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O75818 (RPP40_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonuclease P protein subunit p40

Short name=RNaseP protein p40
EC=3.1.26.5
Alternative name(s):
RNase P subunit 1
Gene names
Name:RPP40
Synonyms:RNASEP1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

Catalytic activity

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

Subunit structure

RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40.

Subcellular location

Nucleusnucleolus Potential.

Sequence caution

The sequence AAC24114.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAH17871.1 differs from that shown. Reason: Frameshift at position 327.

The sequence CAH73740.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O75818-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O75818-2)

The sequence of this isoform differs from the canonical sequence as follows:
     90-112: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 363363Ribonuclease P protein subunit p40
PRO_0000097434

Natural variations

Alternative sequence90 – 11223Missing in isoform 2.
VSP_037346
Natural variant3141V → I.
Corresponds to variant rs12332997 [ dbSNP | Ensembl ].
VAR_055405

Experimental info

Sequence conflict2551Missing in AAC24114. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 26, 2009. Version 3.
Checksum: 9B4495BA6CD40E79

FASTA36341,834
        10         20         30         40         50         60 
MATLRRLREA PRHLLVCEKS NFGNHKSRHR HLVQTHYYNY RVSFLIPECG ILSEELKNLV 

        70         80         90        100        110        120 
MNTGPYYFVK NLPLHELITP EFISTFIKKG SCYALTYNTH IDEDNTVALL PNGKLILSLD 

       130        140        150        160        170        180 
KDTYEETGLQ GHPSQFSGRK IMKFIVSIDL MELSLNLDSK KYERISWSFK EKKPLKFDFL 

       190        200        210        220        230        240 
LAWHKTGSEE STMMSYFSKY QIQEHQPKVA LSTLRDLQCP VLQSSELEGT PEVSCRALEL 

       250        260        270        280        290        300 
FDWLGAVFSN VDLNNEPNNF ISTYCCPEPS TVVAKAYLCT ITGFILPEKI CLLLEHLCHY 

       310        320        330        340        350        360 
FDEPKLAPWV TLSVQGFADS PVSWEKNEHG FRKGGEHLYN FVIFNNQDYW LQMAVGANDH 


CPP 

« Hide

Isoform 2 [UniParc].

Checksum: BBA05462D4E02FE2
Show »

FASTA34039,327

References

« Hide 'large scale' references
[1]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[3]"Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P."
Jarrous N., Eder P.S., Guerrier-Takada C., Hoog C., Altman S.
RNA 4:407-417(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-363, PROTEIN SEQUENCE OF 73-87; 116-125 AND 202-208 (ISOFORM 1).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL359643 Genomic DNA. Translation: CAH73740.1. Different initiation.
BC017871 mRNA. Translation: AAH17871.1. Sequence problems.
U94317 Genomic DNA. Translation: AAC24114.1. Different initiation.
RefSeqNP_001273061.1. NM_001286132.1.
NP_001273062.1. NM_001286133.1.
NP_006629.2. NM_006638.3.
UniGeneHs.511756.

3D structure databases

ProteinModelPortalO75818.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116013. 8 interactions.
IntActO75818. 3 interactions.
MINTMINT-4527266.
STRING9606.ENSP00000369391.

PTM databases

PhosphoSiteO75818.

Proteomic databases

PaxDbO75818.
PRIDEO75818.

Protocols and materials databases

DNASU10799.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000319533; ENSP00000317998; ENSG00000124787. [O75818-2]
ENST00000380051; ENSP00000369391; ENSG00000124787. [O75818-1]
GeneID10799.
KEGGhsa:10799.
UCSCuc003mwl.3. human. [O75818-1]
uc003mwm.3. human. [O75818-2]

Organism-specific databases

CTD10799.
GeneCardsGC06M004942.
H-InvDBHIX0005551.
HIX0005552.
HGNCHGNC:20992. RPP40.
HPAHPA035686.
MIM606117. gene.
neXtProtNX_O75818.
PharmGKBPA134911809.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42164.
HOGENOMHOG000006875.
HOVERGENHBG055018.
InParanoidO75818.
KOK14530.
OMAKGSCYAL.
OrthoDBEOG7ZPNK2.
PhylomeDBO75818.
TreeFamTF330967.

Gene expression databases

ArrayExpressO75818.
BgeeO75818.
CleanExHS_RPP40.
GenevestigatorO75818.

Family and domain databases

InterProIPR013893. RNase_P_Rpp40.
[Graphical view]
PfamPF08584. Ribonuc_P_40. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiRPP40.
GenomeRNAi10799.
NextBio41013.
PROO75818.
SOURCESearch...

Entry information

Entry nameRPP40_HUMAN
AccessionPrimary (citable) accession number: O75818
Secondary accession number(s): Q5VX97, Q8WVK8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 26, 2009
Last modified: April 16, 2014
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM