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O75882

- ATRN_HUMAN

UniProt

O75882 - ATRN_HUMAN

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Protein

Attractin

Gene

ATRN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system (By similarity).By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW
  2. receptor activity Source: ProtInc

GO - Biological processi

  1. cerebellum development Source: Ensembl
  2. inflammatory response Source: UniProtKB-KW
  3. myelination Source: Ensembl
  4. pigmentation Source: Ensembl
  5. regulation of multicellular organism growth Source: Ensembl
  6. response to oxidative stress Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Inflammatory response

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Attractin
Alternative name(s):
DPPT-L
Mahogany homolog
Gene namesi
Name:ATRN
Synonyms:KIAA0548, MGCA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:885. ATRN.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini84 – 12791196ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1280 – 130021HelicalSequence AnalysisAdd
BLAST
Topological domaini1301 – 1429129CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular space Source: UniProt
  3. extracellular vesicular exosome Source: UniProtKB
  4. integral component of plasma membrane Source: ProtInc
  5. plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25178.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence AnalysisAdd
BLAST
Propeptidei29 – 83551 PublicationPRO_0000394771Add
BLAST
Chaini84 – 14291346AttractinPRO_0000007483Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi101 ↔ 111By similarity
Disulfide bondi105 ↔ 118By similarity
Disulfide bondi120 ↔ 129By similarity
Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi237 – 2371N-linked (GlcNAc...)Sequence Analysis
Glycosylationi242 – 2421N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi250 ↔ 260By similarity
Glycosylationi253 – 2531N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi254 ↔ 271By similarity
Glycosylationi264 – 2641N-linked (GlcNAc...)2 Publications
Disulfide bondi273 ↔ 282By similarity
Glycosylationi300 – 3001N-linked (GlcNAc...) (complex)2 Publications
Glycosylationi325 – 3251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi362 – 3621N-linked (GlcNAc...)Sequence Analysis
Glycosylationi383 – 3831N-linked (GlcNAc...) (complex)3 Publications
Glycosylationi416 – 4161N-linked (GlcNAc...)2 Publications
Glycosylationi428 – 4281N-linked (GlcNAc...)1 Publication
Glycosylationi575 – 5751N-linked (GlcNAc...)1 Publication
Glycosylationi623 – 6231N-linked (GlcNAc...)1 Publication
Glycosylationi731 – 7311N-linked (GlcNAc...) (complex)2 Publications
Disulfide bondi816 ↔ 918By similarity
Glycosylationi863 – 8631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi914 – 9141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi923 – 9231N-linked (GlcNAc...)Sequence Analysis
Glycosylationi986 – 9861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1043 – 10431N-linked (GlcNAc...)1 Publication
Glycosylationi1054 – 10541N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1063 ↔ 1071By similarity
Disulfide bondi1065 ↔ 1077By similarity
Glycosylationi1073 – 10731N-linked (GlcNAc...) (complex)1 Publication
Disulfide bondi1080 ↔ 1089By similarity
Glycosylationi1082 – 10821N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1092 ↔ 1106By similarity
Disulfide bondi1127 ↔ 1137By similarity
Disulfide bondi1140 ↔ 1155By similarity
Glycosylationi1198 – 11981N-linked (GlcNAc...)1 Publication
Glycosylationi1206 – 12061N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1250 – 12501N-linked (GlcNAc...)1 Publication
Glycosylationi1259 – 12591N-linked (GlcNAc...)1 Publication

Post-translational modificationi

Heavily glycosylated.6 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO75882.
PaxDbiO75882.
PRIDEiO75882.

PTM databases

PhosphoSiteiO75882.

Expressioni

Tissue specificityi

Isoform 2 is detected in plasma (at protein level). Expressed and secreted by activated T-lymphocytes. Expressed at low to moderate levels in peripheral blood leukocytes, spleen, lymph node, tonsil, bone marrow and fetal liver. At very low levels found in thymus. Isoform 2 is the major isoform in peripheral blood leukocytes.2 Publications

Inductioni

Activation of peripheral blood leukocytes with phytohemagglutinin induces strong expression of the membrane isoform followed by the release of the secreted isoform.

Gene expression databases

BgeeiO75882.
GenevestigatoriO75882.

Organism-specific databases

HPAiHPA008853.

Interactioni

Subunit structurei

Monomer and homotrimer.1 Publication

Protein-protein interaction databases

BioGridi114033. 8 interactions.
IntActiO75882. 6 interactions.

Structurei

3D structure databases

ProteinModelPortaliO75882.
SMRiO75882. Positions 132-245, 791-921, 1063-1151.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini101 – 12929EGF-likePROSITE-ProRule annotationAdd
BLAST
Domaini132 – 248117CUBPROSITE-ProRule annotationAdd
BLAST
Repeati352 – 40251Kelch 1Add
BLAST
Repeati404 – 45148Kelch 2Add
BLAST
Repeati461 – 50848Kelch 3Add
BLAST
Repeati513 – 56452Kelch 4Add
BLAST
Repeati566 – 62459Kelch 5Add
BLAST
Repeati625 – 67147Kelch 6Add
BLAST
Domaini703 – 74846PSI 1Add
BLAST
Domaini755 – 79440PSI 2Add
BLAST
Domaini795 – 919125C-type lectinPROSITE-ProRule annotationAdd
BLAST
Domaini932 – 98352PSI 3Add
BLAST
Domaini986 – 106176PSI 4Add
BLAST
Domaini1063 – 110846Laminin EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini1109 – 115749Laminin EGF-like 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi43 – 7735Leu-richAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation
Contains 1 CUB domain.PROSITE-ProRule annotation
Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated
Contains 2 laminin EGF-like domains.PROSITE-ProRule annotation
Contains 4 PSI domains.Curated

Keywords - Domaini

EGF-like domain, Kelch repeat, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG242225.
GeneTreeiENSGT00390000001118.
HOVERGENiHBG004312.
InParanoidiO75882.
OMAiNPLKGTC.
OrthoDBiEOG7D59MM.
PhylomeDBiO75882.
TreeFamiTF321873.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
2.60.120.290. 1 hit.
3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR000859. CUB_dom.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR002049. EGF_laminin.
IPR011043. Gal_Oxase/kelch_b-propeller.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
[Graphical view]
PfamiPF00431. CUB. 1 hit.
PF01344. Kelch_1. 1 hit.
PF00059. Lectin_C. 1 hit.
PF01437. PSI. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
SM00042. CUB. 1 hit.
SM00181. EGF. 2 hits.
SM00180. EGF_Lam. 1 hit.
SM00423. PSI. 5 hits.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
SSF50965. SSF50965. 1 hit.
SSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
PS01180. CUB. 1 hit.
PS00022. EGF_1. 3 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS01248. EGF_LAM_1. 1 hit.
PS50027. EGF_LAM_2. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O75882-1) [UniParc]FASTAAdd to Basket

Also known as: Membrane

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVAAAAATEA RLRRRTAATA ALAGRSGGPH WDWDVTRAGR PGLGAGLRLP
60 70 80 90 100
RLLSPPLRPR LLLLLLLLSP PLLLLLLPCE AEAAAAAAAV SGSAAAEAKE
110 120 130 140 150
CDRPCVNGGR CNPGTGQCVC PAGWVGEQCQ HCGGRFRLTG SSGFVTDGPG
160 170 180 190 200
NYKYKTKCTW LIEGQPNRIM RLRFNHFATE CSWDHLYVYD GDSIYAPLVA
210 220 230 240 250
AFSGLIVPER DGNETVPEVV ATSGYALLHF FSDAAYNLTG FNITYSFDMC
260 270 280 290 300
PNNCSGRGEC KISNSSDTVE CECSENWKGE ACDIPHCTDN CGFPHRGICN
310 320 330 340 350
SSDVRGCSCF SDWQGPGCSV PVPANQSFWT REEYSNLKLP RASHKAVVNG
360 370 380 390 400
NIMWVVGGYM FNHSDYNMVL AYDLASREWL PLNRSVNNVV VRYGHSLALY
410 420 430 440 450
KDKIYMYGGK IDSTGNVTNE LRVFHIHNES WVLLTPKAKE QYAVVGHSAH
460 470 480 490 500
IVTLKNGRVV MLVIFGHCPL YGYISNVQEY DLDKNTWSIL HTQGALVQGG
510 520 530 540 550
YGHSSVYDHR TRALYVHGGY KAFSANKYRL ADDLYRYDVD TQMWTILKDS
560 570 580 590 600
RFFRYLHTAV IVSGTMLVFG GNTHNDTSMS HGAKCFSSDF MAYDIACDRW
610 620 630 640 650
SVLPRPDLHH DVNRFGHSAV LHNSTMYVFG GFNSLLLSDI LVFTSEQCDA
660 670 680 690 700
HRSEAACLAA GPGIRCVWNT GSSQCISWAL ATDEQEEKLK SECFSKRTLD
710 720 730 740 750
HDRCDQHTDC YSCTANTNDC HWCNDHCVPR NHSCSEGQIS IFRYENCPKD
760 770 780 790 800
NPMYYCNKKT SCRSCALDQN CQWEPRNQEC IALPENICGI GWHLVGNSCL
810 820 830 840 850
KITTAKENYD NAKLFCRNHN ALLASLTTQK KVEFVLKQLR IMQSSQSMSK
860 870 880 890 900
LTLTPWVGLR KINVSYWCWE DMSPFTNSLL QWMPSEPSDA GFCGILSEPS
910 920 930 940 950
TRGLKAATCI NPLNGSVCER PANHSAKQCR TPCALRTACG DCTSGSSECM
960 970 980 990 1000
WCSNMKQCVD SNAYVASFPF GQCMEWYTMS TCPPENCSGY CTCSHCLEQP
1010 1020 1030 1040 1050
GCGWCTDPSN TGKGKCIEGS YKGPVKMPSQ APTGNFYPQP LLNSSMCLED
1060 1070 1080 1090 1100
SRYNWSFIHC PACQCNGHSK CINQSICEKC ENLTTGKHCE TCISGFYGDP
1110 1120 1130 1140 1150
TNGGKCQPCK CNGHASLCNT NTGKCFCTTK GVKGDECQLC EVENRYQGNP
1160 1170 1180 1190 1200
LRGTCYYTLL IDYQFTFSLS QEDDRYYTAI NFVATPDEQN RDLDMFINAS
1210 1220 1230 1240 1250
KNFNLNITWA ASFSAGTQAG EEMPVVSKTN IKEYKDSFSN EKFDFRNHPN
1260 1270 1280 1290 1300
ITFFVYVSNF TWPIKIQIAF SQHSNFMDLV QFFVTFFSCF LSLLLVAAVV
1310 1320 1330 1340 1350
WKIKQSCWAS RRREQLLREM QQMASRPFAS VNVALETDEE PPDLIGGSIK
1360 1370 1380 1390 1400
TVPKPIALEP CFGNKAAVLS VFVRLPRGLG GIPPPGQSGL AVASALVDIS
1410 1420
QQMPIVYKEK SGAVRNRKQQ PPAQPGTCI
Length:1,429
Mass (Da):158,537
Last modified:April 27, 2001 - v2
Checksum:i9F206A319B7E3DD8
GO
Isoform 2 (identifier: O75882-2) [UniParc]FASTAAdd to Basket

Also known as: Secreted

The sequence of this isoform differs from the canonical sequence as follows:
     1268-1429: IAFSQHSNFM...QPPAQPGTCI → VQTEQ

Show »
Length:1,272
Mass (Da):141,429
Checksum:iB2DD527761F6FCEE
GO
Isoform 3 (identifier: O75882-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-104: Missing.
     1268-1429: IAFSQHSNFM...QPPAQPGTCI → VQTEQ

Note: No experimental confirmation available.

Show »
Length:1,198
Mass (Da):133,702
Checksum:i29173E6048FE995E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti69 – 691S → P in AAD03057. 1 PublicationCurated
Sequence conflicti267 – 2671D → E in AAD03057. 1 PublicationCurated
Sequence conflicti413 – 4131S → P in AAD03057. 1 PublicationCurated
Sequence conflicti620 – 6201V → A in BAF85699. (PubMed:14702039)Curated
Sequence conflicti704 – 7041C → G AA sequence (PubMed:7539799)Curated
Sequence conflicti1172 – 11721E → K in AAF72881. (PubMed:10811918)Curated
Sequence conflicti1172 – 11721E → K in AAF72882. (PubMed:10811918)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti303 – 3031D → A.
Corresponds to variant rs6107308 [ dbSNP | Ensembl ].
VAR_048967
Natural varianti426 – 4261I → T.
Corresponds to variant rs17782078 [ dbSNP | Ensembl ].
VAR_048968
Natural varianti1152 – 11521R → K.
Corresponds to variant rs3886999 [ dbSNP | Ensembl ].
VAR_048969
Natural varianti1226 – 12261V → I.
Corresponds to variant rs12329487 [ dbSNP | Ensembl ].
VAR_048970

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei31 – 10474Missing in isoform 3. CuratedVSP_001372Add
BLAST
Alternative sequencei1268 – 1429162IAFSQ…PGTCI → VQTEQ in isoform 2 and isoform 3. 3 PublicationsVSP_001375Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF218915
, AF218889, AF218890, AF218891, AF218892, AF218893, AF218894, AF218895, AF218896, AF218897, AF218898, AF218899, AF218900, AF218901, AF218902, AF218903, AF218904, AF218905, AF218906, AF218907, AF218908, AF218909, AF218911, AF218912, AF218913, AF218914 Genomic DNA. Translation: AAF72881.1.
AF218910
, AF218889, AF218890, AF218891, AF218892, AF218893, AF218894, AF218895, AF218896, AF218897, AF218898, AF218899, AF218900, AF218901, AF218902, AF218903, AF218904, AF218905, AF218906, AF218907, AF218908, AF218909 Genomic DNA. Translation: AAF72882.1.
AF106861 mRNA. Translation: AAD03057.1.
AK293010 mRNA. Translation: BAF85699.1.
AL109805, AL132773, AL353193 Genomic DNA. Translation: CAI21876.1.
AL109805, AL132773, AL353193 Genomic DNA. Translation: CAI21878.1.
AL132773, AL109805, AL353193 Genomic DNA. Translation: CAI22614.1.
AL132773, AL109805, AL353193 Genomic DNA. Translation: CAI22616.1.
AL353193, AL109805, AL132773 Genomic DNA. Translation: CAH70471.1.
AL353193, AL109805, AL132773 Genomic DNA. Translation: CAH70472.1.
BC101705 mRNA. Translation: AAI01706.1.
AB011120 mRNA. Translation: BAA25474.1.
CCDSiCCDS13053.1. [O75882-1]
CCDS13054.1. [O75882-2]
RefSeqiNP_001193976.1. NM_001207047.1.
NP_647537.1. NM_139321.2. [O75882-1]
NP_647538.1. NM_139322.2. [O75882-2]
UniGeneiHs.276252.

Genome annotation databases

EnsembliENST00000262919; ENSP00000262919; ENSG00000088812. [O75882-1]
ENST00000446916; ENSP00000416587; ENSG00000088812. [O75882-2]
GeneIDi8455.
KEGGihsa:8455.
UCSCiuc002wil.2. human. [O75882-2]
uc002wim.2. human. [O75882-1]
uc021vzz.1. human. [O75882-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Attractin-2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF218915
, AF218889 , AF218890 , AF218891 , AF218892 , AF218893 , AF218894 , AF218895 , AF218896 , AF218897 , AF218898 , AF218899 , AF218900 , AF218901 , AF218902 , AF218903 , AF218904 , AF218905 , AF218906 , AF218907 , AF218908 , AF218909 , AF218911 , AF218912 , AF218913 , AF218914 Genomic DNA. Translation: AAF72881.1 .
AF218910
, AF218889 , AF218890 , AF218891 , AF218892 , AF218893 , AF218894 , AF218895 , AF218896 , AF218897 , AF218898 , AF218899 , AF218900 , AF218901 , AF218902 , AF218903 , AF218904 , AF218905 , AF218906 , AF218907 , AF218908 , AF218909 Genomic DNA. Translation: AAF72882.1 .
AF106861 mRNA. Translation: AAD03057.1 .
AK293010 mRNA. Translation: BAF85699.1 .
AL109805 , AL132773 , AL353193 Genomic DNA. Translation: CAI21876.1 .
AL109805 , AL132773 , AL353193 Genomic DNA. Translation: CAI21878.1 .
AL132773 , AL109805 , AL353193 Genomic DNA. Translation: CAI22614.1 .
AL132773 , AL109805 , AL353193 Genomic DNA. Translation: CAI22616.1 .
AL353193 , AL109805 , AL132773 Genomic DNA. Translation: CAH70471.1 .
AL353193 , AL109805 , AL132773 Genomic DNA. Translation: CAH70472.1 .
BC101705 mRNA. Translation: AAI01706.1 .
AB011120 mRNA. Translation: BAA25474.1 .
CCDSi CCDS13053.1. [O75882-1 ]
CCDS13054.1. [O75882-2 ]
RefSeqi NP_001193976.1. NM_001207047.1.
NP_647537.1. NM_139321.2. [O75882-1 ]
NP_647538.1. NM_139322.2. [O75882-2 ]
UniGenei Hs.276252.

3D structure databases

ProteinModelPortali O75882.
SMRi O75882. Positions 132-245, 791-921, 1063-1151.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114033. 8 interactions.
IntActi O75882. 6 interactions.

PTM databases

PhosphoSitei O75882.

Proteomic databases

MaxQBi O75882.
PaxDbi O75882.
PRIDEi O75882.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000262919 ; ENSP00000262919 ; ENSG00000088812 . [O75882-1 ]
ENST00000446916 ; ENSP00000416587 ; ENSG00000088812 . [O75882-2 ]
GeneIDi 8455.
KEGGi hsa:8455.
UCSCi uc002wil.2. human. [O75882-2 ]
uc002wim.2. human. [O75882-1 ]
uc021vzz.1. human. [O75882-3 ]

Organism-specific databases

CTDi 8455.
GeneCardsi GC20P003451.
HGNCi HGNC:885. ATRN.
HPAi HPA008853.
MIMi 603130. gene.
neXtProti NX_O75882.
PharmGKBi PA25178.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG242225.
GeneTreei ENSGT00390000001118.
HOVERGENi HBG004312.
InParanoidi O75882.
OMAi NPLKGTC.
OrthoDBi EOG7D59MM.
PhylomeDBi O75882.
TreeFami TF321873.

Miscellaneous databases

ChiTaRSi ATRN. human.
GeneWikii ATRN.
GenomeRNAii 8455.
NextBioi 31642.
PROi O75882.
SOURCEi Search...

Gene expression databases

Bgeei O75882.
Genevestigatori O75882.

Family and domain databases

Gene3Di 2.120.10.80. 1 hit.
2.60.120.290. 1 hit.
3.10.100.10. 1 hit.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR000859. CUB_dom.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR002049. EGF_laminin.
IPR011043. Gal_Oxase/kelch_b-propeller.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
[Graphical view ]
Pfami PF00431. CUB. 1 hit.
PF01344. Kelch_1. 1 hit.
PF00059. Lectin_C. 1 hit.
PF01437. PSI. 1 hit.
[Graphical view ]
SMARTi SM00034. CLECT. 1 hit.
SM00042. CUB. 1 hit.
SM00181. EGF. 2 hits.
SM00180. EGF_Lam. 1 hit.
SM00423. PSI. 5 hits.
[Graphical view ]
SUPFAMi SSF49854. SSF49854. 1 hit.
SSF50965. SSF50965. 1 hit.
SSF56436. SSF56436. 1 hit.
PROSITEi PS50041. C_TYPE_LECTIN_2. 1 hit.
PS01180. CUB. 1 hit.
PS00022. EGF_1. 3 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS01248. EGF_LAM_1. 1 hit.
PS50027. EGF_LAM_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Secreted and membrane attractin result from alternative splicing of the human ATRN gene."
    Tang W., Gunn T.M., McLaughlin D.F., Barsh G.S., Schlossman S.F., Duke-Cohan J.S.
    Proc. Natl. Acad. Sci. U.S.A. 97:6025-6030(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
  2. "Cloning of cDNA for attractin-2, identical with that of attractin except for a GC-rich 222 bp 5' insertion."
    Duke-Cohan J.S., Gu J., Freeman G.J., Schlossman S.F.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Trachea.
  4. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  6. "A novel form of dipeptidylpeptidase IV found in human serum. Isolation, characterization, and comparison with T lymphocyte membrane dipeptidylpeptidase IV (CD26)."
    Duke-Cohan J.S., Morimoto C., Rocker J.A., Schlossman S.F.
    J. Biol. Chem. 270:14107-14114(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 138-153; 537-548 AND 704-723 (ISOFORMS 1/2/3), SUBCELLULAR LOCATION, GLYCOSYLATION, SUBUNIT.
    Tissue: Serum.
  7. "Attractin (DPPT-L), a member of the CUB family of cell adhesion and guidance proteins, is secreted by activated human T lymphocytes and modulates immune cell interactions."
    Duke-Cohan J.S., Gu J., McLaughlin D.F., Xu Y., Freeman G.J., Schlossman S.F.
    Proc. Natl. Acad. Sci. U.S.A. 95:11336-11341(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 138-153; 280-285; 355-376; 378-394; 405-411; 513-521; 538-547; 705-722; 735-755; 818-829; 851-860; 1145-1152; 1203-1213; 1243-1246 AND 1255-1272 (ISOFORM 2), FUNCTION, SUBCELLULAR LOCATION.
  8. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 978-1429 (ISOFORM 1).
    Tissue: Brain.
  9. Cited for: PROTEIN SEQUENCE OF N-TERMINUS, TISSUE SPECIFICITY, GLYCOSYLATION, IDENTIFICATION BY MASS SPECTROMETRY.
  10. "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
    Bunkenborg J., Pilch B.J., Podtelejnikov A.V., Wisniewski J.R.
    Proteomics 4:454-465(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-264; ASN-383 AND ASN-731.
    Tissue: Plasma.
  11. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-264; ASN-300; ASN-383; ASN-416; ASN-428; ASN-575; ASN-623; ASN-1043; ASN-1198; ASN-1250 AND ASN-1259.
    Tissue: Plasma.
  12. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-416.
    Tissue: Liver.
  13. Cited for: GLYCOSYLATION AT ASN-300; ASN-383; ASN-731 AND ASN-1073.

Entry informationi

Entry nameiATRN_HUMAN
AccessioniPrimary (citable) accession number: O75882
Secondary accession number(s): A8KAE5
, O60295, O95414, Q3MIT3, Q5TDA2, Q5TDA4, Q5VYW3, Q9NTQ3, Q9NTQ4, Q9NU01, Q9NZ57, Q9NZ58, Q9UC75, Q9UDF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: November 26, 2014
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3