O75871 (CEAM4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Carcinoembryonic antigen-related cell adhesion molecule 4

Alternative name(s):
Carcinoembryonic antigen CGM7
Non-specific cross-reacting antigen W236

Gene names

Name:	CEACAM4
Synonyms:	CGM7

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	244 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Granulocyte. Ref.1
Post-translational modification	N-glycosylated. Ref.1
Sequence similarities	Belongs to the immunoglobulin superfamily. CEA family. Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Immunoglobulin domain Signal Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to plasma membrane Traceable author statement. Source: ProtInc membrane fraction Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 35	35	Potential
	Chain	36 – 244	209	Carcinoembryonic antigen-related cell adhesion molecule 4		PRO_0000316847
Regions
	Topological domain	36 – 155	120	Extracellular Potential
	Transmembrane	156 – 176	21	Helical; Potential
	Topological domain	177 – 244	68	Cytoplasmic Potential
	Domain	36 – 139	104	Ig-like V-type
Amino acid modifications
	Glycosylation	57	1	N-linked (GlcNAc...) Potential
	Glycosylation	104	1	N-linked (GlcNAc...) Potential
	Glycosylation	111	1	N-linked (GlcNAc...) Potential
	Glycosylation	126	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	29	1	H → D. Ref.1 Corresponds to variant rs1126454 [ dbSNP | Ensembl ].		VAR_038404
	Natural variant	69	1	K → R. Corresponds to variant rs3848568 [ dbSNP | Ensembl ].		VAR_038405
Experimental info
	Sequence conflict	100	1	T → Q in BAA14320. Ref.1
	Sequence conflict	223 – 225	3	EEL → VEF in BAA14320. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O75871 [UniParc]. Last modified August 1, 1999. Version 2. Checksum: C7D2CB0D1CFDC2EC	FASTA	244	25,909
	10 20 30 40 50 60 MGPPSAAPRG GHRPWQGLLI TASLLTFWHP PTTVQFTIEA LPSSAAEGKD VLLLACNISE 70 80 90 100 110 120 TIQAYYWHKG KTAEGSPLIA GYITDIQANI PGAAYSGRET VYPNGSLLFQ NITLEDAGSY 130 140 150 160 170 180 TLRTINASYD SDQATGQLHV HQNNVPGLPV GAVAGIVTGV LVGVALVAAL VCFLLLSRTG 190 200 210 220 230 240 RASIQRDLRE QPPPASTPGH GPSHRSTFSA PLPSPRTATP IYEELLYSDA NIYCQIDHKA DVVS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of nonspecific cross-reacting antigens in human granulocytes." Kuroki M., Arakawa F., Matsuo Y., Oikawa S., Misumi Y., Nakazato H., Matsuoka Y. J. Biol. Chem. 266:11810-11817(1991) [PubMed: 2050678] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], GLYCOSYLATION, TISSUE SPECIFICITY, VARIANT ASP-29.
[2]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	D90276 mRNA. Translation: BAA14320.1. AC005794 Genomic DNA. Translation: AAC62829.1. AC005955 Genomic DNA. Translation: AAC72273.1. CH471126 Genomic DNA. Translation: EAW57055.1.
IPI	IPI00019020.
PIR	A40428.
RefSeq	NP_001808.2. NM_001817.2.
UniGene	Hs.12.
3D structure databases
ProteinModelPortal	O75871.
SMR	O75871. Positions 30-148.
ModBase	Search...
Protein-protein interaction databases
STRING	O75871.
Proteomic databases
PRIDE	O75871.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000221954; ENSP00000221954; ENSG00000105352.
GeneID	1089.
KEGG	hsa:1089.
UCSC	uc002orh.1. human.
Organism-specific databases
CTD	1089.
GeneCards	GC19M042125.
H-InvDB	HIX0040149.
HGNC	HGNC:1816. CEACAM4.
HPA	HPA012801.
neXtProt	NX_O75871.
PharmGKB	PA26360.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG11957.
GeneTree	ENSGT00550000074209.
HOVERGEN	HBG007922.
InParanoid	O75871.
OrthoDB	EOG4M0F2K.
PhylomeDB	O75871.
Gene expression databases
ArrayExpress	O75871.
Bgee	O75871.
CleanEx	HS_CEACAM4.
Genevestigator	O75871.
Family and domain databases
InterPro	IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR013106. Ig_V-set. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit.
KO	K06499.
Pfam	PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00409. IG. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	4530.

Entry information

Entry name

CEAM4_HUMAN

Accession

Primary (citable) accession number: O75871
Secondary accession number(s): Q03715, Q7LDZ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	August 1, 1999
Last modified:	January 25, 2012
This is version 78 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.