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O75808

- CAN15_HUMAN

UniProt

O75808 - CAN15_HUMAN

Protein

Calpain-15

Gene

CAPN15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei552 – 5521By similarity
    Active sitei717 – 7171By similarity
    Active sitei737 – 7371By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri3 – 3230RanBP2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri44 – 7330RanBP2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri143 – 17230RanBP2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri338 – 36932RanBP2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri412 – 44130RanBP2-type 5PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium-dependent cysteine-type endopeptidase activity Source: RefGenome
    2. cysteine-type peptidase activity Source: ProtInc
    3. peptidase activity Source: ProtInc
    4. sequence-specific DNA binding transcription factor activity Source: ProtInc
    5. zinc ion binding Source: InterPro

    GO - Biological processi

    1. proteolysis Source: RefGenome
    2. regulation of transcription, DNA-templated Source: GOC

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiC02.010.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calpain-15 (EC:3.4.22.-)
    Alternative name(s):
    Small optic lobes homolog
    Gene namesi
    Name:CAPN15
    Synonyms:SOLH
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:11182. CAPN15.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36019.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10861086Calpain-15PRO_0000278770Add
    BLAST

    Proteomic databases

    MaxQBiO75808.
    PaxDbiO75808.
    PRIDEiO75808.

    PTM databases

    PhosphoSiteiO75808.

    Expressioni

    Tissue specificityi

    Widely expressed with higher expression in brain.1 Publication

    Gene expression databases

    ArrayExpressiO75808.
    BgeeiO75808.
    CleanExiHS_SOLH.
    GenevestigatoriO75808.

    Organism-specific databases

    HPAiHPA011960.

    Interactioni

    Protein-protein interaction databases

    BioGridi112533. 2 interactions.
    IntActiO75808. 1 interaction.
    STRINGi9606.ENSP00000219611.

    Structurei

    3D structure databases

    ProteinModelPortaliO75808.
    SMRiO75808. Positions 474-898.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini487 – 793307Calpain catalyticPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi124 – 14219Glu-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C2 family.Curated
    Contains 1 calpain catalytic domain.PROSITE-ProRule annotation
    Contains 5 RanBP2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri3 – 3230RanBP2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri44 – 7330RanBP2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri143 – 17230RanBP2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri338 – 36932RanBP2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri412 – 44130RanBP2-type 5PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG327523.
    HOGENOMiHOG000007650.
    HOVERGENiHBG080984.
    InParanoidiO75808.
    KOiK08582.
    OMAiQRCTLHN.
    OrthoDBiEOG7NKKJJ.
    PhylomeDBiO75808.
    TreeFamiTF322245.

    Family and domain databases

    InterProiIPR022684. Calpain_cysteine_protease.
    IPR000169. Pept_cys_AS.
    IPR001300. Peptidase_C2_calpain_cat.
    IPR001876. Znf_RanBP2.
    [Graphical view]
    PfamiPF00648. Peptidase_C2. 1 hit.
    PF00641. zf-RanBP. 3 hits.
    [Graphical view]
    PRINTSiPR00704. CALPAIN.
    SMARTiSM00230. CysPc. 1 hit.
    SM00547. ZnF_RBZ. 5 hits.
    [Graphical view]
    PROSITEiPS50203. CALPAIN_CAT. 1 hit.
    PS00139. THIOL_PROTEASE_CYS. 1 hit.
    PS01358. ZF_RANBP2_1. 5 hits.
    PS50199. ZF_RANBP2_2. 4 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O75808-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MATVGEWSCV RCTFLNPAGQ RQCSICEAPR HKPDLNHILR LSVEEQKWPC     50
    ARCTFRNFLG KEACEVCGFT PEPAPGAAFL PVLNGVLPKP PAILGEPKGS 100
    CQEEAGPVRT AGLVATEPAR GQCEDKDEEE KEEQEEEEGA AEPRGGWACP 150
    RCTLHNTPVA SSCSVCGGPR RLSLPRIPPE ALVVPEVVAP AGFHVVPAAP 200
    PPGLPGEGAE ANPPATSQGP AAEPEPPRVP PFSPFSSTLQ NNPVPRSRRE 250
    VPPQLQPPVP EAAQPSPSAG CRGAPQGSGW AGASRLAELL SGKRLSVLEE 300
    EATEGGTSRV EAGSSTSGSD IIDLAGDTVR YTPASPSSPD FTTWSCAKCT 350
    LRNPTVAPRC SACGCSKLHG FQEHGEPPTH CPDCGADKPS PCGRSCGRVS 400
    SAQKAARVLP ERPGQWACPA CTLLNALRAK HCAACHTPQL LVAQRRGAAP 450
    LRRRESMHVE QRRQTDEGEA KALWENIVAF CRENNVSFVD DSFPPGPESV 500
    GFPAGDSVQQ RVRQWLRPQE INCSVFRDHR ATWSVFHTLR PSDILQGLLG 550
    NCWFLSALAV LAERPDLVER VMVTRSLCAE GAYQVRLCKD GTWTTVLVDD 600
    MLPCDEAGCL LFSQAQRKQL WVALIEKALA KLHGSYFALQ AGRAIEGLAT 650
    LTGAPCESLA LQLSSTNPRE EPVDTDLIWA KMLSSKEAGF LMGASCGGGN 700
    MKVDDSAYES LGLRPRHAYS ILDVRDVQGT RLLRLRNPWG RFSWNGSWSD 750
    EWPHWPGHLR GELMPHGSSE GVFWMEYGDF VRYFDSVDIC KVHSDWQEAR 800
    VQGCFPSSAS APVGVTALTV LERASLEFAL FQEGSRRSDA VDSHLLDLCI 850
    LVFRATFGSG GHLSLGRLLA HSKRAVKKFV SCDVMLEPGE YAVVCCAFNH 900
    WGPPLPGTPA PQASSPSAGV PRASPEPPGH VLAVYSSRLV MVEPVEAQPT 950
    TLADAIILLT ESRGERHEGR EGMTCYYLTH GWAGLIVVVE NRHPKAYLHV 1000
    QCDCTDSFNV VSTRGSLRTQ DSVPPLHRQV LVILSQLEGN AGFSITHRLA 1050
    HRKAAQAFLS DWTASKGTHS PPLTPEVAGL HGPRPL 1086
    Length:1,086
    Mass (Da):117,314
    Last modified:November 1, 1998 - v1
    Checksum:i9809A5CF9134A12C
    GO
    Isoform 2 (identifier: O75808-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         355-415: TVAPRCSACG...ARVLPERPGQ → CPPGLQPLGR...REPRRAARGP
         416-1086: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:415
    Mass (Da):43,366
    Checksum:i49992E1FBEE9704A
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei355 – 41561TVAPR…ERPGQ → CPPGLQPLGRGPESLPRAAG PRAGCVQLEAGHGGARGSPA DHAGRRHHPAHREPRRAARG P in isoform 2. 1 PublicationVSP_023361Add
    BLAST
    Alternative sequencei416 – 1086671Missing in isoform 2. 1 PublicationVSP_023362Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U85647 mRNA. Translation: AAC33822.1.
    AE006464 Genomic DNA. Translation: AAK61233.1.
    Z97986 Genomic DNA. Translation: CAC14067.1.
    CH471112 Genomic DNA. Translation: EAW85803.1.
    BC001869 mRNA. Translation: AAH01869.1.
    BC021854 mRNA. Translation: AAH21854.1.
    BC112918 mRNA. Translation: AAI12919.1.
    CCDSiCCDS10410.1. [O75808-1]
    RefSeqiNP_005623.1. NM_005632.2. [O75808-1]
    XP_005255573.1. XM_005255516.2. [O75808-1]
    XP_005255574.1. XM_005255517.2. [O75808-1]
    XP_005255575.1. XM_005255518.2. [O75808-1]
    UniGeneiHs.632219.

    Genome annotation databases

    EnsembliENST00000219611; ENSP00000219611; ENSG00000103326. [O75808-1]
    GeneIDi6650.
    KEGGihsa:6650.
    UCSCiuc002chh.1. human. [O75808-2]
    uc002chi.3. human. [O75808-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U85647 mRNA. Translation: AAC33822.1 .
    AE006464 Genomic DNA. Translation: AAK61233.1 .
    Z97986 Genomic DNA. Translation: CAC14067.1 .
    CH471112 Genomic DNA. Translation: EAW85803.1 .
    BC001869 mRNA. Translation: AAH01869.1 .
    BC021854 mRNA. Translation: AAH21854.1 .
    BC112918 mRNA. Translation: AAI12919.1 .
    CCDSi CCDS10410.1. [O75808-1 ]
    RefSeqi NP_005623.1. NM_005632.2. [O75808-1 ]
    XP_005255573.1. XM_005255516.2. [O75808-1 ]
    XP_005255574.1. XM_005255517.2. [O75808-1 ]
    XP_005255575.1. XM_005255518.2. [O75808-1 ]
    UniGenei Hs.632219.

    3D structure databases

    ProteinModelPortali O75808.
    SMRi O75808. Positions 474-898.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112533. 2 interactions.
    IntActi O75808. 1 interaction.
    STRINGi 9606.ENSP00000219611.

    Protein family/group databases

    MEROPSi C02.010.

    PTM databases

    PhosphoSitei O75808.

    Proteomic databases

    MaxQBi O75808.
    PaxDbi O75808.
    PRIDEi O75808.

    Protocols and materials databases

    DNASUi 6650.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000219611 ; ENSP00000219611 ; ENSG00000103326 . [O75808-1 ]
    GeneIDi 6650.
    KEGGi hsa:6650.
    UCSCi uc002chh.1. human. [O75808-2 ]
    uc002chi.3. human. [O75808-1 ]

    Organism-specific databases

    CTDi 6650.
    GeneCardsi GC16P000578.
    HGNCi HGNC:11182. CAPN15.
    HPAi HPA011960.
    MIMi 603267. gene.
    neXtProti NX_O75808.
    PharmGKBi PA36019.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG327523.
    HOGENOMi HOG000007650.
    HOVERGENi HBG080984.
    InParanoidi O75808.
    KOi K08582.
    OMAi QRCTLHN.
    OrthoDBi EOG7NKKJJ.
    PhylomeDBi O75808.
    TreeFami TF322245.

    Miscellaneous databases

    GenomeRNAii 6650.
    NextBioi 25919.
    PROi O75808.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75808.
    Bgeei O75808.
    CleanExi HS_SOLH.
    Genevestigatori O75808.

    Family and domain databases

    InterProi IPR022684. Calpain_cysteine_protease.
    IPR000169. Pept_cys_AS.
    IPR001300. Peptidase_C2_calpain_cat.
    IPR001876. Znf_RanBP2.
    [Graphical view ]
    Pfami PF00648. Peptidase_C2. 1 hit.
    PF00641. zf-RanBP. 3 hits.
    [Graphical view ]
    PRINTSi PR00704. CALPAIN.
    SMARTi SM00230. CysPc. 1 hit.
    SM00547. ZnF_RBZ. 5 hits.
    [Graphical view ]
    PROSITEi PS50203. CALPAIN_CAT. 1 hit.
    PS00139. THIOL_PROTEASE_CYS. 1 hit.
    PS01358. ZF_RANBP2_1. 5 hits.
    PS50199. ZF_RANBP2_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "SOLH, a human homologue of the Drosophila melanogaster small optic lobes gene is a member of the calpain and zinc-finger gene families and maps to human chromosome 16p13.3 near CATM (cataract with microphthalmia)."
      Kamei M., Webb G.C., Young I.G., Campbell H.D.
      Genomics 51:197-206(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Hippocampus.
    2. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
      Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
      Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 525-1086 (ISOFORM 1).
      Tissue: Embryonic stem cell, Lung and Placenta.
    6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCAN15_HUMAN
    AccessioniPrimary (citable) accession number: O75808
    Secondary accession number(s): B1B1M4
    , Q2KHS2, Q8WTY9, Q9BUW0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 20, 2007
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. Peptidase families
      Classification of peptidase families and list of entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3