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Protein

Trafficking protein particle complex subunit 6A

Gene

TRAPPC6A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in vesicular transport during the biogenesis of melanosomes.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-HSA-8876198. RAB GEFs exchange GTP for GDP on RABs.

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 6A
Short name:
TRAPP complex subunit 6A
Gene namesi
ORF Names:HSPC289
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:23069. TRAPPC6A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000007255.
PharmGKBiPA134963625.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002445391 – 159Trafficking protein particle complex subunit 6AAdd BLAST159

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO75865.
PeptideAtlasiO75865.
PRIDEiO75865.

PTM databases

iPTMnetiO75865.
PhosphoSitePlusiO75865.

Expressioni

Gene expression databases

BgeeiENSG00000007255.
CleanExiHS_TRAPPC6A.
ExpressionAtlasiO75865. baseline and differential.
GenevisibleiO75865. HS.

Organism-specific databases

HPAiHPA043043.

Interactioni

Subunit structurei

Part of the multisubunit TRAPP (transport protein particle) complex. Heterodimer with TRAPPC3. The heterodimer TRAPPC3-TRAPPC6A interacts with TRAPPC2L. Interacts with TRAPPC2L.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HEL-S-101V9HW273EBI-743573,EBI-10178933
Hoxa1P090223EBI-743573,EBI-3957603From a different organism.
IKZF3Q9UKT93EBI-743573,EBI-747204
RAB3IPQ96QF04EBI-743573,EBI-747844
TRAPPC3O436177EBI-743573,EBI-743566
ZMIZ2Q8NF64-23EBI-743573,EBI-10182121

Protein-protein interaction databases

BioGridi122538. 23 interactors.
DIPiDIP-37869N.
IntActiO75865. 28 interactors.
MINTiMINT-1484344.

Structurei

Secondary structure

1159
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 17Combined sources14
Helixi27 – 29Combined sources3
Helixi32 – 51Combined sources20
Helixi54 – 57Combined sources4
Helixi62 – 70Combined sources9
Helixi72 – 78Combined sources7
Beta strandi83 – 87Combined sources5
Beta strandi89 – 97Combined sources9
Helixi101 – 103Combined sources3
Helixi110 – 112Combined sources3
Turni113 – 115Combined sources3
Helixi116 – 119Combined sources4
Helixi121 – 133Combined sources13
Beta strandi139 – 146Combined sources8
Beta strandi150 – 155Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2C0JX-ray2.20B1-159[»]
2J3TX-ray2.40B1-159[»]
ProteinModelPortaliO75865.
SMRiO75865.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75865.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000012948.
HOGENOMiHOG000200502.
HOVERGENiHBG056159.
InParanoidiO75865.
KOiK20304.
OMAiGFRVGQA.
OrthoDBiEOG091G0MJ1.
PhylomeDBiO75865.
TreeFamiTF313010.

Family and domain databases

InterProiIPR024096. NO_sig/Golgi_transp_ligand-bd.
IPR007194. TRAPP_component.
[Graphical view]
PfamiPF04051. TRAPP. 1 hit.
[Graphical view]
SUPFAMiSSF111126. SSF111126. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75865-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADTVLFEFL HTEMVAELWA HDPDPGPGGQ KMSLSVLEGM GFRVGQALGE
60 70 80 90 100
RLPRETLAFR EELDVLKFLC KDLWVAVFQK QMDSLRTNHQ GTYVLQDNSF
110 120 130 140 150
PLLLPMASGL QYLEEAPKFL AFTCGLLRGA LYTLGIESVV TASVAALPVC

KFQVVIPKS
Length:159
Mass (Da):17,605
Last modified:June 27, 2006 - v2
Checksum:iE7AF768013E7E031
GO
Isoform 2 (identifier: O75865-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-28: G → GVSAGLRGEEAGATK

Show »
Length:173
Mass (Da):18,932
Checksum:i970E1F95E5A4A22A
GO
Isoform 3 (identifier: O75865-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     29-159: GQKMSLSVLE...CKFQVVIPKS → AAPGDAGLQG...PARRPLYPGH

Note: Gene prediction based on EST data.
Show »
Length:113
Mass (Da):11,648
Checksum:i76EC39FE7B5821F9
GO
Isoform 4 (identifier: O75865-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     29-159: GQKMSLSVLE...CKFQVVIPKS → VSAGLRGEEA...PARRPLYPGH

Note: Gene prediction based on EST data.
Show »
Length:127
Mass (Da):12,976
Checksum:i2169B80FBF05C5D4
GO

Sequence cautioni

The sequence AAC62259 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAF28967 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti99 – 123SFPLL…FLAFT → KLSPPPPDGLWPAVSGGSTQ VPGLH in AAF28967 (Ref. 1) CuratedAdd BLAST25

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01958528G → GVSAGLRGEEAGATK in isoform 2. 1 Publication1
Alternative sequenceiVSP_04701629 – 159GQKMS…VIPKS → AAPGDAGLQGGAGCPQVLVQ RPVGGGVPEADGQPAHQSPG DLRPARQQLPPPPPDGLWPA VSGGSTQVPGLHLRPPARRP LYPGH in isoform 3. CuratedAdd BLAST131
Alternative sequenceiVSP_04701729 – 159GQKMS…VIPKS → VSAGLRGEEAGATKAAPGDA GLQGGAGCPQVLVQRPVGGG VPEADGQPAHQSPGDLRPAR QQLPPPPPDGLWPAVSGGST QVPGLHLRPPARRPLYPGH in isoform 4. CuratedAdd BLAST131

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161407 mRNA. Translation: AAF28967.1. Different initiation.
AC005757 Genomic DNA. Translation: AAC62259.1. Different initiation.
BC001907 mRNA. Translation: AAH01907.1.
BC004450 mRNA. Translation: AAH04450.1.
CCDSiCCDS12655.1. [O75865-2]
CCDS59395.1. [O75865-4]
CCDS59396.1. [O75865-3]
CCDS59397.1. [O75865-1]
RefSeqiNP_001257820.1. NM_001270891.1. [O75865-1]
NP_001257821.1. NM_001270892.1. [O75865-4]
NP_001257822.1. NM_001270893.1. [O75865-3]
NP_077013.1. NM_024108.2. [O75865-2]
UniGeneiHs.466929.

Genome annotation databases

EnsembliENST00000006275; ENSP00000006275; ENSG00000007255. [O75865-2]
ENST00000585934; ENSP00000468612; ENSG00000007255. [O75865-1]
ENST00000588062; ENSP00000468363; ENSG00000007255. [O75865-3]
ENST00000592647; ENSP00000468182; ENSG00000007255. [O75865-4]
GeneIDi79090.
KEGGihsa:79090.
UCSCiuc002pav.5. human. [O75865-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161407 mRNA. Translation: AAF28967.1. Different initiation.
AC005757 Genomic DNA. Translation: AAC62259.1. Different initiation.
BC001907 mRNA. Translation: AAH01907.1.
BC004450 mRNA. Translation: AAH04450.1.
CCDSiCCDS12655.1. [O75865-2]
CCDS59395.1. [O75865-4]
CCDS59396.1. [O75865-3]
CCDS59397.1. [O75865-1]
RefSeqiNP_001257820.1. NM_001270891.1. [O75865-1]
NP_001257821.1. NM_001270892.1. [O75865-4]
NP_001257822.1. NM_001270893.1. [O75865-3]
NP_077013.1. NM_024108.2. [O75865-2]
UniGeneiHs.466929.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2C0JX-ray2.20B1-159[»]
2J3TX-ray2.40B1-159[»]
ProteinModelPortaliO75865.
SMRiO75865.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122538. 23 interactors.
DIPiDIP-37869N.
IntActiO75865. 28 interactors.
MINTiMINT-1484344.

PTM databases

iPTMnetiO75865.
PhosphoSitePlusiO75865.

Proteomic databases

MaxQBiO75865.
PeptideAtlasiO75865.
PRIDEiO75865.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000006275; ENSP00000006275; ENSG00000007255. [O75865-2]
ENST00000585934; ENSP00000468612; ENSG00000007255. [O75865-1]
ENST00000588062; ENSP00000468363; ENSG00000007255. [O75865-3]
ENST00000592647; ENSP00000468182; ENSG00000007255. [O75865-4]
GeneIDi79090.
KEGGihsa:79090.
UCSCiuc002pav.5. human. [O75865-1]

Organism-specific databases

CTDi79090.
GeneCardsiTRAPPC6A.
H-InvDBHIX0202809.
HGNCiHGNC:23069. TRAPPC6A.
HPAiHPA043043.
MIMi610396. gene.
neXtProtiNX_O75865.
OpenTargetsiENSG00000007255.
PharmGKBiPA134963625.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000012948.
HOGENOMiHOG000200502.
HOVERGENiHBG056159.
InParanoidiO75865.
KOiK20304.
OMAiGFRVGQA.
OrthoDBiEOG091G0MJ1.
PhylomeDBiO75865.
TreeFamiTF313010.

Enzyme and pathway databases

ReactomeiR-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-HSA-8876198. RAB GEFs exchange GTP for GDP on RABs.

Miscellaneous databases

ChiTaRSiTRAPPC6A. human.
EvolutionaryTraceiO75865.
GenomeRNAii79090.
PROiO75865.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000007255.
CleanExiHS_TRAPPC6A.
ExpressionAtlasiO75865. baseline and differential.
GenevisibleiO75865. HS.

Family and domain databases

InterProiIPR024096. NO_sig/Golgi_transp_ligand-bd.
IPR007194. TRAPP_component.
[Graphical view]
PfamiPF04051. TRAPP. 1 hit.
[Graphical view]
SUPFAMiSSF111126. SSF111126. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTPC6A_HUMAN
AccessioniPrimary (citable) accession number: O75865
Secondary accession number(s): K7ERB1
, K7ERQ4, Q9BQ45, Q9P092
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: November 30, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.