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Protein

UDP-glucuronosyltransferase 2B17

Gene

UGT2B17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3-alpha,17-beta-diol (3-alpha-diol) > testosterone > androsterone (ADT).

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  • glucuronosyltransferase activity Source: UniProtKB

GO - Biological processi

  • cellular glucuronidation Source: UniProtKB
  • steroid metabolic process Source: ProtInc

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.17. 2681.
ReactomeiR-HSA-156588. Glucuronidation.
SABIO-RKiO75795.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Chemistry databases

SwissLipidsiSLP:000001696.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B17 (EC:2.4.1.17)
Short name:
UDPGT 2B17
Alternative name(s):
C19-steroid-specific UDP-glucuronosyltransferase
Short name:
C19-steroid-specific UDPGT
Gene namesi
Name:UGT2B17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000197888.2.
HGNCiHGNC:12547. UGT2B17.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei495 – 515HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi7367.
MalaCardsiUGT2B17.
MIMi612560. phenotype.
OpenTargetsiENSG00000197888.
PharmGKBiPA37189.

Chemistry databases

ChEMBLiCHEMBL4978.
DrugBankiDB00678. Losartan.

Polymorphism and mutation databases

BioMutaiUGT2B17.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000003604124 – 530UDP-glucuronosyltransferase 2B17Add BLAST507

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi316N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi483N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO75795.
PaxDbiO75795.
PeptideAtlasiO75795.
PRIDEiO75795.

PTM databases

iPTMnetiO75795.
PhosphoSitePlusiO75795.

Expressioni

Tissue specificityi

Expressed in various tissues including the liver, kidney, testis, uterus, placenta, mammary gland, adrenal gland, skin and prostate.

Gene expression databases

BgeeiENSG00000197888.
CleanExiHS_UGT2B17.
GenevisibleiO75795. HS.

Organism-specific databases

HPAiHPA045108.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000320401.

Chemistry databases

BindingDBiO75795.

Structurei

3D structure databases

ProteinModelPortaliO75795.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1192. Eukaryota.
COG1819. LUCA.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiO75795.
KOiK00699.
OMAiELCWEYS.
OrthoDBiEOG091G06JC.
PhylomeDBiO75795.
TreeFamiTF315472.

Family and domain databases

InterProiView protein in InterPro
IPR002213. UDP_glucos_trans.
IPR035595. UDP_glycos_trans_CS.
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiView protein in Pfam
PF00201. UDPGT. 1 hit.
PROSITEiView protein in PROSITE
PS00375. UDPGT. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75795-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLKWMSVFL LMQLSCYFSS GSCGKVLVWP TEYSHWINMK TILEELVQRG
60 70 80 90 100
HEVIVLTSSA SILVNASKSS AIKLEVYPTS LTKNDLEDFF MKMFDRWTYS
110 120 130 140 150
ISKNTFWSYF SQLQELCWEY SDYNIKLCED AVLNKKLMRK LQESKFDVLL
160 170 180 190 200
ADAVNPCGEL LAELLNIPFL YSLRFSVGYT VEKNGGGFLF PPSYVPVVMS
210 220 230 240 250
ELSDQMIFME RIKNMIYMLY FDFWFQAYDL KKWDQFYSEV LGRPTTLFET
260 270 280 290 300
MGKAEMWLIR TYWDFEFPRP FLPNVDFVGG LHCKPAKPLP KEMEEFVQSS
310 320 330 340 350
GENGIVVFSL GSMISNMSEE SANMIASALA QIPQKVLWRF DGKKPNTLGS
360 370 380 390 400
NTRLYKWLPQ NDLLGHPKTK AFITHGGTNG IYEAIYHGIP MVGIPLFADQ
410 420 430 440 450
HDNIAHMKAK GAALSVDIRT MSSRDLLNAL KSVINDPIYK ENIMKLSRIH
460 470 480 490 500
HDQPVKPLDR AVFWIEFVMR HKGAKHLRVA AHNLTWIQYH SLDVIAFLLA
510 520 530
CVATMIFMIT KCCLFCFRKL AKTGKKKKRD
Length:530
Mass (Da):61,095
Last modified:November 1, 1998 - v1
Checksum:i8E59EBC43CF43760
GO

Polymorphismi

Copy-number variation of UGT2B17 defines the bone mineral density quantitative trait locus 12 (BMND12) [MIMi:612560]. Variance in bone mineral density is a susceptibility factor for osteoporotic fractures.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59209 mRNA. Translation: AAC25491.1.
CCDSiCCDS3523.1.
RefSeqiNP_001068.1. NM_001077.3.
UniGeneiHs.575083.

Genome annotation databases

EnsembliENST00000317746; ENSP00000320401; ENSG00000197888.
GeneIDi7367.
KEGGihsa:7367.
UCSCiuc021xov.2. human.

Similar proteinsi

Entry informationi

Entry nameiUDB17_HUMAN
AccessioniPrimary (citable) accession number: O75795
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: September 27, 2017
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families