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O75747

- P3C2G_HUMAN

UniProt

O75747 - P3C2G_HUMAN

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Protein
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
Gene
PIK3C2G
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis By similarity.

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate.

GO - Molecular functioni

  1. 1-phosphatidylinositol-3-kinase activity Source: UniProtKB
  2. 1-phosphatidylinositol-4-phosphate 3-kinase activity Source: RefGenome
  3. ATP binding Source: UniProtKB-KW
  4. phosphatidylinositol binding Source: InterPro
  5. phosphatidylinositol phosphate kinase activity Source: UniProtKB

GO - Biological processi

  1. chemotaxis Source: UniProtKB-KW
  2. phosphatidylinositol biosynthetic process Source: Reactome
  3. phosphatidylinositol-3-phosphate biosynthetic process Source: GOC
  4. phosphatidylinositol-mediated signaling Source: InterPro
  5. phospholipid metabolic process Source: Reactome
  6. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Chemotaxis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS06583-MONOMER.
BRENDAi2.7.1.137. 2681.
ReactomeiREACT_120836. Synthesis of PIPs at the Golgi membrane.
REACT_121025. Synthesis of PIPs at the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma (EC:2.7.1.154)
Short name:
PI3K-C2-gamma
Short name:
PtdIns-3-kinase C2 subunit gamma
Alternative name(s):
Phosphoinositide 3-kinase-C2-gamma
Gene namesi
Name:PIK3C2G
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:8973. PIK3C2G.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. phosphatidylinositol 3-kinase complex Source: RefGenome
  3. plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33306.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14451445Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
PRO_0000088799Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei419 – 4191Phosphotyrosine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO75747.
PRIDEiO75747.

PTM databases

PhosphoSiteiO75747.

Expressioni

Tissue specificityi

Highly expressed in liver, prostate and testis. Lower levels in small intestine, kidney and pancreas.1 Publication

Gene expression databases

ArrayExpressiO75747.
BgeeiO75747.
CleanExiHS_PIK3C2G.
GenevestigatoriO75747.

Interactioni

Protein-protein interaction databases

BioGridi111306. 1 interaction.
STRINGi9606.ENSP00000404845.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1204 – 121411
Beta strandi1217 – 122711
Beta strandi1232 – 12376
Helixi1239 – 125214
Turni1253 – 12553
Helixi1267 – 12715
Helixi1273 – 128715
Helixi1292 – 12954
Helixi1298 – 13058

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WWEX-ray1.25A1204-1307[»]
ProteinModelPortaliO75747.
SMRiO75747. Positions 539-1162, 1204-1307, 1332-1440.

Miscellaneous databases

EvolutionaryTraceiO75747.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini285 – 37187PI3K-RBD
Add
BLAST
Domaini453 – 628176C2 PI3K-type
Add
BLAST
Domaini643 – 819177PIK helical
Add
BLAST
Domaini916 – 1180265PI3K/PI4K
Add
BLAST
Domaini1199 – 1311113PX
Add
BLAST
Domaini1328 – 142497C2
Add
BLAST

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.
Contains 1 C2 domain.
Contains 1 PI3K-RBD domain.
Contains 1 PI3K/PI4K domain.
Contains 1 PIK helical domain.

Phylogenomic databases

eggNOGiCOG5032.
HOGENOMiHOG000168239.
HOVERGENiHBG053398.
InParanoidiO75747.
KOiK00923.
PhylomeDBiO75747.
TreeFamiTF102031.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 2 hits.
3.30.1520.10. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR001683. Phox.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
PF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00142. PI3K_C2. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
SM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 2 hits.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
PS50195. PX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75747-1 [UniParc]FASTAAdd to Basket

« Hide

MAYSWQTDPN PNESHEKQYE HQEFLFVNQP HSSSQVSLGF DQIVDEISGK     50
IPHYESEIDE NTFFVPTAPK WDSTGHSLNE AHQISLNEFT SKSRELSWHQ 100
VSKAPAIGFS PSVLPKPQNT NKECSWGSPI GKHHGADDSR FSILAPSFTS 150
LDKINLEKEL ENENHNYHIG FESSIPPTNS SFSSDFMPKE ENKRSGHVNI 200
VEPSLMLLKG SLQPGMWEST WQKNIESIGC SIQLVEVPQS SNTSLASFCN 250
KVKKIRERYH AADVNFNSGK IWSTTTAFPY QLFSKTKFNI HIFIDNSTQP 300
LHFMPCANYL VKDLIAEILH FCTNDQLLPK DHILSVCGSE EFLQNDHCLG 350
SHKMFQKDKS VIQLHLQKSR EAPGKLSRKH EEDHSQFYLN QLLEFMHIWK 400
VSRQCLLTLI RKYDFHLKYL LKTQENVYNI IEEVKKICSV LGCVETKQIT 450
DAVNELSLIL QRKGENFYQS SETSAKGLIE KVTTELSTSI YQLINVYCNS 500
FYADFQPVNV PRCTSYLNPG LPSHLSFTVY AAHNIPETWV HRINFPLEIK 550
SLPRESMLTV KLFGIACATN NANLLAWTCL PLFPKEKSIL GSMLFSMTLQ 600
SEPPVEMITP GVWDVSQPSP VTLQIDFPAT GWEYMKPDSE ENRSNLEEPL 650
KECIKHIARL SQKQTPLLLS EEKKRYLWFY RFYCNNENCS LPLVLGSAPG 700
WDERTVSEMH TILRRWTFSQ PLEALGLLTS SFPDQEIRKV AVQQLDNLLN 750
DELLEYLPQL VQAVKFEWNL ESPLVQLLLH RSLQSIQVAH RLYWLLKNAE 800
NEAYFKSWYQ KLLAALQFCA GKALNDEFSK EQKLIKILGD IGERVKSASD 850
HQRQEVLKKE IGRLEEFFQD VNTCHLPLNP ALCIKGIDHD ACSYFTSNAL 900
PLKITFINAN PMGKNISIIF KAGDDLRQDM LVLQLIQVMD NIWLQEGLDM 950
QMIIYRCLST GKDQGLVQMV PDAVTLAKIH RHSGLIGPLK ENTIKKWFSQ 1000
HNHLKADYEK ALRNFFYSCA GWCVVTFILG VCDRHNDNIM LTKSGHMFHI 1050
DFGKFLGHAQ TFGGIKRDRA PFIFTSEMEY FITEGGKNPQ HFQDFVELCC 1100
RAYNIIRKHS QLLLNLLEMM LYAGLPELSG IQDLKYVYNN LRPQDTDLEA 1150
TSHFTKKIKE SLECFPVKLN NLIHTLAQMS AISPAKSTSQ TFPQESCLLS 1200
TTRSIERATI LGFSKKSSNL YLIQVTHSNN ETSLTEKSFE QFSKLHSQLQ 1250
KQFASLTLPE FPHWWHLPFT NSDHRRFRDL NHYMEQILNV SHEVTNSDCV 1300
LSFFLSEAVQ QTVEESSPVY LGEKFPDKKP KVQLVISYED VKLTILVKHM 1350
KNIHLPDGSA PSAHVEFYLL PYPSEVRRRK TKSVPKCTDP TYNEIVVYDE 1400
VTELQGHVLM LIVKSKTVFV GAINIRLCSV PLDKEKWYPL GNSII 1445
Length:1,445
Mass (Da):165,715
Last modified:November 30, 2010 - v3
Checksum:i8D02A3620AE4318D
GO

Sequence cautioni

The sequence CAA03853.1 differs from that shown. Reason: Erroneous termination at position 1446. Translated as stop.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti146 – 1461P → L.3 Publications
Corresponds to variant rs11044004 [ dbSNP | Ensembl ].
VAR_056676
Natural varianti261 – 2611A → E.
Corresponds to variant rs7133666 [ dbSNP | Ensembl ].
VAR_056677
Natural varianti911 – 9111P → L.3 Publications
Corresponds to variant rs12312266 [ dbSNP | Ensembl ].
VAR_060323
Natural varianti1290 – 12901V → G.
Corresponds to variant rs12099555 [ dbSNP | Ensembl ].
VAR_060324
Natural varianti1442 – 14421N → T.
Corresponds to variant rs12816860 [ dbSNP | Ensembl ].
VAR_060325

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti129 – 1291Missing in EAW96387. 1 Publication
Sequence conflicti129 – 1291Missing in AAI30278. 1 Publication
Sequence conflicti965 – 9651G → R in CAA03853. 1 Publication
Sequence conflicti1209 – 12091Missing in CAA03853. 1 Publication
Sequence conflicti1314 – 13141Missing in CAA03853. 1 Publication
Sequence conflicti1323 – 13231E → EK in CAA03853. 1 Publication
Sequence conflicti1377 – 13771R → L in CAA03853. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ000008 mRNA. Translation: CAA03853.1. Sequence problems.
AC087236 Genomic DNA. No translation available.
AC087240 Genomic DNA. No translation available.
AC091815 Genomic DNA. No translation available.
AC092851 Genomic DNA. No translation available.
CH471094 Genomic DNA. Translation: EAW96387.1.
BC130277 mRNA. Translation: AAI30278.1.
CCDSiCCDS44839.1.
PIRiPC4347.
RefSeqiNP_001275701.1. NM_001288772.1.
NP_001275703.1. NM_001288774.1.
NP_004561.3. NM_004570.5.
UniGeneiHs.22500.

Genome annotation databases

EnsembliENST00000266497; ENSP00000266497; ENSG00000139144.
ENST00000433979; ENSP00000404845; ENSG00000139144.
GeneIDi5288.
KEGGihsa:5288.
UCSCiuc001rdt.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ000008 mRNA. Translation: CAA03853.1 . Sequence problems.
AC087236 Genomic DNA. No translation available.
AC087240 Genomic DNA. No translation available.
AC091815 Genomic DNA. No translation available.
AC092851 Genomic DNA. No translation available.
CH471094 Genomic DNA. Translation: EAW96387.1 .
BC130277 mRNA. Translation: AAI30278.1 .
CCDSi CCDS44839.1.
PIRi PC4347.
RefSeqi NP_001275701.1. NM_001288772.1.
NP_001275703.1. NM_001288774.1.
NP_004561.3. NM_004570.5.
UniGenei Hs.22500.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2WWE X-ray 1.25 A 1204-1307 [» ]
ProteinModelPortali O75747.
SMRi O75747. Positions 539-1162, 1204-1307, 1332-1440.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111306. 1 interaction.
STRINGi 9606.ENSP00000404845.

Chemistry

BindingDBi O75747.
ChEMBLi CHEMBL1163120.
GuidetoPHARMACOLOGYi 2288.

PTM databases

PhosphoSitei O75747.

Proteomic databases

PaxDbi O75747.
PRIDEi O75747.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000266497 ; ENSP00000266497 ; ENSG00000139144 .
ENST00000433979 ; ENSP00000404845 ; ENSG00000139144 .
GeneIDi 5288.
KEGGi hsa:5288.
UCSCi uc001rdt.3. human.

Organism-specific databases

CTDi 5288.
GeneCardsi GC12P018414.
H-InvDB HIX0036732.
HGNCi HGNC:8973. PIK3C2G.
MIMi 609001. gene.
neXtProti NX_O75747.
PharmGKBi PA33306.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5032.
HOGENOMi HOG000168239.
HOVERGENi HBG053398.
InParanoidi O75747.
KOi K00923.
PhylomeDBi O75747.
TreeFami TF102031.

Enzyme and pathway databases

BioCyci MetaCyc:HS06583-MONOMER.
BRENDAi 2.7.1.137. 2681.
Reactomei REACT_120836. Synthesis of PIPs at the Golgi membrane.
REACT_121025. Synthesis of PIPs at the plasma membrane.

Miscellaneous databases

EvolutionaryTracei O75747.
GeneWikii PIK3C2G.
GenomeRNAii 5288.
NextBioi 20434.
PROi O75747.
SOURCEi Search...

Gene expression databases

ArrayExpressi O75747.
Bgeei O75747.
CleanExi HS_PIK3C2G.
Genevestigatori O75747.

Family and domain databases

Gene3Di 1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 2 hits.
3.30.1520.10. 1 hit.
InterProi IPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR001683. Phox.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
PANTHERi PTHR10048. PTHR10048. 1 hit.
Pfami PF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
PF00787. PX. 1 hit.
[Graphical view ]
SMARTi SM00239. C2. 1 hit.
SM00142. PI3K_C2. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
SM00312. PX. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 2 hits.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEi PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
PS50195. PX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2gamma, and chromosomal assignment of this gene (PIK3C2G) to 12p12."
    Rozycka M., Lu Y.-J., Brown R.A., Lau M.R., Shipley J.M., Fry M.J.
    Genomics 54:569-574(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT LEU-911.
    Tissue: Liver, Mammary gland and Prostate.
  2. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS LEU-146 AND LEU-911.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LEU-146 AND LEU-911.
  5. "Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line."
    Giorgianni F., Zhao Y., Desiderio D.M., Beranova-Giorgianni S.
    Electrophoresis 28:2027-2034(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-419, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Prostate cancer.
  6. Cited for: VARIANT LEU-146.
  7. "Crystal structure of the phox homology domain of human phosphoinositide-3-kinase-C2-gamma."
    Structural genomics consortium (SGC)
    Submitted (NOV-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.25 ANGSTROMS) OF 1204-1307.

Entry informationi

Entry nameiP3C2G_HUMAN
AccessioniPrimary (citable) accession number: O75747
Secondary accession number(s): A1L3U0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 30, 2010
Last modified: September 3, 2014
This is version 138 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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