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Protein

UDP-glucuronosyltransferase 2B17

Gene

UGT2B17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3-alpha,17-beta-diol (3-alpha-diol) > testosterone > androsterone (ADT).

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: UniProtKB

GO - Biological processi

  1. cellular glucuronidation Source: UniProtKB
  2. cellular response to hormone stimulus Source: GO_Central
  3. flavonoid biosynthetic process Source: GO_Central
  4. flavonoid glucuronidation Source: GO_Central
  5. steroid metabolic process Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.17. 2681.
ReactomeiREACT_6784. Glucuronidation.
SABIO-RKO75795.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B17 (EC:2.4.1.17)
Short name:
UDPGT 2B17
Alternative name(s):
C19-steroid-specific UDP-glucuronosyltransferase
Short name:
C19-steroid-specific UDPGT
Gene namesi
Name:UGT2B17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:12547. UGT2B17.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei495 – 51521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. intracellular membrane-bounded organelle Source: GO_Central
  4. membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

MIMi612560. phenotype.
PharmGKBiPA37189.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 530507UDP-glucuronosyltransferase 2B17PRO_0000036041Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi65 – 651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi483 – 4831N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO75795.
PaxDbiO75795.
PRIDEiO75795.

PTM databases

PhosphoSiteiO75795.

Expressioni

Tissue specificityi

Expressed in various tissues including the liver, kidney, testis, uterus, placenta, mammary gland, adrenal gland, skin and prostate.

Gene expression databases

BgeeiO75795.
CleanExiHS_UGT2B17.
GenevestigatoriO75795.

Organism-specific databases

HPAiHPA045108.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000320401.

Structurei

3D structure databases

ProteinModelPortaliO75795.
SMRiO75795. Positions 286-447.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1819.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiO75795.
KOiK00699.
OMAiCEDAVLN.
OrthoDBiEOG7GBFWS.
PhylomeDBiO75795.
TreeFamiTF315472.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75795-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLKWMSVFL LMQLSCYFSS GSCGKVLVWP TEYSHWINMK TILEELVQRG
60 70 80 90 100
HEVIVLTSSA SILVNASKSS AIKLEVYPTS LTKNDLEDFF MKMFDRWTYS
110 120 130 140 150
ISKNTFWSYF SQLQELCWEY SDYNIKLCED AVLNKKLMRK LQESKFDVLL
160 170 180 190 200
ADAVNPCGEL LAELLNIPFL YSLRFSVGYT VEKNGGGFLF PPSYVPVVMS
210 220 230 240 250
ELSDQMIFME RIKNMIYMLY FDFWFQAYDL KKWDQFYSEV LGRPTTLFET
260 270 280 290 300
MGKAEMWLIR TYWDFEFPRP FLPNVDFVGG LHCKPAKPLP KEMEEFVQSS
310 320 330 340 350
GENGIVVFSL GSMISNMSEE SANMIASALA QIPQKVLWRF DGKKPNTLGS
360 370 380 390 400
NTRLYKWLPQ NDLLGHPKTK AFITHGGTNG IYEAIYHGIP MVGIPLFADQ
410 420 430 440 450
HDNIAHMKAK GAALSVDIRT MSSRDLLNAL KSVINDPIYK ENIMKLSRIH
460 470 480 490 500
HDQPVKPLDR AVFWIEFVMR HKGAKHLRVA AHNLTWIQYH SLDVIAFLLA
510 520 530
CVATMIFMIT KCCLFCFRKL AKTGKKKKRD
Length:530
Mass (Da):61,095
Last modified:November 1, 1998 - v1
Checksum:i8E59EBC43CF43760
GO

Polymorphismi

Copy-number variation of UGT2B17 defines the bone mineral density quantitative trait locus 12 (BMND12) [MIMi:612560]. Variance in bone mineral density is a susceptibility factor for osteoporotic fractures.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59209 mRNA. Translation: AAC25491.1.
CCDSiCCDS3523.1.
RefSeqiNP_001068.1. NM_001077.3.
UniGeneiHs.575083.

Genome annotation databases

EnsembliENST00000317746; ENSP00000320401; ENSG00000197888.
GeneIDi7367.
KEGGihsa:7367.
UCSCiuc011clo.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59209 mRNA. Translation: AAC25491.1.
CCDSiCCDS3523.1.
RefSeqiNP_001068.1. NM_001077.3.
UniGeneiHs.575083.

3D structure databases

ProteinModelPortaliO75795.
SMRiO75795. Positions 286-447.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000320401.

Chemistry

BindingDBiO75795.
ChEMBLiCHEMBL4978.
DrugBankiDB00678. Losartan.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

PTM databases

PhosphoSiteiO75795.

Proteomic databases

MaxQBiO75795.
PaxDbiO75795.
PRIDEiO75795.

Protocols and materials databases

DNASUi7367.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317746; ENSP00000320401; ENSG00000197888.
GeneIDi7367.
KEGGihsa:7367.
UCSCiuc011clo.2. human.

Organism-specific databases

CTDi7367.
GeneCardsiGC04M069406.
HGNCiHGNC:12547. UGT2B17.
HPAiHPA045108.
MIMi601903. gene.
612560. phenotype.
neXtProtiNX_O75795.
PharmGKBiPA37189.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1819.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiO75795.
KOiK00699.
OMAiCEDAVLN.
OrthoDBiEOG7GBFWS.
PhylomeDBiO75795.
TreeFamiTF315472.

Enzyme and pathway databases

BRENDAi2.4.1.17. 2681.
ReactomeiREACT_6784. Glucuronidation.
SABIO-RKO75795.

Miscellaneous databases

GeneWikiiUGT2B17.
GenomeRNAii7367.
NextBioi28846.
PROiO75795.
SOURCEiSearch...

Gene expression databases

BgeeiO75795.
CleanExiHS_UGT2B17.
GenevestigatoriO75795.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation and characterization of a novel cDNA encoding a human UDP-glucuronosyltransferase active on C19 steroids."
    Beaulieu M., Levesque E., Hum D.W., Belanger A.
    J. Biol. Chem. 271:22855-22862(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Prostate.
  2. "Chromosomal localization, structure, and regulation of the UGT2B17 gene, encoding a C19 steroid metabolizing enzyme."
    Beaulieu M., Levesque E., Tchernof A., Beatty B.G., Belanger A., Hum D.W.
    DNA Cell Biol. 16:1143-1154(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: INVOLVEMENT IN BONE MINERAL DENSITY VARIANCE.

Entry informationi

Entry nameiUDB17_HUMAN
AccessioniPrimary (citable) accession number: O75795
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: February 4, 2015
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.