O75830 (SPI2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serpin I2

Alternative name(s):
Myoepithelium-derived serine protease inhibitor
Pancpin
Pancreas-specific protein TSA2004
Peptidase inhibitor 14
Short name=PI-14

Gene names

Name:	SERPINI2
Synonyms:	MEPI, PI14

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	405 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Secreted Probable.
Tissue specificity	Expressed in pancreas and adipose tissues. Ref.1
Sequence similarities	Belongs to the serpin family.
Sequence caution	The sequence AAH27859.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Protease inhibitor Serine protease inhibitor
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular component movement Traceable author statement Ref.2. Source: ProtInc regulation of proteolysis Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	serine-type endopeptidase inhibitor activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 405	387	Serpin I2		PRO_0000032525
Sites
	Site	357 – 358	2	Reactive bond By similarity
Amino acid modifications
	Modified residue	184	1	Phosphotyrosine By similarity
	Glycosylation	202	1	N-linked (GlcNAc...) Potential
	Glycosylation	207	1	N-linked (GlcNAc...) Potential
	Glycosylation	306	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	6	1	L → V. Corresponds to variant rs17246389 [ dbSNP | Ensembl ].		VAR_051957
	Natural variant	148	1	E → G. Corresponds to variant rs9841174 [ dbSNP | Ensembl ].		VAR_024357

Sequences

	Sequence		Length	Mass (Da)
	O75830 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 5BA18C60E4FDE9A4	FASTA	405	46,145
	10 20 30 40 50 60 MDTIFLWSLL LLFFGSQASR CSAQKNTEFA VDLYQEVSLS HKDNIIFSPL GITLVLEMVQ 70 80 90 100 110 120 LGAKGKAQQQ IRQTLKQQET SAGEEFFVLK SFFSAISEKK QEFTFNLANA LYLQEGFTVK 130 140 150 160 170 180 EQYLHGNKEF FQSAIKLVDF QDAKACAEMI STWVERKTDG KIKDMFSGEE FGPLTRLVLV 190 200 210 220 230 240 NAIYFKGDWK QKFRKEDTQL INFTKKNGST VKIPMMKALL RTKYGYFSES SLNYQVLELS 250 260 270 280 290 300 YKGDEFSLII ILPAEGMDIE EVEKLITAQQ ILKWLSEMQE EEVEISLPRF KVEQKVDFKD 310 320 330 340 350 360 VLYSLNITEI FSGGCDLSGI TDSSEVYVSQ VTQKVFFEIN EDGSEAATST GIHIPVIMSL 370 380 390 400 AQSQFIANHP FLFIMKHNPT ESILFMGRVT NPDTQEIKGR DLDSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of a novel human pancreas-specific gene, pancpin, that is down-regulated in pancreatic cancer cells." Ozaki K., Nagata M., Suzuki M., Fujiwara T., Miyoshi Y., Ishikawa O., Ohigashi H., Imaoka S., Takahashi E., Nakamura Y. Genes Chromosomes Cancer 22:179-185(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"Suppression of breast cancer growth and metastasis by a serpin myoepithelium-derived serine proteinase inhibitor expressed in the mammary myoepithelial cells." Xiao G., Liu Y.E., Gentz R., Sang Q.A., Ni J., Goldberg I.D., Shi Y.E. Proc. Natl. Acad. Sci. U.S.A. 96:3700-3705(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas and Spleen.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB006423 mRNA. Translation: BAA33766.1. AF130470 mRNA. Translation: AAD34723.1. BC027859 mRNA. Translation: AAH27859.2. Different initiation.
IPI	IPI00795490.
RefSeq	NP_001012303.1. NM_001012303.2. NP_006208.1. NM_006217.4.
UniGene	Hs.445555.
3D structure databases
ProteinModelPortal	O75830.
ModBase	Search...
Protein-protein interaction databases
IntAct	O75830. 2 interactions.
MINT	MINT-1461311.
STRING	9606.ENSP00000264677.
Protein family/group databases
MEROPS	I04.026.
PTM databases
PhosphoSite	O75830.
Proteomic databases
PaxDb	O75830.
PRIDE	O75830.
Protocols and materials databases
DNASU	5276.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000264677; ENSP00000264677; ENSG00000114204. ENST00000461846; ENSP00000417692; ENSG00000114204. ENST00000471111; ENSP00000419407; ENSG00000114204. ENST00000476257; ENSP00000420621; ENSG00000114204.
GeneID	5276.
KEGG	hsa:5276.
UCSC	uc003fer.1. human.
Organism-specific databases
CTD	5276.
GeneCards	GC03M167156.
HGNC	HGNC:8945. SERPINI2.
HPA	HPA030613.
MIM	605587. gene.
neXtProt	NX_O75830.
PharmGKB	PA35513.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG4826.
HOVERGEN	HBG005957.
InParanoid	O75830.
OMA	EVYVSQV.
OrthoDB	EOG43FGX1.
PhylomeDB	O75830.
Gene expression databases
ArrayExpress	O75830.
Bgee	O75830.
CleanEx	HS_SERPINI2.
Genevestigator	O75830.
GermOnline	ENSG00000114204. Homo sapiens.
Family and domain databases
InterPro	IPR023795. Protease_inhib_I4_serpin_CS. IPR023796. Serpin_dom. IPR000215. Serpin_fam. [Graphical view]
PANTHER	PTHR11461. PTHR11461. 1 hit.
Pfam	PF00079. Serpin. 1 hit. [Graphical view]
SMART	SM00093. SERPIN. 1 hit. [Graphical view]
SUPFAM	SSF56574. Prot_inh_serpin. 1 hit.
PROSITE	PS00284. SERPIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SERPINI2. human.
GenomeRNAi	5276.
NextBio	20388.
SOURCE	Search...

Entry information

Entry name

SPI2_HUMAN

Accession

Primary (citable) accession number: O75830

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	November 1, 1998
Last modified:	May 1, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.