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O75830 (SPI2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serpin I2
Alternative name(s):
Myoepithelium-derived serine protease inhibitor
Pancpin
Pancreas-specific protein TSA2004
Peptidase inhibitor 14
Short name=PI-14
Gene names
Name:SERPINI2
Synonyms:MEPI, PI14
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length405 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Secreted Probable.

Tissue specificity

Expressed in pancreas and adipose tissues. Ref.1

Sequence similarities

Belongs to the serpin family.

Sequence caution

The sequence AAH27859.2 differs from that shown. Reason: Erroneous initiation.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

UBQLN1Q9UMX03EBI-750144,EBI-741480

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 405387Serpin I2
PRO_0000032525

Sites

Site357 – 3582Reactive bond By similarity

Amino acid modifications

Glycosylation2021N-linked (GlcNAc...) Potential
Glycosylation2071N-linked (GlcNAc...) Potential
Glycosylation3061N-linked (GlcNAc...) Potential

Natural variations

Natural variant61L → V.
Corresponds to variant rs17246389 [ dbSNP | Ensembl ].
VAR_051957
Natural variant1481E → G.
Corresponds to variant rs9841174 [ dbSNP | Ensembl ].
VAR_024357

Sequences

Sequence LengthMass (Da)Tools
O75830 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 5BA18C60E4FDE9A4

FASTA40546,145
        10         20         30         40         50         60 
MDTIFLWSLL LLFFGSQASR CSAQKNTEFA VDLYQEVSLS HKDNIIFSPL GITLVLEMVQ 

        70         80         90        100        110        120 
LGAKGKAQQQ IRQTLKQQET SAGEEFFVLK SFFSAISEKK QEFTFNLANA LYLQEGFTVK 

       130        140        150        160        170        180 
EQYLHGNKEF FQSAIKLVDF QDAKACAEMI STWVERKTDG KIKDMFSGEE FGPLTRLVLV 

       190        200        210        220        230        240 
NAIYFKGDWK QKFRKEDTQL INFTKKNGST VKIPMMKALL RTKYGYFSES SLNYQVLELS 

       250        260        270        280        290        300 
YKGDEFSLII ILPAEGMDIE EVEKLITAQQ ILKWLSEMQE EEVEISLPRF KVEQKVDFKD 

       310        320        330        340        350        360 
VLYSLNITEI FSGGCDLSGI TDSSEVYVSQ VTQKVFFEIN EDGSEAATST GIHIPVIMSL 

       370        380        390        400 
AQSQFIANHP FLFIMKHNPT ESILFMGRVT NPDTQEIKGR DLDSL 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and characterization of a novel human pancreas-specific gene, pancpin, that is down-regulated in pancreatic cancer cells."
Ozaki K., Nagata M., Suzuki M., Fujiwara T., Miyoshi Y., Ishikawa O., Ohigashi H., Imaoka S., Takahashi E., Nakamura Y.
Genes Chromosomes Cancer 22:179-185(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"Suppression of breast cancer growth and metastasis by a serpin myoepithelium-derived serine proteinase inhibitor expressed in the mammary myoepithelial cells."
Xiao G., Liu Y.E., Gentz R., Sang Q.A., Ni J., Goldberg I.D., Shi Y.E.
Proc. Natl. Acad. Sci. U.S.A. 96:3700-3705(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pancreas and Spleen.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB006423 mRNA. Translation: BAA33766.1.
AF130470 mRNA. Translation: AAD34723.1.
BC027859 mRNA. Translation: AAH27859.2. Different initiation.
RefSeqNP_001012303.1. NM_001012303.2.
NP_006208.1. NM_006217.4.
UniGeneHs.445555.

3D structure databases

ProteinModelPortalO75830.
SMRO75830. Positions 26-394.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111294. 2 interactions.
IntActO75830. 3 interactions.
MINTMINT-1461311.
STRING9606.ENSP00000264677.

Protein family/group databases

MEROPSI04.026.

PTM databases

PhosphoSiteO75830.

Proteomic databases

PaxDbO75830.
PRIDEO75830.

Protocols and materials databases

DNASU5276.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000264677; ENSP00000264677; ENSG00000114204.
ENST00000461846; ENSP00000417692; ENSG00000114204.
ENST00000471111; ENSP00000419407; ENSG00000114204.
ENST00000476257; ENSP00000420621; ENSG00000114204.
GeneID5276.
KEGGhsa:5276.
UCSCuc003fer.2. human.

Organism-specific databases

CTD5276.
GeneCardsGC03M167156.
HGNCHGNC:8945. SERPINI2.
HPAHPA030613.
MIM605587. gene.
neXtProtNX_O75830.
PharmGKBPA35513.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG4826.
HOVERGENHBG005957.
InParanoidO75830.
OMAEVYVSQV.
OrthoDBEOG7327PB.
PhylomeDBO75830.
TreeFamTF343094.

Gene expression databases

ArrayExpressO75830.
BgeeO75830.
CleanExHS_SERPINI2.
GenevestigatorO75830.

Family and domain databases

InterProIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERPTHR11461. PTHR11461. 1 hit.
PfamPF00079. Serpin. 1 hit.
[Graphical view]
SMARTSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMSSF56574. SSF56574. 1 hit.
PROSITEPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSERPINI2. human.
GeneWikiSERPINI2.
GenomeRNAi5276.
NextBio20388.
PROO75830.
SOURCESearch...

Entry information

Entry nameSPI2_HUMAN
AccessionPrimary (citable) accession number: O75830
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1998
Last modified: April 16, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM