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O75841 (UPK1B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uroplakin-1b

Short name=UP1b
Alternative name(s):
Tetraspanin-20
Short name=Tspan-20
Uroplakin Ib
Short name=UPIb
Gene names
Name:UPK1B
Synonyms:TSPAN20
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length260 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions By similarity.

Subunit structure

Heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B) By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Bladder epithelium.

Post-translational modification

N-glycosylated with high-mannose oligosaccharides By similarity.

Sequence similarities

Belongs to the tetraspanin (TM4SF) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 260259Uroplakin-1b
PRO_0000219289

Regions

Topological domain2 – 1514Cytoplasmic Potential
Transmembrane16 – 3621Helical; Potential
Topological domain37 – 6024Extracellular Potential
Transmembrane61 – 8121Helical; Potential
Topological domain82 – 865Cytoplasmic Potential
Transmembrane87 – 10721Helical; Potential
Topological domain108 – 229122Extracellular Potential
Transmembrane230 – 25021Helical; Potential
Topological domain251 – 26010Cytoplasmic Potential

Natural variations

Natural variant1131Q → R. Ref.1 Ref.2 Ref.5 Ref.6 Ref.7
Corresponds to variant rs9840317 [ dbSNP | Ensembl ].
VAR_028780

Experimental info

Sequence conflict1371N → D in BAA33724. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O75841 [UniParc].

Last modified November 30, 2010. Version 5.
Checksum: 0512AF8D33884C0F

FASTA26029,643
        10         20         30         40         50         60 
MAKDNSTVRC FQGLLIFGNV IIGCCGIALT AECIFFVSDQ HSLYPLLEAT DNDDIYGAAW 

        70         80         90        100        110        120 
IGIFVGICLF CLSVLGIVGI MKSSRKILLA YFILMFIVYA FEVASCITAA TQQDFFTPNL 

       130        140        150        160        170        180 
FLKQMLERYQ NNSPPNNDDQ WKNNGVTKTW DRLMLQDNCC GVNGPSDWQK YTSAFRTENN 

       190        200        210        220        230        240 
DADYPWPRQC CVMNNLKEPL NLEACKLGVP GFYHNQGCYE LISGPMNRHA WGVAWFGFAI 

       250        260 
LCWTFWVLLG TMFYWSRIEY 

« Hide

References

« Hide 'large scale' references
[1]"Expression of uroplakin Ib and uroplakin III genes in tissues and peripheral blood of patients with transitional cell carcinoma."
Yuasa T., Yoshiki T., Tanaka T., Kim C.J., Isono T., Okada Y.
Jpn. J. Cancer Res. 89:879-882(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-113.
Tissue: Urinary bladder urothelium.
[2]"Cloning of the human uroplakin 1B cDNA and analysis of its expression in urothelial-tumor cell lines and bladder-carcinoma tissue."
Finch J.L., Miller J., Aspinall J.O., Cowled P.A.
Int. J. Cancer 80:533-538(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-113.
Tissue: Urothelium.
[3]"Molecular cloning of human uroplakin Ib cDNA."
Adachi W., Nishida K., Kinoshita S., Matsubara K., Okubo K.
Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Corneal epithelium.
[4]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-113.
Tissue: Ovary.
[6]"Uroplakin gene expression by normal and neoplastic human urothelium."
Lobban E.D., Smith B.A., Hall G.D., Harnden P., Roberts P., Selby P.J., Trejdosiewicz L.K., Southgate J.
Am. J. Pathol. 153:1957-1967(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-252, VARIANT ARG-113.
[7]"Chromosomal localization of the human urothelial 'tetraspan' gene, UPK1B, to 3q13.3-q21 and detection of a TaqI polymorphism."
Finch J.L., Webb G.C., Evdokiou A., Cowled P.A.
Genomics 40:501-503(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 103-142, VARIANT ARG-113.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB015234 mRNA. Translation: BAA33724.1.
AF042331 mRNA. Translation: AAC77794.1.
AB002155 mRNA. Translation: BAA88878.1.
AC083800 Genomic DNA. No translation available.
BC063568 mRNA. Translation: AAH63568.1.
AF082888 mRNA. Translation: AAD09401.1.
AF067147 Genomic DNA. Translation: AAC17446.1.
RefSeqNP_008883.2. NM_006952.3.
UniGeneHs.271580.

3D structure databases

ProteinModelPortalO75841.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113195. 1 interaction.
STRING9606.ENSP00000264234.

Proteomic databases

PaxDbO75841.
PRIDEO75841.

Protocols and materials databases

DNASU7348.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000264234; ENSP00000264234; ENSG00000114638.
GeneID7348.
KEGGhsa:7348.
UCSCuc003ecc.3. human.

Organism-specific databases

CTD7348.
GeneCardsGC03P118892.
HGNCHGNC:12578. UPK1B.
HPAHPA031799.
HPA031800.
MIM602380. gene.
neXtProtNX_O75841.
PharmGKBPA37210.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG247872.
HOGENOMHOG000230653.
HOVERGENHBG054305.
InParanoidO75841.
KOK17347.
OMAQGCYELI.
PhylomeDBO75841.
TreeFamTF335659.

Gene expression databases

ArrayExpressO75841.
BgeeO75841.
CleanExHS_UPK1B.
GenevestigatorO75841.

Family and domain databases

InterProIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamPF00335. Tetraspannin. 1 hit.
[Graphical view]
PRINTSPR00259. TMFOUR.
SUPFAMSSF48652. SSF48652. 1 hit.
ProtoNetSearch...

Other

ChiTaRSUPK1B. human.
GeneWikiUPK1B.
GenomeRNAi7348.
NextBio28766.
PROO75841.
SOURCESearch...

Entry information

Entry nameUPK1B_HUMAN
AccessionPrimary (citable) accession number: O75841
Secondary accession number(s): O60753, Q9UIM2, Q9UNX6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 30, 2010
Last modified: March 19, 2014
This is version 107 of the entry and version 5 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM