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Protein

Solute carrier family 22 member 3

Gene

SLC22A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.2 Publications

GO - Molecular functioni

GO - Biological processi

  • dopamine transport Source: GO_Central
  • drug transmembrane transport Source: Reactome
  • histamine uptake Source: Ensembl
  • organic cation transport Source: MGI
  • quaternary ammonium group transport Source: MGI
  • regulation of appetite Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000146477-MONOMER.
ReactomeiR-HSA-2161517. Abacavir transmembrane transport.
R-HSA-549127. Organic cation transport.

Protein family/group databases

TCDBi2.A.1.19.24. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 3
Alternative name(s):
Extraneuronal monoamine transporter
Short name:
EMT
Organic cation transporter 3
Gene namesi
Name:SLC22A3
Synonyms:EMTH, OCT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:10967. SLC22A3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Transmembranei269 – 289HelicalSequence analysisAdd BLAST21
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
Transmembranei468 – 488HelicalSequence analysisAdd BLAST21
Transmembranei498 – 518HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6581.
OpenTargetsiENSG00000146477.
PharmGKBiPA330.

Chemistry databases

ChEMBLiCHEMBL2073673.
DrugBankiDB00718. Adefovir Dipivoxil.
DB00182. Amphetamine.
DB00122. Choline.
DB00501. Cimetidine.
DB00575. Clonidine.
DB01394. Colchicine.
DB01151. Desipramine.
DB00988. Dopamine.
DB00783. Estradiol.
DB00536. Guanidine.
DB00667. Histamine Phosphate.
DB00458. Imipramine.
DB00762. Irinotecan.
DB00709. Lamivudine.
DB01042. Melphalan.
DB00331. Metformin.
DB01577. Methamphetamine.
DB00184. Nicotine.
DB00368. Norepinephrine.
DB00526. Oxaliplatin.
DB00925. Phenoxybenzamine.
DB00457. Prazosin.
DB01035. Procainamide.
DB00396. Progesterone.
DB00624. Testosterone.
DB00541. Vincristine.
GuidetoPHARMACOLOGYi1021.

Polymorphism and mutation databases

BioMutaiSLC22A3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002205031 – 556Solute carrier family 22 member 3Add BLAST556

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi72N-linked (GlcNAc...)Sequence analysis1
Glycosylationi99N-linked (GlcNAc...)Sequence analysis1
Glycosylationi119N-linked (GlcNAc...)Sequence analysis1
Glycosylationi322N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO75751.
PeptideAtlasiO75751.
PRIDEiO75751.

PTM databases

iPTMnetiO75751.
PhosphoSitePlusiO75751.

Expressioni

Tissue specificityi

Expressed in placenta, skeletal muscle, prostate, aorta, liver, fetal lung, salivary gland, adrenal gland, kidney and brain cortex. No expression detected in spleen.3 Publications

Gene expression databases

BgeeiENSG00000146477.
CleanExiHS_SLC22A3.
GenevisibleiO75751. HS.

Organism-specific databases

HPAiHPA029750.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ABL1P005192EBI-1752674,EBI-375543

Protein-protein interaction databases

IntActiO75751. 2 interactors.
STRINGi9606.ENSP00000275300.

Chemistry databases

BindingDBiO75751.

Structurei

3D structure databases

ProteinModelPortaliO75751.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRIE. Eukaryota.
ENOG410XSRI. LUCA.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234568.
HOVERGENiHBG061545.
InParanoidiO75751.
KOiK08200.
OMAiCQRYLLE.
OrthoDBiEOG091G05AC.
PhylomeDBiO75751.
TreeFamiTF315847.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR004749. Orgcat_transp/SVOP.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75751-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSFDEALQR VGEFGRFQRR VFLLLCLTGV TFAFLFVGVV FLGTQPDHYW
60 70 80 90 100
CRGPSAAALA ERCGWSPEEE WNRTAPASRG PEPPERRGRC QRYLLEAAND
110 120 130 140 150
SASATSALSC ADPLAAFPNR SAPLVPCRGG WRYAQAHSTI VSEFDLVCVN
160 170 180 190 200
AWMLDLTQAI LNLGFLTGAF TLGYAADRYG RIVIYLLSCL GVGVTGVVVA
210 220 230 240 250
FAPNFPVFVI FRFLQGVFGK GTWMTCYVIV TEIVGSKQRR IVGIVIQMFF
260 270 280 290 300
TLGIIILPGI AYFIPNWQGI QLAITLPSFL FLLYYWVVPE SPRWLITRKK
310 320 330 340 350
GDKALQILRR IAKCNGKYLS SNYSEITVTD EEVSNPSFLD LVRTPQMRKC
360 370 380 390 400
TLILMFAWFT SAVVYQGLVM RLGIIGGNLY IDFFISGVVE LPGALLILLT
410 420 430 440 450
IERLGRRLPF AASNIVAGVA CLVTAFLPEG IAWLRTTVAT LGRLGITMAF
460 470 480 490 500
EIVYLVNSEL YPTTLRNFGV SLCSGLCDFG GIIAPFLLFR LAAVWLELPL
510 520 530 540 550
IIFGILASIC GGLVMLLPET KGIALPETVD DVEKLGSPHS CKCGRNKKTP

VSRSHL
Length:556
Mass (Da):61,280
Last modified:November 1, 1998 - v1
Checksum:iC3CA2D77DD21C658
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02035144T → M.Corresponds to variant rs8187715dbSNPEnsembl.1
Natural variantiVAR_020352116A → S.Corresponds to variant rs8187717dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001417 mRNA. Translation: CAA04751.1.
AK314590 mRNA. Translation: BAG37164.1.
AL591069, AL355506 Genomic DNA. Translation: CAI16539.1.
AL355506, AL591069 Genomic DNA. Translation: CAI20340.1.
CH471051 Genomic DNA. Translation: EAW47599.1.
AF078749 mRNA. Translation: AAD20977.1.
CCDSiCCDS5277.1.
RefSeqiNP_068812.1. NM_021977.3.
UniGeneiHs.567337.

Genome annotation databases

EnsembliENST00000275300; ENSP00000275300; ENSG00000146477.
GeneIDi6581.
KEGGihsa:6581.
UCSCiuc003qti.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001417 mRNA. Translation: CAA04751.1.
AK314590 mRNA. Translation: BAG37164.1.
AL591069, AL355506 Genomic DNA. Translation: CAI16539.1.
AL355506, AL591069 Genomic DNA. Translation: CAI20340.1.
CH471051 Genomic DNA. Translation: EAW47599.1.
AF078749 mRNA. Translation: AAD20977.1.
CCDSiCCDS5277.1.
RefSeqiNP_068812.1. NM_021977.3.
UniGeneiHs.567337.

3D structure databases

ProteinModelPortaliO75751.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO75751. 2 interactors.
STRINGi9606.ENSP00000275300.

Chemistry databases

BindingDBiO75751.
ChEMBLiCHEMBL2073673.
DrugBankiDB00718. Adefovir Dipivoxil.
DB00182. Amphetamine.
DB00122. Choline.
DB00501. Cimetidine.
DB00575. Clonidine.
DB01394. Colchicine.
DB01151. Desipramine.
DB00988. Dopamine.
DB00783. Estradiol.
DB00536. Guanidine.
DB00667. Histamine Phosphate.
DB00458. Imipramine.
DB00762. Irinotecan.
DB00709. Lamivudine.
DB01042. Melphalan.
DB00331. Metformin.
DB01577. Methamphetamine.
DB00184. Nicotine.
DB00368. Norepinephrine.
DB00526. Oxaliplatin.
DB00925. Phenoxybenzamine.
DB00457. Prazosin.
DB01035. Procainamide.
DB00396. Progesterone.
DB00624. Testosterone.
DB00541. Vincristine.
GuidetoPHARMACOLOGYi1021.

Protein family/group databases

TCDBi2.A.1.19.24. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiO75751.
PhosphoSitePlusiO75751.

Polymorphism and mutation databases

BioMutaiSLC22A3.

Proteomic databases

PaxDbiO75751.
PeptideAtlasiO75751.
PRIDEiO75751.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000275300; ENSP00000275300; ENSG00000146477.
GeneIDi6581.
KEGGihsa:6581.
UCSCiuc003qti.5. human.

Organism-specific databases

CTDi6581.
DisGeNETi6581.
GeneCardsiSLC22A3.
HGNCiHGNC:10967. SLC22A3.
HPAiHPA029750.
MIMi604842. gene.
neXtProtiNX_O75751.
OpenTargetsiENSG00000146477.
PharmGKBiPA330.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IRIE. Eukaryota.
ENOG410XSRI. LUCA.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234568.
HOVERGENiHBG061545.
InParanoidiO75751.
KOiK08200.
OMAiCQRYLLE.
OrthoDBiEOG091G05AC.
PhylomeDBiO75751.
TreeFamiTF315847.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000146477-MONOMER.
ReactomeiR-HSA-2161517. Abacavir transmembrane transport.
R-HSA-549127. Organic cation transport.

Miscellaneous databases

ChiTaRSiSLC22A3. human.
GeneWikiiSLC22A3.
GenomeRNAii6581.
PROiO75751.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000146477.
CleanExiHS_SLC22A3.
GenevisibleiO75751. HS.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR004749. Orgcat_transp/SVOP.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS22A3_HUMAN
AccessioniPrimary (citable) accession number: O75751
Secondary accession number(s): Q5SYN6, Q9UP02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 1, 1998
Last modified: November 2, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.