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O75815

- BCAR3_HUMAN

UniProt

O75815 - BCAR3_HUMAN

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Protein

Breast cancer anti-estrogen resistance protein 3

Gene

BCAR3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins.1 Publication

GO - Molecular functioni

  1. guanyl-nucleotide exchange factor activity Source: UniProtKB-KW

GO - Biological processi

  1. lens morphogenesis in camera-type eye Source: Ensembl
  2. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
  3. response to drug Source: ProtInc
  4. signal transduction Source: ProtInc
  5. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Enzyme and pathway databases

SignaLinkiO75815.

Names & Taxonomyi

Protein namesi
Recommended name:
Breast cancer anti-estrogen resistance protein 3
Alternative name(s):
Novel SH2-containing protein 2
SH2 domain-containing protein 3B
Gene namesi
Name:BCAR3
Synonyms:NSP2, SH2D3B
ORF Names:UNQ271/PRO308
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:973. BCAR3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25283.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 825824Breast cancer anti-estrogen resistance protein 3PRO_0000230284Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei32 – 321Phosphoserine1 Publication
Modified residuei83 – 831Phosphoserine1 Publication
Modified residuei182 – 1821Phosphoserine1 Publication
Modified residuei290 – 2901Phosphoserine1 Publication
Modified residuei358 – 3581Phosphoserine1 Publication
Modified residuei363 – 3631Phosphoserine1 Publication
Modified residuei375 – 3751Phosphoserine2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO75815.
PaxDbiO75815.
PRIDEiO75815.

PTM databases

PhosphoSiteiO75815.

Expressioni

Tissue specificityi

Ubiquitously expressed. Found in several cancer cell lines, but not in nonmalignant breast tissue.2 Publications

Gene expression databases

BgeeiO75815.
CleanExiHS_BCAR3.
ExpressionAtlasiO75815. baseline and differential.
GenevestigatoriO75815.

Organism-specific databases

HPAiHPA014858.

Interactioni

Subunit structurei

Interacts with BCAR1, NEDD9, PTK2/FAK1 and PTPN1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ERBB2P046262EBI-702336,EBI-641062
KITP107213EBI-702336,EBI-1379503

Protein-protein interaction databases

BioGridi114000. 11 interactions.
DIPiDIP-33857N.
IntActiO75815. 8 interactions.
STRINGi9606.ENSP00000260502.

Structurei

Secondary structure

1
825
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi517 – 5193
Helixi534 – 54613
Helixi549 – 56315
Helixi571 – 5777
Beta strandi578 – 5803
Helixi582 – 5854
Helixi589 – 5913
Helixi592 – 61423
Helixi620 – 63920
Helixi644 – 65512
Helixi657 – 6604
Helixi663 – 67210
Helixi674 – 6829
Helixi684 – 6929
Helixi696 – 6983
Helixi711 – 7177
Helixi724 – 7263
Helixi732 – 7343
Helixi737 – 75216
Helixi754 – 76411
Turni765 – 7673
Helixi772 – 7776
Helixi780 – 79213
Helixi797 – 81519

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3T6AX-ray2.40A/B/C/D502-825[»]
ProteinModelPortaliO75815.
SMRiO75815. Positions 78-318, 511-818.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini154 – 253100SH2PROSITE-ProRule annotationAdd
BLAST
Domaini548 – 818271Ras-GEFPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi479 – 4824Poly-Asp

Sequence similaritiesi

Contains 1 Ras-GEF domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiNOG149796.
GeneTreeiENSGT00390000008976.
HOGENOMiHOG000231595.
HOVERGENiHBG053174.
InParanoidiO75815.
OMAiLPYGHQL.
OrthoDBiEOG77126R.
PhylomeDBiO75815.
TreeFamiTF323756.

Family and domain databases

Gene3Di1.10.840.10. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR028849. BCAR3.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR000980. SH2.
[Graphical view]
PANTHERiPTHR14247:SF10. PTHR14247:SF10. 1 hit.
PfamiPF00617. RasGEF. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
SMARTiSM00147. RasGEF. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50009. RASGEF_CAT. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O75815-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAGKFASLP RNMPVNHQFP LASSMDLLSS RSPLAEHRPD AYQDVSIHGT
60 70 80 90 100
LPRKKKGPPP IRSCDDFSHM GTLPHSKSPR QNSPVTQDGI QESPWQDRHG
110 120 130 140 150
ETFTFRDPHL LDPTVEYVKF SKERHIMDRT PEKLKKELEE ELLLSSEDLR
160 170 180 190 200
SHAWYHGRIP RQVSENLVQR DGDFLVRDSL SSPGNFVLTC QWKNLAQHFK
210 220 230 240 250
INRTVLRLSE AYSRVQYQFE MESFDSIPGL VRCYVGNRRP ISQQSGAIIF
260 270 280 290 300
QPINRTVPLR CLEEHYGTSP GQAREGSLTK GRPDVAKRLS LTMGGVQARE
310 320 330 340 350
QNLPRGNLLR NKEKSGSQPA CLDHMQDRRA LSLKAHQSES YLPIGCKLPP
360 370 380 390 400
QSSGVDTSPC PNSPVFRTGS EPALSPAVVR RVSSDARAGE ALRGSDSQLC
410 420 430 440 450
PKPPPKPCKV PFLKVPSSPS AWLNSEANYC ELNPAFATGC GRGAKLPSCA
460 470 480 490 500
QGSHTELLTA KQNEAPGPRN SGVNYLILDD DDRERPWEPA AAQMEKGQWD
510 520 530 540 550
KGEFVTPLLE TVSSFRPNEF ESKFLPPENK PLETAMLKRA KELFTNNDPK
560 570 580 590 600
VIAQHVLSMD CRVARILGVS EEMRRNMGVS SGLELITLPH GHQLRLDIIE
610 620 630 640 650
RHNTMAIGIA VDILGCTGTL EDRAATLSKI IQVAVELKDS MGDLYSFSAL
660 670 680 690 700
MKALEMPQIT RLEKTWTALR HQYTQTAILY EKQLKPFSKL LHEGRESTCV
710 720 730 740 750
PPNNVSVPLL MPLVTLMERQ AVTFEGTDMW EKNDQSCEIM LNHLATARFM
760 770 780 790 800
AEAADSYRMN AERILAGFQP DEEMNEICKT EFQMRLLWGS KGAQVNQTER
810 820
YEKFNQILTA LSRKLEPPPV KQAEL
Length:825
Mass (Da):92,566
Last modified:November 1, 1998 - v1
Checksum:iC55D61BB4AC7D0F2
GO
Isoform 2 (identifier: O75815-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-324: Missing.

Note: No experimental confirmation available.

Show »
Length:501
Mass (Da):55,745
Checksum:i50F3B53FB4BAF59E
GO
Isoform 3 (identifier: O75815-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: Missing.
     92-117: ESPWQDRHGETFTFRDPHLLDPTVEY → MPKECSAFHALSAALCCFYHRKSFIG

Note: No experimental confirmation available.

Show »
Length:734
Mass (Da):82,357
Checksum:iF48AF61CA484420A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti519 – 5191E → G in AL833121. (PubMed:17974005)Curated
Sequence conflicti543 – 5431L → P in AL833121. (PubMed:17974005)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti464 – 4641E → G.
Corresponds to variant rs12062278 [ dbSNP | Ensembl ].
VAR_050689
Natural varianti593 – 5931Q → H.
Corresponds to variant rs17110107 [ dbSNP | Ensembl ].
VAR_050690

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 324324Missing in isoform 2. 1 PublicationVSP_017814Add
BLAST
Alternative sequencei1 – 9191Missing in isoform 3. 1 PublicationVSP_046716Add
BLAST
Alternative sequencei92 – 11726ESPWQ…PTVEY → MPKECSAFHALSAALCCFYH RKSFIG in isoform 3. 1 PublicationVSP_046717Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U92715 mRNA. Translation: AAC39777.1.
AF124250 mRNA. Translation: AAD28245.1.
AY358996 mRNA. Translation: AAQ89355.1.
AL833121 mRNA. No translation available.
AL049796 Genomic DNA. No translation available.
AL109613, AL359820 Genomic DNA. Translation: CAI18950.1.
AL359820, AL109613 Genomic DNA. Translation: CAH73975.1.
AL512488 Genomic DNA. No translation available.
CH471097 Genomic DNA. Translation: EAW73065.1.
CH471097 Genomic DNA. Translation: EAW73066.1.
CH471097 Genomic DNA. Translation: EAW73068.1.
BC039895 mRNA. Translation: AAH39895.1.
CCDSiCCDS58010.1. [O75815-3]
CCDS745.1. [O75815-1]
RefSeqiNP_001248337.1. NM_001261408.1. [O75815-1]
NP_001248338.1. NM_001261409.1. [O75815-1]
NP_001248339.1. NM_001261410.1. [O75815-3]
NP_003558.1. NM_003567.3. [O75815-1]
UniGeneiHs.36958.

Genome annotation databases

EnsembliENST00000260502; ENSP00000260502; ENSG00000137936. [O75815-1]
ENST00000370243; ENSP00000359263; ENSG00000137936. [O75815-1]
ENST00000370244; ENSP00000359264; ENSG00000137936. [O75815-1]
ENST00000370247; ENSP00000359267; ENSG00000137936. [O75815-3]
ENST00000539242; ENSP00000441343; ENSG00000137936. [O75815-2]
GeneIDi8412.
KEGGihsa:8412.
UCSCiuc001dpx.5. human. [O75815-1]
uc001dpy.4. human.
uc009wdm.1. human. [O75815-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U92715 mRNA. Translation: AAC39777.1 .
AF124250 mRNA. Translation: AAD28245.1 .
AY358996 mRNA. Translation: AAQ89355.1 .
AL833121 mRNA. No translation available.
AL049796 Genomic DNA. No translation available.
AL109613 , AL359820 Genomic DNA. Translation: CAI18950.1 .
AL359820 , AL109613 Genomic DNA. Translation: CAH73975.1 .
AL512488 Genomic DNA. No translation available.
CH471097 Genomic DNA. Translation: EAW73065.1 .
CH471097 Genomic DNA. Translation: EAW73066.1 .
CH471097 Genomic DNA. Translation: EAW73068.1 .
BC039895 mRNA. Translation: AAH39895.1 .
CCDSi CCDS58010.1. [O75815-3 ]
CCDS745.1. [O75815-1 ]
RefSeqi NP_001248337.1. NM_001261408.1. [O75815-1 ]
NP_001248338.1. NM_001261409.1. [O75815-1 ]
NP_001248339.1. NM_001261410.1. [O75815-3 ]
NP_003558.1. NM_003567.3. [O75815-1 ]
UniGenei Hs.36958.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3T6A X-ray 2.40 A/B/C/D 502-825 [» ]
ProteinModelPortali O75815.
SMRi O75815. Positions 78-318, 511-818.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114000. 11 interactions.
DIPi DIP-33857N.
IntActi O75815. 8 interactions.
STRINGi 9606.ENSP00000260502.

PTM databases

PhosphoSitei O75815.

Proteomic databases

MaxQBi O75815.
PaxDbi O75815.
PRIDEi O75815.

Protocols and materials databases

DNASUi 8412.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000260502 ; ENSP00000260502 ; ENSG00000137936 . [O75815-1 ]
ENST00000370243 ; ENSP00000359263 ; ENSG00000137936 . [O75815-1 ]
ENST00000370244 ; ENSP00000359264 ; ENSG00000137936 . [O75815-1 ]
ENST00000370247 ; ENSP00000359267 ; ENSG00000137936 . [O75815-3 ]
ENST00000539242 ; ENSP00000441343 ; ENSG00000137936 . [O75815-2 ]
GeneIDi 8412.
KEGGi hsa:8412.
UCSCi uc001dpx.5. human. [O75815-1 ]
uc001dpy.4. human.
uc009wdm.1. human. [O75815-2 ]

Organism-specific databases

CTDi 8412.
GeneCardsi GC01M094027.
HGNCi HGNC:973. BCAR3.
HPAi HPA014858.
MIMi 604704. gene.
neXtProti NX_O75815.
PharmGKBi PA25283.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG149796.
GeneTreei ENSGT00390000008976.
HOGENOMi HOG000231595.
HOVERGENi HBG053174.
InParanoidi O75815.
OMAi LPYGHQL.
OrthoDBi EOG77126R.
PhylomeDBi O75815.
TreeFami TF323756.

Enzyme and pathway databases

SignaLinki O75815.

Miscellaneous databases

ChiTaRSi BCAR3. human.
GeneWikii BCAR3.
GenomeRNAii 8412.
NextBioi 31494.
PROi O75815.
SOURCEi Search...

Gene expression databases

Bgeei O75815.
CleanExi HS_BCAR3.
ExpressionAtlasi O75815. baseline and differential.
Genevestigatori O75815.

Family and domain databases

Gene3Di 1.10.840.10. 1 hit.
3.30.505.10. 1 hit.
InterProi IPR028849. BCAR3.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR000980. SH2.
[Graphical view ]
PANTHERi PTHR14247:SF10. PTHR14247:SF10. 1 hit.
Pfami PF00617. RasGEF. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view ]
SMARTi SM00147. RasGEF. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view ]
SUPFAMi SSF48366. SSF48366. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEi PS50009. RASGEF_CAT. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells."
    van Agthoven T., van Agthoven T.L.A., Dekker A., van der Spek P.J., Vreede L., Dorssers L.C.J.
    EMBO J. 17:2799-2808(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, FUNCTION.
    Tissue: Testis.
  2. "NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway."
    Lu Y., Brush J., Stewart T.A.
    J. Biol. Chem. 274:10047-10052(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Kidney.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Heart.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  8. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-182 AND SER-375, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32; SER-83; SER-290; SER-358; SER-363 AND SER-375, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBCAR3_HUMAN
AccessioniPrimary (citable) accession number: O75815
Secondary accession number(s): D3DT43
, Q5TEW3, Q6UW40, Q9BR50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3