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O75791

- GRAP2_HUMAN

UniProt

O75791 - GRAP2_HUMAN

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Protein
GRB2-related adapter protein 2
Gene
GRAP2, GADS, GRB2L, GRID
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.

GO - Molecular functioni

  1. SH3/SH2 adaptor activity Source: ProtInc
  2. protein binding Source: UniProtKB

GO - Biological processi

  1. Fc-epsilon receptor signaling pathway Source: Reactome
  2. Ras protein signal transduction Source: ProtInc
  3. T cell costimulation Source: Reactome
  4. T cell receptor signaling pathway Source: Reactome
  5. cell-cell signaling Source: ProtInc
  6. innate immune response Source: Reactome
  7. positive regulation of signal transduction Source: GOC
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_111040. Signaling by SCF-KIT.
REACT_12623. Generation of second messenger molecules.
REACT_147814. DAP12 signaling.
REACT_163701. FCERI mediated MAPK activation.
REACT_163834. FCERI mediated Ca+2 mobilization.
REACT_19183. CD28 co-stimulation.
SignaLinkiO75791.

Names & Taxonomyi

Protein namesi
Recommended name:
GRB2-related adapter protein 2
Alternative name(s):
Adapter protein GRID
GRB-2-like protein
Short name:
GRB2L
GRBLG
GRBX
Grf40 adapter protein
Short name:
Grf-40
Growth factor receptor-binding protein
Hematopoietic cell-associated adapter protein GrpL
P38
Protein GADS
SH3-SH2-SH3 adapter Mona
Gene namesi
Name:GRAP2
Synonyms:GADS, GRB2L, GRID
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:4563. GRAP2.

Subcellular locationi

Nucleus. Cytoplasm. Endosome 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytosol Source: Reactome
  3. endosome Source: UniProtKB
  4. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28959.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330GRB2-related adapter protein 2
PRO_0000088208Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei45 – 451Phosphotyrosine2 Publications
Modified residuei106 – 1061N6-acetyllysine1 Publication
Modified residuei262 – 2621Phosphothreonine3 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO75791.
PaxDbiO75791.
PRIDEiO75791.

PTM databases

PhosphoSiteiO75791.

Miscellaneous databases

PMAP-CutDBO75791.

Expressioni

Gene expression databases

ArrayExpressiO75791.
BgeeiO75791.
CleanExiHS_GRAP2.
GenevestigatoriO75791.

Organism-specific databases

HPAiCAB022073.
HPA005788.

Interactioni

Subunit structurei

Interacts with phosphorylated LIME1 upon TCR activation By similarity. Interacts with phosphorylated LAT and LAX1 upon TCR activation. Interacts with SHB. Interacts with PTPN23.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Kcnma1Q084603EBI-740418,EBI-1633915From a different organism.
KITP107212EBI-740418,EBI-1379503
LCP2Q1309411EBI-740418,EBI-346946
PTPN23Q9H3S78EBI-740418,EBI-724478

Protein-protein interaction databases

BioGridi114799. 28 interactions.
DIPiDIP-38435N.
IntActiO75791. 19 interactions.
MINTiMINT-140970.
STRINGi9606.ENSP00000339186.

Structurei

3D structure databases

ProteinModelPortaliO75791.
SMRiO75791. Positions 1-186, 273-328.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 5656SH3 1
Add
BLAST
Domaini58 – 14992SH2
Add
BLAST
Domaini271 – 33060SH3 2
Add
BLAST

Sequence similaritiesi

Belongs to the GRB2/sem-5/DRK family.
Contains 1 SH2 domain.
Contains 2 SH3 domains.

Keywords - Domaini

Repeat, SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiNOG272892.
HOGENOMiHOG000251625.
HOVERGENiHBG005404.
InParanoidiO75791.
KOiK07366.
OMAiQFPEWFH.
OrthoDBiEOG75F4F6.
PhylomeDBiO75791.
TreeFamiTF354288.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
PF00018. SH3_1. 2 hits.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O75791-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEAVAKFDFT ASGEDELSFH TGDVLKILSN QEEWFKAELG SQEGYVPKNF    50
IDIQFPKWFH EGLSRHQAEN LLMGKEVGFF IIRASQSSPG DFSISVRHED 100
DVQHFKVMRD NKGNYFLWTE KFPSLNKLVD YYRTNSISRQ KQIFLRDRTR 150
EDQGHRGNSL DRRSQGGPHL SGAVGEEIRP SMNRKLSDHP PTLPLQQHQH 200
QPQPPQYAPA PQQLQQPPQQ RYLQHHHFHQ ERRGGSLDIN DGHCGTGLGS 250
EMNAALMHRR HTDPVQLQAA GRVRWARALY DFEALEDDEL GFHSGEVVEV 300
LDSSNPSWWT GRLHNKLGLF PANYVAPMTR 330
Length:330
Mass (Da):37,909
Last modified:November 1, 1998 - v1
Checksum:i74F4C8D0EBB56D55
GO
Isoform 2 (identifier: O75791-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: MEAVAKFDFT...NQEEWFKAEL → MVSRRPLSTP...ELPRGLLHLC
     40-152: Missing.

Note: No experimental confirmation available.

Show »
Length:217
Mass (Da):24,382
Checksum:iEC20AF61B4EFCD49
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti319 – 3191L → F.1 Publication
Corresponds to variant rs12759 [ dbSNP | Ensembl ].
VAR_012079

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3939MEAVA…FKAEL → MVSRRPLSTPGRELTHGQGG WLLHHPGQPELPRGLLHLC in isoform 2.
VSP_055234Add
BLAST
Alternative sequencei40 – 152113Missing in isoform 2.
VSP_055235Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF102694 mRNA. Translation: AAD04926.1.
AF129476 mRNA. Translation: AAD41782.1.
AF042380 mRNA. Translation: AAC69273.1.
AF236119 mRNA. Translation: AAF60319.1.
AF236120 mRNA. Translation: AAF60320.1.
AF121002 mRNA. Translation: AAF31758.1.
AY069959 mRNA. Translation: AAL58573.1.
Y18051 mRNA. Translation: CAA77021.1.
AJ011736 mRNA. Translation: CAA09757.1.
AF090456 mRNA. Translation: AAD13027.1.
CR456498 mRNA. Translation: CAG30384.1.
AK303470 mRNA. Translation: BAH13969.1.
Z82206 Genomic DNA. Translation: CAI42713.1.
BC025692 mRNA. Translation: AAH25692.1.
BC026002 mRNA. Translation: AAH26002.1.
CCDSiCCDS13999.1. [O75791-1]
PIRiJE0376.
RefSeqiNP_001278753.1. NM_001291824.1.
NP_001278754.1. NM_001291825.1.
NP_001278757.1. NM_001291828.1.
NP_004801.1. NM_004810.3.
UniGeneiHs.517499.

Genome annotation databases

EnsembliENST00000344138; ENSP00000339186; ENSG00000100351.
ENST00000399090; ENSP00000382040; ENSG00000100351.
ENST00000407075; ENSP00000385607; ENSG00000100351.
GeneIDi9402.
KEGGihsa:9402.
UCSCiuc003ayh.2. human. [O75791-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF102694 mRNA. Translation: AAD04926.1 .
AF129476 mRNA. Translation: AAD41782.1 .
AF042380 mRNA. Translation: AAC69273.1 .
AF236119 mRNA. Translation: AAF60319.1 .
AF236120 mRNA. Translation: AAF60320.1 .
AF121002 mRNA. Translation: AAF31758.1 .
AY069959 mRNA. Translation: AAL58573.1 .
Y18051 mRNA. Translation: CAA77021.1 .
AJ011736 mRNA. Translation: CAA09757.1 .
AF090456 mRNA. Translation: AAD13027.1 .
CR456498 mRNA. Translation: CAG30384.1 .
AK303470 mRNA. Translation: BAH13969.1 .
Z82206 Genomic DNA. Translation: CAI42713.1 .
BC025692 mRNA. Translation: AAH25692.1 .
BC026002 mRNA. Translation: AAH26002.1 .
CCDSi CCDS13999.1. [O75791-1 ]
PIRi JE0376.
RefSeqi NP_001278753.1. NM_001291824.1.
NP_001278754.1. NM_001291825.1.
NP_001278757.1. NM_001291828.1.
NP_004801.1. NM_004810.3.
UniGenei Hs.517499.

3D structure databases

ProteinModelPortali O75791.
SMRi O75791. Positions 1-186, 273-328.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114799. 28 interactions.
DIPi DIP-38435N.
IntActi O75791. 19 interactions.
MINTi MINT-140970.
STRINGi 9606.ENSP00000339186.

PTM databases

PhosphoSitei O75791.

Proteomic databases

MaxQBi O75791.
PaxDbi O75791.
PRIDEi O75791.

Protocols and materials databases

DNASUi 9402.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000344138 ; ENSP00000339186 ; ENSG00000100351 .
ENST00000399090 ; ENSP00000382040 ; ENSG00000100351 .
ENST00000407075 ; ENSP00000385607 ; ENSG00000100351 .
GeneIDi 9402.
KEGGi hsa:9402.
UCSCi uc003ayh.2. human. [O75791-1 ]

Organism-specific databases

CTDi 9402.
GeneCardsi GC22P040297.
HGNCi HGNC:4563. GRAP2.
HPAi CAB022073.
HPA005788.
MIMi 604518. gene.
neXtProti NX_O75791.
PharmGKBi PA28959.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG272892.
HOGENOMi HOG000251625.
HOVERGENi HBG005404.
InParanoidi O75791.
KOi K07366.
OMAi QFPEWFH.
OrthoDBi EOG75F4F6.
PhylomeDBi O75791.
TreeFami TF354288.

Enzyme and pathway databases

Reactomei REACT_111040. Signaling by SCF-KIT.
REACT_12623. Generation of second messenger molecules.
REACT_147814. DAP12 signaling.
REACT_163701. FCERI mediated MAPK activation.
REACT_163834. FCERI mediated Ca+2 mobilization.
REACT_19183. CD28 co-stimulation.
SignaLinki O75791.

Miscellaneous databases

ChiTaRSi GRAP2. human.
GeneWikii GRAP2.
GenomeRNAii 9402.
NextBioi 35223.
PMAP-CutDB O75791.
PROi O75791.
SOURCEi Search...

Gene expression databases

ArrayExpressi O75791.
Bgeei O75791.
CleanExi HS_GRAP2.
Genevestigatori O75791.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR000980. SH2.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00017. SH2. 1 hit.
PF00018. SH3_1. 2 hits.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTi SM00252. SH2. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 2 hits.
SSF55550. SSF55550. 1 hit.
PROSITEi PS50001. SH2. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and expression of human grap-2, a novel leukocyte-specific SH2- and SH3-containing adaptor-like protein that binds to gab-1."
    Qiu M., Hua S., Agrawal M., Li G., Cai J., Chan E., Zhou H., Luo Y., Liu M.
    Biochem. Biophys. Res. Commun. 253:443-447(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "GrpL, a Grb2-related adaptor protein, interacts with SLP-76 to regulate nuclear factor of activated T cell activation."
    Law C.-L., Ewings M.K., Chaudhary P.M., Solow S.A., Yun T.J., Marshall A.J., Hood L., Clark E.A.
    J. Exp. Med. 189:1243-1253(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT."
    Asada H., Ishii N., Sasaki Y., Endo K., Kasai H., Tanaka N., Takeshita T., Tsuchiya S., Konno T., Sugamura K.
    J. Exp. Med. 189:1383-1390(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "GRID: a novel Grb-2-related adapter protein that interacts with the activated T cell costimulatory receptor CD28."
    Ellis J.H., Ashman C., Burden M.N., Kilpatrick K.E., Morse M.A., Hamblin P.A.
    J. Immunol. 164:5805-5814(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT PHE-319.
  5. "Genomic organization and restricted expression of the human Mona/Gads gene suggests regulation by two specific promoters."
    Guyot B., Arnaud S., Phothirath P., Bourette R.P., Grasset M.F., Rigal D., Mouchiroud G.
    Gene 290:173-179(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  6. Frearson J.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Blood.
  7. "Cloning of the human and mouse growth factor receptor binding protein like genes."
    Kedra D., Dumanski J.P.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  8. "GrbX, new recruited signaling gene having homology with Grb2."
    Teramoto T., Nagashima M., Terai S., Thorgeirsson S.S.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  10. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Thymus.
  11. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  12. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung and Spleen.
  13. "Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell antigen receptor-mediated signaling."
    Zhang W., Trible R.P., Zhu M., Liu S.K., McGlade C.J., Samelson L.E.
    J. Biol. Chem. 275:23355-23361(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH LAT.
  14. "Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells."
    Lindholm C.K., Henriksson M.L., Hallberg B., Welsh M.
    Eur. J. Biochem. 269:3279-3288(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SHB.
  15. "Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling."
    Zhu M., Janssen E., Leung K., Zhang W.
    J. Biol. Chem. 277:46151-46158(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH LAX1.
  16. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-262, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
    Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C.
    Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-45 AND THR-262, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  18. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-262, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  19. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-45, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  20. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-106, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  21. "Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL."
    Tanase C.A.
    PLoS ONE 5:E14339-E14339(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PTPN23, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiGRAP2_HUMAN
AccessioniPrimary (citable) accession number: O75791
Secondary accession number(s): B7Z8I3, O43726, Q9NRB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: September 3, 2014
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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