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Protein

Trafficking protein particle complex subunit 6A

Gene

TRAPPC6A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in vesicular transport during the biogenesis of melanosomes.By similarity

Caution

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII (Coat Protein 2) Mediated Vesicle Transport
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 6A
Short name:
TRAPP complex subunit 6A
Gene namesi
ORF Names:HSPC289
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000007255.10
HGNCiHGNC:23069 TRAPPC6A
MIMi610396 gene
neXtProtiNX_O75865

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000007255
PharmGKBiPA134963625

Chemistry databases

DrugBankiDB08342 S-PALMITOYL-L-CYSTEINE

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002445391 – 159Trafficking protein particle complex subunit 6AAdd BLAST159

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO75865
MaxQBiO75865
PeptideAtlasiO75865
PRIDEiO75865

PTM databases

iPTMnetiO75865
PhosphoSitePlusiO75865

Expressioni

Gene expression databases

BgeeiENSG00000007255
CleanExiHS_TRAPPC6A
ExpressionAtlasiO75865 baseline and differential
GenevisibleiO75865 HS

Organism-specific databases

HPAiHPA043043

Interactioni

Subunit structurei

Part of the multisubunit TRAPP (transport protein particle) complex. Heterodimer with TRAPPC3. The heterodimer TRAPPC3-TRAPPC6A interacts with TRAPPC2L. Interacts with TRAPPC2L.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi12253823 interactors.
CORUMiO75865
DIPiDIP-37869N
IntActiO75865 43 interactors.
MINTiO75865

Structurei

Secondary structure

1159
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 17Combined sources14
Helixi27 – 29Combined sources3
Helixi32 – 51Combined sources20
Helixi54 – 57Combined sources4
Helixi62 – 70Combined sources9
Helixi72 – 78Combined sources7
Beta strandi83 – 87Combined sources5
Beta strandi89 – 97Combined sources9
Helixi101 – 103Combined sources3
Helixi110 – 112Combined sources3
Turni113 – 115Combined sources3
Helixi116 – 119Combined sources4
Helixi121 – 133Combined sources13
Beta strandi139 – 146Combined sources8
Beta strandi150 – 155Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2C0JX-ray2.20B1-159[»]
2J3TX-ray2.40B1-159[»]
ProteinModelPortaliO75865
SMRiO75865
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75865

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000012948
HOGENOMiHOG000200502
HOVERGENiHBG056159
InParanoidiO75865
KOiK20304
OMAiGFRVGQA
OrthoDBiEOG091G0MJ1
PhylomeDBiO75865
TreeFamiTF313010

Family and domain databases

CDDicd14944 TRAPPC6A_Trs33, 1 hit
InterProiView protein in InterPro
IPR024096 NO_sig/Golgi_transp_ligand-bd
IPR007194 TRAPP_component
IPR037992 TRAPPC6/Trs33
PANTHERiPTHR12817 PTHR12817, 1 hit
PfamiView protein in Pfam
PF04051 TRAPP, 1 hit
SUPFAMiSSF111126 SSF111126, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75865-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADTVLFEFL HTEMVAELWA HDPDPGPGGQ KMSLSVLEGM GFRVGQALGE
60 70 80 90 100
RLPRETLAFR EELDVLKFLC KDLWVAVFQK QMDSLRTNHQ GTYVLQDNSF
110 120 130 140 150
PLLLPMASGL QYLEEAPKFL AFTCGLLRGA LYTLGIESVV TASVAALPVC

KFQVVIPKS
Length:159
Mass (Da):17,605
Last modified:June 27, 2006 - v2
Checksum:iE7AF768013E7E031
GO
Isoform 2 (identifier: O75865-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-28: G → GVSAGLRGEEAGATK

Show »
Length:173
Mass (Da):18,932
Checksum:i970E1F95E5A4A22A
GO
Isoform 3 (identifier: O75865-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     29-159: GQKMSLSVLE...CKFQVVIPKS → AAPGDAGLQG...PARRPLYPGH

Note: Gene prediction based on EST data.
Show »
Length:113
Mass (Da):11,648
Checksum:i76EC39FE7B5821F9
GO
Isoform 4 (identifier: O75865-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     29-159: GQKMSLSVLE...CKFQVVIPKS → VSAGLRGEEA...PARRPLYPGH

Note: Gene prediction based on EST data.
Show »
Length:127
Mass (Da):12,976
Checksum:i2169B80FBF05C5D4
GO

Sequence cautioni

The sequence AAC62259 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAF28967 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti99 – 123SFPLL…FLAFT → KLSPPPPDGLWPAVSGGSTQ VPGLH in AAF28967 (Ref. 1) CuratedAdd BLAST25

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01958528G → GVSAGLRGEEAGATK in isoform 2. 1 Publication1
Alternative sequenceiVSP_04701629 – 159GQKMS…VIPKS → AAPGDAGLQGGAGCPQVLVQ RPVGGGVPEADGQPAHQSPG DLRPARQQLPPPPPDGLWPA VSGGSTQVPGLHLRPPARRP LYPGH in isoform 3. CuratedAdd BLAST131
Alternative sequenceiVSP_04701729 – 159GQKMS…VIPKS → VSAGLRGEEAGATKAAPGDA GLQGGAGCPQVLVQRPVGGG VPEADGQPAHQSPGDLRPAR QQLPPPPPDGLWPAVSGGST QVPGLHLRPPARRPLYPGH in isoform 4. CuratedAdd BLAST131

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161407 mRNA Translation: AAF28967.1 Different initiation.
AC005757 Genomic DNA Translation: AAC62259.1 Different initiation.
BC001907 mRNA Translation: AAH01907.1
BC004450 mRNA Translation: AAH04450.1
CCDSiCCDS12655.1 [O75865-2]
CCDS59395.1 [O75865-4]
CCDS59396.1 [O75865-3]
CCDS59397.1 [O75865-1]
RefSeqiNP_001257820.1, NM_001270891.1 [O75865-1]
NP_001257821.1, NM_001270892.1 [O75865-4]
NP_001257822.1, NM_001270893.1 [O75865-3]
NP_077013.1, NM_024108.2 [O75865-2]
UniGeneiHs.466929

Genome annotation databases

EnsembliENST00000006275; ENSP00000006275; ENSG00000007255 [O75865-2]
ENST00000585934; ENSP00000468612; ENSG00000007255 [O75865-1]
ENST00000588062; ENSP00000468363; ENSG00000007255 [O75865-3]
ENST00000592647; ENSP00000468182; ENSG00000007255 [O75865-4]
GeneIDi79090
KEGGihsa:79090
UCSCiuc002pav.5 human [O75865-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTPC6A_HUMAN
AccessioniPrimary (citable) accession number: O75865
Secondary accession number(s): K7ERB1
, K7ERQ4, Q9BQ45, Q9P092
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: March 28, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome