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O75841

- UPK1B_HUMAN

UniProt

O75841 - UPK1B_HUMAN

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Protein

Uroplakin-1b

Gene
UPK1B, TSPAN20
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions By similarity.

GO - Molecular functioni

  1. structural molecule activity Source: UniProtKB

GO - Biological processi

  1. epithelial cell differentiation Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Uroplakin-1b
Short name:
UP1b
Alternative name(s):
Tetraspanin-20
Short name:
Tspan-20
Uroplakin Ib
Short name:
UPIb
Gene namesi
Name:UPK1B
Synonyms:TSPAN20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:12578. UPK1B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 1514Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei16 – 3621Helical; Reviewed predictionAdd
BLAST
Topological domaini37 – 6024Extracellular Reviewed predictionAdd
BLAST
Transmembranei61 – 8121Helical; Reviewed predictionAdd
BLAST
Topological domaini82 – 865Cytoplasmic Reviewed prediction
Transmembranei87 – 10721Helical; Reviewed predictionAdd
BLAST
Topological domaini108 – 229122Extracellular Reviewed predictionAdd
BLAST
Transmembranei230 – 25021Helical; Reviewed predictionAdd
BLAST
Topological domaini251 – 26010Cytoplasmic Reviewed prediction

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. extracellular vesicular exosome Source: UniProt
  3. integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37210.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 260259Uroplakin-1bPRO_0000219289Add
BLAST

Post-translational modificationi

N-glycosylated with high-mannose oligosaccharides By similarity.

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO75841.
PaxDbiO75841.
PRIDEiO75841.

Expressioni

Tissue specificityi

Bladder epithelium.

Gene expression databases

ArrayExpressiO75841.
BgeeiO75841.
CleanExiHS_UPK1B.
GenevestigatoriO75841.

Organism-specific databases

HPAiHPA031799.
HPA031800.

Interactioni

Subunit structurei

Heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B) By similarity.

Protein-protein interaction databases

BioGridi113195. 1 interaction.
STRINGi9606.ENSP00000264234.

Structurei

3D structure databases

ProteinModelPortaliO75841.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG247872.
HOGENOMiHOG000230653.
HOVERGENiHBG054305.
InParanoidiO75841.
KOiK17347.
OMAiQGCYELI.
PhylomeDBiO75841.
TreeFamiTF335659.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75841-1 [UniParc]FASTAAdd to Basket

« Hide

MAKDNSTVRC FQGLLIFGNV IIGCCGIALT AECIFFVSDQ HSLYPLLEAT    50
DNDDIYGAAW IGIFVGICLF CLSVLGIVGI MKSSRKILLA YFILMFIVYA 100
FEVASCITAA TQQDFFTPNL FLKQMLERYQ NNSPPNNDDQ WKNNGVTKTW 150
DRLMLQDNCC GVNGPSDWQK YTSAFRTENN DADYPWPRQC CVMNNLKEPL 200
NLEACKLGVP GFYHNQGCYE LISGPMNRHA WGVAWFGFAI LCWTFWVLLG 250
TMFYWSRIEY 260
Length:260
Mass (Da):29,643
Last modified:November 30, 2010 - v5
Checksum:i0512AF8D33884C0F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti113 – 1131Q → R.5 Publications
Corresponds to variant rs9840317 [ dbSNP | Ensembl ].
VAR_028780

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti137 – 1371N → D in BAA33724. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB015234 mRNA. Translation: BAA33724.1.
AF042331 mRNA. Translation: AAC77794.1.
AB002155 mRNA. Translation: BAA88878.1.
AC083800 Genomic DNA. No translation available.
BC063568 mRNA. Translation: AAH63568.1.
AF082888 mRNA. Translation: AAD09401.1.
AF067147 Genomic DNA. Translation: AAC17446.1.
CCDSiCCDS2985.1.
RefSeqiNP_008883.2. NM_006952.3.
UniGeneiHs.271580.

Genome annotation databases

EnsembliENST00000264234; ENSP00000264234; ENSG00000114638.
GeneIDi7348.
KEGGihsa:7348.
UCSCiuc003ecc.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB015234 mRNA. Translation: BAA33724.1 .
AF042331 mRNA. Translation: AAC77794.1 .
AB002155 mRNA. Translation: BAA88878.1 .
AC083800 Genomic DNA. No translation available.
BC063568 mRNA. Translation: AAH63568.1 .
AF082888 mRNA. Translation: AAD09401.1 .
AF067147 Genomic DNA. Translation: AAC17446.1 .
CCDSi CCDS2985.1.
RefSeqi NP_008883.2. NM_006952.3.
UniGenei Hs.271580.

3D structure databases

ProteinModelPortali O75841.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113195. 1 interaction.
STRINGi 9606.ENSP00000264234.

Proteomic databases

MaxQBi O75841.
PaxDbi O75841.
PRIDEi O75841.

Protocols and materials databases

DNASUi 7348.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000264234 ; ENSP00000264234 ; ENSG00000114638 .
GeneIDi 7348.
KEGGi hsa:7348.
UCSCi uc003ecc.3. human.

Organism-specific databases

CTDi 7348.
GeneCardsi GC03P118892.
HGNCi HGNC:12578. UPK1B.
HPAi HPA031799.
HPA031800.
MIMi 602380. gene.
neXtProti NX_O75841.
PharmGKBi PA37210.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG247872.
HOGENOMi HOG000230653.
HOVERGENi HBG054305.
InParanoidi O75841.
KOi K17347.
OMAi QGCYELI.
PhylomeDBi O75841.
TreeFami TF335659.

Miscellaneous databases

ChiTaRSi UPK1B. human.
GeneWikii UPK1B.
GenomeRNAii 7348.
NextBioi 28766.
PROi O75841.
SOURCEi Search...

Gene expression databases

ArrayExpressi O75841.
Bgeei O75841.
CleanExi HS_UPK1B.
Genevestigatori O75841.

Family and domain databases

InterProi IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
[Graphical view ]
Pfami PF00335. Tetraspannin. 1 hit.
[Graphical view ]
PRINTSi PR00259. TMFOUR.
SUPFAMi SSF48652. SSF48652. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of uroplakin Ib and uroplakin III genes in tissues and peripheral blood of patients with transitional cell carcinoma."
    Yuasa T., Yoshiki T., Tanaka T., Kim C.J., Isono T., Okada Y.
    Jpn. J. Cancer Res. 89:879-882(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-113.
    Tissue: Urinary bladder urothelium.
  2. "Cloning of the human uroplakin 1B cDNA and analysis of its expression in urothelial-tumor cell lines and bladder-carcinoma tissue."
    Finch J.L., Miller J., Aspinall J.O., Cowled P.A.
    Int. J. Cancer 80:533-538(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-113.
    Tissue: Urothelium.
  3. "Molecular cloning of human uroplakin Ib cDNA."
    Adachi W., Nishida K., Kinoshita S., Matsubara K., Okubo K.
    Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Corneal epithelium.
  4. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-113.
    Tissue: Ovary.
  6. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-252, VARIANT ARG-113.
  7. "Chromosomal localization of the human urothelial 'tetraspan' gene, UPK1B, to 3q13.3-q21 and detection of a TaqI polymorphism."
    Finch J.L., Webb G.C., Evdokiou A., Cowled P.A.
    Genomics 40:501-503(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 103-142, VARIANT ARG-113.

Entry informationi

Entry nameiUPK1B_HUMAN
AccessioniPrimary (citable) accession number: O75841
Secondary accession number(s): O60753, Q9UIM2, Q9UNX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 30, 2010
Last modified: July 9, 2014
This is version 109 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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