Reviewed, UniProtKB/Swiss-Prot O75829 (LECT1_HUMAN)

Names and origin

Protein names

Recommended name:
    Chondromodulin-1
Alternative name(s):
    Chondromodulin-I
      Short name=ChM-I
    Leukocyte cell-derived chemotaxin 1
Cleaved into the following chain:
    1- Recommended name:
            Chondrosurfactant protein
                Short name=CH-SP

Gene names

Name:	LECT1
Synonyms:	CHMI

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development.
Subcellular location	Chondromodulin-1: Secreted. Note: Accumulated in the inter-territorial matrix of cartilage. Chondrosurfactant protein: Endomembrane system; Single-pass membrane protein Potential.
Tissue specificity	Cartilage specific. Weakly expressed in chondrosarcoma.
Developmental stage	Expressed at 9 weeks in developing cartilagenous bone rudiments.
Post-translational modification	After cleavage, the post-translationally modified ChM-I is secreted as a glycoprotein.
Sequence similarities	Belongs to the chondromodulin-1 family. Contains 1 BRICHOS domain.

Ontologies

Keywords
Biological process	Chondrogenesis Differentiation
Cellular component	Membrane Secreted
Coding sequence diversity	Polymorphism
Domain	Transmembrane
Molecular function	Developmental protein
PTM	Cleavage on pair of basic residues Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	cartilage development Inferred from electronic annotation. Source: UniProtKB-KW cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW proteoglycan metabolic process Ref.2 Traceable author statement. Source: ProtInc
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 210	210	Chondrosurfactant protein By similarity		PRO_0000005346
	Propeptide	211 – 214	4	Potential		PRO_0000005347
	Chain	215 – 334	120	Chondromodulin-1		PRO_0000005348
Regions
	Transmembrane	45 – 65	21	Potential
	Domain	104 – 201	98	BRICHOS
Amino acid modifications
	Glycosylation	243	1	N-linked (GlcNAc...) Potential
	Disulfide bond	282 ↔ 286		By similarity
	Disulfide bond	283 ↔ 323		By similarity
Natural variations
	Natural variant	116	1	F → L: dbSNP rs3742298.		VAR_048719
	Natural variant	175	1	V → I: dbSNP rs7330220.		VAR_024413

Sequences

	Sequence		Length	Mass (Da)
	O75829-1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 9E2393111F9D4FE5	FASTA	334	37,102
	10 20 30 40 50 60 MTENSDKVPI ALVGPDDVEF CSPPAYATLT VKPSSPARLL KVGAVVLISG AVLLLFGAIG 70 80 90 100 110 120 AFYFWKGSDS HIYNVHYTMS INGKLQDGSM EIDAGNNLET FKMGSGAEEA IAVNDFQNGI 130 140 150 160 170 180 TGIRFAGGEK CYIKAQVKAR IPEVGAVTKQ SISSKLEGKI MPVKYEENSL IWVAVDQPVK 190 200 210 220 230 240 DNSFLSSKVL ELCGDLPIFW LKPTYPKEIQ RERREVVRKI VPTTTKRPHS GPRSNPGAGR 250 260 270 280 290 300 LNNETRPSVQ EDSQAFNPDN PYHQQEGESM TFDPRLDHEG ICCIECRRSY THCQKICEPL 310 320 330 GGYYPWPYNY QGCRSACRVI MPCSWWVARI LGMV

References

[1]	"Expression of cartilage-specific functional matrix chondromodulin-I mRNA in rabbit growth plate chondrocytes and its responsiveness to growth stimuli in vitro." Shukunami C., Hiraki Y. Biochem. Biophys. Res. Commun. 249:885-890(1998) [PubMed: 9731231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Chondrosarcoma.
[2]	"Molecular cloning of human chondromodulin-I, a cartilage-derived growth modulating factor, and its expression in Chinese hamster ovary cells." Hiraki Y., Mitsui K., Endo N., Takahashi K., Hayami T., Inoue H., Shukunami C., Tokunaga K., Kono T., Yamada M., Takahashi H.E., Kondo J. Eur. J. Biochem. 260:869-878(1999) [PubMed: 10103018] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Tissue: Chondrosarcoma.
[3]	Ozono K. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE OF 1-20.
[4]	"Specific loss of chondromodulin-I gene expression in chondrosarcoma and the suppression of tumor angiogenesis and growth by its recombinant protein in vivo." Hayami T., Shukunami C., Mitsui K., Endo N., Tokunaga K., Kondo J., Takahashi H.E., Hiraki Y. FEBS Lett. 458:436-440(1999) [PubMed: 10570955] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 215-334.
[5]	"Chondromodulin-I as a novel cartilage-specific growth-modulating factor." Hiraki Y., Shukunami C. Pediatr. Nephrol. 14:602-605(2000) [PubMed: 10912526] [Abstract] Cited for: REVIEW.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB006000 mRNA. Translation: BAA33443.1. AF050147 Genomic DNA. Translation: AAC98971.1. AB021290 Genomic DNA. Translation: BAA77384.1. AB005999 mRNA. Translation: BAA86262.1.
IPI	IPI00027162.
RefSeq	NP_008946.1.
UniGene	Hs.421391
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	O75829.
Genome annotation databases
Ensembl	ENSG00000136110. Homo sapiens. [Contig view]
GeneID	11061.
Organism-specific databases
GeneCards	GC13M052175.
HGNC	HGNC:17005. LECT1.
MIM	605147. gene.
PharmGKB	PA134897668.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	O75829.
HOVERGEN	O75829.
OMA	O75829. PAYATVT.
Gene expression databases
ArrayExpress	O75829.
Bgee	O75829.
CleanEx	HS_LECT1.
GermOnline	ENSG00000136110. Homo sapiens.
Family and domain databases
InterPro	IPR007084. BRICHOS. [Graphical view]
Pfam	PF04089. BRICHOS. 1 hit. [Graphical view]
ProDom	PD009591. Pulm_surf_ChM1. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS50869. BRICHOS. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	42031.
PMAP-CutDB	O75829.
SOURCE	Search...

Entry information

Entry name

LECT1_HUMAN

Accession

Primary (citable) accession number: O75829
Secondary accession number(s): Q9UM18

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2001
Last sequence update:	November 1, 1998
Last modified:	June 16, 2009
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)