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Protein

Zinc finger protein 189

Gene

ZNF189

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri148 – 170C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri176 – 198C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri512 – 534C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri540 – 562C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri568 – 590C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri599 – 621C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription by RNA polymerase II Source: ProtInc
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 189
Gene namesi
Name:ZNF189
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000136870.10
HGNCiHGNC:12980 ZNF189
MIMi603132 gene
neXtProtiNX_O75820

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7743
OpenTargetsiENSG00000136870
PharmGKBiPA37561

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474441 – 626Zinc finger protein 189Add BLAST626

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki67Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki88Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki160Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki434Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki452Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiO75820
MaxQBiO75820
PaxDbiO75820
PeptideAtlasiO75820
PRIDEiO75820

PTM databases

iPTMnetiO75820
PhosphoSitePlusiO75820

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000136870
CleanExiHS_ZNF189
ExpressionAtlasiO75820 baseline and differential
GenevisibleiO75820 HS

Organism-specific databases

HPAiHPA034814

Interactioni

Protein-protein interaction databases

BioGridi113528, 9 interactors
IntActiO75820, 14 interactors
MINTiO75820
STRINGi9606.ENSP00000342019

Structurei

3D structure databases

ProteinModelPortaliO75820
SMRiO75820
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 89KRABPROSITE-ProRule annotationAdd BLAST76

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri148 – 170C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri176 – 198C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri512 – 534C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri540 – 562C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri568 – 590C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri599 – 621C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144021
HOVERGENiHBG018163
InParanoidiO75820
KOiK09228
OMAiRMFRGNT
OrthoDBiEOG091G02KC
PhylomeDBiO75820
TreeFamiTF336942

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 16 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 16 hits
PS50157 ZINC_FINGER_C2H2_2, 16 hits

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75820-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASPSPPPES KGLLTFEDVA VFFTQEEWDY LDPAQRSLYK DVMMENYGNL
60 70 80 90 100
VSLDVLNRDK DEEPTVKQEI EEIEEEVEPQ GVIVTRIKSE IDQDPMGRET
110 120 130 140 150
FELVGRLDKQ RGIFLWEIPR ESLTQEQRMF RENTNIIRKR PNSEEKCHKC
160 170 180 190 200
EECGKGFVRK AHFIQHQRVH TGEKPFQCNE CGKSFSRSSF VIEHQRIHTG
210 220 230 240 250
ERPYECNYCG KTFSVSSTLI RHQRIHTGER PYQCNQCKQS FSQRRSLVKH
260 270 280 290 300
QRIHTGEKPH KCSDCGKAFS WKSHLIEHQR THTGEKPYHC TKCKKSFSRN
310 320 330 340 350
SLLVEHQRIH TGERPHKCGE CGKAFRLSTY LIQHQKIHTG EKPFLCIECG
360 370 380 390 400
KSFSRSSFLI EHQRIHTGER PYQCKECGKS FSQLCNLTRH QRIHTGDKPH
410 420 430 440 450
KCEECGKAFS RSSGLIQHQR IHTREKTYPY NETKESFDPN CSLVIQQEVY
460 470 480 490 500
PKEKSYKCDE CGKTFSVSAH LVQHQRIHTG EKPYLCTVCG KSFSRSSFLI
510 520 530 540 550
EHQRIHTGER PYLCRQCGKS FSQLCNLIRH QGVHTGNKPH KCDECGKAFS
560 570 580 590 600
RNSGLIQHQR IHTGEKPYKC EKCDKSFSQQ RSLVNHQKIH AEVKTQETHE
610 620
CDACGEAFNC RISLIQHQKL HTAWMQ
Length:626
Mass (Da):72,976
Last modified:March 7, 2006 - v2
Checksum:iBF6E0F9943F15E4C
GO
Isoform 2 (identifier: O75820-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-25: Missing.

Show »
Length:612
Mass (Da):71,407
Checksum:i37BB52F79CA7643C
GO
Isoform 3 (identifier: O75820-3) [UniParc]FASTAAdd to basket
Also known as: B2

The sequence of this isoform differs from the canonical sequence as follows:
     1-95: Missing.

Show »
Length:531
Mass (Da):62,061
Checksum:iF0DDE4B367716666
GO
Isoform 4 (identifier: O75820-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.

Show »
Length:584
Mass (Da):68,188
Checksum:iB5F6A7FA667E212C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti588K → M in AAC25910 (PubMed:9653648).Curated1
Sequence conflicti588K → M in AAC25909 (PubMed:9653648).Curated1
Sequence conflicti588K → M in AAC39798 (PubMed:9653648).Curated1
Sequence conflicti588K → M in AAC39799 (PubMed:9653648).Curated1
Sequence conflicti588K → M in AAC39800 (PubMed:9653648).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025403221R → K. Corresponds to variant dbSNP:rs10989492Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0069011 – 95Missing in isoform 3. 1 PublicationAdd BLAST95
Alternative sequenceiVSP_0068991 – 42Missing in isoform 4. 2 PublicationsAdd BLAST42
Alternative sequenceiVSP_00690012 – 25Missing in isoform 2. 2 PublicationsAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95992 mRNA Translation: AAC25910.1
U95991 mRNA Translation: AAC25909.1
U75454 mRNA Translation: AAC39798.1
AF025770 mRNA Translation: AAC39799.1
AF025771 mRNA Translation: AAC39800.1
AF025772 Genomic DNA Translation: AAD50527.1
AF025772 Genomic DNA Translation: AAD50528.1
AK290163 mRNA Translation: BAF82852.1
AL353621 Genomic DNA No translation available.
CH471105 Genomic DNA Translation: EAW58949.1
BC092425 mRNA Translation: AAH92425.1
BC126120 mRNA Translation: AAI26121.1
BC143876 mRNA Translation: AAI43877.1
CCDSiCCDS65096.1 [O75820-2]
CCDS6754.1 [O75820-1]
CCDS6755.1 [O75820-4]
RefSeqiNP_001265160.1, NM_001278231.1 [O75820-2]
NP_001265161.1, NM_001278232.1
NP_001265169.1, NM_001278240.1
NP_003443.2, NM_003452.3 [O75820-1]
NP_932094.1, NM_197977.2 [O75820-4]
XP_006717343.1, XM_006717280.3 [O75820-4]
XP_006717344.1, XM_006717281.3 [O75820-4]
XP_011517300.1, XM_011518998.2 [O75820-4]
XP_016870610.1, XM_017015121.1 [O75820-4]
UniGeneiHs.50123

Genome annotation databases

EnsembliENST00000259395; ENSP00000259395; ENSG00000136870 [O75820-4]
ENST00000339664; ENSP00000342019; ENSG00000136870 [O75820-1]
ENST00000374861; ENSP00000363995; ENSG00000136870 [O75820-2]
GeneIDi7743
KEGGihsa:7743
UCSCiuc004bbg.3 human [O75820-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN189_HUMAN
AccessioniPrimary (citable) accession number: O75820
Secondary accession number(s): O75802
, Q5T7D7, Q5T7D8, Q5T7D9, Q9UBL4, Q9UPE9, Q9UPF0, Q9UPF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: March 7, 2006
Last modified: May 23, 2018
This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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