Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O75830

- SPI2_HUMAN

UniProt

O75830 - SPI2_HUMAN

Protein

Serpin I2

Gene

SERPINI2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei357 – 3582Reactive bondBy similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. serine-type endopeptidase inhibitor activity Source: RefGenome

    GO - Biological processi

    1. cellular component movement Source: ProtInc
    2. negative regulation of endopeptidase activity Source: RefGenome
    3. regulation of cell adhesion Source: Ensembl
    4. regulation of proteolysis Source: RefGenome

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Protein family/group databases

    MEROPSiI04.026.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serpin I2
    Alternative name(s):
    Myoepithelium-derived serine protease inhibitor
    Pancpin
    Pancreas-specific protein TSA2004
    Peptidase inhibitor 14
    Short name:
    PI-14
    Gene namesi
    Name:SERPINI2
    Synonyms:MEPI, PI14
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:8945. SERPINI2.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular space Source: InterPro

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35513.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 405387Serpin I2PRO_0000032525Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi207 – 2071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi306 – 3061N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiO75830.
    PRIDEiO75830.

    PTM databases

    PhosphoSiteiO75830.

    Expressioni

    Tissue specificityi

    Expressed in pancreas and adipose tissues.1 Publication

    Gene expression databases

    ArrayExpressiO75830.
    BgeeiO75830.
    CleanExiHS_SERPINI2.
    GenevestigatoriO75830.

    Organism-specific databases

    HPAiHPA030613.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    UBQLN1Q9UMX03EBI-750144,EBI-741480

    Protein-protein interaction databases

    BioGridi111294. 2 interactions.
    IntActiO75830. 3 interactions.
    MINTiMINT-1461311.
    STRINGi9606.ENSP00000264677.

    Structurei

    3D structure databases

    ProteinModelPortaliO75830.
    SMRiO75830. Positions 28-394.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serpin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4826.
    HOVERGENiHBG005957.
    InParanoidiO75830.
    OMAiAQQILKW.
    OrthoDBiEOG7327PB.
    PhylomeDBiO75830.
    TreeFamiTF343094.

    Family and domain databases

    InterProiIPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O75830-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDTIFLWSLL LLFFGSQASR CSAQKNTEFA VDLYQEVSLS HKDNIIFSPL    50
    GITLVLEMVQ LGAKGKAQQQ IRQTLKQQET SAGEEFFVLK SFFSAISEKK 100
    QEFTFNLANA LYLQEGFTVK EQYLHGNKEF FQSAIKLVDF QDAKACAEMI 150
    STWVERKTDG KIKDMFSGEE FGPLTRLVLV NAIYFKGDWK QKFRKEDTQL 200
    INFTKKNGST VKIPMMKALL RTKYGYFSES SLNYQVLELS YKGDEFSLII 250
    ILPAEGMDIE EVEKLITAQQ ILKWLSEMQE EEVEISLPRF KVEQKVDFKD 300
    VLYSLNITEI FSGGCDLSGI TDSSEVYVSQ VTQKVFFEIN EDGSEAATST 350
    GIHIPVIMSL AQSQFIANHP FLFIMKHNPT ESILFMGRVT NPDTQEIKGR 400
    DLDSL 405
    Length:405
    Mass (Da):46,145
    Last modified:November 1, 1998 - v1
    Checksum:i5BA18C60E4FDE9A4
    GO

    Sequence cautioni

    The sequence AAH27859.2 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti6 – 61L → V.
    Corresponds to variant rs17246389 [ dbSNP | Ensembl ].
    VAR_051957
    Natural varianti148 – 1481E → G.
    Corresponds to variant rs9841174 [ dbSNP | Ensembl ].
    VAR_024357

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB006423 mRNA. Translation: BAA33766.1.
    AF130470 mRNA. Translation: AAD34723.1.
    BC027859 mRNA. Translation: AAH27859.2. Different initiation.
    CCDSiCCDS3200.1.
    RefSeqiNP_001012303.1. NM_001012303.2.
    NP_006208.1. NM_006217.4.
    UniGeneiHs.445555.

    Genome annotation databases

    EnsembliENST00000264677; ENSP00000264677; ENSG00000114204.
    ENST00000461846; ENSP00000417692; ENSG00000114204.
    ENST00000471111; ENSP00000419407; ENSG00000114204.
    ENST00000476257; ENSP00000420621; ENSG00000114204.
    GeneIDi5276.
    KEGGihsa:5276.
    UCSCiuc003fer.2. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB006423 mRNA. Translation: BAA33766.1 .
    AF130470 mRNA. Translation: AAD34723.1 .
    BC027859 mRNA. Translation: AAH27859.2 . Different initiation.
    CCDSi CCDS3200.1.
    RefSeqi NP_001012303.1. NM_001012303.2.
    NP_006208.1. NM_006217.4.
    UniGenei Hs.445555.

    3D structure databases

    ProteinModelPortali O75830.
    SMRi O75830. Positions 28-394.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111294. 2 interactions.
    IntActi O75830. 3 interactions.
    MINTi MINT-1461311.
    STRINGi 9606.ENSP00000264677.

    Protein family/group databases

    MEROPSi I04.026.

    PTM databases

    PhosphoSitei O75830.

    Proteomic databases

    PaxDbi O75830.
    PRIDEi O75830.

    Protocols and materials databases

    DNASUi 5276.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264677 ; ENSP00000264677 ; ENSG00000114204 .
    ENST00000461846 ; ENSP00000417692 ; ENSG00000114204 .
    ENST00000471111 ; ENSP00000419407 ; ENSG00000114204 .
    ENST00000476257 ; ENSP00000420621 ; ENSG00000114204 .
    GeneIDi 5276.
    KEGGi hsa:5276.
    UCSCi uc003fer.2. human.

    Organism-specific databases

    CTDi 5276.
    GeneCardsi GC03M167156.
    HGNCi HGNC:8945. SERPINI2.
    HPAi HPA030613.
    MIMi 605587. gene.
    neXtProti NX_O75830.
    PharmGKBi PA35513.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4826.
    HOVERGENi HBG005957.
    InParanoidi O75830.
    OMAi AQQILKW.
    OrthoDBi EOG7327PB.
    PhylomeDBi O75830.
    TreeFami TF343094.

    Miscellaneous databases

    ChiTaRSi SERPINI2. human.
    GeneWikii SERPINI2.
    GenomeRNAii 5276.
    NextBioi 20388.
    PROi O75830.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75830.
    Bgeei O75830.
    CleanExi HS_SERPINI2.
    Genevestigatori O75830.

    Family and domain databases

    InterProi IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of a novel human pancreas-specific gene, pancpin, that is down-regulated in pancreatic cancer cells."
      Ozaki K., Nagata M., Suzuki M., Fujiwara T., Miyoshi Y., Ishikawa O., Ohigashi H., Imaoka S., Takahashi E., Nakamura Y.
      Genes Chromosomes Cancer 22:179-185(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "Suppression of breast cancer growth and metastasis by a serpin myoepithelium-derived serine proteinase inhibitor expressed in the mammary myoepithelial cells."
      Xiao G., Liu Y.E., Gentz R., Sang Q.A., Ni J., Goldberg I.D., Shi Y.E.
      Proc. Natl. Acad. Sci. U.S.A. 96:3700-3705(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pancreas and Spleen.

    Entry informationi

    Entry nameiSPI2_HUMAN
    AccessioniPrimary (citable) accession number: O75830
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3