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O75795 (UDB17_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-glucuronosyltransferase 2B17

Short name=UDPGT 2B17
EC=2.4.1.17
Alternative name(s):
C19-steroid-specific UDP-glucuronosyltransferase
Short name=C19-steroid-specific UDPGT
Gene names
Name:UGT2B17
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length530 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3-alpha,17-beta-diol (3-alpha-diol) > testosterone > androsterone (ADT).

Catalytic activity

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subcellular location

Microsome membrane; Single-pass membrane protein Potential. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.

Tissue specificity

Expressed in various tissues including the liver, kidney, testis, uterus, placenta, mammary gland, adrenal gland, skin and prostate.

Polymorphism

Copy-number variation of UGT2B17 defines the bone mineral density quantitative trait locus 12 (BMND12) [MIM:612560]. Variance in bone mineral density is a susceptibility factor for osteoporotic fractures.

Sequence similarities

Belongs to the UDP-glycosyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 530507UDP-glucuronosyltransferase 2B17
PRO_0000036041

Regions

Transmembrane495 – 51521Helical; Potential

Amino acid modifications

Glycosylation651N-linked (GlcNAc...) Potential
Glycosylation3161N-linked (GlcNAc...) Potential
Glycosylation4831N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O75795 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 8E59EBC43CF43760

FASTA53061,095
        10         20         30         40         50         60 
MSLKWMSVFL LMQLSCYFSS GSCGKVLVWP TEYSHWINMK TILEELVQRG HEVIVLTSSA 

        70         80         90        100        110        120 
SILVNASKSS AIKLEVYPTS LTKNDLEDFF MKMFDRWTYS ISKNTFWSYF SQLQELCWEY 

       130        140        150        160        170        180 
SDYNIKLCED AVLNKKLMRK LQESKFDVLL ADAVNPCGEL LAELLNIPFL YSLRFSVGYT 

       190        200        210        220        230        240 
VEKNGGGFLF PPSYVPVVMS ELSDQMIFME RIKNMIYMLY FDFWFQAYDL KKWDQFYSEV 

       250        260        270        280        290        300 
LGRPTTLFET MGKAEMWLIR TYWDFEFPRP FLPNVDFVGG LHCKPAKPLP KEMEEFVQSS 

       310        320        330        340        350        360 
GENGIVVFSL GSMISNMSEE SANMIASALA QIPQKVLWRF DGKKPNTLGS NTRLYKWLPQ 

       370        380        390        400        410        420 
NDLLGHPKTK AFITHGGTNG IYEAIYHGIP MVGIPLFADQ HDNIAHMKAK GAALSVDIRT 

       430        440        450        460        470        480 
MSSRDLLNAL KSVINDPIYK ENIMKLSRIH HDQPVKPLDR AVFWIEFVMR HKGAKHLRVA 

       490        500        510        520        530 
AHNLTWIQYH SLDVIAFLLA CVATMIFMIT KCCLFCFRKL AKTGKKKKRD 

« Hide

References

[1]"Isolation and characterization of a novel cDNA encoding a human UDP-glucuronosyltransferase active on C19 steroids."
Beaulieu M., Levesque E., Hum D.W., Belanger A.
J. Biol. Chem. 271:22855-22862(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Prostate.
[2]"Chromosomal localization, structure, and regulation of the UGT2B17 gene, encoding a C19 steroid metabolizing enzyme."
Beaulieu M., Levesque E., Tchernof A., Beatty B.G., Belanger A., Hum D.W.
DNA Cell Biol. 16:1143-1154(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Genome-wide copy-number-variation study identified a susceptibility gene, UGT2B17, for osteoporosis."
Yang T.-L., Chen X.-D., Guo Y., Lei S.-F., Wang J.-T., Zhou Q., Pan F., Chen Y., Zhang Z.-X., Dong S.-S., Xu X.-H., Yan H., Liu X., Qiu C., Zhu X.-Z., Chen T., Li M., Zhang H. expand/collapse author list , Zhang L., Drees B.M., Hamilton J.J., Papasian C.J., Recker R.R., Song X.-P., Cheng J., Deng H.-W.
Am. J. Hum. Genet. 83:663-674(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN BONE MINERAL DENSITY VARIANCE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U59209 mRNA. Translation: AAC25491.1.
RefSeqNP_001068.1. NM_001077.3.
UniGeneHs.575083.

3D structure databases

ProteinModelPortalO75795.
SMRO75795. Positions 286-447.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000320401.

Chemistry

BindingDBO75795.
ChEMBLCHEMBL4978.

Protein family/group databases

CAZyGT1. Glycosyltransferase Family 1.

PTM databases

PhosphoSiteO75795.

Proteomic databases

PaxDbO75795.
PRIDEO75795.

Protocols and materials databases

DNASU7367.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000317746; ENSP00000320401; ENSG00000197888.
GeneID7367.
KEGGhsa:7367.
UCSCuc011clo.2. human.

Organism-specific databases

CTD7367.
GeneCardsGC04M069406.
HGNCHGNC:12547. UGT2B17.
HPAHPA045108.
MIM601903. gene.
612560. phenotype.
neXtProtNX_O75795.
PharmGKBPA37189.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1819.
HOGENOMHOG000220831.
HOVERGENHBG004033.
InParanoidO75795.
KOK00699.
OMACEDAVLN.
OrthoDBEOG7GBFWS.
PhylomeDBO75795.
TreeFamTF315472.

Enzyme and pathway databases

BRENDA2.4.1.17. 2681.
ReactomeREACT_111217. Metabolism.
SABIO-RKO75795.

Gene expression databases

BgeeO75795.
CleanExHS_UGT2B17.
GenevestigatorO75795.

Family and domain databases

InterProIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERPTHR11926. PTHR11926. 1 hit.
PfamPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiUGT2B17.
GenomeRNAi7367.
NextBio28846.
PROO75795.
SOURCESearch...

Entry information

Entry nameUDB17_HUMAN
AccessionPrimary (citable) accession number: O75795
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: February 19, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM