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Protein

Paralemmin-1

Gene

PALM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell shape

Names & Taxonomyi

Protein namesi
Recommended name:
Paralemmin-1
Alternative name(s):
Paralemmin
Gene namesi
Name:PALM
Synonyms:KIAA0270
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:8594. PALM.

Subcellular locationi

GO - Cellular componenti

  • apicolateral plasma membrane Source: UniProtKB-SubCell
  • axon Source: UniProtKB-SubCell
  • basolateral plasma membrane Source: UniProtKB-SubCell
  • cytoplasmic vesicle Source: ProtInc
  • dendritic spine membrane Source: Ensembl
  • filopodium membrane Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • intracellular membrane-bounded organelle Source: HPA
  • nucleus Source: HPA
  • plasma membrane Source: UniProtKB
  • postsynaptic density Source: Ensembl

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi381 – 383CKC → SKS: Inhibits axonal and dendritic filopodia formation and reduces axonal and dendritic branching. 1 Publication3

Organism-specific databases

DisGeNETi5064.
OpenTargetsiENSG00000099864.
PharmGKBiPA32923.

Polymorphism and mutation databases

BioMutaiPALM.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000582181 – 384Paralemmin-1Add BLAST384
PropeptideiPRO_0000396689385 – 387Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei116PhosphoserineCombined sources1
Modified residuei124PhosphoserineCombined sources1
Modified residuei141PhosphothreonineCombined sources1
Modified residuei145PhosphothreonineCombined sources1
Modified residuei162PhosphoserineCombined sources1
Modified residuei243PhosphothreonineBy similarity1
Modified residuei245PhosphoserineBy similarity1
Modified residuei346PhosphoserineBy similarity1
Modified residuei367PhosphothreonineBy similarity1
Modified residuei369PhosphoserineBy similarity1
Lipidationi381S-palmitoyl cysteineSequence analysis1
Lipidationi383S-palmitoyl cysteineSequence analysis1
Modified residuei384Cysteine methyl esterSequence analysis1
Lipidationi384S-farnesyl cysteineSequence analysis1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Palmitate, Phosphoprotein, Prenylation

Proteomic databases

EPDiO75781.
MaxQBiO75781.
PaxDbiO75781.
PeptideAtlasiO75781.
PRIDEiO75781.

PTM databases

iPTMnetiO75781.
PhosphoSitePlusiO75781.
SwissPalmiO75781.

Expressioni

Tissue specificityi

Widely expressed with highest expression in brain and testis and intermediate expression in heart and adrenal gland.

Gene expression databases

BgeeiENSG00000099864.
CleanExiHS_PALM.
ExpressionAtlasiO75781. baseline and differential.
GenevisibleiO75781. HS.

Organism-specific databases

HPAiHPA041713.
HPA049578.

Interactioni

Subunit structurei

Interacts with dopamine receptor DRD3.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111100. 21 interactors.
IntActiO75781. 11 interactors.
STRINGi9606.ENSP00000341911.

Structurei

3D structure databases

ProteinModelPortaliO75781.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili9 – 101Sequence analysisAdd BLAST93

Sequence similaritiesi

Belongs to the paralemmin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IKZ0. Eukaryota.
ENOG410ZG4W. LUCA.
GeneTreeiENSGT00530000063206.
HOGENOMiHOG000043092.
HOVERGENiHBG007431.
InParanoidiO75781.
KOiK16519.
OMAiREENQVG.
OrthoDBiEOG091G0713.
PhylomeDBiO75781.
TreeFamiTF105402.

Family and domain databases

InterProiView protein in InterPro
IPR004965. Paralemmin.
PfamiView protein in Pfam
PF03285. Paralemmin. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75781-1) [UniParc]FASTAAdd to basket
Also known as: Paralemmin-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVLAAETTS QQERLQAIAE KRKRQAEIEN KRRQLEDERR QLQHLKSKAL
60 70 80 90 100
RERWLLEGTP SSASEGDEDL RRQMQDDEQK TRLLEDSVSR LEKEIEVLER
110 120 130 140 150
GDSAPATAKE NAAAPSPVRA PAPSPAKEER KTEVVMNSQQ TPVGTPKDKR
160 170 180 190 200
VSNTPLRTVD GSPMMKAAMY SVEITVEKDK VTGETRVLSS TTLLPRQPLP
210 220 230 240 250
LGIKVYEDET KVVHAVDGTA ENGIHPLSSS EVDELIHKAD EVTLSEAGST
260 270 280 290 300
AGAAETRGAV EGAARTTPSR REITGVQAQP GEATSGPPGI QPGQEPPVTM
310 320 330 340 350
IFMGYQNVED EAETKKVLGL QDTITAELVV IEDAAEPKEP APPNGSAAEP
360 370 380
PTEAASREEN QAGPEATTSD PQDLDMKKHR CKCCSIM
Length:387
Mass (Da):42,076
Last modified:March 1, 2001 - v2
Checksum:i46D455D5D12C3135
GO
Isoform 2 (identifier: O75781-2) [UniParc]FASTAAdd to basket
Also known as: Paralemmin-S

The sequence of this isoform differs from the canonical sequence as follows:
     168-211: Missing.

Show »
Length:343
Mass (Da):37,157
Checksum:i8DF5F9BAA42B314F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053803107T → A1 PublicationCorresponds to variant dbSNP:rs1050457Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003918168 – 211Missing in isoform 2. 2 PublicationsAdd BLAST44

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16270
, Y16271, Y16272, Y16273, Y16274, Y16275, Y16276, Y16277 Genomic DNA. Translation: CAA76151.1.
Y16278 mRNA. Translation: CAA76152.1.
Y14770 mRNA. Translation: CAB37400.1.
Y14770 mRNA. Translation: CAB37401.1.
BC032449 mRNA. Translation: AAH32449.1.
AC004030 Genomic DNA. No translation available.
AC005763 Genomic DNA. Translation: AAC62429.1.
D87460 mRNA. Translation: BAA13400.1.
CCDSiCCDS32857.1. [O75781-1]
CCDS32858.1. [O75781-2]
PIRiT00635.
RefSeqiNP_001035224.1. NM_001040134.1. [O75781-2]
NP_002570.2. NM_002579.2. [O75781-1]
UniGeneiHs.631841.

Genome annotation databases

EnsembliENST00000264560; ENSP00000264560; ENSG00000099864. [O75781-2]
ENST00000338448; ENSP00000341911; ENSG00000099864. [O75781-1]
GeneIDi5064.
KEGGihsa:5064.
UCSCiuc002lpm.2. human. [O75781-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPALM_HUMAN
AccessioniPrimary (citable) accession number: O75781
Secondary accession number(s): O43359
, O95673, Q92559, Q9UPJ4, Q9UQS2, Q9UQS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: March 1, 2001
Last modified: August 30, 2017
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families