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Protein

Zinc finger protein 189

Gene

ZNF189

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri148 – 17023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri176 – 19823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri204 – 22623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri232 – 25423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri260 – 28223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri288 – 31023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri316 – 33823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri344 – 36623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri372 – 39423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri400 – 42223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri456 – 47823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri484 – 50623C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri512 – 53423C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri540 – 56223C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri568 – 59023C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri599 – 62123C2H2-type 16PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc

GO - Biological processi

  • mitophagy in response to mitochondrial depolarization Source: ParkinsonsUK-UCL
  • negative regulation of transcription from RNA polymerase II promoter Source: ProtInc
  • positive regulation of defense response to virus by host Source: ParkinsonsUK-UCL
  • transcription, DNA-templated Source: UniProtKB-KW
  • xenophagy Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 189
Gene namesi
Name:ZNF189
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:12980. ZNF189.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37561.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 626626Zinc finger protein 189PRO_0000047444Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki88 – 88Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiO75820.
MaxQBiO75820.
PaxDbiO75820.
PeptideAtlasiO75820.
PRIDEiO75820.

PTM databases

iPTMnetiO75820.
PhosphoSiteiO75820.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000136870.
CleanExiHS_ZNF189.
ExpressionAtlasiO75820. baseline and differential.
GenevisibleiO75820. HS.

Organism-specific databases

HPAiHPA034814.

Interactioni

Protein-protein interaction databases

BioGridi113528. 9 interactions.
IntActiO75820. 14 interactions.
STRINGi9606.ENSP00000342019.

Structurei

3D structure databases

ProteinModelPortaliO75820.
SMRiO75820. Positions 14-53, 139-622.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 8976KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 16 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri148 – 17023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri176 – 19823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri204 – 22623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri232 – 25423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri260 – 28223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri288 – 31023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri316 – 33823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri344 – 36623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri372 – 39423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri400 – 42223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri456 – 47823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri484 – 50623C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri512 – 53423C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri540 – 56223C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri568 – 59023C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri599 – 62123C2H2-type 16PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129692.
HOVERGENiHBG018163.
InParanoidiO75820.
KOiK09228.
OMAiRMFRGNT.
OrthoDBiEOG091G02KC.
PhylomeDBiO75820.
TreeFamiTF336942.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 16 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 6 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75820-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASPSPPPES KGLLTFEDVA VFFTQEEWDY LDPAQRSLYK DVMMENYGNL
60 70 80 90 100
VSLDVLNRDK DEEPTVKQEI EEIEEEVEPQ GVIVTRIKSE IDQDPMGRET
110 120 130 140 150
FELVGRLDKQ RGIFLWEIPR ESLTQEQRMF RENTNIIRKR PNSEEKCHKC
160 170 180 190 200
EECGKGFVRK AHFIQHQRVH TGEKPFQCNE CGKSFSRSSF VIEHQRIHTG
210 220 230 240 250
ERPYECNYCG KTFSVSSTLI RHQRIHTGER PYQCNQCKQS FSQRRSLVKH
260 270 280 290 300
QRIHTGEKPH KCSDCGKAFS WKSHLIEHQR THTGEKPYHC TKCKKSFSRN
310 320 330 340 350
SLLVEHQRIH TGERPHKCGE CGKAFRLSTY LIQHQKIHTG EKPFLCIECG
360 370 380 390 400
KSFSRSSFLI EHQRIHTGER PYQCKECGKS FSQLCNLTRH QRIHTGDKPH
410 420 430 440 450
KCEECGKAFS RSSGLIQHQR IHTREKTYPY NETKESFDPN CSLVIQQEVY
460 470 480 490 500
PKEKSYKCDE CGKTFSVSAH LVQHQRIHTG EKPYLCTVCG KSFSRSSFLI
510 520 530 540 550
EHQRIHTGER PYLCRQCGKS FSQLCNLIRH QGVHTGNKPH KCDECGKAFS
560 570 580 590 600
RNSGLIQHQR IHTGEKPYKC EKCDKSFSQQ RSLVNHQKIH AEVKTQETHE
610 620
CDACGEAFNC RISLIQHQKL HTAWMQ
Length:626
Mass (Da):72,976
Last modified:March 7, 2006 - v2
Checksum:iBF6E0F9943F15E4C
GO
Isoform 2 (identifier: O75820-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-25: Missing.

Show »
Length:612
Mass (Da):71,407
Checksum:i37BB52F79CA7643C
GO
Isoform 3 (identifier: O75820-3) [UniParc]FASTAAdd to basket
Also known as: B2

The sequence of this isoform differs from the canonical sequence as follows:
     1-95: Missing.

Show »
Length:531
Mass (Da):62,061
Checksum:iF0DDE4B367716666
GO
Isoform 4 (identifier: O75820-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.

Show »
Length:584
Mass (Da):68,188
Checksum:iB5F6A7FA667E212C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti588 – 5881K → M in AAC25910 (PubMed:9653648).Curated
Sequence conflicti588 – 5881K → M in AAC25909 (PubMed:9653648).Curated
Sequence conflicti588 – 5881K → M in AAC39798 (PubMed:9653648).Curated
Sequence conflicti588 – 5881K → M in AAC39799 (PubMed:9653648).Curated
Sequence conflicti588 – 5881K → M in AAC39800 (PubMed:9653648).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti221 – 2211R → K.
Corresponds to variant rs10989492 [ dbSNP | Ensembl ].
VAR_025403

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9595Missing in isoform 3. 1 PublicationVSP_006901Add
BLAST
Alternative sequencei1 – 4242Missing in isoform 4. 2 PublicationsVSP_006899Add
BLAST
Alternative sequencei12 – 2514Missing in isoform 2. 2 PublicationsVSP_006900Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95992 mRNA. Translation: AAC25910.1.
U95991 mRNA. Translation: AAC25909.1.
U75454 mRNA. Translation: AAC39798.1.
AF025770 mRNA. Translation: AAC39799.1.
AF025771 mRNA. Translation: AAC39800.1.
AF025772 Genomic DNA. Translation: AAD50527.1.
AF025772 Genomic DNA. Translation: AAD50528.1.
AK290163 mRNA. Translation: BAF82852.1.
AL353621 Genomic DNA. Translation: CAI14611.1.
AL353621 Genomic DNA. Translation: CAI14612.1.
AL353621 Genomic DNA. Translation: CAI14613.1.
CH471105 Genomic DNA. Translation: EAW58949.1.
BC092425 mRNA. Translation: AAH92425.1.
BC126120 mRNA. Translation: AAI26121.1.
BC143876 mRNA. Translation: AAI43877.1.
CCDSiCCDS65096.1. [O75820-2]
CCDS6754.1. [O75820-1]
CCDS6755.1. [O75820-4]
RefSeqiNP_001265160.1. NM_001278231.1. [O75820-2]
NP_001265161.1. NM_001278232.1.
NP_001265169.1. NM_001278240.1.
NP_003443.2. NM_003452.3. [O75820-1]
NP_932094.1. NM_197977.2. [O75820-4]
XP_006717343.1. XM_006717280.3. [O75820-4]
XP_006717344.1. XM_006717281.3. [O75820-4]
XP_011517300.1. XM_011518998.2. [O75820-4]
UniGeneiHs.50123.

Genome annotation databases

EnsembliENST00000259395; ENSP00000259395; ENSG00000136870. [O75820-4]
ENST00000339664; ENSP00000342019; ENSG00000136870. [O75820-1]
ENST00000374861; ENSP00000363995; ENSG00000136870. [O75820-2]
GeneIDi7743.
KEGGihsa:7743.
UCSCiuc004bbg.3. human. [O75820-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95992 mRNA. Translation: AAC25910.1.
U95991 mRNA. Translation: AAC25909.1.
U75454 mRNA. Translation: AAC39798.1.
AF025770 mRNA. Translation: AAC39799.1.
AF025771 mRNA. Translation: AAC39800.1.
AF025772 Genomic DNA. Translation: AAD50527.1.
AF025772 Genomic DNA. Translation: AAD50528.1.
AK290163 mRNA. Translation: BAF82852.1.
AL353621 Genomic DNA. Translation: CAI14611.1.
AL353621 Genomic DNA. Translation: CAI14612.1.
AL353621 Genomic DNA. Translation: CAI14613.1.
CH471105 Genomic DNA. Translation: EAW58949.1.
BC092425 mRNA. Translation: AAH92425.1.
BC126120 mRNA. Translation: AAI26121.1.
BC143876 mRNA. Translation: AAI43877.1.
CCDSiCCDS65096.1. [O75820-2]
CCDS6754.1. [O75820-1]
CCDS6755.1. [O75820-4]
RefSeqiNP_001265160.1. NM_001278231.1. [O75820-2]
NP_001265161.1. NM_001278232.1.
NP_001265169.1. NM_001278240.1.
NP_003443.2. NM_003452.3. [O75820-1]
NP_932094.1. NM_197977.2. [O75820-4]
XP_006717343.1. XM_006717280.3. [O75820-4]
XP_006717344.1. XM_006717281.3. [O75820-4]
XP_011517300.1. XM_011518998.2. [O75820-4]
UniGeneiHs.50123.

3D structure databases

ProteinModelPortaliO75820.
SMRiO75820. Positions 14-53, 139-622.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113528. 9 interactions.
IntActiO75820. 14 interactions.
STRINGi9606.ENSP00000342019.

PTM databases

iPTMnetiO75820.
PhosphoSiteiO75820.

Proteomic databases

EPDiO75820.
MaxQBiO75820.
PaxDbiO75820.
PeptideAtlasiO75820.
PRIDEiO75820.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259395; ENSP00000259395; ENSG00000136870. [O75820-4]
ENST00000339664; ENSP00000342019; ENSG00000136870. [O75820-1]
ENST00000374861; ENSP00000363995; ENSG00000136870. [O75820-2]
GeneIDi7743.
KEGGihsa:7743.
UCSCiuc004bbg.3. human. [O75820-1]

Organism-specific databases

CTDi7743.
GeneCardsiZNF189.
HGNCiHGNC:12980. ZNF189.
HPAiHPA034814.
MIMi603132. gene.
neXtProtiNX_O75820.
PharmGKBiPA37561.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129692.
HOVERGENiHBG018163.
InParanoidiO75820.
KOiK09228.
OMAiRMFRGNT.
OrthoDBiEOG091G02KC.
PhylomeDBiO75820.
TreeFamiTF336942.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii7743.
PROiO75820.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136870.
CleanExiHS_ZNF189.
ExpressionAtlasiO75820. baseline and differential.
GenevisibleiO75820. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 16 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 6 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN189_HUMAN
AccessioniPrimary (citable) accession number: O75820
Secondary accession number(s): O75802
, Q5T7D7, Q5T7D8, Q5T7D9, Q9UBL4, Q9UPE9, Q9UPF0, Q9UPF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: March 7, 2006
Last modified: September 7, 2016
This is version 148 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.