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Protein

Ribonuclease P protein subunit p40

Gene

RPP40

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

GO - Molecular functioni

  • ribonuclease P activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processtRNA processing

Enzyme and pathway databases

ReactomeiR-HSA-6784531 tRNA processing in the nucleus
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein subunit p40 (EC:3.1.26.5)
Short name:
RNaseP protein p40
Alternative name(s):
RNase P subunit 1
Gene namesi
Name:RPP40
Synonyms:RNASEP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000124787.13
HGNCiHGNC:20992 RPP40
MIMi606117 gene
neXtProtiNX_O75818

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000124787
PharmGKBiPA134911809

Polymorphism and mutation databases

BioMutaiRPP40

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000974341 – 363Ribonuclease P protein subunit p40Add BLAST363

Proteomic databases

EPDiO75818
MaxQBiO75818
PaxDbiO75818
PeptideAtlasiO75818
PRIDEiO75818

PTM databases

iPTMnetiO75818
PhosphoSitePlusiO75818

Expressioni

Gene expression databases

BgeeiENSG00000124787
CleanExiHS_RPP40
ExpressionAtlasiO75818 baseline and differential
GenevisibleiO75818 HS

Organism-specific databases

HPAiHPA035685
HPA035686

Interactioni

Subunit structurei

RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40.

Protein-protein interaction databases

BioGridi116013, 20 interactors
CORUMiO75818
IntActiO75818, 5 interactors
STRINGi9606.ENSP00000369391

Structurei

3D structure databases

ProteinModelPortaliO75818
SMRiO75818
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IHPQ Eukaryota
ENOG410ZDGJ LUCA
GeneTreeiENSGT00390000014167
HOGENOMiHOG000006875
HOVERGENiHBG055018
InParanoidiO75818
KOiK14530
OMAiKKGSCYA
OrthoDBiEOG091G0D13
PhylomeDBiO75818
TreeFamiTF330967

Family and domain databases

InterProiView protein in InterPro
IPR013893 RNase_P_Rpp40
PANTHERiPTHR15396 PTHR15396, 1 hit
PfamiView protein in Pfam
PF08584 Ribonuc_P_40, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75818-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATLRRLREA PRHLLVCEKS NFGNHKSRHR HLVQTHYYNY RVSFLIPECG
60 70 80 90 100
ILSEELKNLV MNTGPYYFVK NLPLHELITP EFISTFIKKG SCYALTYNTH
110 120 130 140 150
IDEDNTVALL PNGKLILSLD KDTYEETGLQ GHPSQFSGRK IMKFIVSIDL
160 170 180 190 200
MELSLNLDSK KYERISWSFK EKKPLKFDFL LAWHKTGSEE STMMSYFSKY
210 220 230 240 250
QIQEHQPKVA LSTLRDLQCP VLQSSELEGT PEVSCRALEL FDWLGAVFSN
260 270 280 290 300
VDLNNEPNNF ISTYCCPEPS TVVAKAYLCT ITGFILPEKI CLLLEHLCHY
310 320 330 340 350
FDEPKLAPWV TLSVQGFADS PVSWEKNEHG FRKGGEHLYN FVIFNNQDYW
360
LQMAVGANDH CPP
Length:363
Mass (Da):41,834
Last modified:May 26, 2009 - v3
Checksum:i9B4495BA6CD40E79
GO
Isoform 2 (identifier: O75818-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     90-112: Missing.

Note: No experimental confirmation available.
Show »
Length:340
Mass (Da):39,327
Checksum:iBBA05462D4E02FE2
GO

Sequence cautioni

The sequence AAC24114 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH17871 differs from that shown. Reason: Frameshift at position 327.Curated
The sequence CAH73740 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti255Missing in AAC24114 (PubMed:9630247).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055405314V → I. Corresponds to variant dbSNP:rs12332997Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03734690 – 112Missing in isoform 2. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL359643 Genomic DNA Translation: CAH73740.1 Different initiation.
BC017871 mRNA Translation: AAH17871.1 Sequence problems.
U94317 Genomic DNA Translation: AAC24114.1 Different initiation.
CCDSiCCDS34333.1 [O75818-1]
CCDS69040.1 [O75818-2]
RefSeqiNP_001273061.1, NM_001286132.1 [O75818-2]
NP_001273062.1, NM_001286133.1
NP_006629.2, NM_006638.3 [O75818-1]
UniGeneiHs.511756

Genome annotation databases

EnsembliENST00000319533; ENSP00000317998; ENSG00000124787 [O75818-2]
ENST00000380051; ENSP00000369391; ENSG00000124787 [O75818-1]
GeneIDi10799
KEGGihsa:10799
UCSCiuc003mwl.5 human [O75818-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRPP40_HUMAN
AccessioniPrimary (citable) accession number: O75818
Secondary accession number(s): Q5VX97, Q8WVK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 26, 2009
Last modified: May 23, 2018
This is version 143 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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