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O75841

- UPK1B_HUMAN

UniProt

O75841 - UPK1B_HUMAN

Protein

Uroplakin-1b

Gene

UPK1B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 5 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions By similarity.By similarity

    GO - Molecular functioni

    1. structural molecule activity Source: UniProtKB

    GO - Biological processi

    1. epithelial cell differentiation Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uroplakin-1b
    Short name:
    UP1b
    Alternative name(s):
    Tetraspanin-20
    Short name:
    Tspan-20
    Uroplakin Ib
    Short name:
    UPIb
    Gene namesi
    Name:UPK1B
    Synonyms:TSPAN20
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:12578. UPK1B.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. extracellular vesicular exosome Source: UniProt
    3. integral component of membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37210.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 260259Uroplakin-1bPRO_0000219289Add
    BLAST

    Post-translational modificationi

    N-glycosylated with high-mannose oligosaccharides.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiO75841.
    PaxDbiO75841.
    PRIDEiO75841.

    Expressioni

    Tissue specificityi

    Bladder epithelium.

    Gene expression databases

    ArrayExpressiO75841.
    BgeeiO75841.
    CleanExiHS_UPK1B.
    GenevestigatoriO75841.

    Organism-specific databases

    HPAiHPA031799.
    HPA031800.

    Interactioni

    Subunit structurei

    Heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B).By similarity

    Protein-protein interaction databases

    BioGridi113195. 1 interaction.
    STRINGi9606.ENSP00000264234.

    Structurei

    3D structure databases

    ProteinModelPortaliO75841.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 1514CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini37 – 6024ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini82 – 865CytoplasmicSequence Analysis
    Topological domaini108 – 229122ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini251 – 26010CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei16 – 3621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei61 – 8121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei87 – 10721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei230 – 25021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tetraspanin (TM4SF) family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG247872.
    HOGENOMiHOG000230653.
    HOVERGENiHBG054305.
    InParanoidiO75841.
    KOiK17347.
    OMAiQGCYELI.
    PhylomeDBiO75841.
    TreeFamiTF335659.

    Family and domain databases

    InterProiIPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR008952. Tetraspanin_EC2.
    [Graphical view]
    PfamiPF00335. Tetraspannin. 1 hit.
    [Graphical view]
    PRINTSiPR00259. TMFOUR.
    SUPFAMiSSF48652. SSF48652. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O75841-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKDNSTVRC FQGLLIFGNV IIGCCGIALT AECIFFVSDQ HSLYPLLEAT    50
    DNDDIYGAAW IGIFVGICLF CLSVLGIVGI MKSSRKILLA YFILMFIVYA 100
    FEVASCITAA TQQDFFTPNL FLKQMLERYQ NNSPPNNDDQ WKNNGVTKTW 150
    DRLMLQDNCC GVNGPSDWQK YTSAFRTENN DADYPWPRQC CVMNNLKEPL 200
    NLEACKLGVP GFYHNQGCYE LISGPMNRHA WGVAWFGFAI LCWTFWVLLG 250
    TMFYWSRIEY 260
    Length:260
    Mass (Da):29,643
    Last modified:November 30, 2010 - v5
    Checksum:i0512AF8D33884C0F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti137 – 1371N → D in BAA33724. (PubMed:9818021)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti113 – 1131Q → R.5 Publications
    Corresponds to variant rs9840317 [ dbSNP | Ensembl ].
    VAR_028780

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB015234 mRNA. Translation: BAA33724.1.
    AF042331 mRNA. Translation: AAC77794.1.
    AB002155 mRNA. Translation: BAA88878.1.
    AC083800 Genomic DNA. No translation available.
    BC063568 mRNA. Translation: AAH63568.1.
    AF082888 mRNA. Translation: AAD09401.1.
    AF067147 Genomic DNA. Translation: AAC17446.1.
    CCDSiCCDS2985.1.
    RefSeqiNP_008883.2. NM_006952.3.
    UniGeneiHs.271580.

    Genome annotation databases

    EnsembliENST00000264234; ENSP00000264234; ENSG00000114638.
    GeneIDi7348.
    KEGGihsa:7348.
    UCSCiuc003ecc.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB015234 mRNA. Translation: BAA33724.1 .
    AF042331 mRNA. Translation: AAC77794.1 .
    AB002155 mRNA. Translation: BAA88878.1 .
    AC083800 Genomic DNA. No translation available.
    BC063568 mRNA. Translation: AAH63568.1 .
    AF082888 mRNA. Translation: AAD09401.1 .
    AF067147 Genomic DNA. Translation: AAC17446.1 .
    CCDSi CCDS2985.1.
    RefSeqi NP_008883.2. NM_006952.3.
    UniGenei Hs.271580.

    3D structure databases

    ProteinModelPortali O75841.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113195. 1 interaction.
    STRINGi 9606.ENSP00000264234.

    Proteomic databases

    MaxQBi O75841.
    PaxDbi O75841.
    PRIDEi O75841.

    Protocols and materials databases

    DNASUi 7348.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264234 ; ENSP00000264234 ; ENSG00000114638 .
    GeneIDi 7348.
    KEGGi hsa:7348.
    UCSCi uc003ecc.3. human.

    Organism-specific databases

    CTDi 7348.
    GeneCardsi GC03P118892.
    HGNCi HGNC:12578. UPK1B.
    HPAi HPA031799.
    HPA031800.
    MIMi 602380. gene.
    neXtProti NX_O75841.
    PharmGKBi PA37210.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG247872.
    HOGENOMi HOG000230653.
    HOVERGENi HBG054305.
    InParanoidi O75841.
    KOi K17347.
    OMAi QGCYELI.
    PhylomeDBi O75841.
    TreeFami TF335659.

    Miscellaneous databases

    ChiTaRSi UPK1B. human.
    GeneWikii UPK1B.
    GenomeRNAii 7348.
    NextBioi 28766.
    PROi O75841.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75841.
    Bgeei O75841.
    CleanExi HS_UPK1B.
    Genevestigatori O75841.

    Family and domain databases

    InterProi IPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR008952. Tetraspanin_EC2.
    [Graphical view ]
    Pfami PF00335. Tetraspannin. 1 hit.
    [Graphical view ]
    PRINTSi PR00259. TMFOUR.
    SUPFAMi SSF48652. SSF48652. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Expression of uroplakin Ib and uroplakin III genes in tissues and peripheral blood of patients with transitional cell carcinoma."
      Yuasa T., Yoshiki T., Tanaka T., Kim C.J., Isono T., Okada Y.
      Jpn. J. Cancer Res. 89:879-882(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-113.
      Tissue: Urinary bladder urothelium.
    2. "Cloning of the human uroplakin 1B cDNA and analysis of its expression in urothelial-tumor cell lines and bladder-carcinoma tissue."
      Finch J.L., Miller J., Aspinall J.O., Cowled P.A.
      Int. J. Cancer 80:533-538(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-113.
      Tissue: Urothelium.
    3. "Molecular cloning of human uroplakin Ib cDNA."
      Adachi W., Nishida K., Kinoshita S., Matsubara K., Okubo K.
      Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Corneal epithelium.
    4. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-113.
      Tissue: Ovary.
    6. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-252, VARIANT ARG-113.
    7. "Chromosomal localization of the human urothelial 'tetraspan' gene, UPK1B, to 3q13.3-q21 and detection of a TaqI polymorphism."
      Finch J.L., Webb G.C., Evdokiou A., Cowled P.A.
      Genomics 40:501-503(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 103-142, VARIANT ARG-113.

    Entry informationi

    Entry nameiUPK1B_HUMAN
    AccessioniPrimary (citable) accession number: O75841
    Secondary accession number(s): O60753, Q9UIM2, Q9UNX6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 110 of the entry and version 5 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3