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O75818

- RPP40_HUMAN

UniProt

O75818 - RPP40_HUMAN

Protein

Ribonuclease P protein subunit p40

Gene

RPP40

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 3 (26 May 2009)
      Previous versions | rss
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    Functioni

    Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

    Catalytic activityi

    Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

    GO - Molecular functioni

    1. ribonuclease P activity Source: ProtInc

    GO - Biological processi

    1. RNA phosphodiester bond hydrolysis Source: GOC
    2. RNA phosphodiester bond hydrolysis, endonucleolytic Source: GOC
    3. tRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    tRNA processing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease P protein subunit p40 (EC:3.1.26.5)
    Short name:
    RNaseP protein p40
    Alternative name(s):
    RNase P subunit 1
    Gene namesi
    Name:RPP40
    Synonyms:RNASEP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:20992. RPP40.

    Subcellular locationi

    Nucleusnucleolus Curated

    GO - Cellular componenti

    1. nucleolar ribonuclease P complex Source: ProtInc
    2. nucleus Source: ProtInc

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134911809.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 363363Ribonuclease P protein subunit p40PRO_0000097434Add
    BLAST

    Proteomic databases

    MaxQBiO75818.
    PaxDbiO75818.
    PRIDEiO75818.

    PTM databases

    PhosphoSiteiO75818.

    Expressioni

    Gene expression databases

    ArrayExpressiO75818.
    BgeeiO75818.
    CleanExiHS_RPP40.
    GenevestigatoriO75818.

    Organism-specific databases

    HPAiHPA035686.

    Interactioni

    Subunit structurei

    RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40.

    Protein-protein interaction databases

    BioGridi116013. 10 interactions.
    IntActiO75818. 3 interactions.
    MINTiMINT-4527266.
    STRINGi9606.ENSP00000369391.

    Structurei

    3D structure databases

    ProteinModelPortaliO75818.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG42164.
    HOGENOMiHOG000006875.
    HOVERGENiHBG055018.
    InParanoidiO75818.
    KOiK14530.
    OMAiKGSCYAL.
    OrthoDBiEOG7ZPNK2.
    PhylomeDBiO75818.
    TreeFamiTF330967.

    Family and domain databases

    InterProiIPR013893. RNase_P_Rpp40.
    [Graphical view]
    PfamiPF08584. Ribonuc_P_40. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O75818-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MATLRRLREA PRHLLVCEKS NFGNHKSRHR HLVQTHYYNY RVSFLIPECG    50
    ILSEELKNLV MNTGPYYFVK NLPLHELITP EFISTFIKKG SCYALTYNTH 100
    IDEDNTVALL PNGKLILSLD KDTYEETGLQ GHPSQFSGRK IMKFIVSIDL 150
    MELSLNLDSK KYERISWSFK EKKPLKFDFL LAWHKTGSEE STMMSYFSKY 200
    QIQEHQPKVA LSTLRDLQCP VLQSSELEGT PEVSCRALEL FDWLGAVFSN 250
    VDLNNEPNNF ISTYCCPEPS TVVAKAYLCT ITGFILPEKI CLLLEHLCHY 300
    FDEPKLAPWV TLSVQGFADS PVSWEKNEHG FRKGGEHLYN FVIFNNQDYW 350
    LQMAVGANDH CPP 363
    Length:363
    Mass (Da):41,834
    Last modified:May 26, 2009 - v3
    Checksum:i9B4495BA6CD40E79
    GO
    Isoform 2 (identifier: O75818-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         90-112: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:340
    Mass (Da):39,327
    Checksum:iBBA05462D4E02FE2
    GO

    Sequence cautioni

    The sequence AAH17871.1 differs from that shown. Reason: Frameshift at position 327.
    The sequence AAC24114.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAH73740.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti255 – 2551Missing in AAC24114. (PubMed:9630247)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti314 – 3141V → I.
    Corresponds to variant rs12332997 [ dbSNP | Ensembl ].
    VAR_055405

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei90 – 11223Missing in isoform 2. 1 PublicationVSP_037346Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL359643 Genomic DNA. Translation: CAH73740.1. Different initiation.
    BC017871 mRNA. Translation: AAH17871.1. Sequence problems.
    U94317 Genomic DNA. Translation: AAC24114.1. Different initiation.
    CCDSiCCDS34333.1. [O75818-1]
    CCDS69040.1. [O75818-2]
    RefSeqiNP_001273061.1. NM_001286132.1. [O75818-2]
    NP_001273062.1. NM_001286133.1.
    NP_006629.2. NM_006638.3. [O75818-1]
    UniGeneiHs.511756.

    Genome annotation databases

    EnsembliENST00000319533; ENSP00000317998; ENSG00000124787. [O75818-2]
    ENST00000380051; ENSP00000369391; ENSG00000124787. [O75818-1]
    GeneIDi10799.
    KEGGihsa:10799.
    UCSCiuc003mwl.3. human. [O75818-1]
    uc003mwm.3. human. [O75818-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL359643 Genomic DNA. Translation: CAH73740.1 . Different initiation.
    BC017871 mRNA. Translation: AAH17871.1 . Sequence problems.
    U94317 Genomic DNA. Translation: AAC24114.1 . Different initiation.
    CCDSi CCDS34333.1. [O75818-1 ]
    CCDS69040.1. [O75818-2 ]
    RefSeqi NP_001273061.1. NM_001286132.1. [O75818-2 ]
    NP_001273062.1. NM_001286133.1.
    NP_006629.2. NM_006638.3. [O75818-1 ]
    UniGenei Hs.511756.

    3D structure databases

    ProteinModelPortali O75818.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116013. 10 interactions.
    IntActi O75818. 3 interactions.
    MINTi MINT-4527266.
    STRINGi 9606.ENSP00000369391.

    PTM databases

    PhosphoSitei O75818.

    Proteomic databases

    MaxQBi O75818.
    PaxDbi O75818.
    PRIDEi O75818.

    Protocols and materials databases

    DNASUi 10799.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000319533 ; ENSP00000317998 ; ENSG00000124787 . [O75818-2 ]
    ENST00000380051 ; ENSP00000369391 ; ENSG00000124787 . [O75818-1 ]
    GeneIDi 10799.
    KEGGi hsa:10799.
    UCSCi uc003mwl.3. human. [O75818-1 ]
    uc003mwm.3. human. [O75818-2 ]

    Organism-specific databases

    CTDi 10799.
    GeneCardsi GC06M004942.
    H-InvDB HIX0005551.
    HIX0005552.
    HGNCi HGNC:20992. RPP40.
    HPAi HPA035686.
    MIMi 606117. gene.
    neXtProti NX_O75818.
    PharmGKBi PA134911809.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42164.
    HOGENOMi HOG000006875.
    HOVERGENi HBG055018.
    InParanoidi O75818.
    KOi K14530.
    OMAi KGSCYAL.
    OrthoDBi EOG7ZPNK2.
    PhylomeDBi O75818.
    TreeFami TF330967.

    Miscellaneous databases

    GeneWikii RPP40.
    GenomeRNAii 10799.
    NextBioi 41013.
    PROi O75818.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75818.
    Bgeei O75818.
    CleanExi HS_RPP40.
    Genevestigatori O75818.

    Family and domain databases

    InterProi IPR013893. RNase_P_Rpp40.
    [Graphical view ]
    Pfami PF08584. Ribonuc_P_40. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    3. "Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P."
      Jarrous N., Eder P.S., Guerrier-Takada C., Hoog C., Altman S.
      RNA 4:407-417(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-363, PROTEIN SEQUENCE OF 73-87; 116-125 AND 202-208 (ISOFORM 1).

    Entry informationi

    Entry nameiRPP40_HUMAN
    AccessioniPrimary (citable) accession number: O75818
    Secondary accession number(s): Q5VX97, Q8WVK8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 118 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3