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Protein

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma

Gene

PIK3C2G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis (By similarity).By similarity

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate.

GO - Molecular functioni

GO - Biological processi

  • cell migration Source: GO_Central
  • chemotaxis Source: UniProtKB-KW
  • phosphatidylinositol 3-kinase signaling Source: GO_Central
  • viral RNA genome replication Source: ParkinsonsUK-UCL

Keywordsi

Molecular functionKinase, Transferase
Biological processChemotaxis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS06583-MONOMER
BRENDAi2.7.1.137 2681
2.7.1.154 2681
ReactomeiR-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-1660514 Synthesis of PIPs at the Golgi membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma (EC:2.7.1.154)
Short name:
PI3K-C2-gamma
Short name:
PtdIns-3-kinase C2 subunit gamma
Alternative name(s):
Phosphoinositide 3-kinase-C2-gamma
Gene namesi
Name:PIK3C2G
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000139144.9
HGNCiHGNC:8973 PIK3C2G
MIMi609001 gene
neXtProtiNX_O75747

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5288
OpenTargetsiENSG00000139144
PharmGKBiPA33306

Chemistry databases

ChEMBLiCHEMBL1163120
GuidetoPHARMACOLOGYi2288

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000887991 – 1445Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gammaAdd BLAST1445

Proteomic databases

PaxDbiO75747
PeptideAtlasiO75747
PRIDEiO75747

PTM databases

iPTMnetiO75747
PhosphoSitePlusiO75747

Expressioni

Tissue specificityi

Highly expressed in liver, prostate and testis. Lower levels in small intestine, kidney and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000139144
CleanExiHS_PIK3C2G
ExpressionAtlasiO75747 baseline and differential
GenevisibleiO75747 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000266497

Chemistry databases

BindingDBiO75747

Structurei

Secondary structure

11445
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1202 – 1214Combined sources13
Beta strandi1217 – 1227Combined sources11
Beta strandi1232 – 1237Combined sources6
Helixi1239 – 1252Combined sources14
Turni1253 – 1255Combined sources3
Helixi1267 – 1271Combined sources5
Helixi1273 – 1287Combined sources15
Helixi1292 – 1295Combined sources4
Helixi1298 – 1305Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WWEX-ray1.25A1204-1307[»]
ProteinModelPortaliO75747
SMRiO75747
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75747

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini285 – 371PI3K-RBDPROSITE-ProRule annotationAdd BLAST87
Domaini453 – 628C2 PI3K-typePROSITE-ProRule annotationAdd BLAST176
Domaini643 – 819PIK helicalPROSITE-ProRule annotationAdd BLAST177
Domaini916 – 1180PI3K/PI4KPROSITE-ProRule annotationAdd BLAST265
Domaini1199 – 1311PXPROSITE-ProRule annotationAdd BLAST113
Domaini1328 – 1424C2Add BLAST97

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0905 Eukaryota
COG5032 LUCA
GeneTreeiENSGT00760000119110
HOGENOMiHOG000168239
HOVERGENiHBG053398
InParanoidiO75747
KOiK00923
PhylomeDBiO75747
TreeFamiTF102031

Family and domain databases

CDDicd05177 PI3Kc_C2_gamma, 1 hit
Gene3Di1.10.1070.11, 1 hit
2.60.40.150, 1 hit
3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011009 Kinase-like_dom_sf
IPR001683 Phox
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR037707 PI3K-C2-gamma_dom
IPR002420 PI3K_C2_dom
IPR000341 PI3K_Ras-bd_dom
IPR015433 PI_Kinase
IPR001263 PInositide-3_kin_accessory_dom
IPR036871 PX_dom_sf
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR10048 PTHR10048, 2 hits
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF00454 PI3_PI4_kinase, 1 hit
PF00794 PI3K_rbd, 1 hit
PF00613 PI3Ka, 1 hit
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00145 PI3Ka, 1 hit
SM00146 PI3Kc, 1 hit
SM00312 PX, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF54236 SSF54236, 1 hit
SSF56112 SSF56112, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51547 PI3K_C2, 1 hit
PS51546 PI3K_RBD, 1 hit
PS51545 PIK_HELICAL, 1 hit
PS50195 PX, 1 hit

Sequencei

Sequence statusi: Complete.

O75747-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYSWQTDPN PNESHEKQYE HQEFLFVNQP HSSSQVSLGF DQIVDEISGK
60 70 80 90 100
IPHYESEIDE NTFFVPTAPK WDSTGHSLNE AHQISLNEFT SKSRELSWHQ
110 120 130 140 150
VSKAPAIGFS PSVLPKPQNT NKECSWGSPI GKHHGADDSR FSILAPSFTS
160 170 180 190 200
LDKINLEKEL ENENHNYHIG FESSIPPTNS SFSSDFMPKE ENKRSGHVNI
210 220 230 240 250
VEPSLMLLKG SLQPGMWEST WQKNIESIGC SIQLVEVPQS SNTSLASFCN
260 270 280 290 300
KVKKIRERYH AADVNFNSGK IWSTTTAFPY QLFSKTKFNI HIFIDNSTQP
310 320 330 340 350
LHFMPCANYL VKDLIAEILH FCTNDQLLPK DHILSVCGSE EFLQNDHCLG
360 370 380 390 400
SHKMFQKDKS VIQLHLQKSR EAPGKLSRKH EEDHSQFYLN QLLEFMHIWK
410 420 430 440 450
VSRQCLLTLI RKYDFHLKYL LKTQENVYNI IEEVKKICSV LGCVETKQIT
460 470 480 490 500
DAVNELSLIL QRKGENFYQS SETSAKGLIE KVTTELSTSI YQLINVYCNS
510 520 530 540 550
FYADFQPVNV PRCTSYLNPG LPSHLSFTVY AAHNIPETWV HRINFPLEIK
560 570 580 590 600
SLPRESMLTV KLFGIACATN NANLLAWTCL PLFPKEKSIL GSMLFSMTLQ
610 620 630 640 650
SEPPVEMITP GVWDVSQPSP VTLQIDFPAT GWEYMKPDSE ENRSNLEEPL
660 670 680 690 700
KECIKHIARL SQKQTPLLLS EEKKRYLWFY RFYCNNENCS LPLVLGSAPG
710 720 730 740 750
WDERTVSEMH TILRRWTFSQ PLEALGLLTS SFPDQEIRKV AVQQLDNLLN
760 770 780 790 800
DELLEYLPQL VQAVKFEWNL ESPLVQLLLH RSLQSIQVAH RLYWLLKNAE
810 820 830 840 850
NEAYFKSWYQ KLLAALQFCA GKALNDEFSK EQKLIKILGD IGERVKSASD
860 870 880 890 900
HQRQEVLKKE IGRLEEFFQD VNTCHLPLNP ALCIKGIDHD ACSYFTSNAL
910 920 930 940 950
PLKITFINAN PMGKNISIIF KAGDDLRQDM LVLQLIQVMD NIWLQEGLDM
960 970 980 990 1000
QMIIYRCLST GKDQGLVQMV PDAVTLAKIH RHSGLIGPLK ENTIKKWFSQ
1010 1020 1030 1040 1050
HNHLKADYEK ALRNFFYSCA GWCVVTFILG VCDRHNDNIM LTKSGHMFHI
1060 1070 1080 1090 1100
DFGKFLGHAQ TFGGIKRDRA PFIFTSEMEY FITEGGKNPQ HFQDFVELCC
1110 1120 1130 1140 1150
RAYNIIRKHS QLLLNLLEMM LYAGLPELSG IQDLKYVYNN LRPQDTDLEA
1160 1170 1180 1190 1200
TSHFTKKIKE SLECFPVKLN NLIHTLAQMS AISPAKSTSQ TFPQESCLLS
1210 1220 1230 1240 1250
TTRSIERATI LGFSKKSSNL YLIQVTHSNN ETSLTEKSFE QFSKLHSQLQ
1260 1270 1280 1290 1300
KQFASLTLPE FPHWWHLPFT NSDHRRFRDL NHYMEQILNV SHEVTNSDCV
1310 1320 1330 1340 1350
LSFFLSEAVQ QTVEESSPVY LGEKFPDKKP KVQLVISYED VKLTILVKHM
1360 1370 1380 1390 1400
KNIHLPDGSA PSAHVEFYLL PYPSEVRRRK TKSVPKCTDP TYNEIVVYDE
1410 1420 1430 1440
VTELQGHVLM LIVKSKTVFV GAINIRLCSV PLDKEKWYPL GNSII
Length:1,445
Mass (Da):165,715
Last modified:November 30, 2010 - v3
Checksum:i8D02A3620AE4318D
GO

Sequence cautioni

The sequence CAA03853 differs from that shown. Reason: Erroneous termination at position 1446. Translated as stop.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti129Missing in EAW96387 (Ref. 3) Curated1
Sequence conflicti129Missing in AAI30278 (PubMed:15489334).Curated1
Sequence conflicti965G → R in CAA03853 (PubMed:9878262).Curated1
Sequence conflicti1209Missing in CAA03853 (PubMed:9878262).Curated1
Sequence conflicti1314Missing in CAA03853 (PubMed:9878262).Curated1
Sequence conflicti1323E → EK in CAA03853 (PubMed:9878262).Curated1
Sequence conflicti1377R → L in CAA03853 (PubMed:9878262).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_056676146P → L3 PublicationsCorresponds to variant dbSNP:rs11044004Ensembl.1
Natural variantiVAR_056677261A → E. Corresponds to variant dbSNP:rs7133666Ensembl.1
Natural variantiVAR_060323911P → L3 PublicationsCorresponds to variant dbSNP:rs12312266Ensembl.1
Natural variantiVAR_0603241290V → G. Corresponds to variant dbSNP:rs12099555Ensembl.1
Natural variantiVAR_0603251442N → T. Corresponds to variant dbSNP:rs12816860Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000008 mRNA Translation: CAA03853.1 Sequence problems.
AC087236 Genomic DNA No translation available.
AC087240 Genomic DNA No translation available.
AC091815 Genomic DNA No translation available.
AC092851 Genomic DNA No translation available.
CH471094 Genomic DNA Translation: EAW96387.1
BC130277 mRNA Translation: AAI30278.1
CCDSiCCDS44839.1
PIRiPC4347
RefSeqiNP_001275701.1, NM_001288772.1
NP_001275703.1, NM_001288774.1
NP_004561.3, NM_004570.5
UniGeneiHs.22500

Genome annotation databases

EnsembliENST00000266497; ENSP00000266497; ENSG00000139144
ENST00000433979; ENSP00000404845; ENSG00000139144
GeneIDi5288
KEGGihsa:5288
UCSCiuc001rdt.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiP3C2G_HUMAN
AccessioniPrimary (citable) accession number: O75747
Secondary accession number(s): A1L3U0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 30, 2010
Last modified: May 23, 2018
This is version 168 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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