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Protein

AP-1 complex subunit gamma-like 2

Gene

AP1G2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV).3 Publications

GO - Molecular functioni

GO - Biological processi

  • intracellular protein transport Source: InterPro
  • vesicle-mediated transport Source: UniProtKB
  • viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000092051-MONOMER.
ReactomeiR-HSA-432720. Lysosome Vesicle Biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
AP-1 complex subunit gamma-like 2
Alternative name(s):
Gamma2-adaptin
Short name:
G2ad
Gene namesi
Name:AP1G2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:556. AP1G2.

Subcellular locationi

GO - Cellular componenti

  • AP-1 adaptor complex Source: UniProtKB
  • endosome membrane Source: UniProtKB-SubCell
  • Golgi apparatus Source: ProtInc
  • Golgi-associated vesicle Source: UniProtKB
  • Golgi membrane Source: Reactome
  • membrane Source: UniProtKB
  • transport vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi369L → G: Greatly diminishes interaction with ubiquitin; when associated with G-372. 1 Publication1
Mutagenesisi372A → G: Greatly diminishes interaction with ubiquitin; when associated with G-369. 1 Publication1
Mutagenesisi372A → G: Greatly diminishes interaction with ubiquitin; when associated with G-376. 1 Publication1
Mutagenesisi376S → G: Greatly diminishes interaction with ubiquitin; when associated with G-372. 1 Publication1

Organism-specific databases

DisGeNETi8906.
OpenTargetsiENSG00000213983.
PharmGKBiPA24846.

Polymorphism and mutation databases

BioMutaiAP1G2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001937601 – 785AP-1 complex subunit gamma-like 2Add BLAST785

Proteomic databases

EPDiO75843.
MaxQBiO75843.
PaxDbiO75843.
PeptideAtlasiO75843.
PRIDEiO75843.

PTM databases

iPTMnetiO75843.
PhosphoSitePlusiO75843.

Expressioni

Tissue specificityi

Expressed in all but one (skeletal muscle) tissues examined.

Gene expression databases

BgeeiENSG00000213983.
CleanExiHS_AP1G2.
ExpressionAtlasiO75843. baseline and differential.
GenevisibleiO75843. HS.

Organism-specific databases

HPAiHPA004106.

Interactioni

Subunit structurei

Probably interacts with AP1S1/Sigma1A-adaptin AP1S2/Sigma1B-adaptin. Probably does not interact with APB1. Interacts with HBV major surface antigen L. Interacts with HBV core protein C in a ubiquitin-dependent manner. Binds ubiquitin.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RABEP1Q152762EBI-373637,EBI-447043

Protein-protein interaction databases

BioGridi114420. 24 interactors.
DIPiDIP-31185N.
IntActiO75843. 14 interactors.
MINTiMINT-5005892.
STRINGi9606.ENSP00000312442.

Structurei

Secondary structure

1785
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi670 – 675Combined sources6
Beta strandi678 – 685Combined sources8
Beta strandi693 – 702Combined sources10
Beta strandi704 – 706Combined sources3
Beta strandi708 – 716Combined sources9
Beta strandi721 – 725Combined sources5
Beta strandi731 – 733Combined sources3
Turni735 – 737Combined sources3
Beta strandi741 – 748Combined sources8
Beta strandi758 – 765Combined sources8
Beta strandi768 – 775Combined sources8
Helixi781 – 783Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E9GNMR-A662-785[»]
2YMTX-ray1.80A665-785[»]
3ZHFX-ray1.70A665-785[»]
4BCXX-ray2.00A665-785[»]
ProteinModelPortaliO75843.
SMRiO75843.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75843.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini665 – 780GAEPROSITE-ProRule annotationAdd BLAST116

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni369 – 379Essential for ubiquitin-bindingAdd BLAST11

Sequence similaritiesi

Contains 1 GAE domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1062. Eukaryota.
ENOG410XPKK. LUCA.
GeneTreeiENSGT00390000012618.
HOGENOMiHOG000210271.
HOVERGENiHBG067473.
InParanoidiO75843.
KOiK12391.
OMAiNVRAMMQ.
OrthoDBiEOG091G01RV.
PhylomeDBiO75843.
TreeFamiTF300367.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
2.60.40.1230. 1 hit.
InterProiIPR017107. AP1_complex_gsu.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
IPR008152. Clathrin_a/b/g-adaptin_app_Ig.
IPR008153. Clathrin_g-adaptin_app.
IPR013041. Coatomer/clathrin_app_Ig-like.
[Graphical view]
PfamiPF01602. Adaptin_N. 1 hit.
PF02883. Alpha_adaptinC2. 1 hit.
[Graphical view]
PIRSFiPIRSF037094. AP1_complex_gamma. 1 hit.
SMARTiSM00809. Alpha_adaptinC2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49348. SSF49348. 1 hit.
PROSITEiPS50180. GAE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75843-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVPSLKLQD LIEEIRGAKT QAQEREVIQK ECAHIRASFR DGDPVHRHRQ
60 70 80 90 100
LAKLLYVHML GYPAHFGQME CLKLIASSRF TDKRVGYLGA MLLLDERHDA
110 120 130 140 150
HLLITNSIKN DLSQGIQPVQ GLALCTLSTM GSAEMCRDLA PEVEKLLLQP
160 170 180 190 200
SPYVRKKAIL TAVHMIRKVP ELSSVFLPPC AQLLHERHHG ILLGTITLIT
210 220 230 240 250
ELCERSPAAL RHFRKVVPQL VHILRTLVTM GYSTEHSISG VSDPFLQVQI
260 270 280 290 300
LRLLRILGRN HEESSETMND LLAQVATNTD TSRNAGNAVL FETVLTIMDI
310 320 330 340 350
RSAAGLRVLA VNILGRFLLN SDRNIRYVAL TSLLRLVQSD HSAVQRHRPT
360 370 380 390 400
VVECLRETDA SLSRRALELS LALVNSSNVR AMMQELQAFL ESCPPDLRAD
410 420 430 440 450
CASGILLAAE RFAPTKRWHI DTILHVLTTA GTHVRDDAVA NLTQLIGGAQ
460 470 480 490 500
ELHAYSVRRL YNALAEDISQ QPLVQVAAWC IGEYGDLLLA GNCEEIEPLQ
510 520 530 540 550
VDEEEVLALL EKVLQSHMSL PATRGYALTA LMKLSTRLCG DNNRIRQVVS
560 570 580 590 600
IYGSCLDVEL QQRAVEYDTL FRKYDHMRAA ILEKMPLVER DGPQADEEAK
610 620 630 640 650
ESKEAAQLSE AAPVPTEPQA SQLLDLLDLL DGASGDVQHP PHLDPSPGGA
660 670 680 690 700
LVHLLDLPCV PPPPAPIPDL KVFEREGVQL NLSFIRPPEN PALLLITITA
710 720 730 740 750
TNFSEGDVTH FICQAAVPKS LQLQLQAPSG NTVPARGGLP ITQLFRILNP
760 770 780
NKAPLRLKLR LTYDHFHQSV QEIFEVNNLP VESWQ
Length:785
Mass (Da):87,117
Last modified:November 1, 1998 - v1
Checksum:iC189192C9811111C
GO

Sequence cautioni

The sequence AAC67390 differs from that shown. Reason: Frameshift at position 713.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti204 – 206ERS → GRN in AAC67390 (PubMed:9762922).Curated3
Sequence conflicti399A → C in AAC67390 (PubMed:9762922).Curated1
Sequence conflicti402A → D in AAC67390 (PubMed:9762922).Curated1
Sequence conflicti416K → T in AAC67390 (PubMed:9762922).Curated1
Sequence conflicti429T → S in AAC67390 (PubMed:9762922).Curated1
Sequence conflicti439 – 441VAN → AGHT in AAC67390 (PubMed:9762922).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024363377S → F.Corresponds to variant rs12897422dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015318 mRNA. Translation: BAA33390.1.
AF068706 mRNA. Translation: AAC67390.1. Frameshift.
CH471078 Genomic DNA. Translation: EAW66132.1.
CH471078 Genomic DNA. Translation: EAW66134.1.
CH471078 Genomic DNA. Translation: EAW66138.1.
CCDSiCCDS9602.1.
RefSeqiNP_003908.1. NM_003917.4.
XP_005268229.1. XM_005268172.3.
XP_005268230.1. XM_005268173.3.
UniGeneiHs.343244.
Hs.569375.

Genome annotation databases

EnsembliENST00000308724; ENSP00000312442; ENSG00000213983.
ENST00000397120; ENSP00000380309; ENSG00000213983.
GeneIDi8906.
KEGGihsa:8906.
UCSCiuc001wkl.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015318 mRNA. Translation: BAA33390.1.
AF068706 mRNA. Translation: AAC67390.1. Frameshift.
CH471078 Genomic DNA. Translation: EAW66132.1.
CH471078 Genomic DNA. Translation: EAW66134.1.
CH471078 Genomic DNA. Translation: EAW66138.1.
CCDSiCCDS9602.1.
RefSeqiNP_003908.1. NM_003917.4.
XP_005268229.1. XM_005268172.3.
XP_005268230.1. XM_005268173.3.
UniGeneiHs.343244.
Hs.569375.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E9GNMR-A662-785[»]
2YMTX-ray1.80A665-785[»]
3ZHFX-ray1.70A665-785[»]
4BCXX-ray2.00A665-785[»]
ProteinModelPortaliO75843.
SMRiO75843.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114420. 24 interactors.
DIPiDIP-31185N.
IntActiO75843. 14 interactors.
MINTiMINT-5005892.
STRINGi9606.ENSP00000312442.

PTM databases

iPTMnetiO75843.
PhosphoSitePlusiO75843.

Polymorphism and mutation databases

BioMutaiAP1G2.

Proteomic databases

EPDiO75843.
MaxQBiO75843.
PaxDbiO75843.
PeptideAtlasiO75843.
PRIDEiO75843.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308724; ENSP00000312442; ENSG00000213983.
ENST00000397120; ENSP00000380309; ENSG00000213983.
GeneIDi8906.
KEGGihsa:8906.
UCSCiuc001wkl.4. human.

Organism-specific databases

CTDi8906.
DisGeNETi8906.
GeneCardsiAP1G2.
HGNCiHGNC:556. AP1G2.
HPAiHPA004106.
MIMi603534. gene.
neXtProtiNX_O75843.
OpenTargetsiENSG00000213983.
PharmGKBiPA24846.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1062. Eukaryota.
ENOG410XPKK. LUCA.
GeneTreeiENSGT00390000012618.
HOGENOMiHOG000210271.
HOVERGENiHBG067473.
InParanoidiO75843.
KOiK12391.
OMAiNVRAMMQ.
OrthoDBiEOG091G01RV.
PhylomeDBiO75843.
TreeFamiTF300367.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000092051-MONOMER.
ReactomeiR-HSA-432720. Lysosome Vesicle Biogenesis.

Miscellaneous databases

ChiTaRSiAP1G2. human.
EvolutionaryTraceiO75843.
GeneWikiiAP1G2.
GenomeRNAii8906.
PROiO75843.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000213983.
CleanExiHS_AP1G2.
ExpressionAtlasiO75843. baseline and differential.
GenevisibleiO75843. HS.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
2.60.40.1230. 1 hit.
InterProiIPR017107. AP1_complex_gsu.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
IPR008152. Clathrin_a/b/g-adaptin_app_Ig.
IPR008153. Clathrin_g-adaptin_app.
IPR013041. Coatomer/clathrin_app_Ig-like.
[Graphical view]
PfamiPF01602. Adaptin_N. 1 hit.
PF02883. Alpha_adaptinC2. 1 hit.
[Graphical view]
PIRSFiPIRSF037094. AP1_complex_gamma. 1 hit.
SMARTiSM00809. Alpha_adaptinC2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49348. SSF49348. 1 hit.
PROSITEiPS50180. GAE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAP1G2_HUMAN
AccessioniPrimary (citable) accession number: O75843
Secondary accession number(s): D3DS51, O75504
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 1, 1998
Last modified: November 2, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Does not appear to be a subunit of the clathrin-associated adaptor protein complex 1 (AP-1).Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.