Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serpin I2

Gene

SERPINI2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei357 – 358Reactive bondBy similarity2

GO - Molecular functioni

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.026

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin I2
Alternative name(s):
Myoepithelium-derived serine protease inhibitor
Pancpin
Pancreas-specific protein TSA2004
Peptidase inhibitor 14
Short name:
PI-14
Gene namesi
Name:SERPINI2
Synonyms:MEPI, PI14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000114204.14
HGNCiHGNC:8945 SERPINI2
MIMi605587 gene
neXtProtiNX_O75830

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5276
OpenTargetsiENSG00000114204
PharmGKBiPA35513

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000003252519 – 405Serpin I2Add BLAST387

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi202N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi207N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi306N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO75830
PeptideAtlasiO75830
PRIDEiO75830
ProteomicsDBi50219

PTM databases

iPTMnetiO75830
PhosphoSitePlusiO75830

Expressioni

Tissue specificityi

Expressed in pancreas and adipose tissues.1 Publication

Gene expression databases

BgeeiENSG00000114204
CleanExiHS_SERPINI2
ExpressionAtlasiO75830 baseline and differential
GenevisibleiO75830 HS

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi111294, 6 interactors
IntActiO75830, 5 interactors
MINTiO75830
STRINGi9606.ENSP00000264677

Structurei

3D structure databases

ProteinModelPortaliO75830
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00900000140788
HOVERGENiHBG005957
InParanoidiO75830
PhylomeDBiO75830
TreeFamiTF343094

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75830-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTIFLWSLL LLFFGSQASR CSAQKNTEFA VDLYQEVSLS HKDNIIFSPL
60 70 80 90 100
GITLVLEMVQ LGAKGKAQQQ IRQTLKQQET SAGEEFFVLK SFFSAISEKK
110 120 130 140 150
QEFTFNLANA LYLQEGFTVK EQYLHGNKEF FQSAIKLVDF QDAKACAEMI
160 170 180 190 200
STWVERKTDG KIKDMFSGEE FGPLTRLVLV NAIYFKGDWK QKFRKEDTQL
210 220 230 240 250
INFTKKNGST VKIPMMKALL RTKYGYFSES SLNYQVLELS YKGDEFSLII
260 270 280 290 300
ILPAEGMDIE EVEKLITAQQ ILKWLSEMQE EEVEISLPRF KVEQKVDFKD
310 320 330 340 350
VLYSLNITEI FSGGCDLSGI TDSSEVYVSQ VTQKVFFEIN EDGSEAATST
360 370 380 390 400
GIHIPVIMSL AQSQFIANHP FLFIMKHNPT ESILFMGRVT NPDTQEIKGR

DLDSL
Length:405
Mass (Da):46,145
Last modified:November 1, 1998 - v1
Checksum:i5BA18C60E4FDE9A4
GO

Sequence cautioni

The sequence AAH27859 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0519576L → V. Corresponds to variant dbSNP:rs17246389Ensembl.1
Natural variantiVAR_024357148E → G. Corresponds to variant dbSNP:rs9841174Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006423 mRNA Translation: BAA33766.1
AF130470 mRNA Translation: AAD34723.1
BC027859 mRNA Translation: AAH27859.2 Different initiation.
CCDSiCCDS3200.1
RefSeqiNP_001012303.1, NM_001012303.2
NP_006208.1, NM_006217.4
UniGeneiHs.445555

Genome annotation databases

EnsembliENST00000264677; ENSP00000264677; ENSG00000114204
ENST00000461846; ENSP00000417692; ENSG00000114204
ENST00000471111; ENSP00000419407; ENSG00000114204
ENST00000476257; ENSP00000420621; ENSG00000114204
GeneIDi5276
KEGGihsa:5276
UCSCiuc003fer.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSPI2_HUMAN
AccessioniPrimary (citable) accession number: O75830
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1998
Last modified: June 20, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health