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O75716

- STK16_HUMAN

UniProt

O75716 - STK16_HUMAN

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Protein

Serine/threonine-protein kinase 16

Gene

STK16

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei49 – 491ATPPROSITE-ProRule annotation
Active sitei148 – 1481Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi26 – 349ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
  3. protein serine/threonine kinase activity Source: UniProtKB-KW
  4. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl

GO - Biological processi

  1. cellular response to transforming growth factor beta stimulus Source: Ensembl
  2. protein autophosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1. 2681.
SignaLinkiO75716.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 16 (EC:2.7.11.1)
Alternative name(s):
Myristoylated and palmitoylated serine/threonine-protein kinase
Short name:
MPSK
Protein kinase PKL12
TGF-beta-stimulated factor 1
Short name:
TSF-1
Tyrosine-protein kinase STK16 (EC:2.7.10.2)
hPSK
Gene namesi
Name:STK16
Synonyms:MPSK1, PKL12, TSF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:11394. STK16.

Subcellular locationi

Cytoplasmperinuclear region. Membrane By similarity; Lipid-anchor By similarity
Note: Associates with Golgi and Golgi-derived vesicles.By similarity

GO - Cellular componenti

  1. Golgi-associated vesicle Source: Ensembl
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi2 – 21G → A: Loss of myristoylation. 1 Publication
Mutagenesisi6 – 61C → S: Loss of palmitoylation. 1 Publication
Mutagenesisi8 – 81C → S: Loss of palmitoylation. 1 Publication

Organism-specific databases

PharmGKBiPA36202.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 305304Serine/threonine-protein kinase 16PRO_0000086701Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine1 Publication
Lipidationi6 – 61S-palmitoyl cysteine1 Publication
Lipidationi8 – 81S-palmitoyl cysteine1 Publication
Modified residuei185 – 1851Phosphothreonine; by autocatalysis1 Publication
Modified residuei197 – 1971Phosphoserine; by autocatalysis1 Publication
Modified residuei198 – 1981Phosphotyrosine; by autocatalysis1 Publication

Post-translational modificationi

Mainly autophosphorylated on serine/threonine residues. Also autophosphorylated on Tyr-198.1 Publication
It is uncertain whether palmitoylation is on Cys-6 and/or Cys-8.1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiO75716.
PRIDEiO75716.

PTM databases

PhosphoSiteiO75716.

Expressioni

Tissue specificityi

Ubiquitously expressed at very low levels.1 Publication

Gene expression databases

BgeeiO75716.
CleanExiHS_STK16.
ExpressionAtlasiO75716. baseline and differential.
GenevestigatoriO75716.

Organism-specific databases

HPAiHPA029450.

Interactioni

Subunit structurei

Monomer. Interacts with DRG1 (via its N-terminal); the interaction phosphorylates DRG1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ADAMTSL4Q6UY143EBI-749295,EBI-742002

Protein-protein interaction databases

BioGridi114144. 23 interactions.
DIPiDIP-29598N.
IntActiO75716. 5 interactions.
MINTiMINT-3001680.
STRINGi9606.ENSP00000379964.

Structurei

Secondary structure

1
305
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi13 – 153Combined sources
Beta strandi18 – 2710Combined sources
Beta strandi32 – 398Combined sources
Turni40 – 423Combined sources
Beta strandi45 – 5511Combined sources
Helixi56 – 7015Combined sources
Beta strandi82 – 887Combined sources
Beta strandi91 – 999Combined sources
Helixi106 – 1149Combined sources
Turni115 – 1173Combined sources
Helixi122 – 14120Combined sources
Helixi151 – 1533Combined sources
Beta strandi154 – 1563Combined sources
Beta strandi162 – 1643Combined sources
Beta strandi171 – 1733Combined sources
Beta strandi175 – 1795Combined sources
Helixi180 – 19314Combined sources
Helixi196 – 1983Combined sources
Helixi201 – 2033Combined sources
Beta strandi208 – 2125Combined sources
Helixi215 – 23016Combined sources
Helixi236 – 2405Combined sources
Helixi245 – 2506Combined sources
Helixi263 – 27210Combined sources
Helixi277 – 2793Combined sources
Helixi283 – 29210Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BUJX-ray2.60A/B13-305[»]
ProteinModelPortaliO75716.
SMRiO75716. Positions 13-299.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75716.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 293274Protein kinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni166 – 20237Activation loopAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00550000075037.
HOVERGENiHBG054359.
InParanoidiO75716.
KOiK08856.
OrthoDBiEOG7Z3F55.
PhylomeDBiO75716.
TreeFamiTF350433.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75716-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGHALCVCSR GTVIIDNKRY LFIQKLGEGG FSYVDLVEGL HDGHFYALKR
60 70 80 90 100
ILCHEQQDRE EAQREADMHR LFNHPNILRL VAYCLRERGA KHEAWLLLPF
110 120 130 140 150
FKRGTLWNEI ERLKDKGNFL TEDQILWLLL GICRGLEAIH AKGYAHRDLK
160 170 180 190 200
PTNILLGDEG QPVLMDLGSM NQACIHVEGS RQALTLQDWA AQRCTISYRA
210 220 230 240 250
PELFSVQSHC VIDERTDVWS LGCVLYAMMF GEGPYDMVFQ KGDSVALAVQ
260 270 280 290 300
NQLSIPQSPR HSSALRQLLN SMMTVDPHQR PHIPLLLSQL EALQPPAPGQ

HTTQI
Length:305
Mass (Da):34,656
Last modified:January 23, 2007 - v4
Checksum:i593B2AEB8505009C
GO

Sequence cautioni

The sequence AAV38392.1 differs from that shown. Reason: Frameshift at position 305. Curated
The sequence CAA06700.1 differs from that shown. Reason: Frameshift at position 305. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti59 – 591R → L in AAV38392. 1 PublicationCurated
Sequence conflicti180 – 1801S → P in BAF85383. (PubMed:14702039)Curated
Sequence conflicti213 – 2131D → G in CAA06700. (PubMed:9712705)Curated
Sequence conflicti213 – 2131D → G in CAA09387. 1 PublicationCurated
Sequence conflicti221 – 2211L → F in AAC28337. (PubMed:10364453)Curated
Sequence conflicti222 – 2221G → S in CAA09387. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti41 – 411H → R.1 Publication
Corresponds to variant rs34799131 [ dbSNP | Ensembl ].
VAR_041140
Natural varianti55 – 551E → K.1 Publication
Corresponds to variant rs35947471 [ dbSNP | Ensembl ].
VAR_041141
Natural varianti77 – 771I → V.1 Publication
Corresponds to variant rs34282267 [ dbSNP | Ensembl ].
VAR_041142
Natural varianti266 – 2661R → W.3 Publications
Corresponds to variant rs17849638 [ dbSNP | Ensembl ].
VAR_041143
Natural varianti277 – 2771P → L.1 Publication
Corresponds to variant rs35454203 [ dbSNP | Ensembl ].
VAR_041144

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005791 mRNA. Translation: CAA06700.1. Frameshift.
AF060798 mRNA. Translation: AAC28337.1.
AB020739 mRNA. Translation: BAB16311.1.
AJ010872 mRNA. Translation: CAA09387.1.
AF203910 mRNA. Translation: AAG23728.1.
BT019585 mRNA. Translation: AAV38392.1. Frameshift.
AK292694 mRNA. Translation: BAF85383.1.
CR407675 mRNA. Translation: CAG28603.1.
BC002618 mRNA. Translation: AAH02618.1.
BC053998 mRNA. Translation: AAH53998.1.
CCDSiCCDS42822.1.
RefSeqiNP_001008910.1. NM_001008910.2.
UniGeneiHs.153003.

Genome annotation databases

EnsembliENST00000396738; ENSP00000379964; ENSG00000115661.
ENST00000409638; ENSP00000386928; ENSG00000115661.
GeneIDi8576.
KEGGihsa:8576.
UCSCiuc002vko.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005791 mRNA. Translation: CAA06700.1 . Frameshift.
AF060798 mRNA. Translation: AAC28337.1 .
AB020739 mRNA. Translation: BAB16311.1 .
AJ010872 mRNA. Translation: CAA09387.1 .
AF203910 mRNA. Translation: AAG23728.1 .
BT019585 mRNA. Translation: AAV38392.1 . Frameshift.
AK292694 mRNA. Translation: BAF85383.1 .
CR407675 mRNA. Translation: CAG28603.1 .
BC002618 mRNA. Translation: AAH02618.1 .
BC053998 mRNA. Translation: AAH53998.1 .
CCDSi CCDS42822.1.
RefSeqi NP_001008910.1. NM_001008910.2.
UniGenei Hs.153003.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2BUJ X-ray 2.60 A/B 13-305 [» ]
ProteinModelPortali O75716.
SMRi O75716. Positions 13-299.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114144. 23 interactions.
DIPi DIP-29598N.
IntActi O75716. 5 interactions.
MINTi MINT-3001680.
STRINGi 9606.ENSP00000379964.

Chemistry

BindingDBi O75716.
ChEMBLi CHEMBL3938.
GuidetoPHARMACOLOGYi 2213.

PTM databases

PhosphoSitei O75716.

Proteomic databases

PaxDbi O75716.
PRIDEi O75716.

Protocols and materials databases

DNASUi 8576.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000396738 ; ENSP00000379964 ; ENSG00000115661 .
ENST00000409638 ; ENSP00000386928 ; ENSG00000115661 .
GeneIDi 8576.
KEGGi hsa:8576.
UCSCi uc002vko.2. human.

Organism-specific databases

CTDi 8576.
GeneCardsi GC02P220110.
HGNCi HGNC:11394. STK16.
HPAi HPA029450.
MIMi 604719. gene.
neXtProti NX_O75716.
PharmGKBi PA36202.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00550000075037.
HOVERGENi HBG054359.
InParanoidi O75716.
KOi K08856.
OrthoDBi EOG7Z3F55.
PhylomeDBi O75716.
TreeFami TF350433.

Enzyme and pathway databases

BRENDAi 2.7.11.1. 2681.
SignaLinki O75716.

Miscellaneous databases

ChiTaRSi STK16. human.
EvolutionaryTracei O75716.
GeneWikii STK16.
GenomeRNAii 8576.
NextBioi 32169.
PROi O75716.
SOURCEi Search...

Gene expression databases

Bgeei O75716.
CleanExi HS_STK16.
ExpressionAtlasi O75716. baseline and differential.
Genevestigatori O75716.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, expression analysis, and functional characterization of PKL12, a member of a new subfamily of ser/thr kinases."
    Ligos J.M., Gerwin N., Fernandez P., Gutierrez-Ramos J.-C., Bernad A.
    Biochem. Biophys. Res. Commun. 249:380-384(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Identification and characterization of a myristylated and palmitylated serine/threonine protein kinase."
    Berson A.E., Young C., Morrison S.L., Fujii G.H., Sheung J., Wu B., Bolen J.B., Burkhardt A.L.
    Biochem. Biophys. Res. Commun. 259:533-538(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, FUNCTION, AUTOPHOSPHORYLATION, MYRISTOYLATION AT GLY-2, PALMITOYLATION AT CYS-6 AND CYS-8, MUTAGENESIS OF GLY-2; CYS-6 AND CYS-8.
    Tissue: Dendritic cell.
  3. "A novel transcriptional factor with Ser/Thr kinase activity involved in the transforming growth factor (TGF)-beta signalling pathway."
    Ohta S., Takeuchi M., Deguchi M., Tsuji T., Gahara Y., Nagata K.
    Biochem. J. 350:395-404(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Characterization of a ubiquitous expressed human serine/threonine kinase."
    Wabakken T.K., Aasheim H.-C.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Blood.
  5. Stairs D.B., Ha S.I., Chodosh L.A.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  6. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.
  8. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TRP-266.
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TRP-266.
    Tissue: Colon and Lymph.
  10. "Structure of the human protein kinase MPSK1 reveals an atypical activation loop architecture."
    Eswaran J., Bernad A., Ligos J.M., Guinea B., Debreczeni J.E., Sobott F., Parker S.A., Najmanovich R., Turk B.E., Knapp S.
    Structure 16:115-124(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 13-304 OF WILD TYPE AND IN COMPLEX WITH STAUROSPORINE, SUBUNIT, INTERACTION WITH DRG1, PHOSPHORYLATION AT THR-185; SER-197 AND TYR-198, IDENTIFICATION BY MASS SPECTROMETRY.
  11. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] ARG-41; LYS-55; VAL-77; TRP-266 AND LEU-277.

Entry informationi

Entry nameiSTK16_HUMAN
AccessioniPrimary (citable) accession number: O75716
Secondary accession number(s): A8K9H9
, Q5U0F8, Q96KI2, Q9BUH4, Q9UEN3, Q9UP78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 145 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3