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O75717

- WDHD1_HUMAN

UniProt

O75717 - WDHD1_HUMAN

Protein

WD repeat and HMG-box DNA-binding protein 1

Gene

WDHD1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi1016 – 107964HMG boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. DNA binding Source: ProtInc
    3. protein binding Source: IntAct
    4. RNA binding Source: Ensembl

    GO - Biological processi

    1. heterochromatin maintenance Source: Ensembl
    2. regulation of chromosome organization Source: Ensembl
    3. RNA processing Source: Ensembl

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    SignaLinkiO75717.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    WD repeat and HMG-box DNA-binding protein 1
    Alternative name(s):
    Acidic nucleoplasmic DNA-binding protein 1
    Short name:
    And-1
    Gene namesi
    Name:WDHD1
    Synonyms:AND1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:23170. WDHD1.

    Subcellular locationi

    Nucleusnucleoplasm By similarity

    GO - Cellular componenti

    1. chromosome, centromeric region Source: Ensembl
    2. cytoplasm Source: ProtInc
    3. nucleoplasm Source: ProtInc
    4. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134988782.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11291129WD repeat and HMG-box DNA-binding protein 1PRO_0000051338Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei333 – 3331Phosphoserine3 Publications
    Modified residuei374 – 3741Phosphoserine3 Publications
    Modified residuei383 – 3831Phosphoserine5 Publications
    Modified residuei387 – 3871Phosphoserine2 Publications
    Modified residuei671 – 6711N6-acetyllysineBy similarity
    Modified residuei824 – 8241Phosphothreonine1 Publication
    Modified residuei868 – 8681Phosphoserine3 Publications
    Modified residuei962 – 9621N6-acetyllysine1 Publication
    Modified residuei984 – 9841Phosphoserine1 Publication
    Modified residuei1090 – 10901Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiO75717.
    PaxDbiO75717.
    PRIDEiO75717.

    PTM databases

    PhosphoSiteiO75717.

    Expressioni

    Gene expression databases

    ArrayExpressiO75717.
    BgeeiO75717.
    CleanExiHS_WDHD1.
    GenevestigatoriO75717.

    Organism-specific databases

    HPAiHPA001122.

    Interactioni

    Subunit structurei

    Interacts with the polymerase alpha catalytic subunit POLA1. Interacts with MCM10. Interacts with DNA2.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    KAT2AQ928305EBI-3951691,EBI-477622

    Protein-protein interaction databases

    BioGridi116340. 30 interactions.
    IntActiO75717. 2 interactions.
    STRINGi9606.ENSP00000353793.

    Structurei

    Secondary structure

    1
    1129
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi1021 – 103616
    Helixi1043 – 105412
    Beta strandi1055 – 10573
    Helixi1059 – 106810
    Beta strandi1071 – 10766
    Helixi1081 – 10833

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2D7LNMR-A1017-1084[»]
    ProteinModelPortaliO75717.
    SMRiO75717. Positions 11-284, 1017-1084.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO75717.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati11 – 5040WD 1Add
    BLAST
    Repeati52 – 9140WD 2Add
    BLAST
    Repeati92 – 13140WD 3Add
    BLAST
    Repeati134 – 17340WD 4Add
    BLAST
    Repeati184 – 22340WD 5Add
    BLAST
    Repeati228 – 26740WD 6Add
    BLAST
    Repeati271 – 31040WD 7Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi829 – 8368Glu-rich (acidic)
    Compositional biasi862 – 87817Asp/Glu-rich (acidic)Add
    BLAST

    Sequence similaritiesi

    Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation
    Contains 7 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    HOGENOMiHOG000015160.
    HOVERGENiHBG074190.
    InParanoidiO75717.
    KOiK11274.
    OMAiWTPICNT.
    OrthoDBiEOG7J70F9.
    PhylomeDBiO75717.
    TreeFamiTF105988.

    Family and domain databases

    Gene3Di1.10.30.10. 1 hit.
    2.130.10.10. 1 hit.
    InterProiIPR022100. DUF3639.
    IPR009071. HMG_box_dom.
    IPR013979. TIF_beta_prop-like.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF12341. DUF3639. 1 hit.
    PF08662. eIF2A. 1 hit.
    PF00505. HMG_box. 1 hit.
    PF00400. WD40. 2 hits.
    [Graphical view]
    SMARTiSM00398. HMG. 1 hit.
    SM00320. WD40. 5 hits.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 1 hit.
    SSF50978. SSF50978. 1 hit.
    PROSITEiPS50118. HMG_BOX_2. 1 hit.
    PS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 3 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O75717-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPATRKPMRY GHTEGHTEVC FDDSGSFIVT CGSDGDVRIW EDLDDDDPKF     50
    INVGEKAYSC ALKSGKLVTA VSNNTIQVHT FPEGVPDGIL TRFTTNANHV 100
    VFNGDGTKIA AGSSDFLVKI VDVMDSSQQK TFRGHDAPVL SLSFDPKDIF 150
    LASASCDGSV RVWQISDQTC AISWPLLQKC NDVINAKSIC RLAWQPKSGK 200
    LLAIPVEKSV KLYRRESWSH QFDLSDNFIS QTLNIVTWSP CGQYLAAGSI 250
    NGLIIVWNVE TKDCMERVKH EKGYAICGLA WHPTCGRISY TDAEGNLGLL 300
    ENVCDPSGKT SSSKVSSRVE KDYNDLFDGD DMSNAGDFLN DNAVEIPSFS 350
    KGIINDDEDD EDLMMASGRP RQRSHILEDD ENSVDISMLK TGSSLLKEEE 400
    EDGQEGSIHN LPLVTSQRPF YDGPMPTPRQ KPFQSGSTPL HLTHRFMVWN 450
    SIGIIRCYND EQDNAIDVEF HDTSIHHATH LSNTLNYTIA DLSHEAILLA 500
    CESTDELASK LHCLHFSSWD SSKEWIIDLP QNEDIEAICL GQGWAAAATS 550
    ALLLRLFTIG GVQKEVFSLA GPVVSMAGHG EQLFIVYHRG TGFDGDQCLG 600
    VQLLELGKKK KQILHGDPLP LTRKSYLAWI GFSAEGTPCY VDSEGIVRML 650
    NRGLGNTWTP ICNTREHCKG KSDHYWVVGI HENPQQLRCI PCKGSRFPPT 700
    LPRPAVAILS FKLPYCQIAT EKGQMEEQFW RSVIFHNHLD YLAKNGYEYE 750
    ESTKNQATKE QQELLMKMLA LSCKLEREFR CVELADLMTQ NAVNLAIKYA 800
    SRSRKLILAQ KLSELAVEKA AELTATQVEE EEEEEDFRKK LNAGYSNTAT 850
    EWSQPRFRNQ VEEDAEDSGE ADDEEKPEIH KPGQNSFSKS TNSSDVSAKS 900
    GAVTFSSQGR VNPFKVSASS KEPAMSMNSA RSTNILDNMG KSSKKSTALS 950
    RTTNNEKSPI IKPLIPKPKP KQASAASYFQ KRNSQTNKTE EVKEENLKNV 1000
    LSETPAICPP QNTENQRPKT GFQMWLEENR SNILSDNPDF SDEADIIKEG 1050
    MIRFRVLSTE ERKVWANKAK GETASEGTEA KKRKRVVDES DETENQEEKA 1100
    KENLNLSKKQ KPLDFSTNQK LSAFAFKQE 1129
    Length:1,129
    Mass (Da):125,967
    Last modified:November 1, 1998 - v1
    Checksum:iDD3E3613CA6AE70A
    GO
    Isoform 2 (identifier: O75717-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-123: Missing.

    Note: No experimental confirmation available. Derived from EST data.

    Show »
    Length:1,006
    Mass (Da):112,705
    Checksum:i430FD72EAB983984
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti612 – 6121Q → K in AAH43349. (PubMed:15489334)Curated
    Sequence conflicti612 – 6121Q → K in AAH00622. (PubMed:15489334)Curated
    Sequence conflicti613 – 6131I → K in AAH00622. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti338 – 3381F → L.
    Corresponds to variant rs8020032 [ dbSNP | Ensembl ].
    VAR_053422
    Natural varianti411 – 4111L → P.
    Corresponds to variant rs17128116 [ dbSNP | Ensembl ].
    VAR_053423
    Natural varianti1102 – 11021E → K.
    Corresponds to variant rs41309252 [ dbSNP | Ensembl ].
    VAR_062100

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 123123Missing in isoform 2. CuratedVSP_054775Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ006266 mRNA. Translation: CAA06932.1.
    AL160471 Genomic DNA. No translation available.
    BC000622 mRNA. Translation: AAH00622.1.
    BC043349 mRNA. Translation: AAH43349.1.
    BC063041 mRNA. Translation: AAH63041.1.
    CCDSiCCDS41955.1. [O75717-2]
    CCDS9721.1. [O75717-1]
    RefSeqiNP_001008397.1. NM_001008396.2. [O75717-2]
    NP_009017.1. NM_007086.3. [O75717-1]
    UniGeneiHs.385998.

    Genome annotation databases

    EnsembliENST00000360586; ENSP00000353793; ENSG00000198554. [O75717-1]
    ENST00000420358; ENSP00000399349; ENSG00000198554. [O75717-2]
    GeneIDi11169.
    KEGGihsa:11169.
    UCSCiuc001xbm.2. human. [O75717-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ006266 mRNA. Translation: CAA06932.1 .
    AL160471 Genomic DNA. No translation available.
    BC000622 mRNA. Translation: AAH00622.1 .
    BC043349 mRNA. Translation: AAH43349.1 .
    BC063041 mRNA. Translation: AAH63041.1 .
    CCDSi CCDS41955.1. [O75717-2 ]
    CCDS9721.1. [O75717-1 ]
    RefSeqi NP_001008397.1. NM_001008396.2. [O75717-2 ]
    NP_009017.1. NM_007086.3. [O75717-1 ]
    UniGenei Hs.385998.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2D7L NMR - A 1017-1084 [» ]
    ProteinModelPortali O75717.
    SMRi O75717. Positions 11-284, 1017-1084.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116340. 30 interactions.
    IntActi O75717. 2 interactions.
    STRINGi 9606.ENSP00000353793.

    PTM databases

    PhosphoSitei O75717.

    Proteomic databases

    MaxQBi O75717.
    PaxDbi O75717.
    PRIDEi O75717.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000360586 ; ENSP00000353793 ; ENSG00000198554 . [O75717-1 ]
    ENST00000420358 ; ENSP00000399349 ; ENSG00000198554 . [O75717-2 ]
    GeneIDi 11169.
    KEGGi hsa:11169.
    UCSCi uc001xbm.2. human. [O75717-1 ]

    Organism-specific databases

    CTDi 11169.
    GeneCardsi GC14M055405.
    HGNCi HGNC:23170. WDHD1.
    HPAi HPA001122.
    MIMi 608126. gene.
    neXtProti NX_O75717.
    PharmGKBi PA134988782.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2319.
    HOGENOMi HOG000015160.
    HOVERGENi HBG074190.
    InParanoidi O75717.
    KOi K11274.
    OMAi WTPICNT.
    OrthoDBi EOG7J70F9.
    PhylomeDBi O75717.
    TreeFami TF105988.

    Enzyme and pathway databases

    SignaLinki O75717.

    Miscellaneous databases

    EvolutionaryTracei O75717.
    GeneWikii WDHD1.
    GenomeRNAii 11169.
    NextBioi 42497.
    PROi O75717.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75717.
    Bgeei O75717.
    CleanExi HS_WDHD1.
    Genevestigatori O75717.

    Family and domain databases

    Gene3Di 1.10.30.10. 1 hit.
    2.130.10.10. 1 hit.
    InterProi IPR022100. DUF3639.
    IPR009071. HMG_box_dom.
    IPR013979. TIF_beta_prop-like.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF12341. DUF3639. 1 hit.
    PF08662. eIF2A. 1 hit.
    PF00505. HMG_box. 1 hit.
    PF00400. WD40. 2 hits.
    [Graphical view ]
    SMARTi SM00398. HMG. 1 hit.
    SM00320. WD40. 5 hits.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 1 hit.
    SSF50978. SSF50978. 1 hit.
    PROSITEi PS50118. HMG_BOX_2. 1 hit.
    PS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 3 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Koehler A.
      Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Fetal brain.
    2. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Liver, Skin and Uterus.
    4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-374; SER-383 AND SER-868, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. "Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication."
      Zhu W., Ukomadu C., Jha S., Senga T., Dhar S.K., Wohlschlegel J.A., Nutt L.K., Kornbluth S., Dutta A.
      Genes Dev. 21:2288-2299(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH POLA1 AND MCM10.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-824, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-333; SER-383; SER-387; SER-868 AND SER-1090, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins."
      Im J.S., Ki S.H., Farina A., Jung D.S., Hurwitz J., Lee J.K.
      Proc. Natl. Acad. Sci. U.S.A. 106:15628-15632(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-333; SER-374 AND SER-383, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-962, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-333; SER-383 AND SER-387, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-374; SER-383; SER-868 AND SER-984, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication."
      Duxin J.P., Moore H.R., Sidorova J., Karanja K., Honaker Y., Dao B., Piwnica-Worms H., Campbell J.L., Monnat R.J. Jr., Stewart S.A.
      J. Biol. Chem. 287:21980-21991(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DNA2.
    15. "Solution structure of the HMG box domain from human WD repeat and HMG-box DNA binding protein 1."
      RIKEN structural genomics initiative (RSGI)
      Submitted (MAY-2006) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 1017-1084.

    Entry informationi

    Entry nameiWDHD1_HUMAN
    AccessioniPrimary (citable) accession number: O75717
    Secondary accession number(s): C9JW18, F6W0U7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 22, 2003
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 132 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3