-linked (GlcNAc...) Potential
	Glycosylation	923	1	N-linked (GlcNAc...) Potential
	Glycosylation	986	1	N-linked (GlcNAc...) Potential
	Glycosylation	1043	1	N-linked (GlcNAc...) Ref.10
	Glycosylation	1054	1	N-linked (GlcNAc...) Potential
	Glycosylation	1073	1	N-linked (GlcNAc...) Potential
	Glycosylation	1082	1	N-linked (GlcNAc...) Potential
	Glycosylation	1198	1	N-linked (GlcNAc...) Ref.10
	Glycosylation	1206	1	N-linked (GlcNAc...) Potential
	Glycosylation	1250	1	N-linked (GlcNAc...) Ref.10
	Glycosylation	1259	1	N-linked (GlcNAc...) Ref.10
	Disulfide bond	101 ↔ 111		By similarity
	Disulfide bond	105 ↔ 118		By similarity
	Disulfide bond	120 ↔ 129		By similarity
	Disulfide bond	250 ↔ 260		By similarity
	Disulfide bond	254 ↔ 271		By similarity
	Disulfide bond	273 ↔ 282		By similarity
	Disulfide bond	816 ↔ 918		By similarity
	Disulfide bond	1063 ↔ 1071		By similarity
	Disulfide bond	1065 ↔ 1077		By similarity
	Disulfide bond	1080 ↔ 1089		By similarity
	Disulfide bond	1092 ↔ 1106		By similarity
	Disulfide bond	1127 ↔ 1137		By similarity
	Disulfide bond	1140 ↔ 1155		By similarity
Natural variations
	Alternative sequence	31 – 104	74	Missing in isoform 3.		VSP_001372
	Alternative sequence	1268 – 1429	162	IAFSQ…PGTCI → VQTEQ in isoform 2 and isoform 3.		VSP_001375
	Natural variant	303	1	D → A: dbSNP rs6107308.		VAR_048967
	Natural variant	426	1	I → T: dbSNP rs17782078.		VAR_048968
	Natural variant	1152	1	R → K: dbSNP rs3886999.		VAR_048969
	Natural variant	1226	1	V → I: dbSNP rs12329487.		VAR_048970
Experimental info
	Sequence conflict	69	1	S → P in AAD03057. Ref.2
	Sequence conflict	267	1	D → E in AAD03057. Ref.2
	Sequence conflict	413	1	S → P in AAD03057. Ref.2
	Sequence conflict	620	1	V → A in BAF85699. Ref.3
	Sequence conflict	704	1	C → G AA sequence Ref.6
	Sequence conflict	1172	1	E → K in AAF72881. Ref.1
	Sequence conflict	1172	1	E → K in AAF72882. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Membrane) [UniParc]. Last modified April 27, 2001. Version 2. Checksum: 9F206A319B7E3DD8	FASTA	1,429	158,537
	10 20 30 40 50 60 MVAAAAATEA RLRRRTAATA ALAGRSGGPH WDWDVTRAGR PGLGAGLRLP RLLSPPLRPR 70 80 90 100 110 120 LLLLLLLLSP PLLLLLLPCE AEAAAAAAAV SGSAAAEAKE CDRPCVNGGR CNPGTGQCVC 130 140 150 160 170 180 PAGWVGEQCQ HCGGRFRLTG SSGFVTDGPG NYKYKTKCTW LIEGQPNRIM RLRFNHFATE 190 200 210 220 230 240 CSWDHLYVYD GDSIYAPLVA AFSGLIVPER DGNETVPEVV ATSGYALLHF FSDAAYNLTG 250 260 270 280 290 300 FNITYSFDMC PNNCSGRGEC KISNSSDTVE CECSENWKGE ACDIPHCTDN CGFPHRGICN 310 320 330 340 350 360 SSDVRGCSCF SDWQGPGCSV PVPANQSFWT REEYSNLKLP RASHKAVVNG NIMWVVGGYM 370 380 390 400 410 420 FNHSDYNMVL AYDLASREWL PLNRSVNNVV VRYGHSLALY KDKIYMYGGK IDSTGNVTNE 430 440 450 460 470 480 LRVFHIHNES WVLLTPKAKE QYAVVGHSAH IVTLKNGRVV MLVIFGHCPL YGYISNVQEY 490 500 510 520 530 540 DLDKNTWSIL HTQGALVQGG YGHSSVYDHR TRALYVHGGY KAFSANKYRL ADDLYRYDVD 550 560 570 580 590 600 TQMWTILKDS RFFRYLHTAV IVSGTMLVFG GNTHNDTSMS HGAKCFSSDF MAYDIACDRW 610 620 630 640 650 660 SVLPRPDLHH DVNRFGHSAV LHNSTMYVFG GFNSLLLSDI LVFTSEQCDA HRSEAACLAA 670 680 690 700 710 720 GPGIRCVWNT GSSQCISWAL ATDEQEEKLK SECFSKRTLD HDRCDQHTDC YSCTANTNDC 730 740 750 760 770 780 HWCNDHCVPR NHSCSEGQIS IFRYENCPKD NPMYYCNKKT SCRSCALDQN CQWEPRNQEC 790 800 810 820 830 840 IALPENICGI GWHLVGNSCL KITTAKENYD NAKLFCRNHN ALLASLTTQK KVEFVLKQLR 850 860 870 880 890 900 IMQSSQSMSK LTLTPWVGLR KINVSYWCWE DMSPFTNSLL QWMPSEPSDA GFCGILSEPS 910 920 930 940 950 960 TRGLKAATCI NPLNGSVCER PANHSAKQCR TPCALRTACG DCTSGSSECM WCSNMKQCVD 970 980 990 1000 1010 1020 SNAYVASFPF GQCMEWYTMS TCPPENCSGY CTCSHCLEQP GCGWCTDPSN TGKGKCIEGS 1030 1040 1050 1060 1070 1080 YKGPVKMPSQ APTGNFYPQP LLNSSMCLED SRYNWSFIHC PACQCNGHSK CINQSICEKC 1090 1100 1110 1120 1130 1140 ENLTTGKHCE TCISGFYGDP TNGGKCQPCK CNGHASLCNT NTGKCFCTTK GVKGDECQLC 1150 1160 1170 1180 1190 1200 EVENRYQGNP LRGTCYYTLL IDYQFTFSLS QEDDRYYTAI NFVATPDEQN RDLDMFINAS 1210 1220 1230 1240 1250 1260 KNFNLNITWA ASFSAGTQAG EEMPVVSKTN IKEYKDSFSN EKFDFRNHPN ITFFVYVSNF 1270 1280 1290 1300 1310 1320 TWPIKIQIAF SQHSNFMDLV QFFVTFFSCF LSLLLVAAVV WKIKQSCWAS RRREQLLREM 1330 1340 1350 1360 1370 1380 QQMASRPFAS VNVALETDEE PPDLIGGSIK TVPKPIALEP CFGNKAAVLS VFVRLPRGLG 1390 1400 1410 1420 GIPPPGQSGL AVASALVDIS QQMPIVYKEK SGAVRNRKQQ PPAQPGTCI
	Isoform 2 (Secreted). Checksum: B2DD527761F6FCEE	FASTA	1,272	141,429
	10 20 30 40 50 60 MVAAAAATEA RLRRRTAATA ALAGRSGGPH WDWDVTRAGR PGLGAGLRLP RLLSPPLRPR 70 80 90 100 110 120 LLLLLLLLSP PLLLLLLPCE AEAAAAAAAV SGSAAAEAKE CDRPCVNGGR CNPGTGQCVC 130 140 150 160 170 180 PAGWVGEQCQ HCGGRFRLTG SSGFVTDGPG NYKYKTKCTW LIEGQPNRIM RLRFNHFATE 190 200 210 220 230 240 CSWDHLYVYD GDSIYAPLVA AFSGLIVPER DGNETVPEVV ATSGYALLHF FSDAAYNLTG 250 260 270 280 290 300 FNITYSFDMC PNNCSGRGEC KISNSSDTVE CECSENWKGE ACDIPHCTDN CGFPHRGICN 310 320 330 340 350 360 SSDVRGCSCF SDWQGPGCSV PVPANQSFWT REEYSNLKLP RASHKAVVNG NIMWVVGGYM 370 380 390 400 410 420 FNHSDYNMVL AYDLASREWL PLNRSVNNVV VRYGHSLALY KDKIYMYGGK IDSTGNVTNE 430 440 450 460 470 480 LRVFHIHNES WVLLTPKAKE QYAVVGHSAH IVTLKNGRVV MLVIFGHCPL YGYISNVQEY 490 500 510 520 530 540 DLDKNTWSIL HTQGALVQGG YGHSSVYDHR TRALYVHGGY KAFSANKYRL ADDLYRYDVD 550 560 570 580 590 600 TQMWTILKDS RFFRYLHTAV IVSGTMLVFG GNTHNDTSMS HGAKCFSSDF MAYDIACDRW 610 620 630 640 650 660 SVLPRPDLHH DVNRFGHSAV LHNSTMYVFG GFNSLLLSDI LVFTSEQCDA HRSEAACLAA 670 680 690 700 710 720 GPGIRCVWNT GSSQCISWAL ATDEQEEKLK SECFSKRTLD HDRCDQHTDC YSCTANTNDC 730 740 750 760 770 780 HWCNDHCVPR NHSCSEGQIS IFRYENCPKD NPMYYCNKKT SCRSCALDQN CQWEPRNQEC 790 800 810 820 830 840 IALPENICGI GWHLVGNSCL KITTAKENYD NAKLFCRNHN ALLASLTTQK KVEFVLKQLR 850 860 870 880 890 900 IMQSSQSMSK LTLTPWVGLR KINVSYWCWE DMSPFTNSLL QWMPSEPSDA GFCGILSEPS 910 920 930 940 950 960 TRGLKAATCI NPLNGSVCER PANHSAKQCR TPCALRTACG DCTSGSSECM WCSNMKQCVD 970 980 990 1000 1010 1020 SNAYVASFPF GQCMEWYTMS TCPPENCSGY CTCSHCLEQP GCGWCTDPSN TGKGKCIEGS 1030 1040 1050 1060 1070 1080 YKGPVKMPSQ APTGNFYPQP LLNSSMCLED SRYNWSFIHC PACQCNGHSK CINQSICEKC 1090 1100 1110 1120 1130 1140 ENLTTGKHCE TCISGFYGDP TNGGKCQPCK CNGHASLCNT NTGKCFCTTK GVKGDECQLC 1150 1160 1170 1180 1190 1200 EVENRYQGNP LRGTCYYTLL IDYQFTFSLS QEDDRYYTAI NFVATPDEQN RDLDMFINAS 1210 1220 1230 1240 1250 1260 KNFNLNITWA ASFSAGTQAG EEMPVVSKTN IKEYKDSFSN EKFDFRNHPN ITFFVYVSNF 1270 TWPIKIQVQT EQ
	Isoform 3. Checksum: 29173E6048FE995E	FASTA	1,198	133,702
	10 20 30 40 50 60 MVAAAAATEA RLRRRTAATA ALAGRSGGPH CVNGGRCNPG TGQCVCPAGW VGEQCQHCGG 70 80 90 100 110 120 RFRLTGSSGF VTDGPGNYKY KTKCTWLIEG QPNRIMRLRF NHFATECSWD HLYVYDGDSI 130 140 150 160 170 180 YAPLVAAFSG LIVPERDGNE TVPEVVATSG YALLHFFSDA AYNLTGFNIT YSFDMCPNNC 190 200 210 220 230 240 SGRGECKISN SSDTVECECS ENWKGEACDI PHCTDNCGFP HRGICNSSDV RGCSCFSDWQ 250 260 270 280 290 300 GPGCSVPVPA NQSFWTREEY SNLKLPRASH KAVVNGNIMW VVGGYMFNHS DYNMVLAYDL 310 320 330 340 350 360 ASREWLPLNR SVNNVVVRYG HSLALYKDKI YMYGGKIDST GNVTNELRVF HIHNESWVLL 370 380 390 400 410 420 TPKAKEQYAV VGHSAHIVTL KNGRVVMLVI FGHCPLYGYI SNVQEYDLDK NTWSILHTQG 430 440 450 460 470 480 ALVQGGYGHS SVYDHRTRAL YVHGGYKAFS ANKYRLADDL YRYDVDTQMW TILKDSRFFR 490 500 510 520 530 540 YLHTAVIVSG TMLVFGGNTH NDTSMSHGAK CFSSDFMAYD IACDRWSVLP RPDLHHDVNR 550 560 570 580 590 600 FGHSAVLHNS TMYVFGGFNS LLLSDILVFT SEQCDAHRSE AACLAAGPGI RCVWNTGSSQ 610 620 630 640 650 660 CISWALATDE QEEKLKSECF SKRTLDHDRC DQHTDCYSCT ANTNDCHWCN DHCVPRNHSC 670 680 690 700 710 720 SEGQISIFRY ENCPKDNPMY YCNKKTSCRS CALDQNCQWE PRNQECIALP ENICGIGWHL 730 740 750 760 770 780 VGNSCLKITT AKENYDNAKL FCRNHNALLA SLTTQKKVEF VLKQLRIMQS SQSMSKLTLT 790 800 810 820 830 840 PWVGLRKINV SYWCWEDMSP FTNSLLQWMP SEPSDAGFCG ILSEPSTRGL KAATCINPLN 850 860 870 880 890 900 GSVCERPANH SAKQCRTPCA LRTACGDCTS GSSECMWCSN MKQCVDSNAY VASFPFGQCM 910 920 930 940 950 960 EWYTMSTCPP ENCSGYCTCS HCLEQPGCGW CTDPSNTGKG KCIEGSYKGP VKMPSQAPTG 970 980 990 1000 1010 1020 NFYPQPLLNS SMCLEDSRYN WSFIHCPACQ CNGHSKCINQ SICEKCENLT TGKHCETCIS 1030 1040 1050 1060 1070 1080 GFYGDPTNGG KCQPCKCNGH ASLCNTNTGK CFCTTKGVKG DECQLCEVEN RYQGNPLRGT 1090 1100 1110 1120 1130 1140 CYYTLLIDYQ FTFSLSQEDD RYYTAINFVA TPDEQNRDLD MFINASKNFN LNITWAASFS 1150 1160 1170 1180 1190 AGTQAGEEMP VVSKTNIKEY KDSFSNEKFD FRNHPNITFF VYVSNFTWPI KIQVQTEQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Secreted and membrane attractin result from alternative splicing of the human ATRN gene." Tang W., Gunn T.M., McLaughlin D.F., Barsh G.S., Schlossman S.F., Duke-Cohan J.S. Proc. Natl. Acad. Sci. U.S.A. 97:6025-6030(2000) [PubMed: 10811918] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
[2]	"Cloning of cDNA for attractin-2, identical with that of attractin except for a GC-rich 222 bp 5' insertion." Duke-Cohan J.S., Gu J., Freeman G.J., Schlossman S.F. Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Trachea.
[4]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[6]	"A novel form of dipeptidylpeptidase IV found in human serum. Isolation, characterization, and comparison with T lymphocyte membrane dipeptidylpeptidase IV (CD26)." Duke-Cohan J.S., Morimoto C., Rocker J.A., Schlossman S.F. J. Biol. Chem. 270:14107-14114(1995) [PubMed: 7539799] [Abstract] Cited for: PROTEIN SEQUENCE OF 138-153; 537-548 AND 704-723 (ISOFORMS 1/2/3). Tissue: Serum.
[7]	"Attractin (DPPT-L), a member of the CUB family of cell adhesion and guidance proteins, is secreted by activated human T lymphocytes and modulates immune cell interactions." Duke-Cohan J.S., Gu J., McLaughlin D.F., Xu Y., Freeman G.J., Schlossman S.F. Proc. Natl. Acad. Sci. U.S.A. 95:11336-11341(1998) [PubMed: 9736737] [Abstract] Cited for: PROTEIN SEQUENCE OF 138-153; 280-285; 355-376; 378-394; 405-411; 513-521; 538-547; 705-722; 735-755; 818-829; 851-860; 1145-1152; 1203-1213; 1243-1246 AND 1255-1272 (ISOFORM 2).
[8]	"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:31-39(1998) [PubMed: 9628581] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 978-1429 (ISOFORM 1). Tissue: Brain.
[9]	"Screening for N-glycosylated proteins by liquid chromatography mass spectrometry." Bunkenborg J., Pilch B.J., Podtelejnikov A.V., Wisniewski J.R. Proteomics 4:454-465(2004) [PubMed: 14760718] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-264; ASN-383 AND ASN-731, MASS SPECTROMETRY. Tissue: Plasma.
[10]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed: 16335952] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-264; ASN-300; ASN-383; ASN-416; ASN-428; ASN-575; ASN-623; ASN-1043; ASN-1198; ASN-1250 AND ASN-1259, MASS SPECTROMETRY. Tissue: Plasma.
[11]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-416, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Web resources

Functional Glycomics Gateway - Glycan Binding

Attractin-2

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF218915 , AF218889, AF218890, AF218891, AF218892, AF218893, AF218894, AF218895, AF218896, AF218897, AF218898, AF218899, AF218900, AF218901, AF218902, AF218903, AF218904, AF218905, AF218906, AF218907, AF218908, AF218909, AF218911, AF218912, AF218913, AF218914 Genomic DNA. Translation: AAF72881.1. AF218910 , AF218889, AF218890, AF218891, AF218892, AF218893, AF218894, AF218895, AF218896, AF218897, AF218898, AF218899, AF218900, AF218901, AF218902, AF218903, AF218904, AF218905, AF218906, AF218907, AF218908, AF218909 Genomic DNA. Translation: AAF72882.1. AF106861 mRNA. Translation: AAD03057.1. AK293010 mRNA. Translation: BAF85699.1. AL109805, AL132773, AL353193 Genomic DNA. Translation: CAI21876.1. AL109805, AL132773, AL353193 Genomic DNA. Translation: CAI21878.1. AL132773, AL109805, AL353193 Genomic DNA. Translation: CAI22614.1. AL132773, AL109805, AL353193 Genomic DNA. Translation: CAI22616.1. AL353193, AL109805, AL132773 Genomic DNA. Translation: CAH70471.1. AL353193, AL109805, AL132773 Genomic DNA. Translation: CAH70472.1. BC101705 mRNA. Translation: AAI01706.1. AB011120 mRNA. Translation: BAA25474.1.
IPI	IPI00027235. IPI00162735. IPI00939169.
RefSeq	NP_647537.1. NP_647538.1.
UniGene	Hs.276252
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	O75882. 1 interaction.
STRING	O75882.
PTM databases
PhosphoSite	O75882.
Proteomic databases
PRIDE	O75882.
Genome annotation databases
Ensembl	ENST00000262919; ENSP00000262919; ENSG00000088812; Homo sapiens. [Genome view]
GeneID	8455.
KEGG	hsa:8455.
UCSC	uc002wil.1. human. uc002wim.1. human.
Organism-specific databases
CTD	8455.
GeneCards	GC20P003399.
H-InvDB	HIX0015596.
HGNC	HGNC:885. ATRN.
HPA	HPA008853.
MIM	603130. gene.
PharmGKB	PA25178.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	O75882.
InParanoid	O75882.
OMA	IEGQPNR.
OrthoDB	EOG9Q5C7R.
Gene expression databases
ArrayExpress	O75882.
Bgee	O75882.
Genevestigator	O75882.
GermOnline	ENSG00000088812. Homo sapiens.
Family and domain databases
InterPro	IPR001304. C-type_lectin. IPR016186. C-type_lectin-like. IPR016187. C-type_lectin_fold. IPR000859. CUB. IPR006210. EGF-like. IPR013032. EGF-like_reg_CS. IPR000742. EGF_3. IPR013111. EGF_extracell. IPR002049. EGF_laminin. IPR011043. Gal_Oxase/kelch_b-propeller. IPR015915. Kelch-typ_b-propeller. IPR006652. Kelch_1. IPR003659. Plexin-like. IPR002165. Plexin_repeat. [Graphical view]
Gene3D	G3DSA:3.10.100.10. C-type_lectin-like. 1 hit. G3DSA:2.60.120.290. CUB. 1 hit. G3DSA:2.120.10.80. Kelch-typ_b-propeller. 1 hit.
Pfam	PF00431. CUB. 1 hit. PF07974. EGF_2. 1 hit. PF01344. Kelch_1. 4 hits. PF00053. Laminin_EGF. 2 hits. PF00059. Lectin_C. 1 hit. PF01437. PSI. 4 hits. [Graphical view]
SMART	SM00034. CLECT. 1 hit. SM00042. CUB. 1 hit. SM00181. EGF. 2 hits. SM00180. EGF_Lam. 1 hit. SM00423. PSI. 5 hits. [Graphical view]
PROSITE	PS00615. C_TYPE_LECTIN_1. False negative. PS50041. C_TYPE_LECTIN_2. 1 hit. PS01180. CUB. 1 hit. PS00022. EGF_1. 3 hits. PS01186. EGF_2. 1 hit. PS50026. EGF_3. 2 hits. PS01248. EGF_LAM_1. 1 hit. PS50027. EGF_LAM_2. 3 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	31642.
SOURCE	Search...

Entry information

Entry name

ATRN_HUMAN

Accession

Primary (citable) accession number: O75882
Secondary accession number(s): A8KAE5 , O60295, O95414, Q3MIT3, Q5TDA2, Q5TDA4, Q5VYW3, Q9NTQ3, Q9NTQ4, Q9NU01, Q9NZ57, Q9NZ58, Q9UC75, Q9UDF5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	April 27, 2001
Last modified:	December 15, 2009
This is version 107 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.