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O75791

- GRAP2_HUMAN

UniProt

O75791 - GRAP2_HUMAN

Protein

GRB2-related adapter protein 2

Gene

GRAP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 144 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. SH3/SH2 adaptor activity Source: ProtInc

    GO - Biological processi

    1. cell-cell signaling Source: ProtInc
    2. Fc-epsilon receptor signaling pathway Source: Reactome
    3. innate immune response Source: Reactome
    4. positive regulation of signal transduction Source: GOC
    5. Ras protein signal transduction Source: ProtInc
    6. T cell costimulation Source: Reactome
    7. T cell receptor signaling pathway Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_111040. Signaling by SCF-KIT.
    REACT_12623. Generation of second messenger molecules.
    REACT_147814. DAP12 signaling.
    REACT_163701. FCERI mediated MAPK activation.
    REACT_163834. FCERI mediated Ca+2 mobilization.
    REACT_19183. CD28 co-stimulation.
    SignaLinkiO75791.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GRB2-related adapter protein 2
    Alternative name(s):
    Adapter protein GRID
    GRB-2-like protein
    Short name:
    GRB2L
    GRBLG
    GRBX
    Grf40 adapter protein
    Short name:
    Grf-40
    Growth factor receptor-binding protein
    Hematopoietic cell-associated adapter protein GrpL
    P38
    Protein GADS
    SH3-SH2-SH3 adapter Mona
    Gene namesi
    Name:GRAP2
    Synonyms:GADS, GRB2L, GRID
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:4563. GRAP2.

    Subcellular locationi

    Nucleus 1 Publication. Cytoplasm 1 Publication. Endosome 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytosol Source: Reactome
    3. endosome Source: UniProtKB
    4. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Endosome, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28959.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 330330GRB2-related adapter protein 2PRO_0000088208Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei45 – 451Phosphotyrosine2 Publications
    Modified residuei106 – 1061N6-acetyllysine1 Publication
    Modified residuei262 – 2621Phosphothreonine3 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiO75791.
    PaxDbiO75791.
    PRIDEiO75791.

    PTM databases

    PhosphoSiteiO75791.

    Miscellaneous databases

    PMAP-CutDBO75791.

    Expressioni

    Gene expression databases

    ArrayExpressiO75791.
    BgeeiO75791.
    CleanExiHS_GRAP2.
    GenevestigatoriO75791.

    Organism-specific databases

    HPAiCAB022073.
    HPA005788.

    Interactioni

    Subunit structurei

    Interacts with phosphorylated LIME1 upon TCR activation By similarity. Interacts with phosphorylated LAT and LAX1 upon TCR activation. Interacts with SHB. Interacts with PTPN23.By similarity4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ERBB2P046262EBI-740418,EBI-641062
    Kcnma1Q084603EBI-740418,EBI-1633915From a different organism.
    KITP107212EBI-740418,EBI-1379503
    LCP2Q1309411EBI-740418,EBI-346946
    PTPN23Q9H3S78EBI-740418,EBI-724478

    Protein-protein interaction databases

    BioGridi114799. 28 interactions.
    DIPiDIP-38435N.
    IntActiO75791. 20 interactions.
    MINTiMINT-140970.
    STRINGi9606.ENSP00000339186.

    Structurei

    3D structure databases

    ProteinModelPortaliO75791.
    SMRiO75791. Positions 1-186, 273-328.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 5656SH3 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini58 – 14992SH2PROSITE-ProRule annotationAdd
    BLAST
    Domaini271 – 33060SH3 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the GRB2/sem-5/DRK family.Curated
    Contains 1 SH2 domain.PROSITE-ProRule annotation
    Contains 2 SH3 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, SH2 domain, SH3 domain

    Phylogenomic databases

    eggNOGiNOG272892.
    HOGENOMiHOG000251625.
    HOVERGENiHBG005404.
    InParanoidiO75791.
    KOiK07366.
    OMAiQFPEWFH.
    OrthoDBiEOG75F4F6.
    PhylomeDBiO75791.
    TreeFamiTF354288.

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR000980. SH2.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00017. SH2. 1 hit.
    PF00018. SH3_1. 2 hits.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    SMARTiSM00252. SH2. 1 hit.
    SM00326. SH3. 2 hits.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 2 hits.
    SSF55550. SSF55550. 1 hit.
    PROSITEiPS50001. SH2. 1 hit.
    PS50002. SH3. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O75791-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEAVAKFDFT ASGEDELSFH TGDVLKILSN QEEWFKAELG SQEGYVPKNF    50
    IDIQFPKWFH EGLSRHQAEN LLMGKEVGFF IIRASQSSPG DFSISVRHED 100
    DVQHFKVMRD NKGNYFLWTE KFPSLNKLVD YYRTNSISRQ KQIFLRDRTR 150
    EDQGHRGNSL DRRSQGGPHL SGAVGEEIRP SMNRKLSDHP PTLPLQQHQH 200
    QPQPPQYAPA PQQLQQPPQQ RYLQHHHFHQ ERRGGSLDIN DGHCGTGLGS 250
    EMNAALMHRR HTDPVQLQAA GRVRWARALY DFEALEDDEL GFHSGEVVEV 300
    LDSSNPSWWT GRLHNKLGLF PANYVAPMTR 330
    Length:330
    Mass (Da):37,909
    Last modified:November 1, 1998 - v1
    Checksum:i74F4C8D0EBB56D55
    GO
    Isoform 2 (identifier: O75791-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-39: MEAVAKFDFT...NQEEWFKAEL → MVSRRPLSTP...ELPRGLLHLC
         40-152: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:217
    Mass (Da):24,382
    Checksum:iEC20AF61B4EFCD49
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti319 – 3191L → F.1 Publication
    Corresponds to variant rs12759 [ dbSNP | Ensembl ].
    VAR_012079

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3939MEAVA…FKAEL → MVSRRPLSTPGRELTHGQGG WLLHHPGQPELPRGLLHLC in isoform 2. 1 PublicationVSP_055234Add
    BLAST
    Alternative sequencei40 – 152113Missing in isoform 2. 1 PublicationVSP_055235Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF102694 mRNA. Translation: AAD04926.1.
    AF129476 mRNA. Translation: AAD41782.1.
    AF042380 mRNA. Translation: AAC69273.1.
    AF236119 mRNA. Translation: AAF60319.1.
    AF236120 mRNA. Translation: AAF60320.1.
    AF121002 mRNA. Translation: AAF31758.1.
    AY069959 mRNA. Translation: AAL58573.1.
    Y18051 mRNA. Translation: CAA77021.1.
    AJ011736 mRNA. Translation: CAA09757.1.
    AF090456 mRNA. Translation: AAD13027.1.
    CR456498 mRNA. Translation: CAG30384.1.
    AK303470 mRNA. Translation: BAH13969.1.
    Z82206 Genomic DNA. Translation: CAI42713.1.
    BC025692 mRNA. Translation: AAH25692.1.
    BC026002 mRNA. Translation: AAH26002.1.
    CCDSiCCDS13999.1. [O75791-1]
    PIRiJE0376.
    RefSeqiNP_001278753.1. NM_001291824.1.
    NP_001278754.1. NM_001291825.1.
    NP_001278757.1. NM_001291828.1.
    NP_004801.1. NM_004810.3.
    UniGeneiHs.517499.

    Genome annotation databases

    EnsembliENST00000344138; ENSP00000339186; ENSG00000100351. [O75791-1]
    ENST00000407075; ENSP00000385607; ENSG00000100351. [O75791-1]
    GeneIDi9402.
    KEGGihsa:9402.
    UCSCiuc003ayh.2. human. [O75791-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF102694 mRNA. Translation: AAD04926.1 .
    AF129476 mRNA. Translation: AAD41782.1 .
    AF042380 mRNA. Translation: AAC69273.1 .
    AF236119 mRNA. Translation: AAF60319.1 .
    AF236120 mRNA. Translation: AAF60320.1 .
    AF121002 mRNA. Translation: AAF31758.1 .
    AY069959 mRNA. Translation: AAL58573.1 .
    Y18051 mRNA. Translation: CAA77021.1 .
    AJ011736 mRNA. Translation: CAA09757.1 .
    AF090456 mRNA. Translation: AAD13027.1 .
    CR456498 mRNA. Translation: CAG30384.1 .
    AK303470 mRNA. Translation: BAH13969.1 .
    Z82206 Genomic DNA. Translation: CAI42713.1 .
    BC025692 mRNA. Translation: AAH25692.1 .
    BC026002 mRNA. Translation: AAH26002.1 .
    CCDSi CCDS13999.1. [O75791-1 ]
    PIRi JE0376.
    RefSeqi NP_001278753.1. NM_001291824.1.
    NP_001278754.1. NM_001291825.1.
    NP_001278757.1. NM_001291828.1.
    NP_004801.1. NM_004810.3.
    UniGenei Hs.517499.

    3D structure databases

    ProteinModelPortali O75791.
    SMRi O75791. Positions 1-186, 273-328.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114799. 28 interactions.
    DIPi DIP-38435N.
    IntActi O75791. 20 interactions.
    MINTi MINT-140970.
    STRINGi 9606.ENSP00000339186.

    PTM databases

    PhosphoSitei O75791.

    Proteomic databases

    MaxQBi O75791.
    PaxDbi O75791.
    PRIDEi O75791.

    Protocols and materials databases

    DNASUi 9402.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000344138 ; ENSP00000339186 ; ENSG00000100351 . [O75791-1 ]
    ENST00000407075 ; ENSP00000385607 ; ENSG00000100351 . [O75791-1 ]
    GeneIDi 9402.
    KEGGi hsa:9402.
    UCSCi uc003ayh.2. human. [O75791-1 ]

    Organism-specific databases

    CTDi 9402.
    GeneCardsi GC22P040297.
    HGNCi HGNC:4563. GRAP2.
    HPAi CAB022073.
    HPA005788.
    MIMi 604518. gene.
    neXtProti NX_O75791.
    PharmGKBi PA28959.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG272892.
    HOGENOMi HOG000251625.
    HOVERGENi HBG005404.
    InParanoidi O75791.
    KOi K07366.
    OMAi QFPEWFH.
    OrthoDBi EOG75F4F6.
    PhylomeDBi O75791.
    TreeFami TF354288.

    Enzyme and pathway databases

    Reactomei REACT_111040. Signaling by SCF-KIT.
    REACT_12623. Generation of second messenger molecules.
    REACT_147814. DAP12 signaling.
    REACT_163701. FCERI mediated MAPK activation.
    REACT_163834. FCERI mediated Ca+2 mobilization.
    REACT_19183. CD28 co-stimulation.
    SignaLinki O75791.

    Miscellaneous databases

    ChiTaRSi GRAP2. human.
    GeneWikii GRAP2.
    GenomeRNAii 9402.
    NextBioi 35223.
    PMAP-CutDB O75791.
    PROi O75791.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75791.
    Bgeei O75791.
    CleanExi HS_GRAP2.
    Genevestigatori O75791.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR000980. SH2.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00017. SH2. 1 hit.
    PF00018. SH3_1. 2 hits.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    SMARTi SM00252. SH2. 1 hit.
    SM00326. SH3. 2 hits.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 2 hits.
    SSF55550. SSF55550. 1 hit.
    PROSITEi PS50001. SH2. 1 hit.
    PS50002. SH3. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and expression of human grap-2, a novel leukocyte-specific SH2- and SH3-containing adaptor-like protein that binds to gab-1."
      Qiu M., Hua S., Agrawal M., Li G., Cai J., Chan E., Zhou H., Luo Y., Liu M.
      Biochem. Biophys. Res. Commun. 253:443-447(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "GrpL, a Grb2-related adaptor protein, interacts with SLP-76 to regulate nuclear factor of activated T cell activation."
      Law C.-L., Ewings M.K., Chaudhary P.M., Solow S.A., Yun T.J., Marshall A.J., Hood L., Clark E.A.
      J. Exp. Med. 189:1243-1253(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT."
      Asada H., Ishii N., Sasaki Y., Endo K., Kasai H., Tanaka N., Takeshita T., Tsuchiya S., Konno T., Sugamura K.
      J. Exp. Med. 189:1383-1390(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "GRID: a novel Grb-2-related adapter protein that interacts with the activated T cell costimulatory receptor CD28."
      Ellis J.H., Ashman C., Burden M.N., Kilpatrick K.E., Morse M.A., Hamblin P.A.
      J. Immunol. 164:5805-5814(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT PHE-319.
    5. "Genomic organization and restricted expression of the human Mona/Gads gene suggests regulation by two specific promoters."
      Guyot B., Arnaud S., Phothirath P., Bourette R.P., Grasset M.F., Rigal D., Mouchiroud G.
      Gene 290:173-179(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    6. Frearson J.
      Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Blood.
    7. "Cloning of the human and mouse growth factor receptor binding protein like genes."
      Kedra D., Dumanski J.P.
      Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    8. "GrbX, new recruited signaling gene having homology with Grb2."
      Teramoto T., Nagashima M., Terai S., Thorgeirsson S.S.
      Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    10. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Thymus.
    11. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    12. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung and Spleen.
    13. "Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell antigen receptor-mediated signaling."
      Zhang W., Trible R.P., Zhu M., Liu S.K., McGlade C.J., Samelson L.E.
      J. Biol. Chem. 275:23355-23361(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH LAT.
    14. "Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells."
      Lindholm C.K., Henriksson M.L., Hallberg B., Welsh M.
      Eur. J. Biochem. 269:3279-3288(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SHB.
    15. "Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling."
      Zhu M., Janssen E., Leung K., Zhang W.
      J. Biol. Chem. 277:46151-46158(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH LAX1.
    16. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-262, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
      Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C.
      Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-45 AND THR-262, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    18. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-262, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Platelet.
    19. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-45, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    20. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-106, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    21. "Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL."
      Tanase C.A.
      PLoS ONE 5:E14339-E14339(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PTPN23, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiGRAP2_HUMAN
    AccessioniPrimary (citable) accession number: O75791
    Secondary accession number(s): B7Z8I3, O43726, Q9NRB7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 144 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3