Reviewed, UniProtKB/Swiss-Prot O75800 (ZMY10_HUMAN)

Names and origin

Protein names

Recommended name:
    Zinc finger MYND domain-containing protein 10
Alternative name(s):
    BLu protein

Gene names

Name:	ZMYND10
Synonyms:	BLU
ORF Names:	LUCA12.4

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	440 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Involvement in disease	Defects in ZMYND10 are found in non-small cell lung cancer (NSCLC) cell lines. Ref.6
Sequence similarities	Contains 1 MYND-type zinc finger.
Sequence caution	The sequence AAB67311.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Disease	Disease mutation
Domain	Zinc-finger
Ligand	Metal-binding Zinc
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from direct assay. Source: LIFEdb
Molecular function	protein binding Inferred from physical interaction. Source: IntAct zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TSC22D4	Q9Y3Q8	1	EBI-747061,EBI-739485

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O75800-1)

Also known as: Lung;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O75800-2)

Also known as: Testis;

The sequence of this isoform differs from the canonical sequence as follows:
     200-234: SLSLSTLSRMLSTHNLPCLLVELLEHSPWSRREGG → RQWSVSQPPQLAHLKRIQRLHPVCWFLSPG

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 440

440

Zinc finger MYND domain-containing protein 10

PRO_0000218314

Regions

Zinc finger

394 – 430

37

MYND-type

Natural variations

Alternative sequence

200 – 234

35

SLSLS…RREGG → RQWSVSQPPQLAHLKRIQRL HPVCWFLSPG in isoform 2.

VSP_003328

Natural variant

407

1

R → Q in NSCLC. Ref.6

VAR_014227

Experimental info

Sequence conflict

35

1

Q → R in CAD38688. Ref.2

Sequence conflict

369

1

R → W in AAC24726. Ref.1

Secondary structure

1

.

.

.

.

.

.

.

.

.

440

Helix Strand Turn

Details...

Beta strand

395 – 397

3

Turn

406 – 408

3

Helix

416 – 421

6

Helix

423 – 429

7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Lung) [UniParc]. Last modified November 8, 2002. Version 2. Checksum: 510D41074C956CA3	FASTA	440	50,344
	10 20 30 40 50 60 MGDLELLLPG EAEVLVRGLR SFPLREMGSE GWNQQHENLE KLNMQAILDA TVSQGEPIQE 70 80 90 100 110 120 LLVTHGKVPT LVEELIAVEM WKQKVFPVFC RVEDFKPQNT FPIYMVVHHE ASIINLLETV 130 140 150 160 170 180 FFHKEVCESA EDTVLDLVDY CHRKLTLLVA QSGCGGPPEG EGSQDSNPMQ ELQKQAELME 190 200 210 220 230 240 FEIALKALSV LRYITDCVDS LSLSTLSRML STHNLPCLLV ELLEHSPWSR REGGKLQQFE 250 260 270 280 290 300 GSRWHTVAPS EQQKLSKLDG QVWIALYNLL LSPEAQARYC LTSFAKGRLL KLRAFLTDTL 310 320 330 340 350 360 LDQLPNLAHL QSFLAHLTLT ETQPPKKDLV LEQIPEIWER LERENRGKWQ AIAKHQLQHV 370 380 390 400 410 420 FSPSEQDLRL QARRWAETYR LDVLEAVAPE RPRCAYCSAE ASKRCSRCQN EWYCCRECQV 430 440 KHWEKHGKTC VLAAQGDRAK
	Isoform 2 (Testis). Checksum: 8E4A85DD7782C5D3	FASTA	435	49,989
	10 20 30 40 50 60 MGDLELLLPG EAEVLVRGLR SFPLREMGSE GWNQQHENLE KLNMQAILDA TVSQGEPIQE 70 80 90 100 110 120 LLVTHGKVPT LVEELIAVEM WKQKVFPVFC RVEDFKPQNT FPIYMVVHHE ASIINLLETV 130 140 150 160 170 180 FFHKEVCESA EDTVLDLVDY CHRKLTLLVA QSGCGGPPEG EGSQDSNPMQ ELQKQAELME 190 200 210 220 230 240 FEIALKALSV LRYITDCVDR QWSVSQPPQL AHLKRIQRLH PVCWFLSPGK LQQFEGSRWH 250 260 270 280 290 300 TVAPSEQQKL SKLDGQVWIA LYNLLLSPEA QARYCLTSFA KGRLLKLRAF LTDTLLDQLP 310 320 330 340 350 360 NLAHLQSFLA HLTLTETQPP KKDLVLEQIP EIWERLEREN RGKWQAIAKH QLQHVFSPSE 370 380 390 400 410 420 QDLRLQARRW AETYRLDVLE AVAPERPRCA YCSAEASKRC SRCQNEWYCC RECQVKHWEK 430 HGKTCVLAAQ GDRAK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel gene (BLu) that resides in the lung cancer region on chromosome 3p21.3 has the MYND Zn finger-like module." Duh F.-M., Latif F., Bader S., Sekido Y., Kuzmin I., Minna J.D., Koonin E., Lerman M.I. Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Tissue: Lung and Testis.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Kidney.
[3]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed: 16641997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[6]	"The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes." The international lung cancer chromosome 3p21.3 tumor suppressor gene consortium Lerman M.I., Minna J.D. Cancer Res. 60:6116-6133(2000) [PubMed: 11085536] [Abstract] Cited for: DISCUSSION OF SEQUENCE, VARIANT NSCLC GLN-407.
[7]	"Solution structure of the MYND domain of the human zinc finger MYND domain-containing protein 10." RIKEN structural genomics initiative (RSGI) Submitted (JUN-2006) to the PDB data bank Cited for: STRUCTURE BY NMR OF 384-440.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

U70824 mRNA. Translation: AAC24726.1.
U70880 mRNA. Translation: AAC24728.1.
AL833828 mRNA. Translation: CAD38688.1.
AC002481 Genomic DNA. Translation: AAB67311.1. Sequence problems.
CH471055 Genomic DNA. Translation: EAW65104.1.
BC033732 mRNA. Translation: AAH33732.1.

IPI

IPI00220520.
IPI00304253.

RefSeq

NP_056980.2.

UniGene

Hs.526735
Hs.627171

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2D8Q	NMR	-	A	384-440	[»]
2DAN	NMR	-	A	384-430	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

O75800. 1 interaction.

STRING

O75800.

Proteomic databases

PRIDE

O75800.

Genome annotation databases

Ensembl

ENST00000231749; ENSP00000231749; ENSG00000004838; Homo sapiens. [Genome view]

GeneID

51364.

KEGG

hsa:51364.

UCSC

uc003dag.1. human.
uc010hll.1. human.

Organism-specific databases

CTD

51364.

GeneCards

GC03M050353.

H-InvDB

HIX0003312.

HGNC

HGNC:19412. ZMYND10.

MIM

607070. gene.

PharmGKB

PA134981649.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

O75800.

HOVERGEN

O75800.

OMA

WQAIAKH

OrthoDB

EOG9CZF16

Gene expression databases

ArrayExpress

O75800.

Bgee

O75800.

CleanEx

HS_ZMYND10.

Genevestigator

O75800.

GermOnline

ENSG00000004838. Homo sapiens.

Family and domain databases

InterPro

IPR017333. UCP037948_Znf-MYND.
IPR002893. Znf_MYND.
[Graphical view]

Pfam

PF01753. zf-MYND. 1 hit.
[Graphical view]

PIRSF

PIRSF037948. UCP037948_Znf_MYND10. 1 hit.

PROSITE

PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

54829.

SOURCE

Search...

Entry information

Entry name

ZMY10_HUMAN

Accession

Primary (citable) accession number: O75800
Secondary accession number(s): A6NK41 , O14570, O75801, Q8N4R6, Q8NDN6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	November 8, 2002
Last modified:	November 24, 2009
This is version 75 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.