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O75815

- BCAR3_HUMAN

UniProt

O75815 - BCAR3_HUMAN

Protein

Breast cancer anti-estrogen resistance protein 3

Gene

BCAR3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins.1 Publication

    GO - Molecular functioni

    1. guanyl-nucleotide exchange factor activity Source: UniProtKB-KW
    2. protein binding Source: IntAct

    GO - Biological processi

    1. response to drug Source: ProtInc
    2. signal transduction Source: ProtInc
    3. small GTPase mediated signal transduction Source: InterPro

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Enzyme and pathway databases

    SignaLinkiO75815.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Breast cancer anti-estrogen resistance protein 3
    Alternative name(s):
    Novel SH2-containing protein 2
    SH2 domain-containing protein 3B
    Gene namesi
    Name:BCAR3
    Synonyms:NSP2, SH2D3B
    ORF Names:UNQ271/PRO308
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:973. BCAR3.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25283.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 825824Breast cancer anti-estrogen resistance protein 3PRO_0000230284Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei32 – 321Phosphoserine1 Publication
    Modified residuei83 – 831Phosphoserine1 Publication
    Modified residuei182 – 1821Phosphoserine1 Publication
    Modified residuei290 – 2901Phosphoserine1 Publication
    Modified residuei358 – 3581Phosphoserine1 Publication
    Modified residuei363 – 3631Phosphoserine1 Publication
    Modified residuei375 – 3751Phosphoserine2 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiO75815.
    PaxDbiO75815.
    PRIDEiO75815.

    PTM databases

    PhosphoSiteiO75815.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed. Found in several cancer cell lines, but not in nonmalignant breast tissue.2 Publications

    Gene expression databases

    ArrayExpressiO75815.
    BgeeiO75815.
    CleanExiHS_BCAR3.
    GenevestigatoriO75815.

    Organism-specific databases

    HPAiHPA014858.

    Interactioni

    Subunit structurei

    Interacts with BCAR1, NEDD9, PTK2/FAK1 and PTPN1.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ERBB2P046262EBI-702336,EBI-641062
    KITP107213EBI-702336,EBI-1379503

    Protein-protein interaction databases

    BioGridi114000. 11 interactions.
    DIPiDIP-33857N.
    IntActiO75815. 8 interactions.
    STRINGi9606.ENSP00000260502.

    Structurei

    Secondary structure

    1
    825
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi517 – 5193
    Helixi534 – 54613
    Helixi549 – 56315
    Helixi571 – 5777
    Beta strandi578 – 5803
    Helixi582 – 5854
    Helixi589 – 5913
    Helixi592 – 61423
    Helixi620 – 63920
    Helixi644 – 65512
    Helixi657 – 6604
    Helixi663 – 67210
    Helixi674 – 6829
    Helixi684 – 6929
    Helixi696 – 6983
    Helixi711 – 7177
    Helixi724 – 7263
    Helixi732 – 7343
    Helixi737 – 75216
    Helixi754 – 76411
    Turni765 – 7673
    Helixi772 – 7776
    Helixi780 – 79213
    Helixi797 – 81519

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3T6AX-ray2.40A/B/C/D502-825[»]
    ProteinModelPortaliO75815.
    SMRiO75815. Positions 78-318, 511-818.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini154 – 253100SH2PROSITE-ProRule annotationAdd
    BLAST
    Domaini548 – 818271Ras-GEFPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi479 – 4824Poly-Asp

    Sequence similaritiesi

    Contains 1 Ras-GEF domain.PROSITE-ProRule annotation
    Contains 1 SH2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain

    Phylogenomic databases

    eggNOGiNOG149796.
    HOGENOMiHOG000231595.
    HOVERGENiHBG053174.
    InParanoidiO75815.
    OMAiLPYGHQL.
    OrthoDBiEOG77126R.
    PhylomeDBiO75815.
    TreeFamiTF323756.

    Family and domain databases

    Gene3Di1.10.840.10. 1 hit.
    3.30.505.10. 1 hit.
    InterProiIPR028849. BCAR3.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    IPR000980. SH2.
    [Graphical view]
    PANTHERiPTHR14247:SF10. PTHR14247:SF10. 1 hit.
    PfamiPF00617. RasGEF. 1 hit.
    PF00017. SH2. 1 hit.
    [Graphical view]
    SMARTiSM00147. RasGEF. 1 hit.
    SM00252. SH2. 1 hit.
    [Graphical view]
    SUPFAMiSSF48366. SSF48366. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEiPS50009. RASGEF_CAT. 1 hit.
    PS50001. SH2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O75815-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAGKFASLP RNMPVNHQFP LASSMDLLSS RSPLAEHRPD AYQDVSIHGT    50
    LPRKKKGPPP IRSCDDFSHM GTLPHSKSPR QNSPVTQDGI QESPWQDRHG 100
    ETFTFRDPHL LDPTVEYVKF SKERHIMDRT PEKLKKELEE ELLLSSEDLR 150
    SHAWYHGRIP RQVSENLVQR DGDFLVRDSL SSPGNFVLTC QWKNLAQHFK 200
    INRTVLRLSE AYSRVQYQFE MESFDSIPGL VRCYVGNRRP ISQQSGAIIF 250
    QPINRTVPLR CLEEHYGTSP GQAREGSLTK GRPDVAKRLS LTMGGVQARE 300
    QNLPRGNLLR NKEKSGSQPA CLDHMQDRRA LSLKAHQSES YLPIGCKLPP 350
    QSSGVDTSPC PNSPVFRTGS EPALSPAVVR RVSSDARAGE ALRGSDSQLC 400
    PKPPPKPCKV PFLKVPSSPS AWLNSEANYC ELNPAFATGC GRGAKLPSCA 450
    QGSHTELLTA KQNEAPGPRN SGVNYLILDD DDRERPWEPA AAQMEKGQWD 500
    KGEFVTPLLE TVSSFRPNEF ESKFLPPENK PLETAMLKRA KELFTNNDPK 550
    VIAQHVLSMD CRVARILGVS EEMRRNMGVS SGLELITLPH GHQLRLDIIE 600
    RHNTMAIGIA VDILGCTGTL EDRAATLSKI IQVAVELKDS MGDLYSFSAL 650
    MKALEMPQIT RLEKTWTALR HQYTQTAILY EKQLKPFSKL LHEGRESTCV 700
    PPNNVSVPLL MPLVTLMERQ AVTFEGTDMW EKNDQSCEIM LNHLATARFM 750
    AEAADSYRMN AERILAGFQP DEEMNEICKT EFQMRLLWGS KGAQVNQTER 800
    YEKFNQILTA LSRKLEPPPV KQAEL 825
    Length:825
    Mass (Da):92,566
    Last modified:November 1, 1998 - v1
    Checksum:iC55D61BB4AC7D0F2
    GO
    Isoform 2 (identifier: O75815-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-324: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:501
    Mass (Da):55,745
    Checksum:i50F3B53FB4BAF59E
    GO
    Isoform 3 (identifier: O75815-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-91: Missing.
         92-117: ESPWQDRHGETFTFRDPHLLDPTVEY → MPKECSAFHALSAALCCFYHRKSFIG

    Note: No experimental confirmation available.

    Show »
    Length:734
    Mass (Da):82,357
    Checksum:iF48AF61CA484420A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti519 – 5191E → G in AL833121. (PubMed:17974005)Curated
    Sequence conflicti543 – 5431L → P in AL833121. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti464 – 4641E → G.
    Corresponds to variant rs12062278 [ dbSNP | Ensembl ].
    VAR_050689
    Natural varianti593 – 5931Q → H.
    Corresponds to variant rs17110107 [ dbSNP | Ensembl ].
    VAR_050690

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 324324Missing in isoform 2. 1 PublicationVSP_017814Add
    BLAST
    Alternative sequencei1 – 9191Missing in isoform 3. 1 PublicationVSP_046716Add
    BLAST
    Alternative sequencei92 – 11726ESPWQ…PTVEY → MPKECSAFHALSAALCCFYH RKSFIG in isoform 3. 1 PublicationVSP_046717Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U92715 mRNA. Translation: AAC39777.1.
    AF124250 mRNA. Translation: AAD28245.1.
    AY358996 mRNA. Translation: AAQ89355.1.
    AL833121 mRNA. No translation available.
    AL049796 Genomic DNA. No translation available.
    AL109613, AL359820 Genomic DNA. Translation: CAI18950.1.
    AL359820, AL109613 Genomic DNA. Translation: CAH73975.1.
    AL512488 Genomic DNA. No translation available.
    CH471097 Genomic DNA. Translation: EAW73065.1.
    CH471097 Genomic DNA. Translation: EAW73066.1.
    CH471097 Genomic DNA. Translation: EAW73068.1.
    BC039895 mRNA. Translation: AAH39895.1.
    CCDSiCCDS58010.1. [O75815-3]
    CCDS745.1. [O75815-1]
    RefSeqiNP_001248337.1. NM_001261408.1. [O75815-1]
    NP_001248338.1. NM_001261409.1. [O75815-1]
    NP_001248339.1. NM_001261410.1. [O75815-3]
    NP_003558.1. NM_003567.3. [O75815-1]
    UniGeneiHs.36958.

    Genome annotation databases

    EnsembliENST00000260502; ENSP00000260502; ENSG00000137936. [O75815-1]
    ENST00000370243; ENSP00000359263; ENSG00000137936. [O75815-1]
    ENST00000370244; ENSP00000359264; ENSG00000137936. [O75815-1]
    ENST00000370247; ENSP00000359267; ENSG00000137936. [O75815-3]
    ENST00000539242; ENSP00000441343; ENSG00000137936. [O75815-2]
    GeneIDi8412.
    KEGGihsa:8412.
    UCSCiuc001dpx.5. human. [O75815-1]
    uc001dpy.4. human.
    uc009wdm.1. human. [O75815-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U92715 mRNA. Translation: AAC39777.1 .
    AF124250 mRNA. Translation: AAD28245.1 .
    AY358996 mRNA. Translation: AAQ89355.1 .
    AL833121 mRNA. No translation available.
    AL049796 Genomic DNA. No translation available.
    AL109613 , AL359820 Genomic DNA. Translation: CAI18950.1 .
    AL359820 , AL109613 Genomic DNA. Translation: CAH73975.1 .
    AL512488 Genomic DNA. No translation available.
    CH471097 Genomic DNA. Translation: EAW73065.1 .
    CH471097 Genomic DNA. Translation: EAW73066.1 .
    CH471097 Genomic DNA. Translation: EAW73068.1 .
    BC039895 mRNA. Translation: AAH39895.1 .
    CCDSi CCDS58010.1. [O75815-3 ]
    CCDS745.1. [O75815-1 ]
    RefSeqi NP_001248337.1. NM_001261408.1. [O75815-1 ]
    NP_001248338.1. NM_001261409.1. [O75815-1 ]
    NP_001248339.1. NM_001261410.1. [O75815-3 ]
    NP_003558.1. NM_003567.3. [O75815-1 ]
    UniGenei Hs.36958.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3T6A X-ray 2.40 A/B/C/D 502-825 [» ]
    ProteinModelPortali O75815.
    SMRi O75815. Positions 78-318, 511-818.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114000. 11 interactions.
    DIPi DIP-33857N.
    IntActi O75815. 8 interactions.
    STRINGi 9606.ENSP00000260502.

    PTM databases

    PhosphoSitei O75815.

    Proteomic databases

    MaxQBi O75815.
    PaxDbi O75815.
    PRIDEi O75815.

    Protocols and materials databases

    DNASUi 8412.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000260502 ; ENSP00000260502 ; ENSG00000137936 . [O75815-1 ]
    ENST00000370243 ; ENSP00000359263 ; ENSG00000137936 . [O75815-1 ]
    ENST00000370244 ; ENSP00000359264 ; ENSG00000137936 . [O75815-1 ]
    ENST00000370247 ; ENSP00000359267 ; ENSG00000137936 . [O75815-3 ]
    ENST00000539242 ; ENSP00000441343 ; ENSG00000137936 . [O75815-2 ]
    GeneIDi 8412.
    KEGGi hsa:8412.
    UCSCi uc001dpx.5. human. [O75815-1 ]
    uc001dpy.4. human.
    uc009wdm.1. human. [O75815-2 ]

    Organism-specific databases

    CTDi 8412.
    GeneCardsi GC01M094027.
    HGNCi HGNC:973. BCAR3.
    HPAi HPA014858.
    MIMi 604704. gene.
    neXtProti NX_O75815.
    PharmGKBi PA25283.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG149796.
    HOGENOMi HOG000231595.
    HOVERGENi HBG053174.
    InParanoidi O75815.
    OMAi LPYGHQL.
    OrthoDBi EOG77126R.
    PhylomeDBi O75815.
    TreeFami TF323756.

    Enzyme and pathway databases

    SignaLinki O75815.

    Miscellaneous databases

    ChiTaRSi BCAR3. human.
    GeneWikii BCAR3.
    GenomeRNAii 8412.
    NextBioi 31494.
    PROi O75815.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75815.
    Bgeei O75815.
    CleanExi HS_BCAR3.
    Genevestigatori O75815.

    Family and domain databases

    Gene3Di 1.10.840.10. 1 hit.
    3.30.505.10. 1 hit.
    InterProi IPR028849. BCAR3.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    IPR000980. SH2.
    [Graphical view ]
    PANTHERi PTHR14247:SF10. PTHR14247:SF10. 1 hit.
    Pfami PF00617. RasGEF. 1 hit.
    PF00017. SH2. 1 hit.
    [Graphical view ]
    SMARTi SM00147. RasGEF. 1 hit.
    SM00252. SH2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48366. SSF48366. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEi PS50009. RASGEF_CAT. 1 hit.
    PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells."
      van Agthoven T., van Agthoven T.L.A., Dekker A., van der Spek P.J., Vreede L., Dorssers L.C.J.
      EMBO J. 17:2799-2808(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, FUNCTION.
      Tissue: Testis.
    2. "NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway."
      Lu Y., Brush J., Stewart T.A.
      J. Biol. Chem. 274:10047-10052(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Kidney.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Heart.
    5. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    8. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-182 AND SER-375, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32; SER-83; SER-290; SER-358; SER-363 AND SER-375, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiBCAR3_HUMAN
    AccessioniPrimary (citable) accession number: O75815
    Secondary accession number(s): D3DT43
    , Q5TEW3, Q6UW40, Q9BR50
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3