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O75817 (POP7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonuclease P protein subunit p20

Short name=RNaseP protein p20
EC=3.1.26.5
Alternative name(s):
Ribonucleases P/MRP protein subunit POP7 homolog
Short name=hPOP7
Gene names
Name:POP7
Synonyms:RPP20
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length140 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP complex, which cleaves pre-rRNA sequences.

Catalytic activity

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

Subunit structure

Component of nuclear RNase P and RNase MRP complexes. RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RNase MRP consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21. Interacts with RPP25 and SMN1. RPP20/POP7 is probably a dimer. Ref.1 Ref.5 Ref.6

Subcellular location

Nucleusnucleolus. Cytoplasm. Cytoplasmic granule. Note: Under stress conditions colocalizes with SMN1 in punctuated cytoplasmic granules. Ref.6

Sequence similarities

Belongs to the histone-like Alba family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

RPP25Q9BUL92EBI-366574,EBI-366570
SNRPNP631625EBI-366574,EBI-712493

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 140140Ribonuclease P protein subunit p20
PRO_0000058518

Experimental info

Sequence conflict801R → H in AAC24113. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O75817 [UniParc].

Last modified May 30, 2006. Version 2.
Checksum: CA380F7D273A64B3

FASTA14015,651
        10         20         30         40         50         60 
MAENREPRGA VEAELDPVEY TLRKRLPSRL PRRPNDIYVN MKTDFKAQLA RCQKLLDGGA 

        70         80         90        100        110        120 
RGQNACSEIY IHGLGLAINR AINIALQLQA GSFGSLQVAA NTSTVELVDE LEPETDTREP 

       130        140 
LTRIRNNSAI HIRVFRVTPK 

« Hide

References

« Hide 'large scale' references
[1]"Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P."
Jarrous N., Eder P.S., Guerrier-Takada C., Hoog C., Altman S.
RNA 4:407-417(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 10-20, IDENTIFICATION IN THE RNASE P COMPLEX.
[2]"Human chromosome 7: DNA sequence and biology."
Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. expand/collapse author list , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[5]"Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex."
Welting T.J., van Venrooij W.J., Pruijn G.J.
Nucleic Acids Res. 32:2138-2146(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE RNASE MRP COMPLEX, INTERACTION WITH RPP25.
[6]"Rpp20 interacts with SMN and is re-distributed into SMN granules in response to stress."
Hua Y., Zhou J.
Biochem. Biophys. Res. Commun. 314:268-276(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SMN1, SUBCELLULAR LOCATION.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U94316 mRNA. Translation: AAC24113.1.
CH236956 Genomic DNA. Translation: EAL23821.1.
CH471091 Genomic DNA. Translation: EAW76495.1.
BC001430 mRNA. Translation: AAH01430.1.
RefSeqNP_005828.2. NM_005837.2.
UniGeneHs.416994.

3D structure databases

ProteinModelPortalO75817.
SMRO75817. Positions 34-136.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115542. 15 interactions.
IntActO75817. 2 interactions.
MINTMINT-157501.
STRING9606.ENSP00000304353.

PTM databases

PhosphoSiteO75817.

Proteomic databases

PaxDbO75817.
PeptideAtlasO75817.
PRIDEO75817.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000303151; ENSP00000304353; ENSG00000172336.
GeneID10248.
KEGGhsa:10248.
UCSCuc003uwh.4. human.

Organism-specific databases

CTD10248.
GeneCardsGC07P100303.
HGNCHGNC:19949. POP7.
HPAHPA021007.
MIM606113. gene.
neXtProtNX_O75817.
PharmGKBPA134887425.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG86230.
HOGENOMHOG000253010.
HOVERGENHBG001490.
InParanoidO75817.
KOK14527.
OMACTEIYIH.
OrthoDBEOG7N37FG.
PhylomeDBO75817.
TreeFamTF313948.

Gene expression databases

ArrayExpressO75817.
BgeeO75817.
CleanExHS_POP7.
GenevestigatorO75817.

Family and domain databases

Gene3D3.30.110.20. 1 hit.
InterProIPR002775. DNA/RNA-bd_Alba-like.
IPR014612. RNase_P/MRP_p20.
[Graphical view]
PANTHERPTHR15314. PTHR15314. 1 hit.
PIRSFPIRSF036572. RPP20. 1 hit.
SUPFAMSSF82704. SSF82704. 1 hit.
ProtoNetSearch...

Other

GeneWikiPOP7.
GenomeRNAi10248.
NextBio38828.
PROO75817.
SOURCESearch...

Entry information

Entry namePOP7_HUMAN
AccessionPrimary (citable) accession number: O75817
Secondary accession number(s): A4D2E0, Q9BV74
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 30, 2006
Last modified: April 16, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM