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O75817

- POP7_HUMAN

UniProt

O75817 - POP7_HUMAN

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Protein
Ribonuclease P protein subunit p20
Gene
POP7, RPP20
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP complex, which cleaves pre-rRNA sequences.

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. protein binding Source: IntAct
  3. ribonuclease P activity Source: ProtInc

GO - Biological processi

  1. RNA phosphodiester bond hydrolysis Source: GOC
  2. RNA phosphodiester bond hydrolysis, endonucleolytic Source: GOC
  3. tRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

tRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein subunit p20 (EC:3.1.26.5)
Short name:
RNaseP protein p20
Alternative name(s):
Ribonucleases P/MRP protein subunit POP7 homolog
Short name:
hPOP7
Gene namesi
Name:POP7
Synonyms:RPP20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:19949. POP7.

Subcellular locationi

Nucleusnucleolus. Cytoplasm. Cytoplasmic granule
Note: Under stress conditions colocalizes with SMN1 in punctuated cytoplasmic granules.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleolar ribonuclease P complex Source: ProtInc
  3. nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134887425.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 140140Ribonuclease P protein subunit p20
PRO_0000058518Add
BLAST

Proteomic databases

MaxQBiO75817.
PaxDbiO75817.
PeptideAtlasiO75817.
PRIDEiO75817.

PTM databases

PhosphoSiteiO75817.

Expressioni

Gene expression databases

ArrayExpressiO75817.
BgeeiO75817.
CleanExiHS_POP7.
GenevestigatoriO75817.

Organism-specific databases

HPAiHPA021007.

Interactioni

Subunit structurei

Component of nuclear RNase P and RNase MRP complexes. RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RNase MRP consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21. Interacts with RPP25 and SMN1. RPP20/POP7 is probably a dimer.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RPP25Q9BUL92EBI-366574,EBI-366570
SNRPNP631625EBI-366574,EBI-712493

Protein-protein interaction databases

BioGridi115542. 16 interactions.
IntActiO75817. 2 interactions.
MINTiMINT-157501.
STRINGi9606.ENSP00000304353.

Structurei

3D structure databases

ProteinModelPortaliO75817.
SMRiO75817. Positions 34-136.

Family & Domainsi

Sequence similaritiesi

Belongs to the histone-like Alba family.

Phylogenomic databases

eggNOGiNOG86230.
HOGENOMiHOG000253010.
HOVERGENiHBG001490.
InParanoidiO75817.
KOiK14527.
OMAiCTEIYIH.
OrthoDBiEOG7N37FG.
PhylomeDBiO75817.
TreeFamiTF313948.

Family and domain databases

Gene3Di3.30.110.20. 1 hit.
InterProiIPR002775. DNA/RNA-bd_Alba-like.
IPR014612. RNase_P/MRP_p20.
[Graphical view]
PANTHERiPTHR15314. PTHR15314. 1 hit.
PIRSFiPIRSF036572. RPP20. 1 hit.
SUPFAMiSSF82704. SSF82704. 1 hit.

Sequencei

Sequence statusi: Complete.

O75817-1 [UniParc]FASTAAdd to Basket

« Hide

MAENREPRGA VEAELDPVEY TLRKRLPSRL PRRPNDIYVN MKTDFKAQLA    50
RCQKLLDGGA RGQNACSEIY IHGLGLAINR AINIALQLQA GSFGSLQVAA 100
NTSTVELVDE LEPETDTREP LTRIRNNSAI HIRVFRVTPK 140
Length:140
Mass (Da):15,651
Last modified:May 30, 2006 - v2
Checksum:iCA380F7D273A64B3
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti80 – 801R → H in AAC24113. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U94316 mRNA. Translation: AAC24113.1.
CH236956 Genomic DNA. Translation: EAL23821.1.
CH471091 Genomic DNA. Translation: EAW76495.1.
BC001430 mRNA. Translation: AAH01430.1.
CCDSiCCDS5704.1.
RefSeqiNP_005828.2. NM_005837.2.
UniGeneiHs.416994.

Genome annotation databases

EnsembliENST00000303151; ENSP00000304353; ENSG00000172336.
GeneIDi10248.
KEGGihsa:10248.
UCSCiuc003uwh.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U94316 mRNA. Translation: AAC24113.1 .
CH236956 Genomic DNA. Translation: EAL23821.1 .
CH471091 Genomic DNA. Translation: EAW76495.1 .
BC001430 mRNA. Translation: AAH01430.1 .
CCDSi CCDS5704.1.
RefSeqi NP_005828.2. NM_005837.2.
UniGenei Hs.416994.

3D structure databases

ProteinModelPortali O75817.
SMRi O75817. Positions 34-136.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115542. 16 interactions.
IntActi O75817. 2 interactions.
MINTi MINT-157501.
STRINGi 9606.ENSP00000304353.

PTM databases

PhosphoSitei O75817.

Proteomic databases

MaxQBi O75817.
PaxDbi O75817.
PeptideAtlasi O75817.
PRIDEi O75817.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000303151 ; ENSP00000304353 ; ENSG00000172336 .
GeneIDi 10248.
KEGGi hsa:10248.
UCSCi uc003uwh.4. human.

Organism-specific databases

CTDi 10248.
GeneCardsi GC07P100303.
HGNCi HGNC:19949. POP7.
HPAi HPA021007.
MIMi 606113. gene.
neXtProti NX_O75817.
PharmGKBi PA134887425.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG86230.
HOGENOMi HOG000253010.
HOVERGENi HBG001490.
InParanoidi O75817.
KOi K14527.
OMAi CTEIYIH.
OrthoDBi EOG7N37FG.
PhylomeDBi O75817.
TreeFami TF313948.

Miscellaneous databases

GeneWikii POP7.
GenomeRNAii 10248.
NextBioi 38828.
PROi O75817.
SOURCEi Search...

Gene expression databases

ArrayExpressi O75817.
Bgeei O75817.
CleanExi HS_POP7.
Genevestigatori O75817.

Family and domain databases

Gene3Di 3.30.110.20. 1 hit.
InterProi IPR002775. DNA/RNA-bd_Alba-like.
IPR014612. RNase_P/MRP_p20.
[Graphical view ]
PANTHERi PTHR15314. PTHR15314. 1 hit.
PIRSFi PIRSF036572. RPP20. 1 hit.
SUPFAMi SSF82704. SSF82704. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P."
    Jarrous N., Eder P.S., Guerrier-Takada C., Hoog C., Altman S.
    RNA 4:407-417(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 10-20, IDENTIFICATION IN THE RNASE P COMPLEX.
  2. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  5. "Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex."
    Welting T.J., van Venrooij W.J., Pruijn G.J.
    Nucleic Acids Res. 32:2138-2146(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE RNASE MRP COMPLEX, INTERACTION WITH RPP25.
  6. "Rpp20 interacts with SMN and is re-distributed into SMN granules in response to stress."
    Hua Y., Zhou J.
    Biochem. Biophys. Res. Commun. 314:268-276(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SMN1, SUBCELLULAR LOCATION.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPOP7_HUMAN
AccessioniPrimary (citable) accession number: O75817
Secondary accession number(s): A4D2E0, Q9BV74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 30, 2006
Last modified: September 3, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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