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O75882 (ATRN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 143. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Attractin
Alternative name(s):
DPPT-L
Mahogany homolog
Gene names
Name:ATRN
Synonyms:KIAA0548, MGCA
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1429 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti By similarity. Has a critical role in normal myelination in the central nervous system By similarity. Ref.7

Subunit structure

Monomer and homotrimer. Ref.6

Subcellular location

Isoform 1: Cell membrane; Single-pass type I membrane protein Ref.6 Ref.7.

Isoform 2: Secreted Ref.6 Ref.7.

Isoform 3: Secreted Ref.6 Ref.7.

Tissue specificity

Isoform 2 is detected in plasma (at protein level). Expressed and secreted by activated T-lymphocytes. Expressed at low to moderate levels in peripheral blood leukocytes, spleen, lymph node, tonsil, bone marrow and fetal liver. At very low levels found in thymus. Isoform 2 is the major isoform inperipheral blood leukocytes. Ref.1 Ref.9

Induction

Activation of peripheral blood leukocytes with phytohemagglutinin induces strong expression of the membrane isoform followedby the release of the secreted isoform.

Post-translational modification

Heavily glycosylated. Ref.6 Ref.9 Ref.13

Sequence similarities

Contains 1 C-type lectin domain.

Contains 1 CUB domain.

Contains 1 EGF-like domain.

Contains 6 Kelch repeats.

Contains 2 laminin EGF-like domains.

Contains 4 PSI domains.

Caution

Was originally (Ref.6 and Ref.7) thought to have dipeptidase activity but it was shown later to lack that activity (Ref.9).

Ontologies

Keywords
   Biological processInflammatory response
   Cellular componentCell membrane
Membrane
Secreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainEGF-like domain
Kelch repeat
Laminin EGF-like domain
Repeat
Signal
Transmembrane
Transmembrane helix
   LigandLectin
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processcerebellum development

Inferred from electronic annotation. Source: Ensembl

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

myelination

Inferred from electronic annotation. Source: Ensembl

pigmentation

Inferred from electronic annotation. Source: Ensembl

regulation of multicellular organism growth

Inferred from electronic annotation. Source: Ensembl

response to oxidative stress

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

extracellular space

Inferred from direct assay Ref.9. Source: UniProtKB

extracellular vesicular exosome

Inferred from direct assay PubMed 19056867PubMed 23376485. Source: UniProt

integral component of plasma membrane

Traceable author statement PubMed 10086356. Source: ProtInc

plasma membrane

Non-traceable author statement Ref.7. Source: ProtInc

   Molecular_functioncarbohydrate binding

Inferred from electronic annotation. Source: InterPro

receptor activity

Traceable author statement PubMed 10086356. Source: ProtInc

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O75882-1)

Also known as: Membrane;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O75882-2)

Also known as: Secreted;

The sequence of this isoform differs from the canonical sequence as follows:
     1268-1429: IAFSQHSNFM...QPPAQPGTCI → VQTEQ
Isoform 3 (identifier: O75882-3)

The sequence of this isoform differs from the canonical sequence as follows:
     31-104: Missing.
     1268-1429: IAFSQHSNFM...QPPAQPGTCI → VQTEQ
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Potential
Propeptide29 – 8355 Probable
PRO_0000394771
Chain84 – 14291346Attractin
PRO_0000007483

Regions

Topological domain84 – 12791196Extracellular Potential
Transmembrane1280 – 130021Helical; Potential
Topological domain1301 – 1429129Cytoplasmic Potential
Domain101 – 12929EGF-like
Domain132 – 248117CUB
Repeat352 – 40251Kelch 1
Repeat404 – 45148Kelch 2
Repeat461 – 50848Kelch 3
Repeat513 – 56452Kelch 4
Repeat566 – 62459Kelch 5
Repeat625 – 67147Kelch 6
Domain703 – 74846PSI 1
Domain755 – 79440PSI 2
Domain795 – 919125C-type lectin
Domain932 – 98352PSI 3
Domain986 – 106176PSI 4
Domain1063 – 110846Laminin EGF-like 1
Domain1109 – 115749Laminin EGF-like 2
Compositional bias43 – 7735Leu-rich

Amino acid modifications

Glycosylation2131N-linked (GlcNAc...) Potential
Glycosylation2371N-linked (GlcNAc...) Potential
Glycosylation2421N-linked (GlcNAc...) Potential
Glycosylation2531N-linked (GlcNAc...) Potential
Glycosylation2641N-linked (GlcNAc...) Ref.10 Ref.11
Glycosylation3001N-linked (GlcNAc...) (complex) Ref.11 Ref.13
Glycosylation3251N-linked (GlcNAc...) Potential
Glycosylation3621N-linked (GlcNAc...) Potential
Glycosylation3831N-linked (GlcNAc...) (complex) Ref.10 Ref.11 Ref.13
Glycosylation4161N-linked (GlcNAc...) Ref.11 Ref.12
Glycosylation4281N-linked (GlcNAc...) Ref.11
Glycosylation5751N-linked (GlcNAc...) Ref.11
Glycosylation6231N-linked (GlcNAc...) Ref.11
Glycosylation7311N-linked (GlcNAc...) (complex) Ref.10 Ref.13
Glycosylation8631N-linked (GlcNAc...) Potential
Glycosylation9141N-linked (GlcNAc...) Potential
Glycosylation9231N-linked (GlcNAc...) Potential
Glycosylation9861N-linked (GlcNAc...) Potential
Glycosylation10431N-linked (GlcNAc...) Ref.11
Glycosylation10541N-linked (GlcNAc...) Potential
Glycosylation10731N-linked (GlcNAc...) (complex) Ref.13
Glycosylation10821N-linked (GlcNAc...) Potential
Glycosylation11981N-linked (GlcNAc...) Ref.11
Glycosylation12061N-linked (GlcNAc...) Potential
Glycosylation12501N-linked (GlcNAc...) Ref.11
Glycosylation12591N-linked (GlcNAc...) Ref.11
Disulfide bond101 ↔ 111 By similarity
Disulfide bond105 ↔ 118 By similarity
Disulfide bond120 ↔ 129 By similarity
Disulfide bond250 ↔ 260 By similarity
Disulfide bond254 ↔ 271 By similarity
Disulfide bond273 ↔ 282 By similarity
Disulfide bond816 ↔ 918 By similarity
Disulfide bond1063 ↔ 1071 By similarity
Disulfide bond1065 ↔ 1077 By similarity
Disulfide bond1080 ↔ 1089 By similarity
Disulfide bond1092 ↔ 1106 By similarity
Disulfide bond1127 ↔ 1137 By similarity
Disulfide bond1140 ↔ 1155 By similarity

Natural variations

Alternative sequence31 – 10474Missing in isoform 3.
VSP_001372
Alternative sequence1268 – 1429162IAFSQ…PGTCI → VQTEQ in isoform 2 and isoform 3.
VSP_001375
Natural variant3031D → A.
Corresponds to variant rs6107308 [ dbSNP | Ensembl ].
VAR_048967
Natural variant4261I → T.
Corresponds to variant rs17782078 [ dbSNP | Ensembl ].
VAR_048968
Natural variant11521R → K.
Corresponds to variant rs3886999 [ dbSNP | Ensembl ].
VAR_048969
Natural variant12261V → I.
Corresponds to variant rs12329487 [ dbSNP | Ensembl ].
VAR_048970

Experimental info

Sequence conflict691S → P in AAD03057. Ref.2
Sequence conflict2671D → E in AAD03057. Ref.2
Sequence conflict4131S → P in AAD03057. Ref.2
Sequence conflict6201V → A in BAF85699. Ref.3
Sequence conflict7041C → G AA sequence Ref.6
Sequence conflict11721E → K in AAF72881. Ref.1
Sequence conflict11721E → K in AAF72882. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Membrane) [UniParc].

Last modified April 27, 2001. Version 2.
Checksum: 9F206A319B7E3DD8

FASTA1,429158,537
        10         20         30         40         50         60 
MVAAAAATEA RLRRRTAATA ALAGRSGGPH WDWDVTRAGR PGLGAGLRLP RLLSPPLRPR 

        70         80         90        100        110        120 
LLLLLLLLSP PLLLLLLPCE AEAAAAAAAV SGSAAAEAKE CDRPCVNGGR CNPGTGQCVC 

       130        140        150        160        170        180 
PAGWVGEQCQ HCGGRFRLTG SSGFVTDGPG NYKYKTKCTW LIEGQPNRIM RLRFNHFATE 

       190        200        210        220        230        240 
CSWDHLYVYD GDSIYAPLVA AFSGLIVPER DGNETVPEVV ATSGYALLHF FSDAAYNLTG 

       250        260        270        280        290        300 
FNITYSFDMC PNNCSGRGEC KISNSSDTVE CECSENWKGE ACDIPHCTDN CGFPHRGICN 

       310        320        330        340        350        360 
SSDVRGCSCF SDWQGPGCSV PVPANQSFWT REEYSNLKLP RASHKAVVNG NIMWVVGGYM 

       370        380        390        400        410        420 
FNHSDYNMVL AYDLASREWL PLNRSVNNVV VRYGHSLALY KDKIYMYGGK IDSTGNVTNE 

       430        440        450        460        470        480 
LRVFHIHNES WVLLTPKAKE QYAVVGHSAH IVTLKNGRVV MLVIFGHCPL YGYISNVQEY 

       490        500        510        520        530        540 
DLDKNTWSIL HTQGALVQGG YGHSSVYDHR TRALYVHGGY KAFSANKYRL ADDLYRYDVD 

       550        560        570        580        590        600 
TQMWTILKDS RFFRYLHTAV IVSGTMLVFG GNTHNDTSMS HGAKCFSSDF MAYDIACDRW 

       610        620        630        640        650        660 
SVLPRPDLHH DVNRFGHSAV LHNSTMYVFG GFNSLLLSDI LVFTSEQCDA HRSEAACLAA 

       670        680        690        700        710        720 
GPGIRCVWNT GSSQCISWAL ATDEQEEKLK SECFSKRTLD HDRCDQHTDC YSCTANTNDC 

       730        740        750        760        770        780 
HWCNDHCVPR NHSCSEGQIS IFRYENCPKD NPMYYCNKKT SCRSCALDQN CQWEPRNQEC 

       790        800        810        820        830        840 
IALPENICGI GWHLVGNSCL KITTAKENYD NAKLFCRNHN ALLASLTTQK KVEFVLKQLR 

       850        860        870        880        890        900 
IMQSSQSMSK LTLTPWVGLR KINVSYWCWE DMSPFTNSLL QWMPSEPSDA GFCGILSEPS 

       910        920        930        940        950        960 
TRGLKAATCI NPLNGSVCER PANHSAKQCR TPCALRTACG DCTSGSSECM WCSNMKQCVD 

       970        980        990       1000       1010       1020 
SNAYVASFPF GQCMEWYTMS TCPPENCSGY CTCSHCLEQP GCGWCTDPSN TGKGKCIEGS 

      1030       1040       1050       1060       1070       1080 
YKGPVKMPSQ APTGNFYPQP LLNSSMCLED SRYNWSFIHC PACQCNGHSK CINQSICEKC 

      1090       1100       1110       1120       1130       1140 
ENLTTGKHCE TCISGFYGDP TNGGKCQPCK CNGHASLCNT NTGKCFCTTK GVKGDECQLC 

      1150       1160       1170       1180       1190       1200 
EVENRYQGNP LRGTCYYTLL IDYQFTFSLS QEDDRYYTAI NFVATPDEQN RDLDMFINAS 

      1210       1220       1230       1240       1250       1260 
KNFNLNITWA ASFSAGTQAG EEMPVVSKTN IKEYKDSFSN EKFDFRNHPN ITFFVYVSNF 

      1270       1280       1290       1300       1310       1320 
TWPIKIQIAF SQHSNFMDLV QFFVTFFSCF LSLLLVAAVV WKIKQSCWAS RRREQLLREM 

      1330       1340       1350       1360       1370       1380 
QQMASRPFAS VNVALETDEE PPDLIGGSIK TVPKPIALEP CFGNKAAVLS VFVRLPRGLG 

      1390       1400       1410       1420 
GIPPPGQSGL AVASALVDIS QQMPIVYKEK SGAVRNRKQQ PPAQPGTCI 

« Hide

Isoform 2 (Secreted) [UniParc].

Checksum: B2DD527761F6FCEE
Show »

FASTA1,272141,429
Isoform 3 [UniParc].

Checksum: 29173E6048FE995E
Show »

FASTA1,198133,702

References

« Hide 'large scale' references
[1]"Secreted and membrane attractin result from alternative splicing of the human ATRN gene."
Tang W., Gunn T.M., McLaughlin D.F., Barsh G.S., Schlossman S.F., Duke-Cohan J.S.
Proc. Natl. Acad. Sci. U.S.A. 97:6025-6030(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
[2]"Cloning of cDNA for attractin-2, identical with that of attractin except for a GC-rich 222 bp 5' insertion."
Duke-Cohan J.S., Gu J., Freeman G.J., Schlossman S.F.
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Trachea.
[4]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[6]"A novel form of dipeptidylpeptidase IV found in human serum. Isolation, characterization, and comparison with T lymphocyte membrane dipeptidylpeptidase IV (CD26)."
Duke-Cohan J.S., Morimoto C., Rocker J.A., Schlossman S.F.
J. Biol. Chem. 270:14107-14114(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 138-153; 537-548 AND 704-723 (ISOFORMS 1/2/3), SUBCELLULAR LOCATION, GLYCOSYLATION, SUBUNIT.
Tissue: Serum.
[7]"Attractin (DPPT-L), a member of the CUB family of cell adhesion and guidance proteins, is secreted by activated human T lymphocytes and modulates immune cell interactions."
Duke-Cohan J.S., Gu J., McLaughlin D.F., Xu Y., Freeman G.J., Schlossman S.F.
Proc. Natl. Acad. Sci. U.S.A. 95:11336-11341(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 138-153; 280-285; 355-376; 378-394; 405-411; 513-521; 538-547; 705-722; 735-755; 818-829; 851-860; 1145-1152; 1203-1213; 1243-1246 AND 1255-1272 (ISOFORM 2), FUNCTION, SUBCELLULAR LOCATION.
[8]"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 978-1429 (ISOFORM 1).
Tissue: Brain.
[9]"Does human attractin have DP4 activity?"
Friedrich D., Hoffmann T., Bar J., Wermann M., Manhart S., Heiser U., Demuth H.U.
Biol. Chem. 388:155-162(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF N-TERMINUS, TISSUE SPECIFICITY, GLYCOSYLATION, IDENTIFICATION BY MASS SPECTROMETRY.
[10]"Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
Bunkenborg J., Pilch B.J., Podtelejnikov A.V., Wisniewski J.R.
Proteomics 4:454-465(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-264; ASN-383 AND ASN-731.
Tissue: Plasma.
[11]"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-264; ASN-300; ASN-383; ASN-416; ASN-428; ASN-575; ASN-623; ASN-1043; ASN-1198; ASN-1250 AND ASN-1259.
Tissue: Plasma.
[12]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-416.
Tissue: Liver.
[13]"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Jia W., Lu Z., Fu Y., Wang H.P., Wang L.H., Chi H., Yuan Z.F., Zheng Z.B., Song L.N., Han H.H., Liang Y.M., Wang J.L., Cai Y., Zhang Y.K., Deng Y.L., Ying W.T., He S.M., Qian X.H.
Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION AT ASN-300; ASN-383; ASN-731 AND ASN-1073.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF218915 expand/collapse EMBL AC list , AF218889, AF218890, AF218891, AF218892, AF218893, AF218894, AF218895, AF218896, AF218897, AF218898, AF218899, AF218900, AF218901, AF218902, AF218903, AF218904, AF218905, AF218906, AF218907, AF218908, AF218909, AF218911, AF218912, AF218913, AF218914 Genomic DNA. Translation: AAF72881.1.
AF218910 expand/collapse EMBL AC list , AF218889, AF218890, AF218891, AF218892, AF218893, AF218894, AF218895, AF218896, AF218897, AF218898, AF218899, AF218900, AF218901, AF218902, AF218903, AF218904, AF218905, AF218906, AF218907, AF218908, AF218909 Genomic DNA. Translation: AAF72882.1.
AF106861 mRNA. Translation: AAD03057.1.
AK293010 mRNA. Translation: BAF85699.1.
AL109805, AL132773, AL353193 Genomic DNA. Translation: CAI21876.1.
AL109805, AL132773, AL353193 Genomic DNA. Translation: CAI21878.1.
AL132773, AL109805, AL353193 Genomic DNA. Translation: CAI22614.1.
AL132773, AL109805, AL353193 Genomic DNA. Translation: CAI22616.1.
AL353193, AL109805, AL132773 Genomic DNA. Translation: CAH70471.1.
AL353193, AL109805, AL132773 Genomic DNA. Translation: CAH70472.1.
BC101705 mRNA. Translation: AAI01706.1.
AB011120 mRNA. Translation: BAA25474.1.
CCDSCCDS13053.1. [O75882-1]
CCDS13054.1. [O75882-2]
RefSeqNP_001193976.1. NM_001207047.1.
NP_647537.1. NM_139321.2. [O75882-1]
NP_647538.1. NM_139322.2. [O75882-2]
UniGeneHs.276252.

3D structure databases

ProteinModelPortalO75882.
SMRO75882. Positions 101-322, 791-921, 1063-1151.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114033. 6 interactions.
IntActO75882. 6 interactions.

PTM databases

PhosphoSiteO75882.

Proteomic databases

MaxQBO75882.
PaxDbO75882.
PRIDEO75882.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000262919; ENSP00000262919; ENSG00000088812. [O75882-1]
ENST00000446916; ENSP00000416587; ENSG00000088812. [O75882-2]
GeneID8455.
KEGGhsa:8455.
UCSCuc002wil.2. human. [O75882-2]
uc002wim.2. human. [O75882-1]
uc021vzz.1. human. [O75882-3]

Organism-specific databases

CTD8455.
GeneCardsGC20P003451.
HGNCHGNC:885. ATRN.
HPAHPA008853.
MIM603130. gene.
neXtProtNX_O75882.
PharmGKBPA25178.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG242225.
HOVERGENHBG004312.
InParanoidO75882.
OMANPLKGTC.
OrthoDBEOG7D59MM.
PhylomeDBO75882.
TreeFamTF321873.

Gene expression databases

BgeeO75882.
GenevestigatorO75882.

Family and domain databases

Gene3D2.120.10.80. 1 hit.
2.60.120.290. 1 hit.
3.10.100.10. 1 hit.
InterProIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR000859. CUB_dom.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR002049. EGF_laminin.
IPR011043. Gal_Oxase/kelch_b-propeller.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
[Graphical view]
PfamPF00431. CUB. 1 hit.
PF01344. Kelch_1. 1 hit.
PF00059. Lectin_C. 1 hit.
PF01437. PSI. 1 hit.
[Graphical view]
SMARTSM00034. CLECT. 1 hit.
SM00042. CUB. 1 hit.
SM00181. EGF. 2 hits.
SM00180. EGF_Lam. 1 hit.
SM00423. PSI. 5 hits.
[Graphical view]
SUPFAMSSF49854. SSF49854. 1 hit.
SSF50965. SSF50965. 1 hit.
SSF56436. SSF56436. 1 hit.
PROSITEPS50041. C_TYPE_LECTIN_2. 1 hit.
PS01180. CUB. 1 hit.
PS00022. EGF_1. 3 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS01248. EGF_LAM_1. 1 hit.
PS50027. EGF_LAM_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSATRN. human.
GeneWikiATRN.
GenomeRNAi8455.
NextBio31642.
PROO75882.
SOURCESearch...

Entry information

Entry nameATRN_HUMAN
AccessionPrimary (citable) accession number: O75882
Secondary accession number(s): A8KAE5 expand/collapse secondary AC list , O60295, O95414, Q3MIT3, Q5TDA2, Q5TDA4, Q5VYW3, Q9NTQ3, Q9NTQ4, Q9NU01, Q9NZ57, Q9NZ58, Q9UC75, Q9UDF5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: July 9, 2014
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM