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O75758 (O75758_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified March 19, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length599 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + pyruvate = ADP + phosphoenolpyruvate. RuleBase RU000504

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5. RuleBase RU000504

Sequence similarities

Belongs to the pyruvate kinase family. RuleBase RU000504

Sequences

Sequence LengthMass (Da)Tools
O75758 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 29BCFF812F1181A0

FASTA59964,502
        10         20         30         40         50         60 
MSIQENISSL QLRSWVSKSQ RDLAKSILIG APGVPLTTQQ CGADPQRGRP REVCSGMEGP 

        70         80         90        100        110        120 
AGYLRRASVA QLTQELGTAF FQQQQLPAAM ADTFLEHLCL LDIDSEPVAA RSTSIIATIG 

       130        140        150        160        170        180 
PASRSVERLK EMIKAGMNIA RLNFSHGSHE YHAESIANVR EAVESFAGSP LSYRPVAIAL 

       190        200        210        220        230        240 
DTKGPEIRTG ILQGGPESEV ELVKGSQVLV TVDPAFRTRG NANTVWVDYP NIVRVVPVGG 

       250        260        270        280        290        300 
RIYIDDGLIS LVVQKIGPEG LVTQVENGGV LGSRKGVNLP GAQVDLPGLS EQDVRDLRFG 

       310        320        330        340        350        360 
VEHGVDIVFA SFVRKASDVA AVRAALGPEG HGIKIISKIE NHEGVKRFDE ILEVSDGIMV 

       370        380        390        400        410        420 
ARGDLGIEIP AEKVFLAQKM MIGRCNLAGK PVVCATQMLE SMITKARPTR AETSDVANAV 

       430        440        450        460        470        480 
LDGADCIMLS GETAKGNFPV EAVKMQHAIA REAEAAVYHR QLFEELRRAA PLSRDPTEVT 

       490        500        510        520        530        540 
AIGAVEAAFK CCAAAIIVLT TTGRSAQLLS RYRPRAAVIA VTRSAQAARQ VHLCRGVFPL 

       550        560        570        580        590 
LYREPPEAIW ADDVDRRVQF GIESGKLRGF LRVGDLVIVV TGWRPGSGYT NIMRVLSIS 

« Hide

References

[1]"Human liver type pyruvate kinase: complete amino acid sequence and the expression in mammalian cells."
Tani K., Fujii H., Nagata S., Miwa S.
Proc. Natl. Acad. Sci. U.S.A. 85:1792-1795(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Structural analysis of human pyruvate kinase L-gene and identification of the promoter activity in erythroid cells."
Kanno H., Fujii H., Miwa S.
Biochem. Biophys. Res. Commun. 188:516-523(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D13243 Genomic DNA. Translation: BAA02515.1.
PIRKIHUPL. I52269.
UniGeneHs.95990.

3D structure databases

ProteinModelPortalO75758.
SMRO75758. Positions 82-598.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEO75758.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOGENOMHOG000021559.
HOVERGENHBG000941.

Enzyme and pathway databases

UniPathwayUPA00109; UER00188.

Family and domain databases

Gene3D2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERPTHR11817. PTHR11817. 1 hit.
PfamPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSPR01050. PYRUVTKNASE.
SUPFAMSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsTIGR01064. pyruv_kin. 1 hit.
PROSITEPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameO75758_HUMAN
AccessionPrimary (citable) accession number: O75758
Entry history
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: March 19, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.