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Protein

Protein phosphatase 1 regulatory subunit 15A

Gene

PPP1R15A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'.5 Publications

GO - Molecular functioni

  1. protein kinase binding Source: UniProtKB
  2. protein phosphatase 1 binding Source: ParkinsonsUK-UCL
  3. protein phosphatase type 1 activator activity Source: ParkinsonsUK-UCL
  4. protein phosphatase type 1 regulator activity Source: ParkinsonsUK-UCL

GO - Biological processi

  1. apoptotic process Source: ProtInc
  2. cell cycle arrest Source: ProtInc
  3. cellular response to DNA damage stimulus Source: ProtInc
  4. endoplasmic reticulum unfolded protein response Source: Ensembl
  5. negative regulation of phosphoprotein phosphatase activity Source: ParkinsonsUK-UCL
  6. negative regulation of protein dephosphorylation Source: ParkinsonsUK-UCL
  7. negative regulation of transforming growth factor beta receptor signaling pathway Source: Reactome
  8. positive regulation of gene expression Source: ParkinsonsUK-UCL
  9. positive regulation of peptidyl-serine dephosphorylation Source: ParkinsonsUK-UCL
  10. positive regulation of peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
  11. positive regulation of phosphoprotein phosphatase activity Source: ParkinsonsUK-UCL
  12. positive regulation of transcription from RNA polymerase I promoter Source: ParkinsonsUK-UCL
  13. positive regulation of translational initiation in response to stress Source: ParkinsonsUK-UCL
  14. protein localization to endoplasmic reticulum Source: ParkinsonsUK-UCL
  15. transforming growth factor beta receptor signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Stress response, Translation regulation

Enzyme and pathway databases

ReactomeiREACT_120727. Downregulation of TGF-beta receptor signaling.
SignaLinkiO75807.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 15A
Alternative name(s):
Growth arrest and DNA damage-inducible protein GADD34
Myeloid differentiation primary response protein MyD116 homolog
Gene namesi
Name:PPP1R15A
Synonyms:GADD34
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:14375. PPP1R15A.

Subcellular locationi

Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side 2 Publications. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side 1 Publication
Note: Associates with membranes via an N-terminal amphipathic intramembrane region.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2121Cytoplasmic1 PublicationAdd
BLAST
Intramembranei22 – 3918Helical1 PublicationAdd
BLAST
Topological domaini40 – 674635Cytoplasmic1 PublicationAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: ParkinsonsUK-UCL
  2. cytosol Source: Reactome
  3. endoplasmic reticulum Source: ParkinsonsUK-UCL
  4. endoplasmic reticulum membrane Source: ParkinsonsUK-UCL
  5. Golgi apparatus Source: ParkinsonsUK-UCL
  6. membrane Source: ParkinsonsUK-UCL
  7. mitochondrial outer membrane Source: UniProtKB-SubCell
  8. mitochondrion Source: ParkinsonsUK-UCL
  9. protein phosphatase type 1 complex Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi25 – 251V → R: Localizes to cytoplasm, degraded more slowly. 1 Publication
Mutagenesisi29 – 291L → R: Localizes to cytoplasm. 1 Publication
Mutagenesisi262 – 2621Y → F: Significantly reduced turnover. 1 Publication
Mutagenesisi555 – 5584KVRF → AAAA: Reduces interaction with SMARCB1. 1 Publication
Mutagenesisi556 – 5583VRF → ARA: Impairs PP1 activation. 1 Publication
Mutagenesisi612 – 6121R → K: Reduces PP1-binding; when associated with K-614. 1 Publication
Mutagenesisi614 – 6141R → K: Reduces PP1-binding; when associated with K-612. 1 Publication
Mutagenesisi618 – 6181R → D: Reduces PP1-binding. 1 Publication

Organism-specific databases

PharmGKBiPA33632.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 674674Protein phosphatase 1 regulatory subunit 15APRO_0000320518Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei262 – 2621Phosphotyrosine1 Publication
Modified residuei391 – 3911Phosphotyrosine1 Publication
Modified residuei434 – 4341Phosphotyrosine1 Publication
Modified residuei512 – 5121Phosphotyrosine1 Publication

Post-translational modificationi

Phosphorylated at multiple Ser/Thr residues. Phosphorylated on tyrosine by LYN; which impairs its antiproliferative activity. Phosphorylation at Tyr-262 enhances proteasomal degradation, this position is dephosphorylated by PTPN2.2 Publications
Polyubiquitinated. Exhibits a rapid proteasomal degradation with a half-life under 1 hour, ubiquitination depends on endoplasmic reticulum association.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiO75807.
PaxDbiO75807.
PRIDEiO75807.

PTM databases

PhosphoSiteiO75807.

Expressioni

Inductioni

By methyl methanesulfonate and ionizing irradiation. By IL24/interleukin-24 in melanoma cells; which induces apoptosis.3 Publications

Gene expression databases

BgeeiO75807.
CleanExiHS_PPP1R15A.
GenevestigatoriO75807.

Organism-specific databases

HPAiCAB018395.
HPA020240.

Interactioni

Subunit structurei

Interacts with PCNA (By similarity). Interacts with LYN and KMT2A/MLL1. Interacts with PP1, PPP1R1A and SMARCB1. Interacts with SMAD7. Interacts with BAG1.By similarity7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CTBP2P565452EBI-714746,EBI-741533
PPP1R1AQ135224EBI-714746,EBI-1568511

Protein-protein interaction databases

BioGridi117172. 23 interactions.
IntActiO75807. 12 interactions.
MINTiMINT-1192304.
STRINGi9606.ENSP00000200453.

Structurei

3D structure databases

ProteinModelPortaliO75807.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati337 – 369331Add
BLAST
Repeati384 – 417342Add
BLAST
Repeati427 – 460343Add
BLAST
Repeati477 – 510344Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 6060Required for localization in the endoplasmic reticulumAdd
BLAST
Regioni337 – 5101744 X 34 AA approximate repeatsAdd
BLAST
Regioni337 – 510174Interaction with SMAD7Add
BLAST
Regioni483 – 55573Interaction with KMT2A/MLL1Add
BLAST
Regioni536 – 58348Interaction with SMARCB1Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi112 – 1154Poly-Asp
Compositional biasi160 – 503344Glu-richAdd
BLAST
Compositional biasi518 – 5214Poly-Pro
Compositional biasi661 – 6666Poly-Ala

Sequence similaritiesi

Belongs to the PPP1R15 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG75356.
GeneTreeiENSGT00510000049287.
HOGENOMiHOG000060154.
HOVERGENiHBG052542.
InParanoidiO75807.
KOiK14019.
OMAiWRDAHPF.
OrthoDBiEOG75QR48.
PhylomeDBiO75807.
TreeFamiTF105547.

Family and domain databases

InterProiIPR019523. Prot_Pase1_reg-su15A/B_C.
[Graphical view]
PfamiPF10488. PP1c_bdg. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O75807-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPGQAPHQA TPWRDAHPFF LLSPVMGLLS RAWSRLRGLG PLEPWLVEAV
60 70 80 90 100
KGAALVEAGL EGEARTPLAI PHTPWGRRPE EEAEDSGGPG EDRETLGLKT
110 120 130 140 150
SSSLPEAWGL LDDDDGMYGE REATSVPRGQ GSQFADGQRA PLSPSLLIRT
160 170 180 190 200
LQGSDKNPGE EKAEEEGVAE EEGVNKFSYP PSHRECCPAV EEEDDEEAVK
210 220 230 240 250
KEAHRTSTSA LSPGSKPSTW VSCPGEEENQ ATEDKRTERS KGARKTSVSP
260 270 280 290 300
RSSGSDPRSW EYRSGEASEE KEEKAHKETG KGEAAPGPQS SAPAQRPQLK
310 320 330 340 350
SWWCQPSDEE EGEVKALGAA EKDGEAECPP CIPPPSAFLK AWVYWPGEDT
360 370 380 390 400
EEEEDEEEDE DSDSGSDEEE GEAEASSSTP ATGVFLKSWV YQPGEDTEEE
410 420 430 440 450
EDEDSDTGSA EDEREAETSA STPPASAFLK AWVYRPGEDT EEEEDEDVDS
460 470 480 490 500
EDKEDDSEAA LGEAESDPHP SHPDQRAHFR GWGYRPGKET EEEEAAEDWG
510 520 530 540 550
EAEPCPFRVA IYVPGEKPPP PWAPPRLPLR LQRRLKRPET PTHDPDPETP
560 570 580 590 600
LKARKVRFSE KVTVHFLAVW AGPAQAARQG PWEQLARDRS RFARRITQAQ
610 620 630 640 650
EELSPCLTPA ARARAWARLR NPPLAPIPAL TQTLPSSSVP SSPVQTTPLS
660 670
QAVATPSRSS AAAAAALDLS GRRG
Length:674
Mass (Da):73,478
Last modified:November 1, 1998 - v1
Checksum:iB257AA17456D1403
GO
Isoform 2 (identifier: O75807-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-16: A → D
     17-175: Missing.

Note: No experimental confirmation available.

Show »
Length:515
Mass (Da):56,515
Checksum:i1411EE8095E602B0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti80 – 801E → G in BAA91649. (PubMed:14702039)Curated
Sequence conflicti297 – 2971P → L in CAG33540. 1 PublicationCurated
Sequence conflicti669 – 6691L → P in BAG59265. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti31 – 311R → H.
Corresponds to variant rs564196 [ dbSNP | Ensembl ].
VAR_039186
Natural varianti32 – 321A → T.1 Publication
Corresponds to variant rs3786734 [ dbSNP | Ensembl ].
VAR_039187
Natural varianti199 – 1991V → A.
Corresponds to variant rs611251 [ dbSNP | Ensembl ].
VAR_039188
Natural varianti251 – 2511R → P.
Corresponds to variant rs557806 [ dbSNP | Ensembl ].
VAR_039189
Natural varianti277 – 2771K → E.1 Publication
Corresponds to variant rs610308 [ dbSNP | Ensembl ].
VAR_039190
Natural varianti312 – 3121G → S.1 Publication
Corresponds to variant rs11541192 [ dbSNP | Ensembl ].
VAR_062226
Natural varianti316 – 3161A → P.1 Publication
Corresponds to variant rs556052 [ dbSNP | Ensembl ].
VAR_039191
Natural varianti381 – 3811A → V.
Corresponds to variant rs1050166 [ dbSNP | Ensembl ].
VAR_039192
Natural varianti476 – 4761R → S.1 Publication
Corresponds to variant rs35087747 [ dbSNP | Ensembl ].
VAR_039193
Natural varianti594 – 5941R → C.
Corresponds to variant rs2270946 [ dbSNP | Ensembl ].
VAR_039194
Natural varianti597 – 5971T → A.1 Publication
Corresponds to variant rs500079 [ dbSNP | Ensembl ].
VAR_039195

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei16 – 161A → D in isoform 2. 1 PublicationVSP_057083
Alternative sequencei17 – 175159Missing in isoform 2. 1 PublicationVSP_057084Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83981 mRNA. Translation: AAC25631.1.
CR457259 mRNA. Translation: CAG33540.1.
AK001361 mRNA. Translation: BAA91649.1.
AK296668 mRNA. Translation: BAG59265.1.
CH471177 Genomic DNA. Translation: EAW52409.1.
BC003067 mRNA. Translation: AAH03067.1.
CCDSiCCDS12738.1. [O75807-1]
RefSeqiNP_055145.3. NM_014330.3. [O75807-1]
UniGeneiHs.631593.

Genome annotation databases

EnsembliENST00000200453; ENSP00000200453; ENSG00000087074. [O75807-1]
GeneIDi23645.
KEGGihsa:23645.
UCSCiuc002pky.4. human. [O75807-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83981 mRNA. Translation: AAC25631.1.
CR457259 mRNA. Translation: CAG33540.1.
AK001361 mRNA. Translation: BAA91649.1.
AK296668 mRNA. Translation: BAG59265.1.
CH471177 Genomic DNA. Translation: EAW52409.1.
BC003067 mRNA. Translation: AAH03067.1.
CCDSiCCDS12738.1. [O75807-1]
RefSeqiNP_055145.3. NM_014330.3. [O75807-1]
UniGeneiHs.631593.

3D structure databases

ProteinModelPortaliO75807.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117172. 23 interactions.
IntActiO75807. 12 interactions.
MINTiMINT-1192304.
STRINGi9606.ENSP00000200453.

PTM databases

PhosphoSiteiO75807.

Proteomic databases

MaxQBiO75807.
PaxDbiO75807.
PRIDEiO75807.

Protocols and materials databases

DNASUi23645.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000200453; ENSP00000200453; ENSG00000087074. [O75807-1]
GeneIDi23645.
KEGGihsa:23645.
UCSCiuc002pky.4. human. [O75807-1]

Organism-specific databases

CTDi23645.
GeneCardsiGC19P049375.
H-InvDBHIX0015305.
HIX0174313.
HGNCiHGNC:14375. PPP1R15A.
HPAiCAB018395.
HPA020240.
MIMi611048. gene.
neXtProtiNX_O75807.
PharmGKBiPA33632.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG75356.
GeneTreeiENSGT00510000049287.
HOGENOMiHOG000060154.
HOVERGENiHBG052542.
InParanoidiO75807.
KOiK14019.
OMAiWRDAHPF.
OrthoDBiEOG75QR48.
PhylomeDBiO75807.
TreeFamiTF105547.

Enzyme and pathway databases

ReactomeiREACT_120727. Downregulation of TGF-beta receptor signaling.
SignaLinkiO75807.

Miscellaneous databases

ChiTaRSiPPP1R15A. human.
GeneWikiiPPP1R15A.
GenomeRNAii23645.
NextBioi35472843.
PROiO75807.
SOURCEiSearch...

Gene expression databases

BgeeiO75807.
CleanExiHS_PPP1R15A.
GenevestigatoriO75807.

Family and domain databases

InterProiIPR019523. Prot_Pase1_reg-su15A/B_C.
[Graphical view]
PfamiPF10488. PP1c_bdg. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mammalian GADD34, an apoptosis- and DNA damage-inducible gene."
    Hollander M.C., Zhan Q., Bae I., Fornace A.J. Jr.
    J. Biol. Chem. 272:13731-13737(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-32.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS GLU-277; SER-312; PRO-316; SER-476 AND ALA-597.
    Tissue: Umbilical cord blood.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  6. "The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth."
    Zhan Q., Lord K.A., Alamo I. Jr., Hollander M.C., Carrier F., Ron D., Kohn K.W., Hoffman B., Liebermann D.A., Fornace A.J. Jr.
    Mol. Cell. Biol. 14:2361-2371(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Leukemic HRX fusion proteins inhibit GADD34-induced apoptosis and associate with the GADD34 and hSNF5/INI1 proteins."
    Adler H.T., Chinery R., Wu D.Y., Kussick S.J., Payne J.M., Fornace A.J. Jr., Tkachuk D.C.
    Mol. Cell. Biol. 19:7050-7060(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH KMT2A/MLL1 AND SMARCB1, INDUCTION.
  8. "Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis."
    Grishin A.V., Azhipa O., Semenov I., Corey S.J.
    Proc. Natl. Acad. Sci. U.S.A. 98:10172-10177(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH LYN, PHOSPHORYLATION.
  9. "Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1."
    Connor J.H., Weiser D.C., Li S., Hallenbeck J.M., Shenolikar S.
    Mol. Cell. Biol. 21:6841-6850(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PP1 AND PPP1R1A, FUNCTION.
  10. "The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity."
    Wu D.Y., Tkachuck D.C., Roberson R.S., Schubach W.H.
    J. Biol. Chem. 277:27706-27715(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SMARCB1 AND PP1, MUTAGENESIS OF 555-LYS--PHE-558.
  11. "mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK."
    Sarkar D., Su Z.-Z., Lebedeva I.V., Sauane M., Gopalkrishnan R.V., Valerie K., Dent P., Fisher P.B.
    Proc. Natl. Acad. Sci. U.S.A. 99:10054-10059(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  12. Cited for: FUNCTION.
  13. "Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2."
    Brush M.H., Weiser D.C., Shenolikar S.
    Mol. Cell. Biol. 23:1292-1303(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF 556-VAL--SER-558; ARG-612; ARG-614 AND ARG-618, SUBCELLULAR LOCATION.
  14. "Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions."
    Hung W.J., Roberson R.S., Taft J., Wu D.Y.
    Mol. Cell. Biol. 23:3477-3486(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BAG1.
  15. "GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor."
    Shi W., Sun C., He B., Xiong W., Shi X., Yao D., Cao X.
    J. Cell Biol. 164:291-300(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SMAD7.
  16. "A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress."
    Boyce M., Bryant K.F., Jousse C., Long K., Harding H.P., Scheuner D., Kaufman R.J., Ma D., Coen D.M., Ron D., Yuan J.
    Science 307:935-939(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PP1.
  17. "Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 protein."
    Zhou W., Brush M.H., Choy M.S., Shenolikar S.
    J. Biol. Chem. 286:21687-21696(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TOPOLOGY, INTRAMEMBRANE REGION, MUTAGENESIS OF VAL-25 AND LEU-29.
  18. "Phosphorylation at tyrosine 262 promotes GADD34 protein turnover."
    Zhou W., Jeyaraman K., Yusoff P., Shenolikar S.
    J. Biol. Chem. 288:33146-33155(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT TYR-262; TYR-391; TYR-434 AND TYR-512, UBIQUITINATION, MUTAGENESIS OF TYR-262.

Entry informationi

Entry nameiPR15A_HUMAN
AccessioniPrimary (citable) accession number: O75807
Secondary accession number(s): B4DKQ3, Q6IA96, Q9NVU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: November 1, 1998
Last modified: February 4, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.