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Protein

Cell division cycle protein 123 homolog

Gene

CDC123

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for S phase entry of the cell cycle.By similarity

GO - Biological processi

  • cell cycle arrest Source: ProtInc
  • cell division Source: UniProtKB-KW
  • formation of cytoplasmic translation initiation complex Source: GO_Central
  • positive regulation of cell proliferation Source: ProtInc
  • regulation of mitotic cell cycle Source: HGNC
  • regulation of translation Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division cycle protein 123 homolog
Short name:
Protein D123
Alternative name(s):
HT-1080
PZ32
Gene namesi
Name:CDC123
Synonyms:C10orf7, D123
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:16827. CDC123.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162382148.

Polymorphism and mutation databases

BioMutaiCDC123.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 336336Cell division cycle protein 123 homologPRO_0000228662Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei60 – 601PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO75794.
MaxQBiO75794.
PaxDbiO75794.
PeptideAtlasiO75794.
PRIDEiO75794.

PTM databases

iPTMnetiO75794.
PhosphoSiteiO75794.

Expressioni

Tissue specificityi

Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes with the highest expression in testis.1 Publication

Gene expression databases

BgeeiO75794.
CleanExiHS_CDC123.
ExpressionAtlasiO75794. baseline and differential.
GenevisibleiO75794. HS.

Organism-specific databases

HPAiHPA037830.
HPA057540.

Interactioni

Protein-protein interaction databases

BioGridi114392. 15 interactions.
IntActiO75794. 11 interactions.
MINTiMINT-1189211.
STRINGi9606.ENSP00000281141.

Structurei

3D structure databases

ProteinModelPortaliO75794.
SMRiO75794. Positions 1-333.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CDC123 family.Curated

Phylogenomic databases

eggNOGiKOG2983. Eukaryota.
ENOG410XSVC. LUCA.
GeneTreeiENSGT00390000003057.
HOVERGENiHBG080491.
InParanoidiO75794.
OMAiNCQFSVW.
OrthoDBiEOG7673B4.
PhylomeDBiO75794.
TreeFamiTF323348.

Family and domain databases

InterProiIPR009772. CDC123.
[Graphical view]
PANTHERiPTHR15323:SF6. PTHR15323:SF6. 1 hit.
PfamiPF07065. D123. 1 hit.
[Graphical view]
PIRSFiPIRSF007807. Cdc123. 1 hit.

Sequencei

Sequence statusi: Complete.

O75794-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKEHVLHCQ FSAWYPFFRG VTIKSVILPL PQNVKDYLLD DGTLVVSGRD
60 70 80 90 100
DPPTHSQPDS DDEAEEIQWS DDENTATLTA PEFPEFATKV QEAINSLGGS
110 120 130 140 150
VFPKLNWSAP RDAYWIAMNS SLKCKTLSDI FLLFKSSDFI TRDFTQPFIH
160 170 180 190 200
CTDDSPDPCI EYELVLRKWC ELIPGAEFRC FVKENKLIGI SQRDYTQYYD
210 220 230 240 250
HISKQKEEIR RCIQDFFKKH IQYKFLDEDF VFDIYRDSRG KVWLIDFNPF
260 270 280 290 300
GEVTDSLLFT WEELISENNL NGDFSEVDAQ EQDSPAFRCT NSEVTVQPSP
310 320 330
YLSYRLPKDF VDLSTGEDAH KLIDFLKLKR NQQEDD
Length:336
Mass (Da):39,135
Last modified:November 1, 1998 - v1
Checksum:iB13CF241D06C9D25
GO

Sequence cautioni

The sequence CAI12495.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI12496.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI12497.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI12499.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI12500.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti93 – 931A → P in BAA03593 (PubMed:8601400).Curated
Sequence conflicti317 – 3171E → R in BAA03593 (PubMed:8601400).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14878 mRNA. Translation: BAA03593.1.
U27112 mRNA. Translation: AAC34738.1.
CR456966 mRNA. Translation: CAG33247.1.
AK289362 mRNA. Translation: BAF82051.1.
AL512770 Genomic DNA. Translation: CAI12495.1. Sequence problems.
AL512770 Genomic DNA. Translation: CAI12496.1. Sequence problems.
AL512770 Genomic DNA. Translation: CAI12497.1. Sequence problems.
AL512770 Genomic DNA. Translation: CAI12498.1.
AL512770 Genomic DNA. Translation: CAI12499.1. Sequence problems.
AL512770 Genomic DNA. Translation: CAI12500.1. Sequence problems.
CH471072 Genomic DNA. Translation: EAW86317.1.
BC001600 mRNA. Translation: AAH01600.1.
BC009598 mRNA. Translation: AAH09598.1.
CCDSiCCDS7090.1.
RefSeqiNP_006014.2. NM_006023.2.
UniGeneiHs.412842.
Hs.703246.

Genome annotation databases

EnsembliENST00000281141; ENSP00000281141; ENSG00000151465.
GeneIDi8872.
KEGGihsa:8872.
UCSCiuc001ill.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14878 mRNA. Translation: BAA03593.1.
U27112 mRNA. Translation: AAC34738.1.
CR456966 mRNA. Translation: CAG33247.1.
AK289362 mRNA. Translation: BAF82051.1.
AL512770 Genomic DNA. Translation: CAI12495.1. Sequence problems.
AL512770 Genomic DNA. Translation: CAI12496.1. Sequence problems.
AL512770 Genomic DNA. Translation: CAI12497.1. Sequence problems.
AL512770 Genomic DNA. Translation: CAI12498.1.
AL512770 Genomic DNA. Translation: CAI12499.1. Sequence problems.
AL512770 Genomic DNA. Translation: CAI12500.1. Sequence problems.
CH471072 Genomic DNA. Translation: EAW86317.1.
BC001600 mRNA. Translation: AAH01600.1.
BC009598 mRNA. Translation: AAH09598.1.
CCDSiCCDS7090.1.
RefSeqiNP_006014.2. NM_006023.2.
UniGeneiHs.412842.
Hs.703246.

3D structure databases

ProteinModelPortaliO75794.
SMRiO75794. Positions 1-333.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114392. 15 interactions.
IntActiO75794. 11 interactions.
MINTiMINT-1189211.
STRINGi9606.ENSP00000281141.

PTM databases

iPTMnetiO75794.
PhosphoSiteiO75794.

Polymorphism and mutation databases

BioMutaiCDC123.

Proteomic databases

EPDiO75794.
MaxQBiO75794.
PaxDbiO75794.
PeptideAtlasiO75794.
PRIDEiO75794.

Protocols and materials databases

DNASUi8872.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281141; ENSP00000281141; ENSG00000151465.
GeneIDi8872.
KEGGihsa:8872.
UCSCiuc001ill.4. human.

Organism-specific databases

CTDi8872.
GeneCardsiCDC123.
HGNCiHGNC:16827. CDC123.
HPAiHPA037830.
HPA057540.
neXtProtiNX_O75794.
PharmGKBiPA162382148.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2983. Eukaryota.
ENOG410XSVC. LUCA.
GeneTreeiENSGT00390000003057.
HOVERGENiHBG080491.
InParanoidiO75794.
OMAiNCQFSVW.
OrthoDBiEOG7673B4.
PhylomeDBiO75794.
TreeFamiTF323348.

Miscellaneous databases

ChiTaRSiCDC123. human.
GeneWikiiCDC123.
GenomeRNAii8872.
PROiO75794.

Gene expression databases

BgeeiO75794.
CleanExiHS_CDC123.
ExpressionAtlasiO75794. baseline and differential.
GenevisibleiO75794. HS.

Family and domain databases

InterProiIPR009772. CDC123.
[Graphical view]
PANTHERiPTHR15323:SF6. PTHR15323:SF6. 1 hit.
PfamiPF07065. D123. 1 hit.
[Graphical view]
PIRSFiPIRSF007807. Cdc123. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "An amino acid change in novel protein D123 is responsible for temperature-sensitive G1-phase arrest in a mutant of rat fibroblast line 3Y1."
    Okuda A., Kimura G.
    Exp. Cell Res. 223:242-249(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Foreskin.
  2. "Expression study on D123 gene product: evidence for high positivity in testis."
    Onisto M., Zeilante P., Scannapieco P., Pellati D., Pozza M., Caenazzo C., Negro A., Garbisa S.
    Exp. Cell Res. 242:451-459(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Fibrosarcoma.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow and Lymph.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCD123_HUMAN
AccessioniPrimary (citable) accession number: O75794
Secondary accession number(s): A8JZZ7
, Q14107, Q5T0L4, Q5T0L5, Q5T0L7, Q5T0L8, Q5T0L9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: November 1, 1998
Last modified: July 6, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.