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Protein

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma

Gene

PIK3C2G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis (By similarity).By similarity

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate.

GO - Molecular functioni

GO - Biological processi

  • chemotaxis Source: UniProtKB-KW
  • phosphatidylinositol biosynthetic process Source: Reactome
  • phosphatidylinositol-mediated signaling Source: InterPro
  • viral RNA genome replication Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Chemotaxis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS06583-MONOMER.
ZFISH:HS06583-MONOMER.
BRENDAi2.7.1.137. 2681.
2.7.1.154. 2681.
ReactomeiR-HSA-1660499. Synthesis of PIPs at the plasma membrane.
R-HSA-1660514. Synthesis of PIPs at the Golgi membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma (EC:2.7.1.154)
Short name:
PI3K-C2-gamma
Short name:
PtdIns-3-kinase C2 subunit gamma
Alternative name(s):
Phosphoinositide 3-kinase-C2-gamma
Gene namesi
Name:PIK3C2G
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:8973. PIK3C2G.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5288.
OpenTargetsiENSG00000139144.
PharmGKBiPA33306.

Chemistry databases

ChEMBLiCHEMBL1163120.
GuidetoPHARMACOLOGYi2288.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000887991 – 1445Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gammaAdd BLAST1445

Proteomic databases

PaxDbiO75747.
PeptideAtlasiO75747.
PRIDEiO75747.

PTM databases

iPTMnetiO75747.
PhosphoSitePlusiO75747.

Expressioni

Tissue specificityi

Highly expressed in liver, prostate and testis. Lower levels in small intestine, kidney and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000139144.
CleanExiHS_PIK3C2G.
ExpressionAtlasiO75747. baseline and differential.
GenevisibleiO75747. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000266497.

Chemistry databases

BindingDBiO75747.

Structurei

Secondary structure

11445
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1204 – 1214Combined sources11
Beta strandi1217 – 1227Combined sources11
Beta strandi1232 – 1237Combined sources6
Helixi1239 – 1252Combined sources14
Turni1253 – 1255Combined sources3
Helixi1267 – 1271Combined sources5
Helixi1273 – 1287Combined sources15
Helixi1292 – 1295Combined sources4
Helixi1298 – 1305Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WWEX-ray1.25A1204-1307[»]
ProteinModelPortaliO75747.
SMRiO75747.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75747.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini285 – 371PI3K-RBDPROSITE-ProRule annotationAdd BLAST87
Domaini453 – 628C2 PI3K-typePROSITE-ProRule annotationAdd BLAST176
Domaini643 – 819PIK helicalPROSITE-ProRule annotationAdd BLAST177
Domaini916 – 1180PI3K/PI4KPROSITE-ProRule annotationAdd BLAST265
Domaini1199 – 1311PXPROSITE-ProRule annotationAdd BLAST113
Domaini1328 – 1424C2Add BLAST97

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotation
Contains 1 C2 domain.Curated
Contains 1 C2 PI3K-type domain.PROSITE-ProRule annotation
Contains 1 PI3K-RBD domain.PROSITE-ProRule annotation
Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation
Contains 1 PIK helical domain.PROSITE-ProRule annotation
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0905. Eukaryota.
COG5032. LUCA.
GeneTreeiENSGT00760000119110.
HOGENOMiHOG000168239.
HOVERGENiHBG053398.
InParanoidiO75747.
KOiK00923.
PhylomeDBiO75747.
TreeFamiTF102031.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 2 hits.
3.30.1520.10. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR001683. Phox.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF00168. C2. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
PF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
SM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 2 hits.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
PS50195. PX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75747-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYSWQTDPN PNESHEKQYE HQEFLFVNQP HSSSQVSLGF DQIVDEISGK
60 70 80 90 100
IPHYESEIDE NTFFVPTAPK WDSTGHSLNE AHQISLNEFT SKSRELSWHQ
110 120 130 140 150
VSKAPAIGFS PSVLPKPQNT NKECSWGSPI GKHHGADDSR FSILAPSFTS
160 170 180 190 200
LDKINLEKEL ENENHNYHIG FESSIPPTNS SFSSDFMPKE ENKRSGHVNI
210 220 230 240 250
VEPSLMLLKG SLQPGMWEST WQKNIESIGC SIQLVEVPQS SNTSLASFCN
260 270 280 290 300
KVKKIRERYH AADVNFNSGK IWSTTTAFPY QLFSKTKFNI HIFIDNSTQP
310 320 330 340 350
LHFMPCANYL VKDLIAEILH FCTNDQLLPK DHILSVCGSE EFLQNDHCLG
360 370 380 390 400
SHKMFQKDKS VIQLHLQKSR EAPGKLSRKH EEDHSQFYLN QLLEFMHIWK
410 420 430 440 450
VSRQCLLTLI RKYDFHLKYL LKTQENVYNI IEEVKKICSV LGCVETKQIT
460 470 480 490 500
DAVNELSLIL QRKGENFYQS SETSAKGLIE KVTTELSTSI YQLINVYCNS
510 520 530 540 550
FYADFQPVNV PRCTSYLNPG LPSHLSFTVY AAHNIPETWV HRINFPLEIK
560 570 580 590 600
SLPRESMLTV KLFGIACATN NANLLAWTCL PLFPKEKSIL GSMLFSMTLQ
610 620 630 640 650
SEPPVEMITP GVWDVSQPSP VTLQIDFPAT GWEYMKPDSE ENRSNLEEPL
660 670 680 690 700
KECIKHIARL SQKQTPLLLS EEKKRYLWFY RFYCNNENCS LPLVLGSAPG
710 720 730 740 750
WDERTVSEMH TILRRWTFSQ PLEALGLLTS SFPDQEIRKV AVQQLDNLLN
760 770 780 790 800
DELLEYLPQL VQAVKFEWNL ESPLVQLLLH RSLQSIQVAH RLYWLLKNAE
810 820 830 840 850
NEAYFKSWYQ KLLAALQFCA GKALNDEFSK EQKLIKILGD IGERVKSASD
860 870 880 890 900
HQRQEVLKKE IGRLEEFFQD VNTCHLPLNP ALCIKGIDHD ACSYFTSNAL
910 920 930 940 950
PLKITFINAN PMGKNISIIF KAGDDLRQDM LVLQLIQVMD NIWLQEGLDM
960 970 980 990 1000
QMIIYRCLST GKDQGLVQMV PDAVTLAKIH RHSGLIGPLK ENTIKKWFSQ
1010 1020 1030 1040 1050
HNHLKADYEK ALRNFFYSCA GWCVVTFILG VCDRHNDNIM LTKSGHMFHI
1060 1070 1080 1090 1100
DFGKFLGHAQ TFGGIKRDRA PFIFTSEMEY FITEGGKNPQ HFQDFVELCC
1110 1120 1130 1140 1150
RAYNIIRKHS QLLLNLLEMM LYAGLPELSG IQDLKYVYNN LRPQDTDLEA
1160 1170 1180 1190 1200
TSHFTKKIKE SLECFPVKLN NLIHTLAQMS AISPAKSTSQ TFPQESCLLS
1210 1220 1230 1240 1250
TTRSIERATI LGFSKKSSNL YLIQVTHSNN ETSLTEKSFE QFSKLHSQLQ
1260 1270 1280 1290 1300
KQFASLTLPE FPHWWHLPFT NSDHRRFRDL NHYMEQILNV SHEVTNSDCV
1310 1320 1330 1340 1350
LSFFLSEAVQ QTVEESSPVY LGEKFPDKKP KVQLVISYED VKLTILVKHM
1360 1370 1380 1390 1400
KNIHLPDGSA PSAHVEFYLL PYPSEVRRRK TKSVPKCTDP TYNEIVVYDE
1410 1420 1430 1440
VTELQGHVLM LIVKSKTVFV GAINIRLCSV PLDKEKWYPL GNSII
Length:1,445
Mass (Da):165,715
Last modified:November 30, 2010 - v3
Checksum:i8D02A3620AE4318D
GO

Sequence cautioni

The sequence CAA03853 differs from that shown. Reason: Erroneous termination at position 1446. Translated as stop.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti129Missing in EAW96387 (Ref. 3) Curated1
Sequence conflicti129Missing in AAI30278 (PubMed:15489334).Curated1
Sequence conflicti965G → R in CAA03853 (PubMed:9878262).Curated1
Sequence conflicti1209Missing in CAA03853 (PubMed:9878262).Curated1
Sequence conflicti1314Missing in CAA03853 (PubMed:9878262).Curated1
Sequence conflicti1323E → EK in CAA03853 (PubMed:9878262).Curated1
Sequence conflicti1377R → L in CAA03853 (PubMed:9878262).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_056676146P → L.3 PublicationsCorresponds to variant rs11044004dbSNPEnsembl.1
Natural variantiVAR_056677261A → E.Corresponds to variant rs7133666dbSNPEnsembl.1
Natural variantiVAR_060323911P → L.3 PublicationsCorresponds to variant rs12312266dbSNPEnsembl.1
Natural variantiVAR_0603241290V → G.Corresponds to variant rs12099555dbSNPEnsembl.1
Natural variantiVAR_0603251442N → T.Corresponds to variant rs12816860dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000008 mRNA. Translation: CAA03853.1. Sequence problems.
AC087236 Genomic DNA. No translation available.
AC087240 Genomic DNA. No translation available.
AC091815 Genomic DNA. No translation available.
AC092851 Genomic DNA. No translation available.
CH471094 Genomic DNA. Translation: EAW96387.1.
BC130277 mRNA. Translation: AAI30278.1.
CCDSiCCDS44839.1.
PIRiPC4347.
RefSeqiNP_001275701.1. NM_001288772.1.
NP_001275703.1. NM_001288774.1.
NP_004561.3. NM_004570.5.
UniGeneiHs.22500.

Genome annotation databases

EnsembliENST00000266497; ENSP00000266497; ENSG00000139144.
ENST00000433979; ENSP00000404845; ENSG00000139144.
GeneIDi5288.
KEGGihsa:5288.
UCSCiuc001rdt.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000008 mRNA. Translation: CAA03853.1. Sequence problems.
AC087236 Genomic DNA. No translation available.
AC087240 Genomic DNA. No translation available.
AC091815 Genomic DNA. No translation available.
AC092851 Genomic DNA. No translation available.
CH471094 Genomic DNA. Translation: EAW96387.1.
BC130277 mRNA. Translation: AAI30278.1.
CCDSiCCDS44839.1.
PIRiPC4347.
RefSeqiNP_001275701.1. NM_001288772.1.
NP_001275703.1. NM_001288774.1.
NP_004561.3. NM_004570.5.
UniGeneiHs.22500.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WWEX-ray1.25A1204-1307[»]
ProteinModelPortaliO75747.
SMRiO75747.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000266497.

Chemistry databases

BindingDBiO75747.
ChEMBLiCHEMBL1163120.
GuidetoPHARMACOLOGYi2288.

PTM databases

iPTMnetiO75747.
PhosphoSitePlusiO75747.

Proteomic databases

PaxDbiO75747.
PeptideAtlasiO75747.
PRIDEiO75747.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266497; ENSP00000266497; ENSG00000139144.
ENST00000433979; ENSP00000404845; ENSG00000139144.
GeneIDi5288.
KEGGihsa:5288.
UCSCiuc001rdt.4. human.

Organism-specific databases

CTDi5288.
DisGeNETi5288.
GeneCardsiPIK3C2G.
H-InvDBHIX0036732.
HGNCiHGNC:8973. PIK3C2G.
MIMi609001. gene.
neXtProtiNX_O75747.
OpenTargetsiENSG00000139144.
PharmGKBiPA33306.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0905. Eukaryota.
COG5032. LUCA.
GeneTreeiENSGT00760000119110.
HOGENOMiHOG000168239.
HOVERGENiHBG053398.
InParanoidiO75747.
KOiK00923.
PhylomeDBiO75747.
TreeFamiTF102031.

Enzyme and pathway databases

BioCyciMetaCyc:HS06583-MONOMER.
ZFISH:HS06583-MONOMER.
BRENDAi2.7.1.137. 2681.
2.7.1.154. 2681.
ReactomeiR-HSA-1660499. Synthesis of PIPs at the plasma membrane.
R-HSA-1660514. Synthesis of PIPs at the Golgi membrane.

Miscellaneous databases

EvolutionaryTraceiO75747.
GeneWikiiPIK3C2G.
GenomeRNAii5288.
PROiO75747.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139144.
CleanExiHS_PIK3C2G.
ExpressionAtlasiO75747. baseline and differential.
GenevisibleiO75747. HS.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 2 hits.
3.30.1520.10. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR001683. Phox.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF00168. C2. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
PF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
SM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 2 hits.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
PS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP3C2G_HUMAN
AccessioniPrimary (citable) accession number: O75747
Secondary accession number(s): A1L3U0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 30, 2010
Last modified: November 2, 2016
This is version 159 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.