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Protein

Uroplakin-1b

Gene

UPK1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity).By similarity

GO - Molecular functioni

  • structural molecule activity Source: UniProtKB

GO - Biological processi

  • cell surface receptor signaling pathway Source: GO_Central
  • epithelial cell differentiation Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000114638-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uroplakin-1b
Short name:
UP1b
Alternative name(s):
Tetraspanin-20
Short name:
Tspan-20
Uroplakin Ib
Short name:
UPIb
Gene namesi
Name:UPK1B
Synonyms:TSPAN20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:12578. UPK1B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 15CytoplasmicSequence analysisAdd BLAST14
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Topological domaini37 – 60ExtracellularSequence analysisAdd BLAST24
Transmembranei61 – 81HelicalSequence analysisAdd BLAST21
Topological domaini82 – 86CytoplasmicSequence analysis5
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 229ExtracellularSequence analysisAdd BLAST122
Transmembranei230 – 250HelicalSequence analysisAdd BLAST21
Topological domaini251 – 260CytoplasmicSequence analysis10

GO - Cellular componenti

  • apical plasma membrane Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi7348.
OpenTargetsiENSG00000114638.
PharmGKBiPA37210.

Polymorphism and mutation databases

BioMutaiUPK1B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002192892 – 260Uroplakin-1bAdd BLAST259

Post-translational modificationi

N-glycosylated with high-mannose oligosaccharides.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO75841.
PaxDbiO75841.
PeptideAtlasiO75841.
PRIDEiO75841.

PTM databases

iPTMnetiO75841.
PhosphoSitePlusiO75841.

Expressioni

Tissue specificityi

Bladder epithelium.

Gene expression databases

BgeeiENSG00000114638.
CleanExiHS_UPK1B.
ExpressionAtlasiO75841. baseline and differential.
GenevisibleiO75841. HS.

Organism-specific databases

HPAiHPA031799.
HPA031800.

Interactioni

Subunit structurei

Heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B).By similarity

Protein-protein interaction databases

BioGridi113195. 4 interactors.
IntActiO75841. 1 interactor.
STRINGi9606.ENSP00000264234.

Structurei

3D structure databases

ProteinModelPortaliO75841.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00390000000126.
HOGENOMiHOG000230653.
HOVERGENiHBG054305.
InParanoidiO75841.
KOiK17347.
OMAiGYYHNQG.
OrthoDBiEOG091G0G8N.
PhylomeDBiO75841.
TreeFamiTF335659.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75841-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKDNSTVRC FQGLLIFGNV IIGCCGIALT AECIFFVSDQ HSLYPLLEAT
60 70 80 90 100
DNDDIYGAAW IGIFVGICLF CLSVLGIVGI MKSSRKILLA YFILMFIVYA
110 120 130 140 150
FEVASCITAA TQQDFFTPNL FLKQMLERYQ NNSPPNNDDQ WKNNGVTKTW
160 170 180 190 200
DRLMLQDNCC GVNGPSDWQK YTSAFRTENN DADYPWPRQC CVMNNLKEPL
210 220 230 240 250
NLEACKLGVP GFYHNQGCYE LISGPMNRHA WGVAWFGFAI LCWTFWVLLG
260
TMFYWSRIEY
Length:260
Mass (Da):29,643
Last modified:November 30, 2010 - v5
Checksum:i0512AF8D33884C0F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti137N → D in BAA33724 (PubMed:9818021).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028780113Q → R.5 PublicationsCorresponds to variant rs9840317dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015234 mRNA. Translation: BAA33724.1.
AF042331 mRNA. Translation: AAC77794.1.
AB002155 mRNA. Translation: BAA88878.1.
AC083800 Genomic DNA. No translation available.
BC063568 mRNA. Translation: AAH63568.1.
AF082888 mRNA. Translation: AAD09401.1.
AF067147 Genomic DNA. Translation: AAC17446.1.
CCDSiCCDS2985.1.
RefSeqiNP_008883.2. NM_006952.3.
UniGeneiHs.271580.

Genome annotation databases

EnsembliENST00000264234; ENSP00000264234; ENSG00000114638.
GeneIDi7348.
KEGGihsa:7348.
UCSCiuc003ecc.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015234 mRNA. Translation: BAA33724.1.
AF042331 mRNA. Translation: AAC77794.1.
AB002155 mRNA. Translation: BAA88878.1.
AC083800 Genomic DNA. No translation available.
BC063568 mRNA. Translation: AAH63568.1.
AF082888 mRNA. Translation: AAD09401.1.
AF067147 Genomic DNA. Translation: AAC17446.1.
CCDSiCCDS2985.1.
RefSeqiNP_008883.2. NM_006952.3.
UniGeneiHs.271580.

3D structure databases

ProteinModelPortaliO75841.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113195. 4 interactors.
IntActiO75841. 1 interactor.
STRINGi9606.ENSP00000264234.

PTM databases

iPTMnetiO75841.
PhosphoSitePlusiO75841.

Polymorphism and mutation databases

BioMutaiUPK1B.

Proteomic databases

MaxQBiO75841.
PaxDbiO75841.
PeptideAtlasiO75841.
PRIDEiO75841.

Protocols and materials databases

DNASUi7348.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264234; ENSP00000264234; ENSG00000114638.
GeneIDi7348.
KEGGihsa:7348.
UCSCiuc003ecc.4. human.

Organism-specific databases

CTDi7348.
DisGeNETi7348.
GeneCardsiUPK1B.
HGNCiHGNC:12578. UPK1B.
HPAiHPA031799.
HPA031800.
MIMi602380. gene.
neXtProtiNX_O75841.
OpenTargetsiENSG00000114638.
PharmGKBiPA37210.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00390000000126.
HOGENOMiHOG000230653.
HOVERGENiHBG054305.
InParanoidiO75841.
KOiK17347.
OMAiGYYHNQG.
OrthoDBiEOG091G0G8N.
PhylomeDBiO75841.
TreeFamiTF335659.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000114638-MONOMER.

Miscellaneous databases

ChiTaRSiUPK1B. human.
GeneWikiiUPK1B.
GenomeRNAii7348.
PROiO75841.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000114638.
CleanExiHS_UPK1B.
ExpressionAtlasiO75841. baseline and differential.
GenevisibleiO75841. HS.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUPK1B_HUMAN
AccessioniPrimary (citable) accession number: O75841
Secondary accession number(s): O60753, Q9UIM2, Q9UNX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 30, 2010
Last modified: November 30, 2016
This is version 129 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.