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Reviewed, UniProtKB/Swiss-Prot O75762 (TRPA1_HUMAN)

Last modified November 3, 2009. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Transient receptor potential cation channel subfamily A member 1
Alternative name(s):
    Ankyrin-like with transmembrane domains protein 1
    Transformation-sensitive protein p120
Gene names
Name: TRPA1
Synonyms: ANKTM1
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length1119 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Probable.

Tissue specificity

Expressed at very low level. Expressed at very low level in human fibroblasts and at a moderate level in liposarcoma cells. Ref.1

Miscellaneous

Inhibited by ruthenium red, a potent blocker of TRPV channels By similarity.

Sequence similarities

Belongs to the transient receptor family.

Contains 15 ANK repeats.

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Ontologies

Keywords
   Biological processIon transport
Sensory transduction
Transport
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainANK repeat
Repeat
Transmembrane
   Molecular functionIonic channel
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componentintegral to plasma membrane Ref.1

Traceable author statement. Source: ProtInc

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11191119Transient receptor potential cation channel subfamily A member 1
PRO_0000215369

Regions

Topological domain1 – 719719Cytoplasmic Potential
Transmembrane720 – 740211 Potential
Topological domain741 – 77232Extracellular Potential
Transmembrane773 – 793212 Potential
Topological domain794 – 80512Cytoplasmic Potential
Transmembrane806 – 826213 Potential
Topological domain827 – 8293Extracellular Potential
Transmembrane830 – 850214 Potential
Topological domain851 – 87323Cytoplasmic Potential
Transmembrane874 – 894215 Potential
Topological domain895 – 94046Extracellular Potential
Transmembrane941 – 961216 Potential
Topological domain962 – 1119158Cytoplasmic Potential
Repeat62 – 9231ANK 1
Repeat97 – 12630ANK 2
Repeat130 – 16031ANK 3
Repeat164 – 19330ANK 4
Repeat197 – 22630ANK 5
Repeat238 – 26730ANK 6
Repeat271 – 30131ANK 7
Repeat308 – 33730ANK 8
Repeat341 – 37030ANK 9
Repeat412 – 44130ANK 10
Repeat445 – 47430ANK 11
Repeat481 – 51030ANK 12
Repeat513 – 54230ANK 13
Repeat547 – 57630ANK 14
Repeat579 – 60931ANK 15

Amino acid modifications

Glycosylation7471N-linked (GlcNAc...) Potential
Glycosylation7531N-linked (GlcNAc...) Potential

Natural variations

Natural variant31R → C: dbSNP rs13268757. Ref.1
VAR_020660
Natural variant581R → T: dbSNP rs16937976. Ref.1
VAR_047471
Natural variant1791E → K: dbSNP rs920829.
VAR_020661
Natural variant1861N → K: dbSNP rs7819749. Ref.2
VAR_020662
Natural variant10181H → R: dbSNP rs959976.
VAR_020663

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Sequences

Sequence LengthMass (Da)Tools
O75762-1 [UniParc].

Last modified November 25, 2008. Version 2.
Checksum: FBFE5C6C105B0B3C

FASTA1,119127,487
        10         20         30         40         50         60 
MKRSLRKMWR PGEKKEPQGV VYEDVPDDTE DFKESLKVVF EGSAYGLQNF NKQKKLKRCD 

        70         80         90        100        110        120 
DMDTFFLHYA AAEGQIELME KITRDSSLEV LHEMDDYGNT PLHCAVEKNQ IESVKFLLSR 

       130        140        150        160        170        180 
GANPNLRNFN MMAPLHIAVQ GMNNEVMKVL LEHRTIDVNL EGENGNTAVI IACTTNNSEA 

       190        200        210        220        230        240 
LQILLNKGAK PCKSNKWGCF PIHQAAFSGS KECMEIILRF GEEHGYSRQL HINFMNNGKA 

       250        260        270        280        290        300 
TPLHLAVQNG DLEMIKMCLD NGAQIDPVEK GRCTAIHFAA TQGATEIVKL MISSYSGSVD 

       310        320        330        340        350        360 
IVNTTDGCHE TMLHRASLFD HHELADYLIS VGADINKIDS EGRSPLILAT ASASWNIVNL 

       370        380        390        400        410        420 
LLSKGAQVDI KDNFGRNFLH LTVQQPYGLK NLRPEFMQMQ QIKELVMDED NDGCTPLHYA 

       430        440        450        460        470        480 
CRQGGPGSVN NLLGFNVSIH SKSKDKKSPL HFAASYGRIN TCQRLLQDIS DTRLLNEGDL 

       490        500        510        520        530        540 
HGMTPLHLAA KNGHDKVVQL LLKKGALFLS DHNGWTALHH ASMGGYTQTM KVILDTNLKC 

       550        560        570        580        590        600 
TDRLDEDGNT ALHFAAREGH AKAVALLLSH NADIVLNKQQ ASFLHLALHN KRKEVVLTII 

       610        620        630        640        650        660 
RSKRWDECLK IFSHNSPGNK CPITEMIEYL PECMKVLLDF CMLHSTEDKS CRDYYIEYNF 

       670        680        690        700        710        720 
KYLQCPLEFT KKTPTQDVIY EPLTALNAMV QNNRIELLNH PVCKEYLLMK WLAYGFRAHM 

       730        740        750        760        770        780 
MNLGSYCLGL IPMTILVVNI KPGMAFNSTG IINETSDHSE ILDTTNSYLI KTCMILVFLS 

       790        800        810        820        830        840 
SIFGYCKEAG QIFQQKRNYF MDISNVLEWI IYTTGIIFVL PLFVEIPAHL QWQCGAIAVY 

       850        860        870        880        890        900 
FYWMNFLLYL QRFENCGIFI VMLEVILKTL LRSTVVFIFL LLAFGLSFYI LLNLQDPFSS 

       910        920        930        940        950        960 
PLLSIIQTFS MMLGDINYRE SFLEPYLRNE LAHPVLSFAQ LVSFTIFVPI VLMNLLIGLA 

       970        980        990       1000       1010       1020 
VGDIAEVQKH ASLKRIAMQV ELHTSLEKKL PLWFLRKVDQ KSTIVYPNKP RSGGMLFHIF 

      1030       1040       1050       1060       1070       1080 
CFLFCTGEIR QEIPNADKSL EMEILKQKYR LKDLTFLLEK QHELIKLIIQ KMEIISETED 

      1090       1100       1110 
DDSHCSFQDR FKKEQMEQRN SRWNTVLRAV KAKTHHLEP

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References

« Hide 'large scale' references
[1]"An ankyrin-like protein with transmembrane domains is specifically lost after oncogenic transformation of human fibroblasts."
Jaquemar D., Schenker T., Trueb B.
J. Biol. Chem. 274:7325-7333(1999) [PubMed: 10066796] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANTS CYS-3 AND THR-58.
Tissue: Lung.
[2]"DNA sequence and analysis of human chromosome 8."
Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. expand/collapse author list , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
Nature 439:331-335(2006) [PubMed: 16421571] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LYS-186.
+Additional computationally mapped references.

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Web resources

Protein Spotlight

The power behind pain - Issue 82 of May 2007

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Cross-references

Sequence databases

Y10601 mRNA. Translation: CAA71610.1.
AC022867 Genomic DNA. No translation available.
IPIIPI00015963.
UniGeneHs.137674

3D structure databases

HSSPHSSP built from PDB template 1UOH based on UniProtKB O75832.
ModBaseSearch...

Protein-protein interaction databases

STRINGO75762.

Protein family/group databases

TCDB1.A.4.6.3. transient receptor potential Ca2+ channel (TRP-CC) family.

Proteomic databases

PRIDEO75762.

Genome annotation databases

EnsemblENST00000262209; ENSP00000262209; ENSG00000104321; Homo sapiens. [Genome view]
UCSCuc003xza.1. human.

Organism-specific databases

GeneCardsGC08M073096.
H-InvDBHIX0034373.
HGNCHGNC:497. TRPA1.
HPAHPA026630.
MIM604775. gene.
PharmGKBPA24808.
GenAtlasSearch...

Phylogenomic databases

HOGENOMO75762.
HOVERGENO75762.

Gene expression databases

ArrayExpressO75762.
BgeeO75762.
CleanExHS_TRPA1.
GenevestigatorO75762.
GermOnlineENSG00000104321. Homo sapiens.

Family and domain databases

InterProIPR002110. ANK.
IPR005821. Ion_trans.
[Graphical view]
PfamPF00023. Ank. 13 hits.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 9 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

DrugBankDB00825. Menthol.
SOURCESearch...

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Entry information

Entry nameTRPA1_HUMAN
AccessionPrimary (citable) accession number: O75762
Secondary accession number(s): A6NIN6
Entry history
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: November 25, 2008
Last modified: November 3, 2009
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents