ID   SPI2_HUMAN              Reviewed;         405 AA.
AC   O75830;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   27-MAR-2024, entry version 190.
DE   RecName: Full=Serpin I2;
DE   AltName: Full=Myoepithelium-derived serine protease inhibitor;
DE   AltName: Full=Pancpin;
DE   AltName: Full=Pancreas-specific protein TSA2004;
DE   AltName: Full=Peptidase inhibitor 14;
DE            Short=PI-14;
DE   Flags: Precursor;
GN   Name=SERPINI2; Synonyms=MEPI, PI14;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=9624529;
RX   DOI=10.1002/(sici)1098-2264(199807)22:3<179::aid-gcc3>3.3.co;2-u;
RA   Ozaki K., Nagata M., Suzuki M., Fujiwara T., Miyoshi Y., Ishikawa O.,
RA   Ohigashi H., Imaoka S., Takahashi E., Nakamura Y.;
RT   "Isolation and characterization of a novel human pancreas-specific gene,
RT   pancpin, that is down-regulated in pancreatic cancer cells.";
RL   Genes Chromosomes Cancer 22:179-185(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10097100; DOI=10.1073/pnas.96.7.3700;
RA   Xiao G., Liu Y.E., Gentz R., Sang Q.A., Ni J., Goldberg I.D., Shi Y.E.;
RT   "Suppression of breast cancer growth and metastasis by a serpin
RT   myoepithelium-derived serine proteinase inhibitor expressed in the mammary
RT   myoepithelial cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 96:3700-3705(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Pancreas, and Spleen;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       O75830; P37235: HPCAL1; NbExp=3; IntAct=EBI-750144, EBI-749311;
CC       O75830; O43765: SGTA; NbExp=3; IntAct=EBI-750144, EBI-347996;
CC       O75830; Q96EQ0: SGTB; NbExp=4; IntAct=EBI-750144, EBI-744081;
CC       O75830; Q9UMX0: UBQLN1; NbExp=10; IntAct=EBI-750144, EBI-741480;
CC       O75830; Q9UMX0-2: UBQLN1; NbExp=3; IntAct=EBI-750144, EBI-10173939;
CC       O75830; Q9UHD9: UBQLN2; NbExp=3; IntAct=EBI-750144, EBI-947187;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in pancreas and adipose tissues.
CC       {ECO:0000269|PubMed:9624529}.
CC   -!- SIMILARITY: Belongs to the serpin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH27859.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AB006423; BAA33766.1; -; mRNA.
DR   EMBL; AF130470; AAD34723.1; -; mRNA.
DR   EMBL; BC027859; AAH27859.2; ALT_INIT; mRNA.
DR   CCDS; CCDS3200.1; -.
DR   RefSeq; NP_001012303.1; NM_001012303.2.
DR   RefSeq; NP_006208.1; NM_006217.4.
DR   AlphaFoldDB; O75830; -.
DR   SMR; O75830; -.
DR   BioGRID; 111294; 15.
DR   IntAct; O75830; 10.
DR   MINT; O75830; -.
DR   STRING; 9606.ENSP00000481699; -.
DR   MEROPS; I04.026; -.
DR   GlyCosmos; O75830; 3 sites, No reported glycans.
DR   GlyGen; O75830; 3 sites.
DR   iPTMnet; O75830; -.
DR   PhosphoSitePlus; O75830; -.
DR   BioMuta; SERPINI2; -.
DR   EPD; O75830; -.
DR   jPOST; O75830; -.
DR   MassIVE; O75830; -.
DR   PaxDb; 9606-ENSP00000481699; -.
DR   PeptideAtlas; O75830; -.
DR   ProteomicsDB; 50219; -.
DR   Antibodypedia; 33688; 294 antibodies from 34 providers.
DR   DNASU; 5276; -.
DR   Ensembl; ENST00000264677.9; ENSP00000264677.4; ENSG00000114204.16.
DR   Ensembl; ENST00000461846.5; ENSP00000417692.1; ENSG00000114204.16.
DR   Ensembl; ENST00000471111.5; ENSP00000419407.1; ENSG00000114204.16.
DR   GeneID; 5276; -.
DR   KEGG; hsa:5276; -.
DR   MANE-Select; ENST00000264677.9; ENSP00000264677.4; NM_006217.6; NP_006208.1.
DR   UCSC; uc003fer.3; human.
DR   AGR; HGNC:8945; -.
DR   CTD; 5276; -.
DR   DisGeNET; 5276; -.
DR   GeneCards; SERPINI2; -.
DR   HGNC; HGNC:8945; SERPINI2.
DR   HPA; ENSG00000114204; Tissue enriched (pancreas).
DR   MIM; 605587; gene.
DR   neXtProt; NX_O75830; -.
DR   OpenTargets; ENSG00000114204; -.
DR   PharmGKB; PA35513; -.
DR   VEuPathDB; HostDB:ENSG00000114204; -.
DR   eggNOG; KOG2392; Eukaryota.
DR   GeneTree; ENSGT00940000161641; -.
DR   HOGENOM; CLU_023330_0_4_1; -.
DR   InParanoid; O75830; -.
DR   OMA; IPMMHLQ; -.
DR   OrthoDB; 3218836at2759; -.
DR   PhylomeDB; O75830; -.
DR   TreeFam; TF343094; -.
DR   PathwayCommons; O75830; -.
DR   SignaLink; O75830; -.
DR   BioGRID-ORCS; 5276; 8 hits in 1142 CRISPR screens.
DR   ChiTaRS; SERPINI2; human.
DR   GeneWiki; SERPINI2; -.
DR   GenomeRNAi; 5276; -.
DR   Pharos; O75830; Tbio.
DR   PRO; PR:O75830; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; O75830; Protein.
DR   Bgee; ENSG00000114204; Expressed in body of pancreas and 110 other cell types or tissues.
DR   ExpressionAtlas; O75830; baseline and differential.
DR   GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR   CDD; cd19576; serpinI2_pancpin; 1.
DR   Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 1.
DR   Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 1.
DR   InterPro; IPR023795; Serpin_CS.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461; SERINE PROTEASE INHIBITOR, SERPIN; 1.
DR   PANTHER; PTHR11461:SF51; SERPIN I2; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; Serpins; 1.
DR   PROSITE; PS00284; SERPIN; 1.
DR   Genevisible; O75830; HS.
PE   1: Evidence at protein level;
KW   Glycoprotein; Protease inhibitor; Reference proteome; Secreted;
KW   Serine protease inhibitor; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..405
FT                   /note="Serpin I2"
FT                   /id="PRO_0000032525"
FT   SITE            357..358
FT                   /note="Reactive bond"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        202
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        207
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        306
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VARIANT         6
FT                   /note="L -> V (in dbSNP:rs17246389)"
FT                   /id="VAR_051957"
FT   VARIANT         148
FT                   /note="E -> G (in dbSNP:rs9841174)"
FT                   /id="VAR_024357"
SQ   SEQUENCE   405 AA;  46145 MW;  5BA18C60E4FDE9A4 CRC64;
     MDTIFLWSLL LLFFGSQASR CSAQKNTEFA VDLYQEVSLS HKDNIIFSPL GITLVLEMVQ
     LGAKGKAQQQ IRQTLKQQET SAGEEFFVLK SFFSAISEKK QEFTFNLANA LYLQEGFTVK
     EQYLHGNKEF FQSAIKLVDF QDAKACAEMI STWVERKTDG KIKDMFSGEE FGPLTRLVLV
     NAIYFKGDWK QKFRKEDTQL INFTKKNGST VKIPMMKALL RTKYGYFSES SLNYQVLELS
     YKGDEFSLII ILPAEGMDIE EVEKLITAQQ ILKWLSEMQE EEVEISLPRF KVEQKVDFKD
     VLYSLNITEI FSGGCDLSGI TDSSEVYVSQ VTQKVFFEIN EDGSEAATST GIHIPVIMSL
     AQSQFIANHP FLFIMKHNPT ESILFMGRVT NPDTQEIKGR DLDSL
//