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Protein

Paralemmin-1

Gene

PALM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell shape

Names & Taxonomyi

Protein namesi
Recommended name:
Paralemmin-1
Alternative name(s):
Paralemmin
Gene namesi
Name:PALM
Synonyms:KIAA0270
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:8594. PALM.

Subcellular locationi

GO - Cellular componenti

  • apicolateral plasma membrane Source: UniProtKB-SubCell
  • axon Source: UniProtKB-SubCell
  • basolateral plasma membrane Source: UniProtKB-SubCell
  • cytoplasmic, membrane-bounded vesicle Source: ProtInc
  • dendritic spine Source: UniProtKB-SubCell
  • dendritic spine membrane Source: Ensembl
  • filopodium membrane Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • intracellular membrane-bounded organelle Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: HPA
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi381 – 3833CKC → SKS: Inhibits axonal and dendritic filopodia formation and reduces axonal and dendritic branching. 1 Publication

Organism-specific databases

PharmGKBiPA32923.

Polymorphism and mutation databases

BioMutaiPALM.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 384384Paralemmin-1PRO_0000058218Add
BLAST
Propeptidei385 – 3873Removed in mature formSequence analysisPRO_0000396689

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei116 – 1161PhosphoserineCombined sources
Modified residuei124 – 1241PhosphoserineCombined sources
Modified residuei141 – 1411PhosphothreonineCombined sources
Modified residuei145 – 1451PhosphothreonineCombined sources
Modified residuei162 – 1621PhosphoserineCombined sources
Modified residuei243 – 2431PhosphothreonineBy similarity
Modified residuei245 – 2451PhosphoserineBy similarity
Modified residuei346 – 3461PhosphoserineBy similarity
Modified residuei367 – 3671PhosphothreonineBy similarity
Modified residuei369 – 3691PhosphoserineBy similarity
Lipidationi381 – 3811S-palmitoyl cysteineSequence analysis
Lipidationi383 – 3831S-palmitoyl cysteineSequence analysis
Modified residuei384 – 3841Cysteine methyl esterSequence analysis
Lipidationi384 – 3841S-farnesyl cysteineSequence analysis

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Palmitate, Phosphoprotein, Prenylation

Proteomic databases

EPDiO75781.
MaxQBiO75781.
PaxDbiO75781.
PeptideAtlasiO75781.
PRIDEiO75781.

PTM databases

iPTMnetiO75781.
PhosphoSiteiO75781.
SwissPalmiO75781.

Expressioni

Tissue specificityi

Widely expressed with highest expression in brain and testis and intermediate expression in heart and adrenal gland.

Gene expression databases

BgeeiENSG00000099864.
CleanExiHS_PALM.
ExpressionAtlasiO75781. baseline and differential.
GenevisibleiO75781. HS.

Organism-specific databases

HPAiHPA041713.
HPA049578.

Interactioni

Subunit structurei

Interacts with dopamine receptor DRD3.1 Publication

Protein-protein interaction databases

BioGridi111100. 17 interactions.
IntActiO75781. 11 interactions.
STRINGi9606.ENSP00000341911.

Structurei

3D structure databases

ProteinModelPortaliO75781.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili9 – 10193Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the paralemmin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IKZ0. Eukaryota.
ENOG410ZG4W. LUCA.
GeneTreeiENSGT00530000063206.
HOGENOMiHOG000043092.
HOVERGENiHBG007431.
InParanoidiO75781.
KOiK16519.
OMAiREENQVG.
OrthoDBiEOG091G0713.
PhylomeDBiO75781.
TreeFamiTF105402.

Family and domain databases

InterProiIPR004965. Paralemmin.
[Graphical view]
PfamiPF03285. Paralemmin. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75781-1) [UniParc]FASTAAdd to basket
Also known as: Paralemmin-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVLAAETTS QQERLQAIAE KRKRQAEIEN KRRQLEDERR QLQHLKSKAL
60 70 80 90 100
RERWLLEGTP SSASEGDEDL RRQMQDDEQK TRLLEDSVSR LEKEIEVLER
110 120 130 140 150
GDSAPATAKE NAAAPSPVRA PAPSPAKEER KTEVVMNSQQ TPVGTPKDKR
160 170 180 190 200
VSNTPLRTVD GSPMMKAAMY SVEITVEKDK VTGETRVLSS TTLLPRQPLP
210 220 230 240 250
LGIKVYEDET KVVHAVDGTA ENGIHPLSSS EVDELIHKAD EVTLSEAGST
260 270 280 290 300
AGAAETRGAV EGAARTTPSR REITGVQAQP GEATSGPPGI QPGQEPPVTM
310 320 330 340 350
IFMGYQNVED EAETKKVLGL QDTITAELVV IEDAAEPKEP APPNGSAAEP
360 370 380
PTEAASREEN QAGPEATTSD PQDLDMKKHR CKCCSIM
Length:387
Mass (Da):42,076
Last modified:March 1, 2001 - v2
Checksum:i46D455D5D12C3135
GO
Isoform 2 (identifier: O75781-2) [UniParc]FASTAAdd to basket
Also known as: Paralemmin-S

The sequence of this isoform differs from the canonical sequence as follows:
     168-211: Missing.

Show »
Length:343
Mass (Da):37,157
Checksum:i8DF5F9BAA42B314F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti107 – 1071T → A.1 Publication
Corresponds to variant rs1050457 [ dbSNP | Ensembl ].
VAR_053803

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei168 – 21144Missing in isoform 2. 2 PublicationsVSP_003918Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16270
, Y16271, Y16272, Y16273, Y16274, Y16275, Y16276, Y16277 Genomic DNA. Translation: CAA76151.1.
Y16278 mRNA. Translation: CAA76152.1.
Y14770 mRNA. Translation: CAB37400.1.
Y14770 mRNA. Translation: CAB37401.1.
BC032449 mRNA. Translation: AAH32449.1.
AC004030 Genomic DNA. No translation available.
AC005763 Genomic DNA. Translation: AAC62429.1.
D87460 mRNA. Translation: BAA13400.1.
CCDSiCCDS32857.1. [O75781-1]
CCDS32858.1. [O75781-2]
PIRiT00635.
RefSeqiNP_001035224.1. NM_001040134.1. [O75781-2]
NP_002570.2. NM_002579.2. [O75781-1]
UniGeneiHs.631841.

Genome annotation databases

EnsembliENST00000264560; ENSP00000264560; ENSG00000099864. [O75781-2]
ENST00000338448; ENSP00000341911; ENSG00000099864. [O75781-1]
GeneIDi5064.
KEGGihsa:5064.
UCSCiuc002lpm.2. human. [O75781-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16270
, Y16271, Y16272, Y16273, Y16274, Y16275, Y16276, Y16277 Genomic DNA. Translation: CAA76151.1.
Y16278 mRNA. Translation: CAA76152.1.
Y14770 mRNA. Translation: CAB37400.1.
Y14770 mRNA. Translation: CAB37401.1.
BC032449 mRNA. Translation: AAH32449.1.
AC004030 Genomic DNA. No translation available.
AC005763 Genomic DNA. Translation: AAC62429.1.
D87460 mRNA. Translation: BAA13400.1.
CCDSiCCDS32857.1. [O75781-1]
CCDS32858.1. [O75781-2]
PIRiT00635.
RefSeqiNP_001035224.1. NM_001040134.1. [O75781-2]
NP_002570.2. NM_002579.2. [O75781-1]
UniGeneiHs.631841.

3D structure databases

ProteinModelPortaliO75781.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111100. 17 interactions.
IntActiO75781. 11 interactions.
STRINGi9606.ENSP00000341911.

PTM databases

iPTMnetiO75781.
PhosphoSiteiO75781.
SwissPalmiO75781.

Polymorphism and mutation databases

BioMutaiPALM.

Proteomic databases

EPDiO75781.
MaxQBiO75781.
PaxDbiO75781.
PeptideAtlasiO75781.
PRIDEiO75781.

Protocols and materials databases

DNASUi5064.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264560; ENSP00000264560; ENSG00000099864. [O75781-2]
ENST00000338448; ENSP00000341911; ENSG00000099864. [O75781-1]
GeneIDi5064.
KEGGihsa:5064.
UCSCiuc002lpm.2. human. [O75781-1]

Organism-specific databases

CTDi5064.
GeneCardsiPALM.
HGNCiHGNC:8594. PALM.
HPAiHPA041713.
HPA049578.
MIMi608134. gene.
neXtProtiNX_O75781.
PharmGKBiPA32923.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKZ0. Eukaryota.
ENOG410ZG4W. LUCA.
GeneTreeiENSGT00530000063206.
HOGENOMiHOG000043092.
HOVERGENiHBG007431.
InParanoidiO75781.
KOiK16519.
OMAiREENQVG.
OrthoDBiEOG091G0713.
PhylomeDBiO75781.
TreeFamiTF105402.

Miscellaneous databases

GeneWikiiPALM.
GenomeRNAii5064.
PROiO75781.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000099864.
CleanExiHS_PALM.
ExpressionAtlasiO75781. baseline and differential.
GenevisibleiO75781. HS.

Family and domain databases

InterProiIPR004965. Paralemmin.
[Graphical view]
PfamiPF03285. Paralemmin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPALM_HUMAN
AccessioniPrimary (citable) accession number: O75781
Secondary accession number(s): O43359
, O95673, Q92559, Q9UPJ4, Q9UQS2, Q9UQS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.