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Protein

Epididymal secretory glutathione peroxidase

Gene

GPX5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei73By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Enzyme and pathway databases

BioCyciZFISH:HS01336-MONOMER.
BRENDAi1.11.1.9. 2681.
ReactomeiR-HSA-3299685. Detoxification of Reactive Oxygen Species.

Protein family/group databases

PeroxiBasei3604. HsGPx05-A.
3629. HsGPx05-B.

Names & Taxonomyi

Protein namesi
Recommended name:
Epididymal secretory glutathione peroxidase (EC:1.11.1.9)
Alternative name(s):
Epididymis-specific glutathione peroxidase-like protein
Short name:
EGLP
Glutathione peroxidase 5
Short name:
GPx-5
Short name:
GSHPx-5
Gene namesi
Name:GPX5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4557. GPX5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi2880.
OpenTargetsiENSG00000224586.
ENSG00000257770.
PharmGKBiPA28953.

Chemistry databases

DrugBankiDB00143. Glutathione.

Polymorphism and mutation databases

BioMutaiGPX5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001307622 – 221Epididymal secretory glutathione peroxidaseAdd BLAST200

Proteomic databases

PaxDbiO75715.
PeptideAtlasiO75715.
PRIDEiO75715.

PTM databases

iPTMnetiO75715.
PhosphoSitePlusiO75715.

Expressioni

Tissue specificityi

Epididymis.

Gene expression databases

BgeeiENSG00000224586.
CleanExiHS_GPX5.
ExpressionAtlasiO75715. baseline and differential.
GenevisibleiO75715. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000392398.

Structurei

Secondary structure

1221
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi40 – 42Combined sources3
Beta strandi44 – 51Combined sources8
Beta strandi53 – 55Combined sources3
Helixi56 – 59Combined sources4
Beta strandi62 – 69Combined sources8
Beta strandi71 – 73Combined sources3
Helixi74 – 78Combined sources5
Helixi79 – 89Combined sources11
Helixi90 – 92Combined sources3
Beta strandi94 – 100Combined sources7
Helixi112 – 114Combined sources3
Helixi115 – 121Combined sources7
Beta strandi131 – 135Combined sources5
Beta strandi140 – 142Combined sources3
Helixi147 – 155Combined sources9
Turni166 – 168Combined sources3
Beta strandi171 – 173Combined sources3
Beta strandi185 – 188Combined sources4
Beta strandi194 – 198Combined sources5
Helixi204 – 214Combined sources11
Helixi215 – 217Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2I3YX-ray2.00A28-220[»]
ProteinModelPortaliO75715.
SMRiO75715.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75715.

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1651. Eukaryota.
COG0386. LUCA.
GeneTreeiENSGT00760000119230.
HOGENOMiHOG000115921.
HOVERGENiHBG004333.
InParanoidiO75715.
KOiK00432.
OMAiTFYQLTA.
OrthoDBiEOG091G10LN.
PhylomeDBiO75715.
TreeFamiTF105318.

Family and domain databases

CDDicd00340. GSH_Peroxidase. 1 hit.
Gene3Di3.40.30.10. 1 hit.
InterProiIPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75715-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTTQLRVVHL LPLLLACFVQ TSPKQEKMKM DCHKDEKGTI YDYEAIALNK
60 70 80 90 100
NEYVSFKQYV GKHILFVNVA TYCGLTAQYP ELNALQEELK PYGLVVLGFP
110 120 130 140 150
CNQFGKQEPG DNKEILPGLK YVRPGGGFVP SFQLFEKGDV NGEKEQKVFS
160 170 180 190 200
FLKHSCPHPS EILGTFKSIS WDPVKVHDIR WNFEKFLVGP DGIPVMRWSH
210 220
RATVSSVKTD ILAYLKQFKT K
Length:221
Mass (Da):25,202
Last modified:November 1, 1998 - v1
Checksum:iCE3E7BFD53CE979F
GO
Isoform 2 (identifier: O75715-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-221: ELNALQEELK...LAYLKQFKTK → GMSVQGEDLYLVSSFLRKGM

Note: No experimental confirmation available.
Show »
Length:100
Mass (Da):11,429
Checksum:i04BFE67B6E77684F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06120685L → P.Corresponds to variant rs58554303dbSNPEnsembl.1
Natural variantiVAR_01204085L → V.1 PublicationCorresponds to variant rs769188dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04304681 – 221ELNAL…QFKTK → GMSVQGEDLYLVSSFLRKGM in isoform 2. 1 PublicationAdd BLAST141

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005277 mRNA. Translation: CAA06463.1.
AY882013 Genomic DNA. Translation: AAW56939.1.
AL049543 Genomic DNA. Translation: CAB71121.1.
CH471081 Genomic DNA. Translation: EAX03168.1.
BC128159 mRNA. Translation: AAI28160.1.
BC128160 mRNA. Translation: AAI28161.1.
CCDSiCCDS4652.1. [O75715-1]
CCDS4653.1. [O75715-2]
RefSeqiNP_001500.1. NM_001509.2. [O75715-1]
NP_003987.2. NM_003996.3. [O75715-2]
UniGeneiHs.248129.

Genome annotation databases

EnsembliENST00000412168; ENSP00000392398; ENSG00000224586. [O75715-1]
ENST00000469384; ENSP00000419935; ENSG00000224586. [O75715-2]
ENST00000550775; ENSP00000450365; ENSG00000257770. [O75715-1]
ENST00000551639; ENSP00000449271; ENSG00000257770. [O75715-2]
GeneIDi2880.
KEGGihsa:2880.
UCSCiuc003nlm.3. human. [O75715-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005277 mRNA. Translation: CAA06463.1.
AY882013 Genomic DNA. Translation: AAW56939.1.
AL049543 Genomic DNA. Translation: CAB71121.1.
CH471081 Genomic DNA. Translation: EAX03168.1.
BC128159 mRNA. Translation: AAI28160.1.
BC128160 mRNA. Translation: AAI28161.1.
CCDSiCCDS4652.1. [O75715-1]
CCDS4653.1. [O75715-2]
RefSeqiNP_001500.1. NM_001509.2. [O75715-1]
NP_003987.2. NM_003996.3. [O75715-2]
UniGeneiHs.248129.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2I3YX-ray2.00A28-220[»]
ProteinModelPortaliO75715.
SMRiO75715.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000392398.

Chemistry databases

DrugBankiDB00143. Glutathione.

Protein family/group databases

PeroxiBasei3604. HsGPx05-A.
3629. HsGPx05-B.

PTM databases

iPTMnetiO75715.
PhosphoSitePlusiO75715.

Polymorphism and mutation databases

BioMutaiGPX5.

Proteomic databases

PaxDbiO75715.
PeptideAtlasiO75715.
PRIDEiO75715.

Protocols and materials databases

DNASUi2880.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000412168; ENSP00000392398; ENSG00000224586. [O75715-1]
ENST00000469384; ENSP00000419935; ENSG00000224586. [O75715-2]
ENST00000550775; ENSP00000450365; ENSG00000257770. [O75715-1]
ENST00000551639; ENSP00000449271; ENSG00000257770. [O75715-2]
GeneIDi2880.
KEGGihsa:2880.
UCSCiuc003nlm.3. human. [O75715-1]

Organism-specific databases

CTDi2880.
DisGeNETi2880.
GeneCardsiGPX5.
HGNCiHGNC:4557. GPX5.
MIMi603435. gene.
neXtProtiNX_O75715.
OpenTargetsiENSG00000224586.
ENSG00000257770.
PharmGKBiPA28953.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1651. Eukaryota.
COG0386. LUCA.
GeneTreeiENSGT00760000119230.
HOGENOMiHOG000115921.
HOVERGENiHBG004333.
InParanoidiO75715.
KOiK00432.
OMAiTFYQLTA.
OrthoDBiEOG091G10LN.
PhylomeDBiO75715.
TreeFamiTF105318.

Enzyme and pathway databases

BioCyciZFISH:HS01336-MONOMER.
BRENDAi1.11.1.9. 2681.
ReactomeiR-HSA-3299685. Detoxification of Reactive Oxygen Species.

Miscellaneous databases

EvolutionaryTraceiO75715.
GeneWikiiGPX5.
GenomeRNAii2880.
PROiO75715.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000224586.
CleanExiHS_GPX5.
ExpressionAtlasiO75715. baseline and differential.
GenevisibleiO75715. HS.

Family and domain databases

CDDicd00340. GSH_Peroxidase. 1 hit.
Gene3Di3.40.30.10. 1 hit.
InterProiIPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPX5_HUMAN
AccessioniPrimary (citable) accession number: O75715
Secondary accession number(s): A1A4Y0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: November 2, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.