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Protein

Carcinoembryonic antigen-related cell adhesion molecule 4

Gene

CEACAM4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Granulocyte orphan receptor that acts as an trigger efficient phagocytosis of attached particles.1 Publication

GO - Biological processi

  • phagocytosis Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Carcinoembryonic antigen-related cell adhesion molecule 4
Alternative name(s):
Carcinoembryonic antigen CGM7
Non-specific cross-reacting antigen W236
Gene namesi
Name:CEACAM4
Synonyms:CGM7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:1816. CEACAM4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini36 – 155120ExtracellularSequence analysisAdd
BLAST
Transmembranei156 – 17621HelicalSequence analysisAdd
BLAST
Topological domaini177 – 24468CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi222 – 2221Y → F: No internalization of bacteria; when associated with F-233. 1 Publication
Mutagenesisi233 – 2331Y → F: No internalization of bacteria; when associated with F-222. 1 Publication

Organism-specific databases

PharmGKBiPA26360.

Polymorphism and mutation databases

BioMutaiCEACAM4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535Sequence analysisAdd
BLAST
Chaini36 – 244209Carcinoembryonic antigen-related cell adhesion molecule 4PRO_0000316847Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence analysis
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence analysis
Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence analysis
Glycosylationi126 – 1261N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated.1 Publication
The cytoplasmic ITAM-like sequence becomes tyrosine phosphorylated by SRC family PTKs upon ligand-mediated receptor clustering and allows to initiate phagocytosis of bound ligand.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO75871.
PRIDEiO75871.

PTM databases

iPTMnetiO75871.

Expressioni

Tissue specificityi

Granulocytes.1 Publication

Gene expression databases

BgeeiO75871.
CleanExiHS_CEACAM4.
ExpressionAtlasiO75871. baseline and differential.
GenevisibleiO75871. HS.

Organism-specific databases

HPAiHPA012801.

Interactioni

Subunit structurei

Interacts through its phosphorylated ITAM domain with the SH2 domain-containing cytoplasmic proteins involved in signaling processes during phagocytosis.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000221954.

Structurei

3D structure databases

ProteinModelPortaliO75871.
SMRiO75871. Positions 35-141.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 139104Ig-like V-typeAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi222 – 23615ITAMCuratedAdd
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JEDW. Eukaryota.
ENOG41119IN. LUCA.
GeneTreeiENSGT00760000119187.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiO75871.
KOiK06499.
PhylomeDBiO75871.
TreeFamiTF336859.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75871-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPPSAAPRG GHRPWQGLLI TASLLTFWHP PTTVQFTIEA LPSSAAEGKD
60 70 80 90 100
VLLLACNISE TIQAYYWHKG KTAEGSPLIA GYITDIQANI PGAAYSGRET
110 120 130 140 150
VYPNGSLLFQ NITLEDAGSY TLRTINASYD SDQATGQLHV HQNNVPGLPV
160 170 180 190 200
GAVAGIVTGV LVGVALVAAL VCFLLLSRTG RASIQRDLRE QPPPASTPGH
210 220 230 240
GPSHRSTFSA PLPSPRTATP IYEELLYSDA NIYCQIDHKA DVVS
Length:244
Mass (Da):25,909
Last modified:August 1, 1999 - v2
Checksum:iC7D2CB0D1CFDC2EC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti100 – 1001T → Q in BAA14320 (PubMed:2050678).Curated
Sequence conflicti223 – 2253EEL → VEF in BAA14320 (PubMed:2050678).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti29 – 291H → D.1 Publication
Corresponds to variant rs1126454 [ dbSNP | Ensembl ].
VAR_038404
Natural varianti69 – 691K → R.
Corresponds to variant rs3848568 [ dbSNP | Ensembl ].
VAR_038405

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90276 mRNA. Translation: BAA14320.1.
AC005794 Genomic DNA. Translation: AAC62829.1.
AC005955 Genomic DNA. Translation: AAC72273.1.
CH471126 Genomic DNA. Translation: EAW57055.1.
CCDSiCCDS33033.1.
PIRiA40428.
RefSeqiNP_001808.2. NM_001817.3.
UniGeneiHs.12.

Genome annotation databases

EnsembliENST00000221954; ENSP00000221954; ENSG00000105352.
ENST00000616476; ENSP00000481247; ENSG00000274131.
GeneIDi1089.
KEGGihsa:1089.
UCSCiuc002orh.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90276 mRNA. Translation: BAA14320.1.
AC005794 Genomic DNA. Translation: AAC62829.1.
AC005955 Genomic DNA. Translation: AAC72273.1.
CH471126 Genomic DNA. Translation: EAW57055.1.
CCDSiCCDS33033.1.
PIRiA40428.
RefSeqiNP_001808.2. NM_001817.3.
UniGeneiHs.12.

3D structure databases

ProteinModelPortaliO75871.
SMRiO75871. Positions 35-141.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000221954.

PTM databases

iPTMnetiO75871.

Polymorphism and mutation databases

BioMutaiCEACAM4.

Proteomic databases

PaxDbiO75871.
PRIDEiO75871.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221954; ENSP00000221954; ENSG00000105352.
ENST00000616476; ENSP00000481247; ENSG00000274131.
GeneIDi1089.
KEGGihsa:1089.
UCSCiuc002orh.1. human.

Organism-specific databases

CTDi1089.
GeneCardsiCEACAM4.
H-InvDBHIX0040149.
HGNCiHGNC:1816. CEACAM4.
HPAiHPA012801.
neXtProtiNX_O75871.
PharmGKBiPA26360.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JEDW. Eukaryota.
ENOG41119IN. LUCA.
GeneTreeiENSGT00760000119187.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiO75871.
KOiK06499.
PhylomeDBiO75871.
TreeFamiTF336859.

Miscellaneous databases

GenomeRNAii1089.
PROiO75871.

Gene expression databases

BgeeiO75871.
CleanExiHS_CEACAM4.
ExpressionAtlasiO75871. baseline and differential.
GenevisibleiO75871. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of nonspecific cross-reacting antigens in human granulocytes."
    Kuroki M., Arakawa F., Matsuo Y., Oikawa S., Misumi Y., Nakazato H., Matsuoka Y.
    J. Biol. Chem. 266:11810-11817(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], GLYCOSYLATION, TISSUE SPECIFICITY, VARIANT ASP-29.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The granulocyte orphan receptor CEACAM4 is able to trigger phagocytosis of bacteria."
    Delgado Tascon J., Adrian J., Kopp K., Scholz P., Tschan M.P., Kuespert K., Hauck C.R.
    J. Leukoc. Biol. 97:521-531(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION, MUTAGENESIS OF TYR-222 AND TYR-233.

Entry informationi

Entry nameiCEAM4_HUMAN
AccessioniPrimary (citable) accession number: O75871
Secondary accession number(s): Q03715, Q7LDZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 1, 1999
Last modified: June 8, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

To study the function of the orphan receptor CEACAM4 chimeric proteins containing the extracellular bacteria-binding domain of CEACAM3 and the transmembrane and cytoplasmic part of CEACAM4 has been used.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.