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Protein

Protein phosphatase 1 regulatory subunit 37

Gene

PPP1R37

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.1 Publication

GO - Molecular functioni

  • phosphatase binding Source: UniProtKB
  • protein phosphatase inhibitor activity Source: UniProtKB-KW

GO - Biological processi

  • negative regulation of phosphatase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Protein phosphatase inhibitor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000104866-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 37
Alternative name(s):
Leucine-rich repeat-containing protein 68
Gene namesi
Name:PPP1R37
Synonyms:KIAA1986, LRRC68
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:27607. PPP1R37.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000104866.

Polymorphism and mutation databases

BioMutaiPPP1R37.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003209391 – 691Protein phosphatase 1 regulatory subunit 37Add BLAST691

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei50PhosphoserineCombined sources1
Modified residuei56PhosphoserineBy similarity1
Modified residuei561PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO75864.
PaxDbiO75864.
PeptideAtlasiO75864.
PRIDEiO75864.

PTM databases

iPTMnetiO75864.
PhosphoSitePlusiO75864.

Expressioni

Gene expression databases

BgeeiENSG00000104866.
CleanExiHS_LRRC68.
ExpressionAtlasiO75864. baseline and differential.
GenevisibleiO75864. HS.

Organism-specific databases

HPAiHPA041500.

Interactioni

Subunit structurei

Interacts with PPP1CA.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP1CAP621362EBI-5235692,EBI-357253

GO - Molecular functioni

  • phosphatase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi129838. 6 interactors.
IntActiO75864. 8 interactors.
MINTiMINT-1193517.
STRINGi9606.ENSP00000221462.

Structurei

3D structure databases

ProteinModelPortaliO75864.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati220 – 240LRR 1Add BLAST21
Repeati248 – 269LRR 2Add BLAST22
Repeati277 – 297LRR 3Add BLAST21
Repeati306 – 326LRR 4Add BLAST21
Repeati334 – 354LRR 5Add BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi514 – 522Poly-Glu9
Compositional biasi527 – 653Pro-richAdd BLAST127

Sequence similaritiesi

Belongs to the PPP1R37 family.Curated
Contains 5 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG1908. Eukaryota.
ENOG410XSTR. LUCA.
GeneTreeiENSGT00730000111194.
HOGENOMiHOG000074153.
HOVERGENiHBG108102.
InParanoidiO75864.
KOiK17576.
OMAiNGCKRNL.
OrthoDBiEOG091G0KU7.
PhylomeDBiO75864.
TreeFamiTF328391.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
PfamiPF13516. LRR_6. 3 hits.
[Graphical view]
PROSITEiPS51450. LRR. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75864-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEIAPQEAPP VPGADGDIEE APAEAGSPSP ASPPADGRLK AAAKRVTFPS
60 70 80 90 100
DEDIVSGAVE PKDPWRHAQN VTVDEVIGAY KQACQKLNCR QIPKLLRQLQ
110 120 130 140 150
EFTDLGHRLD CLDLKGEKLD YKTCEALEEV FKRLQFKVVD LEQTNLDEDG
160 170 180 190 200
ASALFDMIEY YESATHLNIS FNKHIGTRGW QAAAHMMRKT SCLQYLDARN
210 220 230 240 250
TPLLDHSAPF VARALRIRSS LAVLHLENAS LSGRPLMLLA TALKMNMNLR
260 270 280 290 300
ELYLADNKLN GLQDSAQLGN LLKFNCSLQI LDLRNNHVLD SGLAYICEGL
310 320 330 340 350
KEQRKGLVTL VLWNNQLTHT GMAFLGMTLP HTQSLETLNL GHNPIGNEGV
360 370 380 390 400
RHLKNGLISN RSVLRLGLAS TKLTCEGAVA VAEFIAESPR LLRLDLRENE
410 420 430 440 450
IKTGGLMALS LALKVNHSLL RLDLDREPKK EAVKSFIETQ KALLAEIQNG
460 470 480 490 500
CKRNLVLARE REEKEQPPQL SASMPETTAT EPQPDDEPAA GVQNGAPSPA
510 520 530 540 550
PSPDSDSDSD SDGEEEEEEE GERDETPCPA LVPPTDSLGP GDRSPPGSPS
560 570 580 590 600
TPTEQRISVS SPGRGHKVFV VTRVESPPER AEPPASPTPP SPPPPPSPPA
610 620 630 640 650
SPSLPPAGAI DTRDTGSSEP QPPPEPPRSG PPLPNGLKPE FALALPPEPP
660 670 680 690
PGPEVKGGSC GLEHELSCSK NEKELEELLL EASQESGQET L
Length:691
Mass (Da):74,767
Last modified:March 21, 2012 - v4
Checksum:i45578CC726B2063F
GO
Isoform 2 (identifier: O75864-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-473: Missing.
     665-691: ELSCSKNEKELEELLLEASQESGQETL → GERGPRAGVE...WELFLGWGGM

Note: Due to an intron retention. No experimental confirmation available.
Show »
Length:257
Mass (Da):26,289
Checksum:i20BCEEA179AD22B3
GO

Sequence cautioni

The sequence AAC62258 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAB85572 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0317541 – 473Missing in isoform 2. 1 PublicationAdd BLAST473
Alternative sequenceiVSP_031755665 – 691ELSCS…GQETL → GERGPRAGVEGPWVLYVTPG KPLPVVGLSFPLFKMVLAGA SKVGLSSHLHPASLGSWELF LGWGGM in isoform 2. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075866 mRNA. Translation: BAB85572.1. Different initiation.
AC011489 Genomic DNA. No translation available.
AC005757 Genomic DNA. Translation: AAC62258.1. Sequence problems.
BC035704 mRNA. Translation: AAH35704.1.
BQ638089 mRNA. No translation available.
CCDSiCCDS56096.1. [O75864-1]
RefSeqiNP_061994.1. NM_019121.1. [O75864-1]
UniGeneiHs.285363.

Genome annotation databases

EnsembliENST00000221462; ENSP00000221462; ENSG00000104866. [O75864-1]
GeneIDi284352.
KEGGihsa:284352.
UCSCiuc021uvs.2. human. [O75864-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075866 mRNA. Translation: BAB85572.1. Different initiation.
AC011489 Genomic DNA. No translation available.
AC005757 Genomic DNA. Translation: AAC62258.1. Sequence problems.
BC035704 mRNA. Translation: AAH35704.1.
BQ638089 mRNA. No translation available.
CCDSiCCDS56096.1. [O75864-1]
RefSeqiNP_061994.1. NM_019121.1. [O75864-1]
UniGeneiHs.285363.

3D structure databases

ProteinModelPortaliO75864.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129838. 6 interactors.
IntActiO75864. 8 interactors.
MINTiMINT-1193517.
STRINGi9606.ENSP00000221462.

PTM databases

iPTMnetiO75864.
PhosphoSitePlusiO75864.

Polymorphism and mutation databases

BioMutaiPPP1R37.

Proteomic databases

MaxQBiO75864.
PaxDbiO75864.
PeptideAtlasiO75864.
PRIDEiO75864.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221462; ENSP00000221462; ENSG00000104866. [O75864-1]
GeneIDi284352.
KEGGihsa:284352.
UCSCiuc021uvs.2. human. [O75864-1]

Organism-specific databases

CTDi284352.
GeneCardsiPPP1R37.
H-InvDBHIX0015224.
HGNCiHGNC:27607. PPP1R37.
HPAiHPA041500.
neXtProtiNX_O75864.
OpenTargetsiENSG00000104866.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1908. Eukaryota.
ENOG410XSTR. LUCA.
GeneTreeiENSGT00730000111194.
HOGENOMiHOG000074153.
HOVERGENiHBG108102.
InParanoidiO75864.
KOiK17576.
OMAiNGCKRNL.
OrthoDBiEOG091G0KU7.
PhylomeDBiO75864.
TreeFamiTF328391.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000104866-MONOMER.

Miscellaneous databases

GenomeRNAii284352.
PROiO75864.

Gene expression databases

BgeeiENSG00000104866.
CleanExiHS_LRRC68.
ExpressionAtlasiO75864. baseline and differential.
GenevisibleiO75864. HS.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
PfamiPF13516. LRR_6. 3 hits.
[Graphical view]
PROSITEiPS51450. LRR. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPR37_HUMAN
AccessioniPrimary (citable) accession number: O75864
Secondary accession number(s): B5MDA4, Q8IWK3, Q8TF16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 21, 2012
Last modified: November 30, 2016
This is version 111 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.