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O75751

- S22A3_HUMAN

UniProt

O75751 - S22A3_HUMAN

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Protein

Solute carrier family 22 member 3

Gene

SLC22A3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.2 Publications

GO - Molecular functioni

  1. dopamine transmembrane transporter activity Source: Ensembl
  2. organic cation transmembrane transporter activity Source: MGI
  3. quaternary ammonium group transmembrane transporter activity Source: MGI
  4. toxin transporter activity Source: Ensembl

GO - Biological processi

  1. dopamine transport Source: Ensembl
  2. drug transmembrane transport Source: Reactome
  3. histamine uptake Source: Ensembl
  4. organic cation transport Source: MGI
  5. quaternary ammonium group transport Source: MGI
  6. regulation of appetite Source: Ensembl
  7. small molecule metabolic process Source: Reactome
  8. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_120801. Abacavir transmembrane transport.
REACT_22357. Organic cation transport.

Protein family/group databases

TCDBi2.A.1.19.24. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 3
Alternative name(s):
Extraneuronal monoamine transporter
Short name:
EMT
Organic cation transporter 3
Gene namesi
Name:SLC22A3
Synonyms:EMTH, OCT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:10967. SLC22A3.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. membrane Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA330.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Solute carrier family 22 member 3PRO_0000220503Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi322 – 3221N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO75751.
PaxDbiO75751.
PRIDEiO75751.

PTM databases

PhosphoSiteiO75751.

Expressioni

Tissue specificityi

Expressed in placenta, skeletal muscle, prostate, aorta, liver, fetal lung, salivary gland, adrenal gland, kidney and brain cortex. No expression detected in spleen.3 Publications

Gene expression databases

BgeeiO75751.
CleanExiHS_SLC22A3.
ExpressionAtlasiO75751. baseline and differential.
GenevestigatoriO75751.

Organism-specific databases

HPAiHPA029750.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ABL1P005192EBI-1752674,EBI-375543

Protein-protein interaction databases

IntActiO75751. 2 interactions.
STRINGi9606.ENSP00000275300.

Structurei

3D structure databases

ProteinModelPortaliO75751.
SMRiO75751. Positions 153-527.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4121HelicalSequence AnalysisAdd
BLAST
Transmembranei182 – 20221HelicalSequence AnalysisAdd
BLAST
Transmembranei241 – 26121HelicalSequence AnalysisAdd
BLAST
Transmembranei269 – 28921HelicalSequence AnalysisAdd
BLAST
Transmembranei381 – 40121HelicalSequence AnalysisAdd
BLAST
Transmembranei468 – 48821HelicalSequence AnalysisAdd
BLAST
Transmembranei498 – 51821HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234568.
HOVERGENiHBG061545.
InParanoidiO75751.
KOiK08200.
OrthoDBiEOG78PV8N.
PhylomeDBiO75751.
TreeFamiTF315847.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004749. Orgcat_transp.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75751-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSFDEALQR VGEFGRFQRR VFLLLCLTGV TFAFLFVGVV FLGTQPDHYW
60 70 80 90 100
CRGPSAAALA ERCGWSPEEE WNRTAPASRG PEPPERRGRC QRYLLEAAND
110 120 130 140 150
SASATSALSC ADPLAAFPNR SAPLVPCRGG WRYAQAHSTI VSEFDLVCVN
160 170 180 190 200
AWMLDLTQAI LNLGFLTGAF TLGYAADRYG RIVIYLLSCL GVGVTGVVVA
210 220 230 240 250
FAPNFPVFVI FRFLQGVFGK GTWMTCYVIV TEIVGSKQRR IVGIVIQMFF
260 270 280 290 300
TLGIIILPGI AYFIPNWQGI QLAITLPSFL FLLYYWVVPE SPRWLITRKK
310 320 330 340 350
GDKALQILRR IAKCNGKYLS SNYSEITVTD EEVSNPSFLD LVRTPQMRKC
360 370 380 390 400
TLILMFAWFT SAVVYQGLVM RLGIIGGNLY IDFFISGVVE LPGALLILLT
410 420 430 440 450
IERLGRRLPF AASNIVAGVA CLVTAFLPEG IAWLRTTVAT LGRLGITMAF
460 470 480 490 500
EIVYLVNSEL YPTTLRNFGV SLCSGLCDFG GIIAPFLLFR LAAVWLELPL
510 520 530 540 550
IIFGILASIC GGLVMLLPET KGIALPETVD DVEKLGSPHS CKCGRNKKTP

VSRSHL
Length:556
Mass (Da):61,280
Last modified:November 1, 1998 - v1
Checksum:iC3CA2D77DD21C658
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti44 – 441T → M.
Corresponds to variant rs8187715 [ dbSNP | Ensembl ].
VAR_020351
Natural varianti116 – 1161A → S.
Corresponds to variant rs8187717 [ dbSNP | Ensembl ].
VAR_020352

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ001417 mRNA. Translation: CAA04751.1.
AK314590 mRNA. Translation: BAG37164.1.
AL591069, AL355506 Genomic DNA. Translation: CAI16539.1.
AL355506, AL591069 Genomic DNA. Translation: CAI20340.1.
CH471051 Genomic DNA. Translation: EAW47599.1.
AF078749 mRNA. Translation: AAD20977.1.
CCDSiCCDS5277.1.
RefSeqiNP_068812.1. NM_021977.3.
UniGeneiHs.567337.

Genome annotation databases

EnsembliENST00000275300; ENSP00000275300; ENSG00000146477.
GeneIDi6581.
KEGGihsa:6581.
UCSCiuc003qti.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ001417 mRNA. Translation: CAA04751.1 .
AK314590 mRNA. Translation: BAG37164.1 .
AL591069 , AL355506 Genomic DNA. Translation: CAI16539.1 .
AL355506 , AL591069 Genomic DNA. Translation: CAI20340.1 .
CH471051 Genomic DNA. Translation: EAW47599.1 .
AF078749 mRNA. Translation: AAD20977.1 .
CCDSi CCDS5277.1.
RefSeqi NP_068812.1. NM_021977.3.
UniGenei Hs.567337.

3D structure databases

ProteinModelPortali O75751.
SMRi O75751. Positions 153-527.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O75751. 2 interactions.
STRINGi 9606.ENSP00000275300.

Chemistry

ChEMBLi CHEMBL2073673.
DrugBanki DB00718. Adefovir Dipivoxil.
DB00182. Amphetamine.
DB00122. Choline.
DB00501. Cimetidine.
DB00575. Clonidine.
DB01394. Colchicine.
DB01151. Desipramine.
DB00988. Dopamine.
DB00783. Estradiol.
DB00536. Guanidine.
DB00667. Histamine Phosphate.
DB00458. Imipramine.
DB00762. Irinotecan.
DB00709. Lamivudine.
DB01042. Melphalan.
DB00331. Metformin.
DB01577. Methamphetamine.
DB00184. Nicotine.
DB00368. Norepinephrine.
DB00526. Oxaliplatin.
DB00925. Phenoxybenzamine.
DB00457. Prazosin.
DB01035. Procainamide.
DB00396. Progesterone.
DB00624. Testosterone.
DB00541. Vincristine.

Protein family/group databases

TCDBi 2.A.1.19.24. the major facilitator superfamily (mfs).

PTM databases

PhosphoSitei O75751.

Proteomic databases

MaxQBi O75751.
PaxDbi O75751.
PRIDEi O75751.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000275300 ; ENSP00000275300 ; ENSG00000146477 .
GeneIDi 6581.
KEGGi hsa:6581.
UCSCi uc003qti.4. human.

Organism-specific databases

CTDi 6581.
GeneCardsi GC06P160739.
HGNCi HGNC:10967. SLC22A3.
HPAi HPA029750.
MIMi 604842. gene.
neXtProti NX_O75751.
PharmGKBi PA330.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0477.
GeneTreei ENSGT00760000118852.
HOGENOMi HOG000234568.
HOVERGENi HBG061545.
InParanoidi O75751.
KOi K08200.
OrthoDBi EOG78PV8N.
PhylomeDBi O75751.
TreeFami TF315847.

Enzyme and pathway databases

Reactomei REACT_120801. Abacavir transmembrane transport.
REACT_22357. Organic cation transport.

Miscellaneous databases

ChiTaRSi SLC22A3. human.
GeneWikii SLC22A3.
GenomeRNAii 6581.
NextBioi 25609.
PROi O75751.
SOURCEi Search...

Gene expression databases

Bgeei O75751.
CleanExi HS_SLC22A3.
ExpressionAtlasi O75751. baseline and differential.
Genevestigatori O75751.

Family and domain databases

InterProi IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004749. Orgcat_transp.
IPR005829. Sugar_transporter_CS.
[Graphical view ]
Pfami PF07690. MFS_1. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 2 hits.
TIGRFAMsi TIGR00898. 2A0119. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter."
    Gruendemann D., Schechinger B., Rappold G.A., Schoemig E.
    Nat. Neurosci. 1:349-351(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Kidney.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tongue.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27."
    Verhaagh S., Schweifer N., Barlow D.P., Zwart R.
    Genomics 55:209-218(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 513-556, TISSUE SPECIFICITY.
  6. "Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney."
    Wu X., Huang W., Ganapathy M.E., Wang H., Kekuda R., Conway S.J., Leibach F.H., Ganapathy V.
    Am. J. Physiol. 279:F449-F458(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
    Tissue: Kidney.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiS22A3_HUMAN
AccessioniPrimary (citable) accession number: O75751
Secondary accession number(s): Q5SYN6, Q9UP02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3