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Protein

Ribonuclease P protein subunit p20

Gene

POP7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP complex, which cleaves pre-rRNA sequences.

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • ribonuclease P activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

tRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein subunit p20 (EC:3.1.26.5)
Short name:
RNaseP protein p20
Alternative name(s):
Ribonucleases P/MRP protein subunit POP7 homolog
Short name:
hPOP7
Gene namesi
Name:POP7
Synonyms:RPP20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:19949. POP7.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nucleolar ribonuclease P complex Source: ProtInc
  • nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134887425.

Polymorphism and mutation databases

BioMutaiPOP7.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 140140Ribonuclease P protein subunit p20PRO_0000058518Add
BLAST

Proteomic databases

MaxQBiO75817.
PaxDbiO75817.
PeptideAtlasiO75817.
PRIDEiO75817.

PTM databases

PhosphoSiteiO75817.

Expressioni

Gene expression databases

BgeeiO75817.
CleanExiHS_POP7.
ExpressionAtlasiO75817. baseline and differential.
GenevisibleiO75817. HS.

Organism-specific databases

HPAiHPA021007.

Interactioni

Subunit structurei

Component of nuclear RNase P and RNase MRP complexes. RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RNase MRP consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21. Interacts with RPP25 and SMN1. RPP20/POP7 is probably a dimer.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RPP25Q9BUL92EBI-366574,EBI-366570
RPP25LQ8N5L85EBI-366574,EBI-10189722
SNRPNP631625EBI-366574,EBI-712493

Protein-protein interaction databases

BioGridi115542. 19 interactions.
IntActiO75817. 3 interactions.
MINTiMINT-157501.
STRINGi9606.ENSP00000304353.

Structurei

3D structure databases

ProteinModelPortaliO75817.
SMRiO75817. Positions 34-136.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone-like Alba family.Curated

Phylogenomic databases

eggNOGiNOG86230.
GeneTreeiENSGT00510000048483.
HOGENOMiHOG000253010.
HOVERGENiHBG001490.
InParanoidiO75817.
KOiK14527.
OMAiNHIYITR.
OrthoDBiEOG7N37FG.
PhylomeDBiO75817.
TreeFamiTF313948.

Family and domain databases

Gene3Di3.30.110.20. 1 hit.
InterProiIPR002775. DNA/RNA-bd_Alba-like.
IPR014612. RNase_P/MRP_p20.
[Graphical view]
PANTHERiPTHR15314. PTHR15314. 1 hit.
PIRSFiPIRSF036572. RPP20. 1 hit.
SUPFAMiSSF82704. SSF82704. 1 hit.

Sequencei

Sequence statusi: Complete.

O75817-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENREPRGA VEAELDPVEY TLRKRLPSRL PRRPNDIYVN MKTDFKAQLA
60 70 80 90 100
RCQKLLDGGA RGQNACSEIY IHGLGLAINR AINIALQLQA GSFGSLQVAA
110 120 130 140
NTSTVELVDE LEPETDTREP LTRIRNNSAI HIRVFRVTPK
Length:140
Mass (Da):15,651
Last modified:May 30, 2006 - v2
Checksum:iCA380F7D273A64B3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti80 – 801R → H in AAC24113 (PubMed:9630247).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94316 mRNA. Translation: AAC24113.1.
CH236956 Genomic DNA. Translation: EAL23821.1.
CH471091 Genomic DNA. Translation: EAW76495.1.
BC001430 mRNA. Translation: AAH01430.1.
CCDSiCCDS5704.1.
RefSeqiNP_005828.2. NM_005837.2.
UniGeneiHs.416994.

Genome annotation databases

EnsembliENST00000303151; ENSP00000304353; ENSG00000172336.
GeneIDi10248.
KEGGihsa:10248.
UCSCiuc003uwh.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94316 mRNA. Translation: AAC24113.1.
CH236956 Genomic DNA. Translation: EAL23821.1.
CH471091 Genomic DNA. Translation: EAW76495.1.
BC001430 mRNA. Translation: AAH01430.1.
CCDSiCCDS5704.1.
RefSeqiNP_005828.2. NM_005837.2.
UniGeneiHs.416994.

3D structure databases

ProteinModelPortaliO75817.
SMRiO75817. Positions 34-136.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115542. 19 interactions.
IntActiO75817. 3 interactions.
MINTiMINT-157501.
STRINGi9606.ENSP00000304353.

PTM databases

PhosphoSiteiO75817.

Polymorphism and mutation databases

BioMutaiPOP7.

Proteomic databases

MaxQBiO75817.
PaxDbiO75817.
PeptideAtlasiO75817.
PRIDEiO75817.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303151; ENSP00000304353; ENSG00000172336.
GeneIDi10248.
KEGGihsa:10248.
UCSCiuc003uwh.4. human.

Organism-specific databases

CTDi10248.
GeneCardsiGC07P100303.
HGNCiHGNC:19949. POP7.
HPAiHPA021007.
MIMi606113. gene.
neXtProtiNX_O75817.
PharmGKBiPA134887425.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG86230.
GeneTreeiENSGT00510000048483.
HOGENOMiHOG000253010.
HOVERGENiHBG001490.
InParanoidiO75817.
KOiK14527.
OMAiNHIYITR.
OrthoDBiEOG7N37FG.
PhylomeDBiO75817.
TreeFamiTF313948.

Miscellaneous databases

GeneWikiiPOP7.
GenomeRNAii10248.
NextBioi38828.
PROiO75817.
SOURCEiSearch...

Gene expression databases

BgeeiO75817.
CleanExiHS_POP7.
ExpressionAtlasiO75817. baseline and differential.
GenevisibleiO75817. HS.

Family and domain databases

Gene3Di3.30.110.20. 1 hit.
InterProiIPR002775. DNA/RNA-bd_Alba-like.
IPR014612. RNase_P/MRP_p20.
[Graphical view]
PANTHERiPTHR15314. PTHR15314. 1 hit.
PIRSFiPIRSF036572. RPP20. 1 hit.
SUPFAMiSSF82704. SSF82704. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P."
    Jarrous N., Eder P.S., Guerrier-Takada C., Hoog C., Altman S.
    RNA 4:407-417(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 10-20, IDENTIFICATION IN THE RNASE P COMPLEX.
  2. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  5. "Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex."
    Welting T.J., van Venrooij W.J., Pruijn G.J.
    Nucleic Acids Res. 32:2138-2146(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE RNASE MRP COMPLEX, INTERACTION WITH RPP25.
  6. "Rpp20 interacts with SMN and is re-distributed into SMN granules in response to stress."
    Hua Y., Zhou J.
    Biochem. Biophys. Res. Commun. 314:268-276(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SMN1, SUBCELLULAR LOCATION.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPOP7_HUMAN
AccessioniPrimary (citable) accession number: O75817
Secondary accession number(s): A4D2E0, Q9BV74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 30, 2006
Last modified: July 22, 2015
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.