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O75817

- POP7_HUMAN

UniProt

O75817 - POP7_HUMAN

Protein

Ribonuclease P protein subunit p20

Gene

POP7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP complex, which cleaves pre-rRNA sequences.

    Catalytic activityi

    Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. protein binding Source: IntAct
    3. ribonuclease P activity Source: ProtInc

    GO - Biological processi

    1. RNA phosphodiester bond hydrolysis Source: GOC
    2. RNA phosphodiester bond hydrolysis, endonucleolytic Source: GOC
    3. tRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    tRNA processing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease P protein subunit p20 (EC:3.1.26.5)
    Short name:
    RNaseP protein p20
    Alternative name(s):
    Ribonucleases P/MRP protein subunit POP7 homolog
    Short name:
    hPOP7
    Gene namesi
    Name:POP7
    Synonyms:RPP20
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:19949. POP7.

    Subcellular locationi

    Nucleusnucleolus 1 Publication. Cytoplasm 1 Publication. Cytoplasmic granule 1 Publication
    Note: Under stress conditions colocalizes with SMN1 in punctuated cytoplasmic granules.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleolar ribonuclease P complex Source: ProtInc
    3. nucleus Source: ProtInc

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134887425.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 140140Ribonuclease P protein subunit p20PRO_0000058518Add
    BLAST

    Proteomic databases

    MaxQBiO75817.
    PaxDbiO75817.
    PeptideAtlasiO75817.
    PRIDEiO75817.

    PTM databases

    PhosphoSiteiO75817.

    Expressioni

    Gene expression databases

    ArrayExpressiO75817.
    BgeeiO75817.
    CleanExiHS_POP7.
    GenevestigatoriO75817.

    Organism-specific databases

    HPAiHPA021007.

    Interactioni

    Subunit structurei

    Component of nuclear RNase P and RNase MRP complexes. RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RNase MRP consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21. Interacts with RPP25 and SMN1. RPP20/POP7 is probably a dimer.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    RPP25Q9BUL92EBI-366574,EBI-366570
    SNRPNP631625EBI-366574,EBI-712493

    Protein-protein interaction databases

    BioGridi115542. 16 interactions.
    IntActiO75817. 2 interactions.
    MINTiMINT-157501.
    STRINGi9606.ENSP00000304353.

    Structurei

    3D structure databases

    ProteinModelPortaliO75817.
    SMRiO75817. Positions 34-136.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histone-like Alba family.Curated

    Phylogenomic databases

    eggNOGiNOG86230.
    HOGENOMiHOG000253010.
    HOVERGENiHBG001490.
    InParanoidiO75817.
    KOiK14527.
    OMAiCTEIYIH.
    OrthoDBiEOG7N37FG.
    PhylomeDBiO75817.
    TreeFamiTF313948.

    Family and domain databases

    Gene3Di3.30.110.20. 1 hit.
    InterProiIPR002775. DNA/RNA-bd_Alba-like.
    IPR014612. RNase_P/MRP_p20.
    [Graphical view]
    PANTHERiPTHR15314. PTHR15314. 1 hit.
    PIRSFiPIRSF036572. RPP20. 1 hit.
    SUPFAMiSSF82704. SSF82704. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O75817-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAENREPRGA VEAELDPVEY TLRKRLPSRL PRRPNDIYVN MKTDFKAQLA    50
    RCQKLLDGGA RGQNACSEIY IHGLGLAINR AINIALQLQA GSFGSLQVAA 100
    NTSTVELVDE LEPETDTREP LTRIRNNSAI HIRVFRVTPK 140
    Length:140
    Mass (Da):15,651
    Last modified:May 30, 2006 - v2
    Checksum:iCA380F7D273A64B3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti80 – 801R → H in AAC24113. (PubMed:9630247)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U94316 mRNA. Translation: AAC24113.1.
    CH236956 Genomic DNA. Translation: EAL23821.1.
    CH471091 Genomic DNA. Translation: EAW76495.1.
    BC001430 mRNA. Translation: AAH01430.1.
    CCDSiCCDS5704.1.
    RefSeqiNP_005828.2. NM_005837.2.
    UniGeneiHs.416994.

    Genome annotation databases

    EnsembliENST00000303151; ENSP00000304353; ENSG00000172336.
    GeneIDi10248.
    KEGGihsa:10248.
    UCSCiuc003uwh.4. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U94316 mRNA. Translation: AAC24113.1 .
    CH236956 Genomic DNA. Translation: EAL23821.1 .
    CH471091 Genomic DNA. Translation: EAW76495.1 .
    BC001430 mRNA. Translation: AAH01430.1 .
    CCDSi CCDS5704.1.
    RefSeqi NP_005828.2. NM_005837.2.
    UniGenei Hs.416994.

    3D structure databases

    ProteinModelPortali O75817.
    SMRi O75817. Positions 34-136.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115542. 16 interactions.
    IntActi O75817. 2 interactions.
    MINTi MINT-157501.
    STRINGi 9606.ENSP00000304353.

    PTM databases

    PhosphoSitei O75817.

    Proteomic databases

    MaxQBi O75817.
    PaxDbi O75817.
    PeptideAtlasi O75817.
    PRIDEi O75817.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000303151 ; ENSP00000304353 ; ENSG00000172336 .
    GeneIDi 10248.
    KEGGi hsa:10248.
    UCSCi uc003uwh.4. human.

    Organism-specific databases

    CTDi 10248.
    GeneCardsi GC07P100303.
    HGNCi HGNC:19949. POP7.
    HPAi HPA021007.
    MIMi 606113. gene.
    neXtProti NX_O75817.
    PharmGKBi PA134887425.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG86230.
    HOGENOMi HOG000253010.
    HOVERGENi HBG001490.
    InParanoidi O75817.
    KOi K14527.
    OMAi CTEIYIH.
    OrthoDBi EOG7N37FG.
    PhylomeDBi O75817.
    TreeFami TF313948.

    Miscellaneous databases

    GeneWikii POP7.
    GenomeRNAii 10248.
    NextBioi 38828.
    PROi O75817.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75817.
    Bgeei O75817.
    CleanExi HS_POP7.
    Genevestigatori O75817.

    Family and domain databases

    Gene3Di 3.30.110.20. 1 hit.
    InterProi IPR002775. DNA/RNA-bd_Alba-like.
    IPR014612. RNase_P/MRP_p20.
    [Graphical view ]
    PANTHERi PTHR15314. PTHR15314. 1 hit.
    PIRSFi PIRSF036572. RPP20. 1 hit.
    SUPFAMi SSF82704. SSF82704. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P."
      Jarrous N., Eder P.S., Guerrier-Takada C., Hoog C., Altman S.
      RNA 4:407-417(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 10-20, IDENTIFICATION IN THE RNASE P COMPLEX.
    2. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    5. "Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex."
      Welting T.J., van Venrooij W.J., Pruijn G.J.
      Nucleic Acids Res. 32:2138-2146(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE RNASE MRP COMPLEX, INTERACTION WITH RPP25.
    6. "Rpp20 interacts with SMN and is re-distributed into SMN granules in response to stress."
      Hua Y., Zhou J.
      Biochem. Biophys. Res. Commun. 314:268-276(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SMN1, SUBCELLULAR LOCATION.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPOP7_HUMAN
    AccessioniPrimary (citable) accession number: O75817
    Secondary accession number(s): A4D2E0, Q9BV74
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: May 30, 2006
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3