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O75795

- UDB17_HUMAN

UniProt

O75795 - UDB17_HUMAN

Protein

UDP-glucuronosyltransferase 2B17

Gene

UGT2B17

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3-alpha,17-beta-diol (3-alpha-diol) > testosterone > androsterone (ADT).

    Catalytic activityi

    UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

    GO - Molecular functioni

    1. glucuronosyltransferase activity Source: UniProt

    GO - Biological processi

    1. cellular glucuronidation Source: UniProt
    2. steroid metabolic process Source: ProtInc

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BRENDAi2.4.1.17. 2681.
    ReactomeiREACT_6784. Glucuronidation.
    SABIO-RKO75795.

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 2B17 (EC:2.4.1.17)
    Short name:
    UDPGT 2B17
    Alternative name(s):
    C19-steroid-specific UDP-glucuronosyltransferase
    Short name:
    C19-steroid-specific UDPGT
    Gene namesi
    Name:UGT2B17
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:12547. UGT2B17.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane Source: ProtInc

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    Pathology & Biotechi

    Organism-specific databases

    MIMi612560. phenotype.
    PharmGKBiPA37189.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 530507UDP-glucuronosyltransferase 2B17PRO_0000036041Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi65 – 651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi483 – 4831N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiO75795.
    PaxDbiO75795.
    PRIDEiO75795.

    PTM databases

    PhosphoSiteiO75795.

    Expressioni

    Tissue specificityi

    Expressed in various tissues including the liver, kidney, testis, uterus, placenta, mammary gland, adrenal gland, skin and prostate.

    Gene expression databases

    BgeeiO75795.
    CleanExiHS_UGT2B17.
    GenevestigatoriO75795.

    Organism-specific databases

    HPAiHPA045108.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000320401.

    Structurei

    3D structure databases

    ProteinModelPortaliO75795.
    SMRiO75795. Positions 286-447.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei495 – 51521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1819.
    HOGENOMiHOG000220831.
    HOVERGENiHBG004033.
    InParanoidiO75795.
    KOiK00699.
    OMAiCEDAVLN.
    OrthoDBiEOG7GBFWS.
    PhylomeDBiO75795.
    TreeFamiTF315472.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O75795-1 [UniParc]FASTAAdd to Basket

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    MSLKWMSVFL LMQLSCYFSS GSCGKVLVWP TEYSHWINMK TILEELVQRG    50
    HEVIVLTSSA SILVNASKSS AIKLEVYPTS LTKNDLEDFF MKMFDRWTYS 100
    ISKNTFWSYF SQLQELCWEY SDYNIKLCED AVLNKKLMRK LQESKFDVLL 150
    ADAVNPCGEL LAELLNIPFL YSLRFSVGYT VEKNGGGFLF PPSYVPVVMS 200
    ELSDQMIFME RIKNMIYMLY FDFWFQAYDL KKWDQFYSEV LGRPTTLFET 250
    MGKAEMWLIR TYWDFEFPRP FLPNVDFVGG LHCKPAKPLP KEMEEFVQSS 300
    GENGIVVFSL GSMISNMSEE SANMIASALA QIPQKVLWRF DGKKPNTLGS 350
    NTRLYKWLPQ NDLLGHPKTK AFITHGGTNG IYEAIYHGIP MVGIPLFADQ 400
    HDNIAHMKAK GAALSVDIRT MSSRDLLNAL KSVINDPIYK ENIMKLSRIH 450
    HDQPVKPLDR AVFWIEFVMR HKGAKHLRVA AHNLTWIQYH SLDVIAFLLA 500
    CVATMIFMIT KCCLFCFRKL AKTGKKKKRD 530
    Length:530
    Mass (Da):61,095
    Last modified:November 1, 1998 - v1
    Checksum:i8E59EBC43CF43760
    GO

    Polymorphismi

    Copy-number variation of UGT2B17 defines the bone mineral density quantitative trait locus 12 (BMND12) [MIMi:612560]. Variance in bone mineral density is a susceptibility factor for osteoporotic fractures.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U59209 mRNA. Translation: AAC25491.1.
    CCDSiCCDS3523.1.
    RefSeqiNP_001068.1. NM_001077.3.
    UniGeneiHs.575083.

    Genome annotation databases

    EnsembliENST00000317746; ENSP00000320401; ENSG00000197888.
    GeneIDi7367.
    KEGGihsa:7367.
    UCSCiuc011clo.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U59209 mRNA. Translation: AAC25491.1 .
    CCDSi CCDS3523.1.
    RefSeqi NP_001068.1. NM_001077.3.
    UniGenei Hs.575083.

    3D structure databases

    ProteinModelPortali O75795.
    SMRi O75795. Positions 286-447.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000320401.

    Chemistry

    BindingDBi O75795.
    ChEMBLi CHEMBL4978.

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    PTM databases

    PhosphoSitei O75795.

    Proteomic databases

    MaxQBi O75795.
    PaxDbi O75795.
    PRIDEi O75795.

    Protocols and materials databases

    DNASUi 7367.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000317746 ; ENSP00000320401 ; ENSG00000197888 .
    GeneIDi 7367.
    KEGGi hsa:7367.
    UCSCi uc011clo.2. human.

    Organism-specific databases

    CTDi 7367.
    GeneCardsi GC04M069406.
    HGNCi HGNC:12547. UGT2B17.
    HPAi HPA045108.
    MIMi 601903. gene.
    612560. phenotype.
    neXtProti NX_O75795.
    PharmGKBi PA37189.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1819.
    HOGENOMi HOG000220831.
    HOVERGENi HBG004033.
    InParanoidi O75795.
    KOi K00699.
    OMAi CEDAVLN.
    OrthoDBi EOG7GBFWS.
    PhylomeDBi O75795.
    TreeFami TF315472.

    Enzyme and pathway databases

    BRENDAi 2.4.1.17. 2681.
    Reactomei REACT_6784. Glucuronidation.
    SABIO-RK O75795.

    Miscellaneous databases

    GeneWikii UGT2B17.
    GenomeRNAii 7367.
    NextBioi 28846.
    PROi O75795.
    SOURCEi Search...

    Gene expression databases

    Bgeei O75795.
    CleanExi HS_UGT2B17.
    Genevestigatori O75795.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of a novel cDNA encoding a human UDP-glucuronosyltransferase active on C19 steroids."
      Beaulieu M., Levesque E., Hum D.W., Belanger A.
      J. Biol. Chem. 271:22855-22862(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Prostate.
    2. "Chromosomal localization, structure, and regulation of the UGT2B17 gene, encoding a C19 steroid metabolizing enzyme."
      Beaulieu M., Levesque E., Tchernof A., Beatty B.G., Belanger A., Hum D.W.
      DNA Cell Biol. 16:1143-1154(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Cited for: INVOLVEMENT IN BONE MINERAL DENSITY VARIANCE.

    Entry informationi

    Entry nameiUDB17_HUMAN
    AccessioniPrimary (citable) accession number: O75795
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3