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Protein

Serpin I2

Gene

SERPINI2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei357 – 3582Reactive bondBy similarity

GO - Molecular functioni

  • serine-type endopeptidase inhibitor activity Source: ProtInc

GO - Biological processi

  • movement of cell or subcellular component Source: ProtInc
  • negative regulation of endopeptidase activity Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.026.

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin I2
Alternative name(s):
Myoepithelium-derived serine protease inhibitor
Pancpin
Pancreas-specific protein TSA2004
Peptidase inhibitor 14
Short name:
PI-14
Gene namesi
Name:SERPINI2
Synonyms:MEPI, PI14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:8945. SERPINI2.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35513.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 405387Serpin I2PRO_0000032525Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi207 – 2071N-linked (GlcNAc...)Sequence Analysis
Glycosylationi306 – 3061N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO75830.
PRIDEiO75830.

PTM databases

PhosphoSiteiO75830.

Expressioni

Tissue specificityi

Expressed in pancreas and adipose tissues.1 Publication

Gene expression databases

BgeeiO75830.
CleanExiHS_SERPINI2.
ExpressionAtlasiO75830. baseline and differential.
GenevisibleiO75830. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
UBQLN1Q9UMX06EBI-750144,EBI-741480
UBQLN1Q9UMX0-23EBI-750144,EBI-10173939

Protein-protein interaction databases

BioGridi111294. 2 interactions.
IntActiO75830. 3 interactions.
MINTiMINT-1461311.
STRINGi9606.ENSP00000264677.

Structurei

3D structure databases

ProteinModelPortaliO75830.
SMRiO75830. Positions 28-394.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118839.
HOVERGENiHBG005957.
InParanoidiO75830.
OrthoDBiEOG7327PB.
PhylomeDBiO75830.
TreeFamiTF343094.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75830-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTIFLWSLL LLFFGSQASR CSAQKNTEFA VDLYQEVSLS HKDNIIFSPL
60 70 80 90 100
GITLVLEMVQ LGAKGKAQQQ IRQTLKQQET SAGEEFFVLK SFFSAISEKK
110 120 130 140 150
QEFTFNLANA LYLQEGFTVK EQYLHGNKEF FQSAIKLVDF QDAKACAEMI
160 170 180 190 200
STWVERKTDG KIKDMFSGEE FGPLTRLVLV NAIYFKGDWK QKFRKEDTQL
210 220 230 240 250
INFTKKNGST VKIPMMKALL RTKYGYFSES SLNYQVLELS YKGDEFSLII
260 270 280 290 300
ILPAEGMDIE EVEKLITAQQ ILKWLSEMQE EEVEISLPRF KVEQKVDFKD
310 320 330 340 350
VLYSLNITEI FSGGCDLSGI TDSSEVYVSQ VTQKVFFEIN EDGSEAATST
360 370 380 390 400
GIHIPVIMSL AQSQFIANHP FLFIMKHNPT ESILFMGRVT NPDTQEIKGR

DLDSL
Length:405
Mass (Da):46,145
Last modified:November 1, 1998 - v1
Checksum:i5BA18C60E4FDE9A4
GO

Sequence cautioni

The sequence AAH27859.2 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61L → V.
Corresponds to variant rs17246389 [ dbSNP | Ensembl ].
VAR_051957
Natural varianti148 – 1481E → G.
Corresponds to variant rs9841174 [ dbSNP | Ensembl ].
VAR_024357

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006423 mRNA. Translation: BAA33766.1.
AF130470 mRNA. Translation: AAD34723.1.
BC027859 mRNA. Translation: AAH27859.2. Different initiation.
CCDSiCCDS3200.1.
RefSeqiNP_001012303.1. NM_001012303.2.
NP_006208.1. NM_006217.4.
UniGeneiHs.445555.

Genome annotation databases

EnsembliENST00000264677; ENSP00000264677; ENSG00000114204.
ENST00000461846; ENSP00000417692; ENSG00000114204.
ENST00000471111; ENSP00000419407; ENSG00000114204.
ENST00000476257; ENSP00000420621; ENSG00000114204.
GeneIDi5276.
KEGGihsa:5276.
UCSCiuc003fer.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006423 mRNA. Translation: BAA33766.1.
AF130470 mRNA. Translation: AAD34723.1.
BC027859 mRNA. Translation: AAH27859.2. Different initiation.
CCDSiCCDS3200.1.
RefSeqiNP_001012303.1. NM_001012303.2.
NP_006208.1. NM_006217.4.
UniGeneiHs.445555.

3D structure databases

ProteinModelPortaliO75830.
SMRiO75830. Positions 28-394.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111294. 2 interactions.
IntActiO75830. 3 interactions.
MINTiMINT-1461311.
STRINGi9606.ENSP00000264677.

Protein family/group databases

MEROPSiI04.026.

PTM databases

PhosphoSiteiO75830.

Proteomic databases

PaxDbiO75830.
PRIDEiO75830.

Protocols and materials databases

DNASUi5276.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264677; ENSP00000264677; ENSG00000114204.
ENST00000461846; ENSP00000417692; ENSG00000114204.
ENST00000471111; ENSP00000419407; ENSG00000114204.
ENST00000476257; ENSP00000420621; ENSG00000114204.
GeneIDi5276.
KEGGihsa:5276.
UCSCiuc003fer.2. human.

Organism-specific databases

CTDi5276.
GeneCardsiGC03M167156.
HGNCiHGNC:8945. SERPINI2.
MIMi605587. gene.
neXtProtiNX_O75830.
PharmGKBiPA35513.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118839.
HOVERGENiHBG005957.
InParanoidiO75830.
OrthoDBiEOG7327PB.
PhylomeDBiO75830.
TreeFamiTF343094.

Miscellaneous databases

ChiTaRSiSERPINI2. human.
GeneWikiiSERPINI2.
GenomeRNAii5276.
NextBioi20388.
PROiO75830.
SOURCEiSearch...

Gene expression databases

BgeeiO75830.
CleanExiHS_SERPINI2.
ExpressionAtlasiO75830. baseline and differential.
GenevisibleiO75830. HS.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of a novel human pancreas-specific gene, pancpin, that is down-regulated in pancreatic cancer cells."
    Ozaki K., Nagata M., Suzuki M., Fujiwara T., Miyoshi Y., Ishikawa O., Ohigashi H., Imaoka S., Takahashi E., Nakamura Y.
    Genes Chromosomes Cancer 22:179-185(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Suppression of breast cancer growth and metastasis by a serpin myoepithelium-derived serine proteinase inhibitor expressed in the mammary myoepithelial cells."
    Xiao G., Liu Y.E., Gentz R., Sang Q.A., Ni J., Goldberg I.D., Shi Y.E.
    Proc. Natl. Acad. Sci. U.S.A. 96:3700-3705(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas and Spleen.

Entry informationi

Entry nameiSPI2_HUMAN
AccessioniPrimary (citable) accession number: O75830
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1998
Last modified: July 22, 2015
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.