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O75830

- SPI2_HUMAN

UniProt

O75830 - SPI2_HUMAN

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Protein

Serpin I2

Gene

SERPINI2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei357 – 3582Reactive bondBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: RefGenome

GO - Biological processi

  1. cellular component movement Source: ProtInc
  2. negative regulation of endopeptidase activity Source: RefGenome
  3. regulation of cell adhesion Source: Ensembl
  4. regulation of proteolysis Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.026.

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin I2
Alternative name(s):
Myoepithelium-derived serine protease inhibitor
Pancpin
Pancreas-specific protein TSA2004
Peptidase inhibitor 14
Short name:
PI-14
Gene namesi
Name:SERPINI2
Synonyms:MEPI, PI14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:8945. SERPINI2.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular space Source: InterPro
  2. extracellular vesicular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35513.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 405387Serpin I2PRO_0000032525Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi207 – 2071N-linked (GlcNAc...)Sequence Analysis
Glycosylationi306 – 3061N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO75830.
PRIDEiO75830.

PTM databases

PhosphoSiteiO75830.

Expressioni

Tissue specificityi

Expressed in pancreas and adipose tissues.1 Publication

Gene expression databases

BgeeiO75830.
CleanExiHS_SERPINI2.
ExpressionAtlasiO75830. baseline and differential.
GenevestigatoriO75830.

Organism-specific databases

HPAiHPA030613.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
UBQLN1Q9UMX03EBI-750144,EBI-741480

Protein-protein interaction databases

BioGridi111294. 2 interactions.
IntActiO75830. 3 interactions.
MINTiMINT-1461311.
STRINGi9606.ENSP00000264677.

Structurei

3D structure databases

ProteinModelPortaliO75830.
SMRiO75830. Positions 28-394.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118789.
HOVERGENiHBG005957.
InParanoidiO75830.
OMAiAQQILKW.
OrthoDBiEOG7327PB.
PhylomeDBiO75830.
TreeFamiTF343094.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75830-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDTIFLWSLL LLFFGSQASR CSAQKNTEFA VDLYQEVSLS HKDNIIFSPL
60 70 80 90 100
GITLVLEMVQ LGAKGKAQQQ IRQTLKQQET SAGEEFFVLK SFFSAISEKK
110 120 130 140 150
QEFTFNLANA LYLQEGFTVK EQYLHGNKEF FQSAIKLVDF QDAKACAEMI
160 170 180 190 200
STWVERKTDG KIKDMFSGEE FGPLTRLVLV NAIYFKGDWK QKFRKEDTQL
210 220 230 240 250
INFTKKNGST VKIPMMKALL RTKYGYFSES SLNYQVLELS YKGDEFSLII
260 270 280 290 300
ILPAEGMDIE EVEKLITAQQ ILKWLSEMQE EEVEISLPRF KVEQKVDFKD
310 320 330 340 350
VLYSLNITEI FSGGCDLSGI TDSSEVYVSQ VTQKVFFEIN EDGSEAATST
360 370 380 390 400
GIHIPVIMSL AQSQFIANHP FLFIMKHNPT ESILFMGRVT NPDTQEIKGR

DLDSL
Length:405
Mass (Da):46,145
Last modified:November 1, 1998 - v1
Checksum:i5BA18C60E4FDE9A4
GO

Sequence cautioni

The sequence AAH27859.2 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61L → V.
Corresponds to variant rs17246389 [ dbSNP | Ensembl ].
VAR_051957
Natural varianti148 – 1481E → G.
Corresponds to variant rs9841174 [ dbSNP | Ensembl ].
VAR_024357

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB006423 mRNA. Translation: BAA33766.1.
AF130470 mRNA. Translation: AAD34723.1.
BC027859 mRNA. Translation: AAH27859.2. Different initiation.
CCDSiCCDS3200.1.
RefSeqiNP_001012303.1. NM_001012303.2.
NP_006208.1. NM_006217.4.
UniGeneiHs.445555.

Genome annotation databases

EnsembliENST00000264677; ENSP00000264677; ENSG00000114204.
ENST00000461846; ENSP00000417692; ENSG00000114204.
ENST00000471111; ENSP00000419407; ENSG00000114204.
ENST00000476257; ENSP00000420621; ENSG00000114204.
ENST00000616363; ENSP00000481699; ENSG00000114204.
GeneIDi5276.
KEGGihsa:5276.
UCSCiuc003fer.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB006423 mRNA. Translation: BAA33766.1 .
AF130470 mRNA. Translation: AAD34723.1 .
BC027859 mRNA. Translation: AAH27859.2 . Different initiation.
CCDSi CCDS3200.1.
RefSeqi NP_001012303.1. NM_001012303.2.
NP_006208.1. NM_006217.4.
UniGenei Hs.445555.

3D structure databases

ProteinModelPortali O75830.
SMRi O75830. Positions 28-394.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111294. 2 interactions.
IntActi O75830. 3 interactions.
MINTi MINT-1461311.
STRINGi 9606.ENSP00000264677.

Protein family/group databases

MEROPSi I04.026.

PTM databases

PhosphoSitei O75830.

Proteomic databases

PaxDbi O75830.
PRIDEi O75830.

Protocols and materials databases

DNASUi 5276.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000264677 ; ENSP00000264677 ; ENSG00000114204 .
ENST00000461846 ; ENSP00000417692 ; ENSG00000114204 .
ENST00000471111 ; ENSP00000419407 ; ENSG00000114204 .
ENST00000476257 ; ENSP00000420621 ; ENSG00000114204 .
ENST00000616363 ; ENSP00000481699 ; ENSG00000114204 .
GeneIDi 5276.
KEGGi hsa:5276.
UCSCi uc003fer.2. human.

Organism-specific databases

CTDi 5276.
GeneCardsi GC03M167156.
HGNCi HGNC:8945. SERPINI2.
HPAi HPA030613.
MIMi 605587. gene.
neXtProti NX_O75830.
PharmGKBi PA35513.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4826.
GeneTreei ENSGT00760000118789.
HOVERGENi HBG005957.
InParanoidi O75830.
OMAi AQQILKW.
OrthoDBi EOG7327PB.
PhylomeDBi O75830.
TreeFami TF343094.

Miscellaneous databases

ChiTaRSi SERPINI2. human.
GeneWikii SERPINI2.
GenomeRNAii 5276.
NextBioi 20388.
PROi O75830.
SOURCEi Search...

Gene expression databases

Bgeei O75830.
CleanExi HS_SERPINI2.
ExpressionAtlasi O75830. baseline and differential.
Genevestigatori O75830.

Family and domain databases

InterProi IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
PROSITEi PS00284. SERPIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of a novel human pancreas-specific gene, pancpin, that is down-regulated in pancreatic cancer cells."
    Ozaki K., Nagata M., Suzuki M., Fujiwara T., Miyoshi Y., Ishikawa O., Ohigashi H., Imaoka S., Takahashi E., Nakamura Y.
    Genes Chromosomes Cancer 22:179-185(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Suppression of breast cancer growth and metastasis by a serpin myoepithelium-derived serine proteinase inhibitor expressed in the mammary myoepithelial cells."
    Xiao G., Liu Y.E., Gentz R., Sang Q.A., Ni J., Goldberg I.D., Shi Y.E.
    Proc. Natl. Acad. Sci. U.S.A. 96:3700-3705(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas and Spleen.

Entry informationi

Entry nameiSPI2_HUMAN
AccessioniPrimary (citable) accession number: O75830
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3