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Protein

Ribonuclease P protein subunit p20

Gene

POP7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP complex, which cleaves pre-rRNA sequences.

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

GO - Molecular functioni

  • ribonuclease P activity Source: ProtInc
  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processtRNA processing

Enzyme and pathway databases

ReactomeiR-HSA-6784531. tRNA processing in the nucleus.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein subunit p20 (EC:3.1.26.5)
Short name:
RNaseP protein p20
Alternative name(s):
Ribonucleases P/MRP protein subunit POP7 homolog
Short name:
hPOP7
Gene namesi
Name:POP7
Synonyms:RPP20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000172336.4.
HGNCiHGNC:19949. POP7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10248.
OpenTargetsiENSG00000172336.
PharmGKBiPA134887425.

Polymorphism and mutation databases

BioMutaiPOP7.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000585181 – 140Ribonuclease P protein subunit p20Add BLAST140

Proteomic databases

EPDiO75817.
MaxQBiO75817.
PaxDbiO75817.
PeptideAtlasiO75817.
PRIDEiO75817.

PTM databases

iPTMnetiO75817.
PhosphoSitePlusiO75817.

Expressioni

Gene expression databases

BgeeiENSG00000172336.
CleanExiHS_POP7.
ExpressionAtlasiO75817. baseline and differential.
GenevisibleiO75817. HS.

Organism-specific databases

HPAiHPA021007.

Interactioni

Subunit structurei

Component of nuclear RNase P and RNase MRP complexes. RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RNase MRP consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21. Interacts with RPP25 and SMN1. RPP20/POP7 is probably a dimer.3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi115542. 31 interactors.
CORUMiO75817.
IntActiO75817. 7 interactors.
MINTiMINT-157501.
STRINGi9606.ENSP00000304353.

Structurei

3D structure databases

ProteinModelPortaliO75817.
SMRiO75817.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone-like Alba family.Curated

Phylogenomic databases

eggNOGiENOG410IXMT. Eukaryota.
ENOG4111R36. LUCA.
GeneTreeiENSGT00510000048483.
HOGENOMiHOG000253010.
HOVERGENiHBG001490.
InParanoidiO75817.
KOiK14527.
OMAiGQNACTE.
OrthoDBiEOG091G0Y8P.
PhylomeDBiO75817.
TreeFamiTF313948.

Family and domain databases

Gene3Di3.30.110.20. 1 hit.
InterProiView protein in InterPro
IPR002775. DNA/RNA-bd_Alba-like.
IPR014612. Pop7/Rpp20.
PANTHERiPTHR15314. PTHR15314. 1 hit.
PfamiView protein in Pfam
PF12328. Rpp20. 1 hit.
PIRSFiPIRSF036572. RPP20. 1 hit.
SUPFAMiSSF82704. SSF82704. 1 hit.

Sequencei

Sequence statusi: Complete.

O75817-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENREPRGA VEAELDPVEY TLRKRLPSRL PRRPNDIYVN MKTDFKAQLA
60 70 80 90 100
RCQKLLDGGA RGQNACSEIY IHGLGLAINR AINIALQLQA GSFGSLQVAA
110 120 130 140
NTSTVELVDE LEPETDTREP LTRIRNNSAI HIRVFRVTPK
Length:140
Mass (Da):15,651
Last modified:May 30, 2006 - v2
Checksum:iCA380F7D273A64B3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti80R → H in AAC24113 (PubMed:9630247).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94316 mRNA. Translation: AAC24113.1.
CH236956 Genomic DNA. Translation: EAL23821.1.
CH471091 Genomic DNA. Translation: EAW76495.1.
BC001430 mRNA. Translation: AAH01430.1.
CCDSiCCDS5704.1.
RefSeqiNP_005828.2. NM_005837.2.
UniGeneiHs.416994.

Genome annotation databases

EnsembliENST00000303151; ENSP00000304353; ENSG00000172336.
GeneIDi10248.
KEGGihsa:10248.
UCSCiuc003uwh.5. human.

Similar proteinsi

Entry informationi

Entry nameiPOP7_HUMAN
AccessioniPrimary (citable) accession number: O75817
Secondary accession number(s): A4D2E0, Q9BV74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 30, 2006
Last modified: September 27, 2017
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families