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Protein

Calpain-15

Gene

CAPN15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei552By similarity1
Active sitei717By similarity1
Active sitei737By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri3 – 32RanBP2-type 1PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri44 – 73RanBP2-type 2PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri143 – 172RanBP2-type 3PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri338 – 369RanBP2-type 4PROSITE-ProRule annotationAdd BLAST32
Zinc fingeri412 – 441RanBP2-type 5PROSITE-ProRule annotationAdd BLAST30

GO - Molecular functioni

  • calcium-dependent cysteine-type endopeptidase activity Source: GO_Central
  • cysteine-type peptidase activity Source: ProtInc
  • DNA binding transcription factor activity Source: ProtInc
  • metal ion binding Source: UniProtKB-KW
  • peptidase activity Source: ProtInc

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-1474228 Degradation of the extracellular matrix

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain-15 (EC:3.4.22.-)
Alternative name(s):
Small optic lobes homolog
Gene namesi
Name:CAPN15
Synonyms:SOLH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000103326.10
HGNCiHGNC:11182 CAPN15
MIMi603267 gene
neXtProtiNX_O75808

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000103326
PharmGKBiPA36019

Polymorphism and mutation databases

BioMutaiCAPN15

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002787701 – 1086Calpain-15Add BLAST1086

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei296PhosphoserineCombined sources1
Modified residuei335PhosphoserineCombined sources1
Modified residuei338PhosphoserineCombined sources1
Modified residuei1070PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO75808
MaxQBiO75808
PaxDbiO75808
PeptideAtlasiO75808
PRIDEiO75808

PTM databases

iPTMnetiO75808
PhosphoSitePlusiO75808

Expressioni

Tissue specificityi

Widely expressed with higher expression in brain.1 Publication

Gene expression databases

BgeeiENSG00000103326
CleanExiHS_SOLH
ExpressionAtlasiO75808 baseline and differential
GenevisibleiO75808 HS

Organism-specific databases

HPAiHPA011960

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TRAF2Q129334EBI-6149008,EBI-355744

Protein-protein interaction databases

BioGridi112533, 12 interactors
IntActiO75808, 5 interactors
STRINGi9606.ENSP00000219611

Structurei

3D structure databases

ProteinModelPortaliO75808
SMRiO75808
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini487 – 793Calpain catalyticPROSITE-ProRule annotationAdd BLAST307

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi124 – 142Glu-richAdd BLAST19

Sequence similaritiesi

Belongs to the peptidase C2 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri3 – 32RanBP2-type 1PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri44 – 73RanBP2-type 2PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri143 – 172RanBP2-type 3PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri338 – 369RanBP2-type 4PROSITE-ProRule annotationAdd BLAST32
Zinc fingeri412 – 441RanBP2-type 5PROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0045 Eukaryota
ENOG410XP0B LUCA
GeneTreeiENSGT00750000117668
HOGENOMiHOG000007650
HOVERGENiHBG080984
InParanoidiO75808
KOiK08582
OMAiMHVEKRR
OrthoDBiEOG091G02OL
PhylomeDBiO75808
TreeFamiTF322245

Family and domain databases

CDDicd00044 CysPc, 1 hit
InterProiView protein in InterPro
IPR022684 Calpain_cysteine_protease
IPR000169 Pept_cys_AS
IPR001300 Peptidase_C2_calpain_cat
IPR001876 Znf_RanBP2
IPR036443 Znf_RanBP2_sf
PfamiView protein in Pfam
PF00648 Peptidase_C2, 1 hit
PF00641 zf-RanBP, 3 hits
PRINTSiPR00704 CALPAIN
SMARTiView protein in SMART
SM00230 CysPc, 1 hit
SM00547 ZnF_RBZ, 5 hits
SUPFAMiSSF90209 SSF90209, 3 hits
PROSITEiView protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit
PS01358 ZF_RANBP2_1, 5 hits
PS50199 ZF_RANBP2_2, 4 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75808-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATVGEWSCV RCTFLNPAGQ RQCSICEAPR HKPDLNHILR LSVEEQKWPC
60 70 80 90 100
ARCTFRNFLG KEACEVCGFT PEPAPGAAFL PVLNGVLPKP PAILGEPKGS
110 120 130 140 150
CQEEAGPVRT AGLVATEPAR GQCEDKDEEE KEEQEEEEGA AEPRGGWACP
160 170 180 190 200
RCTLHNTPVA SSCSVCGGPR RLSLPRIPPE ALVVPEVVAP AGFHVVPAAP
210 220 230 240 250
PPGLPGEGAE ANPPATSQGP AAEPEPPRVP PFSPFSSTLQ NNPVPRSRRE
260 270 280 290 300
VPPQLQPPVP EAAQPSPSAG CRGAPQGSGW AGASRLAELL SGKRLSVLEE
310 320 330 340 350
EATEGGTSRV EAGSSTSGSD IIDLAGDTVR YTPASPSSPD FTTWSCAKCT
360 370 380 390 400
LRNPTVAPRC SACGCSKLHG FQEHGEPPTH CPDCGADKPS PCGRSCGRVS
410 420 430 440 450
SAQKAARVLP ERPGQWACPA CTLLNALRAK HCAACHTPQL LVAQRRGAAP
460 470 480 490 500
LRRRESMHVE QRRQTDEGEA KALWENIVAF CRENNVSFVD DSFPPGPESV
510 520 530 540 550
GFPAGDSVQQ RVRQWLRPQE INCSVFRDHR ATWSVFHTLR PSDILQGLLG
560 570 580 590 600
NCWFLSALAV LAERPDLVER VMVTRSLCAE GAYQVRLCKD GTWTTVLVDD
610 620 630 640 650
MLPCDEAGCL LFSQAQRKQL WVALIEKALA KLHGSYFALQ AGRAIEGLAT
660 670 680 690 700
LTGAPCESLA LQLSSTNPRE EPVDTDLIWA KMLSSKEAGF LMGASCGGGN
710 720 730 740 750
MKVDDSAYES LGLRPRHAYS ILDVRDVQGT RLLRLRNPWG RFSWNGSWSD
760 770 780 790 800
EWPHWPGHLR GELMPHGSSE GVFWMEYGDF VRYFDSVDIC KVHSDWQEAR
810 820 830 840 850
VQGCFPSSAS APVGVTALTV LERASLEFAL FQEGSRRSDA VDSHLLDLCI
860 870 880 890 900
LVFRATFGSG GHLSLGRLLA HSKRAVKKFV SCDVMLEPGE YAVVCCAFNH
910 920 930 940 950
WGPPLPGTPA PQASSPSAGV PRASPEPPGH VLAVYSSRLV MVEPVEAQPT
960 970 980 990 1000
TLADAIILLT ESRGERHEGR EGMTCYYLTH GWAGLIVVVE NRHPKAYLHV
1010 1020 1030 1040 1050
QCDCTDSFNV VSTRGSLRTQ DSVPPLHRQV LVILSQLEGN AGFSITHRLA
1060 1070 1080
HRKAAQAFLS DWTASKGTHS PPLTPEVAGL HGPRPL
Length:1,086
Mass (Da):117,314
Last modified:November 1, 1998 - v1
Checksum:i9809A5CF9134A12C
GO
Isoform 2 (identifier: O75808-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     355-415: TVAPRCSACG...ARVLPERPGQ → CPPGLQPLGR...REPRRAARGP
     416-1086: Missing.

Note: No experimental confirmation available.
Show »
Length:415
Mass (Da):43,366
Checksum:i49992E1FBEE9704A
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023361355 – 415TVAPR…ERPGQ → CPPGLQPLGRGPESLPRAAG PRAGCVQLEAGHGGARGSPA DHAGRRHHPAHREPRRAARG P in isoform 2. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_023362416 – 1086Missing in isoform 2. 1 PublicationAdd BLAST671

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85647 mRNA Translation: AAC33822.1
AE006464 Genomic DNA Translation: AAK61233.1
Z97986 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85803.1
BC001869 mRNA Translation: AAH01869.1
BC021854 mRNA Translation: AAH21854.1
BC112918 mRNA Translation: AAI12919.1
CCDSiCCDS10410.1 [O75808-1]
RefSeqiNP_005623.1, NM_005632.2 [O75808-1]
UniGeneiHs.632219

Genome annotation databases

EnsembliENST00000219611; ENSP00000219611; ENSG00000103326 [O75808-1]
GeneIDi6650
KEGGihsa:6650
UCSCiuc002chi.3 human [O75808-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCAN15_HUMAN
AccessioniPrimary (citable) accession number: O75808
Secondary accession number(s): B1B1M4
, Q2KHS2, Q8WTY9, Q9BUW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health