O75694 (NU155_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nuclear pore complex protein Nup155

Alternative name(s):
155 kDa nucleoporin
Nucleoporin Nup155

Gene names

Name:	NUP155
Synonyms:	KIAA0791

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1391 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Essential component of nuclear pore complex. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport By similarity.
Subunit structure	Interacts with GLE1. Able to form a heterotrimer with GLE1 and NUPL2 in vitro. Forms a complex with NUP53, NUP93, NUP205 and lamin B. Ref.7 Ref.8
Subcellular location	Nucleus › nuclear pore complex By similarity. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side By similarity. Note: In mitosis, assumes a diffuse cytoplasmic distribution probably as a monomer, before reversing back into a punctate nuclear surface localization at the end of mitosis By similarity.
Tissue specificity	Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Post-translational modification	Phosphorylated. Phosphorylation and dephosphorylation may be important for the function of NUP155 and may play a role in the reversible disassembly of the nuclear pore complex during mitosis By similarity.
Sequence similarities	Belongs to the non-repetitive/WGA-negative nucleoporin family.
Sequence caution	The sequence AAD52966.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence BAA34511.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Protein transport Translocation Transport mRNA transport
Cellular component	Membrane Nuclear pore complex Nucleus
Coding sequence diversity	Alternative splicing
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	carbohydrate metabolic process Traceable author statement. Source: Reactome cytokine-mediated signaling pathway Traceable author statement. Source: Reactome glucose transport Traceable author statement. Source: Reactome mRNA export from nucleus Inferred from electronic annotation. Source: Compara nuclear envelope organization Inferred from direct assay PubMed 19070573. Source: MGI protein import into nucleus Inferred from electronic annotation. Source: Compara regulation of atrial cardiac muscle cell action potential Inferred from electronic annotation. Source: Compara regulation of glucose transport Traceable author statement. Source: Reactome small molecule metabolic process Traceable author statement. Source: Reactome transmembrane transport Traceable author statement. Source: Reactome viral reproduction Traceable author statement. Source: Reactome
Cellular_component	nuclear envelope Inferred from direct assay PubMed 19070573. Source: MGI nuclear membrane Inferred from electronic annotation. Source: UniProtKB-SubCell nuclear pore Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	structural constituent of nuclear pore Inferred from electronic annotation. Source: InterPro transporter activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O75694-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O75694-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-59: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1391	1391	Nuclear pore complex protein Nup155		PRO_0000204844
Regions
	Compositional bias	585 – 655	71	Pro-rich
Amino acid modifications
	Glycosylation	526	1	O-linked (GlcNAc) By similarity
Natural variations
	Alternative sequence	1 – 59	59	Missing in isoform 2.		VSP_014437

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 7F07A103AFF7EE1D	FASTA	1,391	155,199
	10 20 30 40 50 60 MPSSLLGAAM PASTSAAALQ EALENAGRLI DRQLQEDRMY PDLSELLMVS APNNPTVSGM 70 80 90 100 110 120 SDMDYPLQGP GLLSVPNLPE ISSIRRVPLP PELVEQFGHM QCNCMMGVFP PISRAWLTID 130 140 150 160 170 180 SDIFMWNYED GGDLAYFDGL SETILAVGLV KPKAGIFQPH VRHLLVLATP VDIVILGLSY 190 200 210 220 230 240 ANLQTGSGVL NDSLSGGMQL LPDPLYSLPT DNTYLLTITS TDNGRIFLAG KDGCLYEVAY 250 260 270 280 290 300 QAEAGWFSQR CRKINHSKSS LSFLVPSLLQ FTFSEDDPIL QIAIDNSRNI LYTRSEKGVI 310 320 330 340 350 360 QVYDLGQDGQ GMSRVASVSQ NAIVSAAGNI ARTIDRSVFK PIVQIAVIEN SESLDCQLLA 370 380 390 400 410 420 VTHAGVRLYF STCPFRQPLA RPNTLTLVHV RLPPGFSASS TVEKPSKVHR ALYSKGILLM 430 440 450 460 470 480 AASENEDNDI LWCVNHDTFP FQKPMMETQM TAGVDGHSWA LSAIDELKVD KIITPLNKDH 490 500 510 520 530 540 IPITDSPVVV QQHMLPPKKF VLLSAQGSLM FHKLRPVDQL RHLLVSNVGG DGEEIERFFK 550 560 570 580 590 600 LHQEDQACAT CLILACSTAA CDREVSAWAT RAFFRYGGEA QMRFPTTLPP PSNVGPILGS 610 620 630 640 650 660 PVYSSSPVPS GSPYPNPSFL GTPSHGIQPP AMSTPVCALG NPATQATNMS CVTGPEIVYS 670 680 690 700 710 720 GKHNGICIYF SRIMGNIWDA SLVVERIFKS GNREITAIES SVPCQLLESV LQELKGLQEF 730 740 750 760 770 780 LDRNSQFAGG PLGNPNTTAK VQQRLIGFMR PENGNPQQMQ QELQRKFHEA QLSEKISLQA 790 800 810 820 830 840 IQQLVRKSYQ ALALWKLLCE HQFTIIVAEL QKELQEQLKI TTFKDLVIRD KELTGALIAS 850 860 870 880 890 900 LINCYIRDNA AVDGISLHLQ DICPLLYSTD DAICSKANEL LQRSRQVQNK TEKERMLRES 910 920 930 940 950 960 LKEYQKISNQ VDLSNVCAQY RQVRFYEGVV ELSLTAAEKK DPQGLGLHFY KHGEPEEDIV 970 980 990 1000 1010 1020 GLQAFQERLN SYKCITDTLQ ELVNQSKAAP QSPSVPKKPG PPVLSSDPNM LSNEEAGHHF 1030 1040 1050 1060 1070 1080 EQMLKLSQRS KDELFSIALY NWLIQVDLAD KLLQVASPFL EPHLVRMAKV DQNRVRYMDL 1090 1100 1110 1120 1130 1140 LWRYYEKNRS FSNAARVLSR LADMHSTEIS LQQRLEYIAR AILSAKSSTA ISSIAADGEF 1150 1160 1170 1180 1190 1200 LHELEEKMEV ARIQLQIQET LQRQYSHHSS VQDAVSQLDS ELMDITKLYG EFADPFKLAE 1210 1220 1230 1240 1250 1260 CKLAIIHCAG YSDPILVQTL WQDIIEKELS DSVTLSSSDR MHALSLKIVL LGKIYAGTPR 1270 1280 1290 1300 1310 1320 FFPLDFIVQF LEQQVCTLNW DVGFVIQTMN EIGVPLPRLL EVYDQLFKSR DPFWNRMKKP 1330 1340 1350 1360 1370 1380 LHLLDCIHVL LIRYVENPSQ VLNCERRRFT NLCLDAVCGY LVELQSMSSS VAVQAITGNF 1390 KSLQAKLERL H
	Isoform 2 [UniParc]. Checksum: D84A93B75A3F66A6	FASTA	1,332	149,016
	10 20 30 40 50 60 MSDMDYPLQG PGLLSVPNLP EISSIRRVPL PPELVEQFGH MQCNCMMGVF PPISRAWLTI 70 80 90 100 110 120 DSDIFMWNYE DGGDLAYFDG LSETILAVGL VKPKAGIFQP HVRHLLVLAT PVDIVILGLS 130 140 150 160 170 180 YANLQTGSGV LNDSLSGGMQ LLPDPLYSLP TDNTYLLTIT STDNGRIFLA GKDGCLYEVA 190 200 210 220 230 240 YQAEAGWFSQ RCRKINHSKS SLSFLVPSLL QFTFSEDDPI LQIAIDNSRN ILYTRSEKGV 250 260 270 280 290 300 IQVYDLGQDG QGMSRVASVS QNAIVSAAGN IARTIDRSVF KPIVQIAVIE NSESLDCQLL 310 320 330 340 350 360 AVTHAGVRLY FSTCPFRQPL ARPNTLTLVH VRLPPGFSAS STVEKPSKVH RALYSKGILL 370 380 390 400 410 420 MAASENEDND ILWCVNHDTF PFQKPMMETQ MTAGVDGHSW ALSAIDELKV DKIITPLNKD 430 440 450 460 470 480 HIPITDSPVV VQQHMLPPKK FVLLSAQGSL MFHKLRPVDQ LRHLLVSNVG GDGEEIERFF 490 500 510 520 530 540 KLHQEDQACA TCLILACSTA ACDREVSAWA TRAFFRYGGE AQMRFPTTLP PPSNVGPILG 550 560 570 580 590 600 SPVYSSSPVP SGSPYPNPSF LGTPSHGIQP PAMSTPVCAL GNPATQATNM SCVTGPEIVY 610 620 630 640 650 660 SGKHNGICIY FSRIMGNIWD ASLVVERIFK SGNREITAIE SSVPCQLLES VLQELKGLQE 670 680 690 700 710 720 FLDRNSQFAG GPLGNPNTTA KVQQRLIGFM RPENGNPQQM QQELQRKFHE AQLSEKISLQ 730 740 750 760 770 780 AIQQLVRKSY QALALWKLLC EHQFTIIVAE LQKELQEQLK ITTFKDLVIR DKELTGALIA 790 800 810 820 830 840 SLINCYIRDN AAVDGISLHL QDICPLLYST DDAICSKANE LLQRSRQVQN KTEKERMLRE 850 860 870 880 890 900 SLKEYQKISN QVDLSNVCAQ YRQVRFYEGV VELSLTAAEK KDPQGLGLHF YKHGEPEEDI 910 920 930 940 950 960 VGLQAFQERL NSYKCITDTL QELVNQSKAA PQSPSVPKKP GPPVLSSDPN MLSNEEAGHH 970 980 990 1000 1010 1020 FEQMLKLSQR SKDELFSIAL YNWLIQVDLA DKLLQVASPF LEPHLVRMAK VDQNRVRYMD 1030 1040 1050 1060 1070 1080 LLWRYYEKNR SFSNAARVLS RLADMHSTEI SLQQRLEYIA RAILSAKSST AISSIAADGE 1090 1100 1110 1120 1130 1140 FLHELEEKME VARIQLQIQE TLQRQYSHHS SVQDAVSQLD SELMDITKLY GEFADPFKLA 1150 1160 1170 1180 1190 1200 ECKLAIIHCA GYSDPILVQT LWQDIIEKEL SDSVTLSSSD RMHALSLKIV LLGKIYAGTP 1210 1220 1230 1240 1250 1260 RFFPLDFIVQ FLEQQVCTLN WDVGFVIQTM NEIGVPLPRL LEVYDQLFKS RDPFWNRMKK 1270 1280 1290 1300 1310 1320 PLHLLDCIHV LLIRYVENPS QVLNCERRRF TNLCLDAVCG YLVELQSMSS SVAVQAITGN 1330 FKSLQAKLER LH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Localization of a human nucleoporin 155 gene (NUP155) to the 5p13 region and cloning of its cDNA." Zhang X., Yang H., Corydon M.J., Pedersen S., Korenberg J.R., Chen X.N., Laporte J., Gregersen N., Niebuhr E., Liu G., Bolund L. Genomics 57:144-151(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Testis.
[2]	"Genomic organization, transcript variants and comparative analysis of the human nucleoporin 155 (NUP155) gene." Zhang X., Yang H., Yu J., Chen C., Zhang G., Bao J., Du Y., Kibukawa M., Li Z., Wang J., Hu S., Dong W., Wang J., Gregersen N., Niebuhr E., Bolund L. Gene 288:9-18(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[4]	Ohara O., Suyama M., Nagase T., Ishikawa K., Kikuno R. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis.
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 728-1391. Tissue: Testis.
[7]	"The mRNA export factor human Gle1 interacts with the nuclear pore complex protein Nup155." Rayala H.J., Kendirgi F., Barry D.M., Majerus P.W., Wente S.R. Mol. Cell. Proteomics 3:145-155(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH GLE1.
[8]	"Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex." Hawryluk-Gara L.A., Shibuya E.K., Wozniak R.W. Mol. Biol. Cell 16:2382-2394(2005) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN A COMPLEX WITH LAMIN B; NUP53; NUP93 AND NUP205.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[10]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[11]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ007558 mRNA. Translation: CAA07553.1. AF165926 Genomic DNA. Translation: AAD52966.1. Sequence problems. AB018334 mRNA. Translation: BAA34511.2. Different initiation. BC039257 mRNA. Translation: AAH39257.1. AL117585 mRNA. Translation: CAB56007.1.
IPI	IPI00026625. IPI00376609.
PIR	T17317.
RefSeq	NP_004289.1. NM_004298.2. NP_705618.1. NM_153485.1.
UniGene	Hs.547696.
3D structure databases
ProteinModelPortal	O75694.
ModBase	Search...
Protein-protein interaction databases
IntAct	O75694. 9 interactions.
MINT	MINT-1200468.
STRING	9606.ENSP00000231498.
PTM databases
PhosphoSite	O75694.
Proteomic databases
PaxDb	O75694.
PRIDE	O75694.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000231498; ENSP00000231498; ENSG00000113569. ENST00000381843; ENSP00000371265; ENSG00000113569.
GeneID	9631.
KEGG	hsa:9631.
UCSC	uc003jkt.1. human.
Organism-specific databases
CTD	9631.
GeneCards	GC05M037327.
HGNC	HGNC:8063. NUP155.
HPA	HPA037774. HPA037775.
MIM	606694. gene.
neXtProt	NX_O75694.
Orphanet	334. Familial atrial fibrillation.
PharmGKB	PA31849.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5308.
HOGENOM	HOG000043927.
HOVERGEN	HBG052680.
InParanoid	O75694.
KO	K14312.
OMA	SSDRMHA.
OrthoDB	EOG4VHK5K.
PhylomeDB	O75694.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism. REACT_116125. Disease. REACT_15518. Transmembrane transport of small molecules. REACT_6900. Immune System.
Gene expression databases
ArrayExpress	O75694.
Bgee	O75694.
CleanEx	HS_NUP155.
Genevestigator	O75694.
GermOnline	ENSG00000113569. Homo sapiens.
Family and domain databases
InterPro	IPR007187. Nucleoporin_Nup133/Nup155_C. IPR014908. Nucleoporin_Nup133/Nup155_N. IPR004870. Nucleoporin_Nup155. [Graphical view]
PANTHER	PTHR10350. PTHR10350. 1 hit.
Pfam	PF03177. Nucleoporin_C. 1 hit. PF08801. Nucleoporin_N. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	9631.
NextBio	36143.
SOURCE	Search...

Entry information

Entry name

NU155_HUMAN

Accession

Primary (citable) accession number: O75694
Secondary accession number(s): Q9UBE9, Q9UFL5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1998
Last modified:	April 3, 2013
This is version 113 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.