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Protein

Scrapie-responsive protein 1

Gene

SCRG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • nervous system development Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Scrapie-responsive protein 1
Alternative name(s):
Scrapie-responsive gene 1 protein
Short name:
ScRG-1
Gene namesi
Name:SCRG1
ORF Names:UNQ390/PRO725
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:17036. SCRG1.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: ProtInc
  • Golgi apparatus Source: Ensembl
  • neuron projection terminus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165664478.

Polymorphism and mutation databases

BioMutaiSCRG1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 20201 PublicationAdd
BLAST
Chaini21 – 9878Scrapie-responsive protein 1PRO_0000022283Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi72 – 721N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO75711.
PRIDEiO75711.

PTM databases

iPTMnetiO75711.
PhosphoSiteiO75711.

Expressioni

Tissue specificityi

Expressed abundantly in the central nervous system of adult, but not at all in fetal brain. High levels of SCRG1 transcripts are also observed in testis and aorta.

Gene expression databases

BgeeiO75711.
ExpressionAtlasiO75711. baseline and differential.
GenevisibleiO75711. HS.

Organism-specific databases

HPAiHPA012882.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CATSPER1Q8NEC53EBI-10189029,EBI-744545

Protein-protein interaction databases

BioGridi116469. 1 interaction.
IntActiO75711. 1 interaction.
STRINGi9606.ENSP00000296506.

Structurei

3D structure databases

ProteinModelPortaliO75711.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SCRG1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0WG. Eukaryota.
ENOG410YPGI. LUCA.
HOGENOMiHOG000294139.
HOVERGENiHBG054216.
InParanoidiO75711.
OMAiIFFGPKI.
OrthoDBiEOG7WX0BS.
PhylomeDBiO75711.
TreeFamiTF335779.

Family and domain databases

InterProiIPR028063. SCRG1.
[Graphical view]
PANTHERiPTHR17463. PTHR17463. 1 hit.
PfamiPF15224. SCRG1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75711-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLMVLVFTI GLTLLLGVQA MPANRLSCYR KILKDHNCHN LPEGVADLTQ
60 70 80 90
IDVNVQDHFW DGKGCEMICY CNFSELLCCP KDVFFGPKIS FVIPCNNQ
Length:98
Mass (Da):11,081
Last modified:November 1, 1998 - v1
Checksum:iA5F1FD40BF5401C0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti42 – 421P → L.
Corresponds to variant rs2306465 [ dbSNP | Ensembl ].
VAR_020329

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224677 mRNA. Translation: CAA12059.1.
AY359040 mRNA. Translation: AAQ89399.1.
CCDSiCCDS3818.1.
RefSeqiNP_009212.1. NM_007281.2.
UniGeneiHs.7122.

Genome annotation databases

EnsembliENST00000296506; ENSP00000296506; ENSG00000164106.
GeneIDi11341.
KEGGihsa:11341.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224677 mRNA. Translation: CAA12059.1.
AY359040 mRNA. Translation: AAQ89399.1.
CCDSiCCDS3818.1.
RefSeqiNP_009212.1. NM_007281.2.
UniGeneiHs.7122.

3D structure databases

ProteinModelPortaliO75711.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116469. 1 interaction.
IntActiO75711. 1 interaction.
STRINGi9606.ENSP00000296506.

PTM databases

iPTMnetiO75711.
PhosphoSiteiO75711.

Polymorphism and mutation databases

BioMutaiSCRG1.

Proteomic databases

PaxDbiO75711.
PRIDEiO75711.

Protocols and materials databases

DNASUi11341.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296506; ENSP00000296506; ENSG00000164106.
GeneIDi11341.
KEGGihsa:11341.

Organism-specific databases

CTDi11341.
GeneCardsiSCRG1.
HGNCiHGNC:17036. SCRG1.
HPAiHPA012882.
MIMi603163. gene.
neXtProtiNX_O75711.
PharmGKBiPA165664478.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0WG. Eukaryota.
ENOG410YPGI. LUCA.
HOGENOMiHOG000294139.
HOVERGENiHBG054216.
InParanoidiO75711.
OMAiIFFGPKI.
OrthoDBiEOG7WX0BS.
PhylomeDBiO75711.
TreeFamiTF335779.

Miscellaneous databases

ChiTaRSiSCRG1. human.
GenomeRNAii11341.
PROiO75711.
SOURCEiSearch...

Gene expression databases

BgeeiO75711.
ExpressionAtlasiO75711. baseline and differential.
GenevisibleiO75711. HS.

Family and domain databases

InterProiIPR028063. SCRG1.
[Graphical view]
PANTHERiPTHR17463. PTHR17463. 1 hit.
PfamiPF15224. SCRG1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 21-35.

Entry informationi

Entry nameiSCRG1_HUMAN
AccessioniPrimary (citable) accession number: O75711
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: June 8, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.