O75758 (O75758_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Recommended name: Pyruvate kinase RuleBase RU000504 EC=2.7.1.40 RuleBase RU000504
Organism	Homo sapiens (Human) EMBL BAA02515.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	599 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + pyruvate = ADP + phosphoenolpyruvate. RuleBase RU000504
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5. RuleBase RU000504
Sequence similarities	Belongs to the pyruvate kinase family. RuleBase RU000504

Ontologies

Keywords
Biological process	Glycolysis RuleBase RU000504
Ligand	Magnesium RuleBase RU000504 Pyruvate EMBL BAA02515.1
Molecular function	Kinase RuleBase RU000504 EMBL BAA02515.1 Transferase
Gene Ontology (GO)
Biological_process	glycolysis Non-traceable author statement. Source: UniProtKB
Molecular_function	magnesium ion binding Inferred from electronic annotation. Source: InterPro potassium ion binding Inferred from electronic annotation. Source: InterPro pyruvate kinase activity Non-traceable author statement Ref.2. Source: UniProtKB
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O75758 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 29BCFF812F1181A0	FASTA	599	64,502
	10 20 30 40 50 60 MSIQENISSL QLRSWVSKSQ RDLAKSILIG APGVPLTTQQ CGADPQRGRP REVCSGMEGP 70 80 90 100 110 120 AGYLRRASVA QLTQELGTAF FQQQQLPAAM ADTFLEHLCL LDIDSEPVAA RSTSIIATIG 130 140 150 160 170 180 PASRSVERLK EMIKAGMNIA RLNFSHGSHE YHAESIANVR EAVESFAGSP LSYRPVAIAL 190 200 210 220 230 240 DTKGPEIRTG ILQGGPESEV ELVKGSQVLV TVDPAFRTRG NANTVWVDYP NIVRVVPVGG 250 260 270 280 290 300 RIYIDDGLIS LVVQKIGPEG LVTQVENGGV LGSRKGVNLP GAQVDLPGLS EQDVRDLRFG 310 320 330 340 350 360 VEHGVDIVFA SFVRKASDVA AVRAALGPEG HGIKIISKIE NHEGVKRFDE ILEVSDGIMV 370 380 390 400 410 420 ARGDLGIEIP AEKVFLAQKM MIGRCNLAGK PVVCATQMLE SMITKARPTR AETSDVANAV 430 440 450 460 470 480 LDGADCIMLS GETAKGNFPV EAVKMQHAIA REAEAAVYHR QLFEELRRAA PLSRDPTEVT 490 500 510 520 530 540 AIGAVEAAFK CCAAAIIVLT TTGRSAQLLS RYRPRAAVIA VTRSAQAARQ VHLCRGVFPL 550 560 570 580 590 LYREPPEAIW ADDVDRRVQF GIESGKLRGF LRVGDLVIVV TGWRPGSGYT NIMRVLSIS

References

[1]	"Human liver type pyruvate kinase: complete amino acid sequence and the expression in mammalian cells." Tani K., Fujii H., Nagata S., Miwa S. Proc. Natl. Acad. Sci. U.S.A. 85:1792-1795(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Structural analysis of human pyruvate kinase L-gene and identification of the promoter activity in erythroid cells." Kanno H., Fujii H., Miwa S. Biochem. Biophys. Res. Commun. 188:516-523(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D13243 Genomic DNA. Translation: BAA02515.1.
IPI	IPI00743713.
PIR	KIHUPL. I52269.
UniGene	Hs.95990.
3D structure databases
ProteinModelPortal	O75758.
SMR	O75758. Positions 82-598.
ModBase	Search...
Proteomic databases
PRIDE	O75758.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOGENOM	HOG000021559.
HOVERGEN	HBG000941.
Enzyme and pathway databases
UniPathway	UPA00109; UER00188.
Gene expression databases
ArrayExpress	O75758.
Family and domain databases
Gene3D	2.40.33.10. 1 hit. 3.20.20.60. 2 hits. 3.40.1380.20. 1 hit.
InterPro	IPR001697. Pyr_Knase. IPR015813. Pyrv/PenolPyrv_Kinase-like_dom. IPR011037. Pyrv_Knase-like_insert_dom. IPR015794. Pyrv_Knase_a/b. IPR018209. Pyrv_Knase_AS. IPR015793. Pyrv_Knase_brl. IPR015795. Pyrv_Knase_C. IPR015806. Pyrv_Knase_insert_dom. [Graphical view]
PANTHER	PTHR11817. PTHR11817. 1 hit.
Pfam	PF00224. PK. 1 hit. PF02887. PK_C. 1 hit. [Graphical view]
PRINTS	PR01050. PYRUVTKNASE.
SUPFAM	SSF50800. PK_B_barrel_like. 1 hit. SSF52935. Pyruvate_kinase. 1 hit. SSF51621. Pyrv/PenolPyrv_Kinase_cat. 1 hit.
TIGRFAMs	TIGR01064. pyruv_kin. 1 hit.
PROSITE	PS00110. PYRUVATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

O75758_HUMAN

Accession

Primary (citable) accession number: O75758

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1998
Last sequence update:	November 1, 1998
Last modified:	May 29, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.