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Protein

Solute carrier family 22 member 3

Gene

SLC22A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.2 Publications

GO - Molecular functioni

GO - Biological processi

  • dopamine transport Source: GO_Central
  • drug transmembrane transport Source: Reactome
  • histamine uptake Source: Ensembl
  • organic cation transport Source: MGI
  • quaternary ammonium group transport Source: MGI
  • regulation of appetite Source: Ensembl

Keywordsi

Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-2161517. Abacavir transmembrane transport.
R-HSA-549127. Organic cation transport.

Protein family/group databases

TCDBi2.A.1.19.24. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 3
Alternative name(s):
Extraneuronal monoamine transporter
Short name:
EMT
Organic cation transporter 3
Gene namesi
Name:SLC22A3
Synonyms:EMTH, OCT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000146477.5.
HGNCiHGNC:10967. SLC22A3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Transmembranei269 – 289HelicalSequence analysisAdd BLAST21
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
Transmembranei468 – 488HelicalSequence analysisAdd BLAST21
Transmembranei498 – 518HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6581.
OpenTargetsiENSG00000146477.
PharmGKBiPA330.

Chemistry databases

ChEMBLiCHEMBL2073673.
DrugBankiDB00718. Adefovir Dipivoxil.
DB08838. Agmatine.
DB00182. Amphetamine.
DB00122. Choline.
DB00501. Cimetidine.
DB00575. Clonidine.
DB01394. Colchicine.
DB01151. Desipramine.
DB00988. Dopamine.
DB00783. Estradiol.
DB00536. Guanidine.
DB05381. Histamine.
DB00458. Imipramine.
DB00762. Irinotecan.
DB00709. Lamivudine.
DB01042. Melphalan.
DB00331. Metformin.
DB01577. Methamphetamine.
DB00184. Nicotine.
DB00368. Norepinephrine.
DB00526. Oxaliplatin.
DB00925. Phenoxybenzamine.
DB00457. Prazosin.
DB01035. Procainamide.
DB00396. Progesterone.
DB00624. Testosterone.
DB08837. Tetraethylammonium.
DB08841. Tyramine.
DB00541. Vincristine.
GuidetoPHARMACOLOGYi1021.

Polymorphism and mutation databases

BioMutaiSLC22A3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002205031 – 556Solute carrier family 22 member 3Add BLAST556

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi119N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi322N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO75751.
PeptideAtlasiO75751.
PRIDEiO75751.

PTM databases

iPTMnetiO75751.
PhosphoSitePlusiO75751.

Expressioni

Tissue specificityi

Expressed in placenta, skeletal muscle, prostate, aorta, liver, fetal lung, salivary gland, adrenal gland, kidney and brain cortex. No expression detected in spleen.3 Publications

Gene expression databases

BgeeiENSG00000146477.
CleanExiHS_SLC22A3.
GenevisibleiO75751. HS.

Organism-specific databases

HPAiHPA029750.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ABL1P005192EBI-1752674,EBI-375543

Protein-protein interaction databases

IntActiO75751. 2 interactors.
STRINGi9606.ENSP00000275300.

Chemistry databases

BindingDBiO75751.

Structurei

3D structure databases

ProteinModelPortaliO75751.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRIE. Eukaryota.
ENOG410XSRI. LUCA.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234568.
HOVERGENiHBG061545.
InParanoidiO75751.
KOiK08200.
OMAiWSPEEEW.
OrthoDBiEOG091G05AC.
PhylomeDBiO75751.
TreeFamiTF315847.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiView protein in InterPro
IPR011701. MFS.
IPR020846. MFS_dom.
IPR036259. MFS_trans_sf.
IPR004749. Orgcat_transp/SVOP.
IPR005829. Sugar_transporter_CS.
PfamiView protein in Pfam
PF07690. MFS_1. 1 hit.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiView protein in PROSITE
PS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.

Sequencei

Sequence statusi: Complete.

O75751-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSFDEALQR VGEFGRFQRR VFLLLCLTGV TFAFLFVGVV FLGTQPDHYW
60 70 80 90 100
CRGPSAAALA ERCGWSPEEE WNRTAPASRG PEPPERRGRC QRYLLEAAND
110 120 130 140 150
SASATSALSC ADPLAAFPNR SAPLVPCRGG WRYAQAHSTI VSEFDLVCVN
160 170 180 190 200
AWMLDLTQAI LNLGFLTGAF TLGYAADRYG RIVIYLLSCL GVGVTGVVVA
210 220 230 240 250
FAPNFPVFVI FRFLQGVFGK GTWMTCYVIV TEIVGSKQRR IVGIVIQMFF
260 270 280 290 300
TLGIIILPGI AYFIPNWQGI QLAITLPSFL FLLYYWVVPE SPRWLITRKK
310 320 330 340 350
GDKALQILRR IAKCNGKYLS SNYSEITVTD EEVSNPSFLD LVRTPQMRKC
360 370 380 390 400
TLILMFAWFT SAVVYQGLVM RLGIIGGNLY IDFFISGVVE LPGALLILLT
410 420 430 440 450
IERLGRRLPF AASNIVAGVA CLVTAFLPEG IAWLRTTVAT LGRLGITMAF
460 470 480 490 500
EIVYLVNSEL YPTTLRNFGV SLCSGLCDFG GIIAPFLLFR LAAVWLELPL
510 520 530 540 550
IIFGILASIC GGLVMLLPET KGIALPETVD DVEKLGSPHS CKCGRNKKTP

VSRSHL
Length:556
Mass (Da):61,280
Last modified:November 1, 1998 - v1
Checksum:iC3CA2D77DD21C658
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02035144T → M. Corresponds to variant dbSNP:rs8187715Ensembl.1
Natural variantiVAR_020352116A → S. Corresponds to variant dbSNP:rs8187717Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001417 mRNA. Translation: CAA04751.1.
AK314590 mRNA. Translation: BAG37164.1.
AL591069 Genomic DNA. No translation available.
AL355506 Genomic DNA. No translation available.
CH471051 Genomic DNA. Translation: EAW47599.1.
AF078749 mRNA. Translation: AAD20977.1.
CCDSiCCDS5277.1.
RefSeqiNP_068812.1. NM_021977.3.
UniGeneiHs.567337.

Genome annotation databases

EnsembliENST00000275300; ENSP00000275300; ENSG00000146477.
GeneIDi6581.
KEGGihsa:6581.
UCSCiuc003qti.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiS22A3_HUMAN
AccessioniPrimary (citable) accession number: O75751
Secondary accession number(s): Q5SYN6, Q9UP02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 1, 1998
Last modified: November 22, 2017
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families