O75808 (CAN15_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Calpain-15
EC=3.4.22.-

Alternative name(s):
Small optic lobes homolog

Gene names

Name:	SOLH
Synonyms:	CAPN15

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1086 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Tissue specificity	Widely expressed with higher expression in brain. Ref.1
Sequence similarities	Belongs to the peptidase C2 family. Contains 1 calpain catalytic domain. Contains 5 RanBP2-type zinc fingers.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Repeat Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Protease Thiol protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	calcium-dependent cysteine-type endopeptidase activity Traceable author statement Ref.1. Source: ProtInc sequence-specific DNA binding transcription factor activity Traceable author statement Ref.1. Source: ProtInc zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O75808-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O75808-2)

The sequence of this isoform differs from the canonical sequence as follows:
     355-415: TVAPRCSACG...ARVLPERPGQ → CPPGLQPLGR...REPRRAARGP
     416-1086: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1086	1086	Calpain-15		PRO_0000278770
Regions
	Domain	487 – 793	307	Calpain catalytic
	Zinc finger	3 – 32	30	RanBP2-type 1
	Zinc finger	44 – 73	30	RanBP2-type 2
	Zinc finger	143 – 172	30	RanBP2-type 3
	Zinc finger	338 – 369	32	RanBP2-type 4
	Zinc finger	412 – 441	30	RanBP2-type 5
	Compositional bias	124 – 142	19	Glu-rich
Sites
	Active site	552	1	By similarity
	Active site	717	1	By similarity
	Active site	737	1	By similarity
Natural variations
	Alternative sequence	355 – 415	61	TVAPR…ERPGQ → CPPGLQPLGRGPESLPRAAG PRAGCVQLEAGHGGARGSPA DHAGRRHHPAHREPRRAARG P in isoform 2.		VSP_023361
	Alternative sequence	416 – 1086	671	Missing in isoform 2.		VSP_023362

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 9809A5CF9134A12C	FASTA	1,086	117,314
	10 20 30 40 50 60 MATVGEWSCV RCTFLNPAGQ RQCSICEAPR HKPDLNHILR LSVEEQKWPC ARCTFRNFLG 70 80 90 100 110 120 KEACEVCGFT PEPAPGAAFL PVLNGVLPKP PAILGEPKGS CQEEAGPVRT AGLVATEPAR 130 140 150 160 170 180 GQCEDKDEEE KEEQEEEEGA AEPRGGWACP RCTLHNTPVA SSCSVCGGPR RLSLPRIPPE 190 200 210 220 230 240 ALVVPEVVAP AGFHVVPAAP PPGLPGEGAE ANPPATSQGP AAEPEPPRVP PFSPFSSTLQ 250 260 270 280 290 300 NNPVPRSRRE VPPQLQPPVP EAAQPSPSAG CRGAPQGSGW AGASRLAELL SGKRLSVLEE 310 320 330 340 350 360 EATEGGTSRV EAGSSTSGSD IIDLAGDTVR YTPASPSSPD FTTWSCAKCT LRNPTVAPRC 370 380 390 400 410 420 SACGCSKLHG FQEHGEPPTH CPDCGADKPS PCGRSCGRVS SAQKAARVLP ERPGQWACPA 430 440 450 460 470 480 CTLLNALRAK HCAACHTPQL LVAQRRGAAP LRRRESMHVE QRRQTDEGEA KALWENIVAF 490 500 510 520 530 540 CRENNVSFVD DSFPPGPESV GFPAGDSVQQ RVRQWLRPQE INCSVFRDHR ATWSVFHTLR 550 560 570 580 590 600 PSDILQGLLG NCWFLSALAV LAERPDLVER VMVTRSLCAE GAYQVRLCKD GTWTTVLVDD 610 620 630 640 650 660 MLPCDEAGCL LFSQAQRKQL WVALIEKALA KLHGSYFALQ AGRAIEGLAT LTGAPCESLA 670 680 690 700 710 720 LQLSSTNPRE EPVDTDLIWA KMLSSKEAGF LMGASCGGGN MKVDDSAYES LGLRPRHAYS 730 740 750 760 770 780 ILDVRDVQGT RLLRLRNPWG RFSWNGSWSD EWPHWPGHLR GELMPHGSSE GVFWMEYGDF 790 800 810 820 830 840 VRYFDSVDIC KVHSDWQEAR VQGCFPSSAS APVGVTALTV LERASLEFAL FQEGSRRSDA 850 860 870 880 890 900 VDSHLLDLCI LVFRATFGSG GHLSLGRLLA HSKRAVKKFV SCDVMLEPGE YAVVCCAFNH 910 920 930 940 950 960 WGPPLPGTPA PQASSPSAGV PRASPEPPGH VLAVYSSRLV MVEPVEAQPT TLADAIILLT 970 980 990 1000 1010 1020 ESRGERHEGR EGMTCYYLTH GWAGLIVVVE NRHPKAYLHV QCDCTDSFNV VSTRGSLRTQ 1030 1040 1050 1060 1070 1080 DSVPPLHRQV LVILSQLEGN AGFSITHRLA HRKAAQAFLS DWTASKGTHS PPLTPEVAGL HGPRPL
	Isoform 2 [UniParc]. Checksum: 49992E1FBEE9704A	FASTA	415	43,366
	10 20 30 40 50 60 MATVGEWSCV RCTFLNPAGQ RQCSICEAPR HKPDLNHILR LSVEEQKWPC ARCTFRNFLG 70 80 90 100 110 120 KEACEVCGFT PEPAPGAAFL PVLNGVLPKP PAILGEPKGS CQEEAGPVRT AGLVATEPAR 130 140 150 160 170 180 GQCEDKDEEE KEEQEEEEGA AEPRGGWACP RCTLHNTPVA SSCSVCGGPR RLSLPRIPPE 190 200 210 220 230 240 ALVVPEVVAP AGFHVVPAAP PPGLPGEGAE ANPPATSQGP AAEPEPPRVP PFSPFSSTLQ 250 260 270 280 290 300 NNPVPRSRRE VPPQLQPPVP EAAQPSPSAG CRGAPQGSGW AGASRLAELL SGKRLSVLEE 310 320 330 340 350 360 EATEGGTSRV EAGSSTSGSD IIDLAGDTVR YTPASPSSPD FTTWSCAKCT LRNPCPPGLQ 370 380 390 400 410 PLGRGPESLP RAAGPRAGCV QLEAGHGGAR GSPADHAGRR HHPAHREPRR AARGP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"SOLH, a human homologue of the Drosophila melanogaster small optic lobes gene is a member of the calpain and zinc-finger gene families and maps to human chromosome 16p13.3 near CATM (cataract with microphthalmia)." Kamei M., Webb G.C., Young I.G., Campbell H.D. Genomics 51:197-206(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY. Tissue: Hippocampus.
[2]	"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16." Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R. Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 525-1086 (ISOFORM 1). Tissue: Embryonic stem cell, Lung and Placenta.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U85647 mRNA. Translation: AAC33822.1. AE006464 Genomic DNA. Translation: AAK61233.1. Z97986 Genomic DNA. Translation: CAC14067.1. CH471112 Genomic DNA. Translation: EAW85803.1. BC001869 mRNA. Translation: AAH01869.1. BC021854 mRNA. Translation: AAH21854.1. BC112918 mRNA. Translation: AAI12919.1.
IPI	IPI00024190. IPI00828058.
RefSeq	NP_005623.1. NM_005632.2.
UniGene	Hs.632219.
3D structure databases
HSSP	HSSP built from PDB template 1QXP based on UniProtKB P97571.
ProteinModelPortal	O75808.
ModBase	Search...
Protein-protein interaction databases
IntAct	O75808. 1 interaction.
STRING	9606.ENSP00000219611.
Protein family/group databases
MEROPS	C02.010.
PTM databases
PhosphoSite	O75808.
Proteomic databases
PaxDb	O75808.
PRIDE	O75808.
Protocols and materials databases
DNASU	6650.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000219611; ENSP00000219611; ENSG00000103326.
GeneID	6650.
KEGG	hsa:6650.
UCSC	uc002chi.3. human.
Organism-specific databases
CTD	6650.
GeneCards	GC16P000577.
HGNC	HGNC:11182. SOLH.
HPA	HPA011960.
MIM	603267. gene.
neXtProt	NX_O75808.
PharmGKB	PA36019.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG327523.
HOGENOM	HOG000007650.
HOVERGEN	HBG080984.
InParanoid	O75808.
KO	K08582.
OMA	QRCTLHN.
OrthoDB	EOG46T30S.
PhylomeDB	O75808.
Gene expression databases
ArrayExpress	O75808.
Bgee	O75808.
CleanEx	HS_SOLH.
Genevestigator	O75808.
Family and domain databases
InterPro	IPR022684. Calpain_cysteine_protease. IPR000169. Pept_cys_AS. IPR001300. Peptidase_C2_calpain_cat. IPR001876. Znf_RanBP2. [Graphical view]
Pfam	PF00648. Peptidase_C2. 1 hit. PF00641. zf-RanBP. 3 hits. [Graphical view]
PRINTS	PR00704. CALPAIN.
SMART	SM00230. CysPc. 1 hit. SM00547. ZnF_RBZ. 5 hits. [Graphical view]
PROSITE	PS50203. CALPAIN_CAT. 1 hit. PS00640. THIOL_PROTEASE_ASN. False negative. PS00139. THIOL_PROTEASE_CYS. 1 hit. PS00639. THIOL_PROTEASE_HIS. False negative. PS01358. ZF_RANBP2_1. 5 hits. PS50199. ZF_RANBP2_2. 4 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	6650.
NextBio	25919.
SOURCE	Search...

Entry information

Entry name

CAN15_HUMAN

Accession

Primary (citable) accession number: O75808
Secondary accession number(s): B1B1M4 , Q2KHS2, Q8WTY9, Q9BUW0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
Last sequence update:	November 1, 1998
Last modified:	May 1, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.