O75817 (POP7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribonuclease P protein subunit p20
Short name=RNaseP protein p20
EC=3.1.26.5

Alternative name(s):
Ribonucleases P/MRP protein subunit POP7 homolog
Short name=hPOP7

Gene names

Name:	POP7
Synonyms:	RPP20

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	140 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Catalytic activity	Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.
Subunit structure	Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of a RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RNase MRP consists of a RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21. Interacts with RPP25. RPP20/POP7 is probably a dimer. Ref.5
Subcellular location	Nucleus › nucleolus Potential.
Sequence similarities	Belongs to the histone-like Alba family.

Ontologies

Keywords
Biological process	tRNA processing
Cellular component	Nucleus
Molecular function	Hydrolase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	tRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleolar ribonuclease P complex Traceable author statement Ref.1. Source: ProtInc
Molecular_function	ribonuclease P activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
RPP25	Q9BUL9	2	EBI-366574,EBI-366570
SNRPN	P63162	5	EBI-366574,EBI-712493

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 140	140	Ribonuclease P protein subunit p20		PRO_0000058518
Experimental info
	Sequence conflict	80	1	R → H in AAC24113. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O75817 [UniParc]. Last modified May 30, 2006. Version 2. Checksum: CA380F7D273A64B3	FASTA	140	15,651
	10 20 30 40 50 60 MAENREPRGA VEAELDPVEY TLRKRLPSRL PRRPNDIYVN MKTDFKAQLA RCQKLLDGGA 70 80 90 100 110 120 RGQNACSEIY IHGLGLAINR AINIALQLQA GSFGSLQVAA NTSTVELVDE LEPETDTREP 130 140 LTRIRNNSAI HIRVFRVTPK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P." Jarrous N., Eder P.S., Guerrier-Takada C., Hoog C., Altman S. RNA 4:407-417(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 10-20.
[2]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[5]	"Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex." Welting T.J., van Venrooij W.J., Pruijn G.J. Nucleic Acids Res. 32:2138-2146(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH RPP25.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U94316 mRNA. Translation: AAC24113.1. CH236956 Genomic DNA. Translation: EAL23821.1. CH471091 Genomic DNA. Translation: EAW76495.1. BC001430 mRNA. Translation: AAH01430.1.
IPI	IPI00027142.
RefSeq	NP_005828.2. NM_005837.2.
UniGene	Hs.416994.
3D structure databases
ProteinModelPortal	O75817.
SMR	O75817. Positions 34-136.
ModBase	Search...
Protein-protein interaction databases
IntAct	O75817. 2 interactions.
MINT	MINT-157501.
STRING	9606.ENSP00000304353.
PTM databases
PhosphoSite	O75817.
Proteomic databases
PaxDb	O75817.
PeptideAtlas	O75817.
PRIDE	O75817.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000303151; ENSP00000304353; ENSG00000172336.
GeneID	10248.
KEGG	hsa:10248.
UCSC	uc003uwh.4. human.
Organism-specific databases
CTD	10248.
GeneCards	GC07P100303.
HGNC	HGNC:19949. POP7.
HPA	HPA021007.
MIM	606113. gene.
neXtProt	NX_O75817.
PharmGKB	PA134887425.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG86230.
HOGENOM	HOG000253010.
HOVERGEN	HBG001490.
InParanoid	O75817.
KO	K14527.
OMA	CTEIYIH.
OrthoDB	EOG4WDDDB.
PhylomeDB	O75817.
Gene expression databases
ArrayExpress	O75817.
Bgee	O75817.
CleanEx	HS_POP7.
Genevestigator	O75817.
GermOnline	ENSG00000172336. Homo sapiens.
Family and domain databases
InterPro	IPR014612. RNase_P/MRP_p20. [Graphical view]
PANTHER	PTHR15314. PTHR15314. 1 hit.
PIRSF	PIRSF036572. RPP20. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	10248.
NextBio	38828.
SOURCE	Search...

Entry information

Entry name

POP7_HUMAN

Accession

Primary (citable) accession number: O75817
Secondary accession number(s): A4D2E0, Q9BV74

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	May 30, 2006
Last modified:	May 29, 2013
This is version 105 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.