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O75694

- NU155_HUMAN

UniProt

O75694 - NU155_HUMAN

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Protein

Nuclear pore complex protein Nup155

Gene

NUP155

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport.By similarity

GO - Molecular functioni

  1. structural constituent of nuclear pore Source: InterPro
  2. transporter activity Source: ProtInc

GO - Biological processi

  1. atrial cardiac muscle cell action potential Source: Ensembl
  2. carbohydrate metabolic process Source: Reactome
  3. cytokine-mediated signaling pathway Source: Reactome
  4. glucose transport Source: Reactome
  5. hexose transport Source: Reactome
  6. mitotic cell cycle Source: Reactome
  7. mitotic nuclear envelope disassembly Source: Reactome
  8. mRNA export from nucleus Source: Ensembl
  9. nuclear envelope organization Source: MGI
  10. protein import into nucleus Source: Ensembl
  11. regulation of glucose transport Source: Reactome
  12. small molecule metabolic process Source: Reactome
  13. transmembrane transport Source: Reactome
  14. viral process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiREACT_115831. ISG15 antiviral mechanism.
REACT_163931. Nuclear Pore Complex (NPC) Disassembly.
REACT_267668. Transcriptional regulation by small RNAs.
REACT_6190. Rev-mediated nuclear export of HIV RNA.
REACT_6354. Viral Messenger RNA Synthesis.
REACT_6804. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_7991. Vpr-mediated nuclear import of PICs.
REACT_9395. Nuclear import of Rev protein.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear pore complex protein Nup155
Alternative name(s):
155 kDa nucleoporin
Nucleoporin Nup155
Gene namesi
Name:NUP155
Synonyms:KIAA0791
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:8063. NUP155.

Subcellular locationi

Nucleusnuclear pore complex By similarity. Nucleus membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Nucleus membrane By similarity; Peripheral membrane protein By similarity; Nucleoplasmic side By similarity
Note: In mitosis, assumes a diffuse cytoplasmic distribution probably as a monomer, before reversing back into a punctate nuclear surface localization at the end of mitosis.By similarity

GO - Cellular componenti

  1. membrane Source: UniProtKB
  2. nuclear envelope Source: MGI
  3. nuclear pore Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

Pathology & Biotechi

Involvement in diseasei

Atrial fibrillation, familial, 15 (ATFB15) [MIM:615770]: A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti391 – 3911R → H in ATFB15; fails to accumulate at various foci of the nuclear envelope and is diffusely distributed in the cytoplasm; shows significantly reduced permeability of the nuclear envelope compared to wild-type. 1 Publication
VAR_071762

Keywords - Diseasei

Atrial fibrillation, Disease mutation

Organism-specific databases

MIMi615770. phenotype.
Orphaneti334. Familial atrial fibrillation.
PharmGKBiPA31849.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13911391Nuclear pore complex protein Nup155PRO_0000204844Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi526 – 5261O-linked (GlcNAc)By similarity

Post-translational modificationi

Phosphorylated. Phosphorylation and dephosphorylation may be important for the function of NUP155 and may play a role in the reversible disassembly of the nuclear pore complex during mitosis (By similarity).By similarity
Disulfide-linked to NUP62. The the inner channel of the NPC has a different redox environment from the cytoplasm and allows the formation of interchain disulfide bonds between some nucleoporins, the significant increase of these linkages upon oxidative stress reduces the permeability of the NPC (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO75694.
PaxDbiO75694.
PRIDEiO75694.

PTM databases

PhosphoSiteiO75694.

Expressioni

Tissue specificityi

Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Gene expression databases

BgeeiO75694.
CleanExiHS_NUP155.
ExpressionAtlasiO75694. baseline and differential.
GenevestigatoriO75694.

Organism-specific databases

HPAiHPA037774.
HPA037775.

Interactioni

Subunit structurei

Interacts with GLE1. Able to form a heterotrimer with GLE1 and NUPL2 in vitro. Forms a complex with NUP53, NUP93, NUP205 and lamin B.2 Publications

Protein-protein interaction databases

BioGridi114990. 25 interactions.
IntActiO75694. 16 interactions.
MINTiMINT-1200468.
STRINGi9606.ENSP00000231498.

Structurei

3D structure databases

ProteinModelPortaliO75694.
SMRiO75694. Positions 89-590, 871-1311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi585 – 65571Pro-richAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5308.
GeneTreeiENSGT00390000016532.
HOGENOMiHOG000043927.
HOVERGENiHBG052680.
InParanoidiO75694.
KOiK14312.
OMAiAPQSMQV.
OrthoDBiEOG7JQBMH.
PhylomeDBiO75694.
TreeFamiTF105951.

Family and domain databases

InterProiIPR007187. Nucleoporin_Nup133/Nup155_C.
IPR014908. Nucleoporin_Nup133/Nup155_N.
IPR004870. Nucleoporin_Nup155.
[Graphical view]
PANTHERiPTHR10350. PTHR10350. 1 hit.
PfamiPF03177. Nucleoporin_C. 1 hit.
PF08801. Nucleoporin_N. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O75694-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSSLLGAAM PASTSAAALQ EALENAGRLI DRQLQEDRMY PDLSELLMVS
60 70 80 90 100
APNNPTVSGM SDMDYPLQGP GLLSVPNLPE ISSIRRVPLP PELVEQFGHM
110 120 130 140 150
QCNCMMGVFP PISRAWLTID SDIFMWNYED GGDLAYFDGL SETILAVGLV
160 170 180 190 200
KPKAGIFQPH VRHLLVLATP VDIVILGLSY ANLQTGSGVL NDSLSGGMQL
210 220 230 240 250
LPDPLYSLPT DNTYLLTITS TDNGRIFLAG KDGCLYEVAY QAEAGWFSQR
260 270 280 290 300
CRKINHSKSS LSFLVPSLLQ FTFSEDDPIL QIAIDNSRNI LYTRSEKGVI
310 320 330 340 350
QVYDLGQDGQ GMSRVASVSQ NAIVSAAGNI ARTIDRSVFK PIVQIAVIEN
360 370 380 390 400
SESLDCQLLA VTHAGVRLYF STCPFRQPLA RPNTLTLVHV RLPPGFSASS
410 420 430 440 450
TVEKPSKVHR ALYSKGILLM AASENEDNDI LWCVNHDTFP FQKPMMETQM
460 470 480 490 500
TAGVDGHSWA LSAIDELKVD KIITPLNKDH IPITDSPVVV QQHMLPPKKF
510 520 530 540 550
VLLSAQGSLM FHKLRPVDQL RHLLVSNVGG DGEEIERFFK LHQEDQACAT
560 570 580 590 600
CLILACSTAA CDREVSAWAT RAFFRYGGEA QMRFPTTLPP PSNVGPILGS
610 620 630 640 650
PVYSSSPVPS GSPYPNPSFL GTPSHGIQPP AMSTPVCALG NPATQATNMS
660 670 680 690 700
CVTGPEIVYS GKHNGICIYF SRIMGNIWDA SLVVERIFKS GNREITAIES
710 720 730 740 750
SVPCQLLESV LQELKGLQEF LDRNSQFAGG PLGNPNTTAK VQQRLIGFMR
760 770 780 790 800
PENGNPQQMQ QELQRKFHEA QLSEKISLQA IQQLVRKSYQ ALALWKLLCE
810 820 830 840 850
HQFTIIVAEL QKELQEQLKI TTFKDLVIRD KELTGALIAS LINCYIRDNA
860 870 880 890 900
AVDGISLHLQ DICPLLYSTD DAICSKANEL LQRSRQVQNK TEKERMLRES
910 920 930 940 950
LKEYQKISNQ VDLSNVCAQY RQVRFYEGVV ELSLTAAEKK DPQGLGLHFY
960 970 980 990 1000
KHGEPEEDIV GLQAFQERLN SYKCITDTLQ ELVNQSKAAP QSPSVPKKPG
1010 1020 1030 1040 1050
PPVLSSDPNM LSNEEAGHHF EQMLKLSQRS KDELFSIALY NWLIQVDLAD
1060 1070 1080 1090 1100
KLLQVASPFL EPHLVRMAKV DQNRVRYMDL LWRYYEKNRS FSNAARVLSR
1110 1120 1130 1140 1150
LADMHSTEIS LQQRLEYIAR AILSAKSSTA ISSIAADGEF LHELEEKMEV
1160 1170 1180 1190 1200
ARIQLQIQET LQRQYSHHSS VQDAVSQLDS ELMDITKLYG EFADPFKLAE
1210 1220 1230 1240 1250
CKLAIIHCAG YSDPILVQTL WQDIIEKELS DSVTLSSSDR MHALSLKIVL
1260 1270 1280 1290 1300
LGKIYAGTPR FFPLDFIVQF LEQQVCTLNW DVGFVIQTMN EIGVPLPRLL
1310 1320 1330 1340 1350
EVYDQLFKSR DPFWNRMKKP LHLLDCIHVL LIRYVENPSQ VLNCERRRFT
1360 1370 1380 1390
NLCLDAVCGY LVELQSMSSS VAVQAITGNF KSLQAKLERL H
Length:1,391
Mass (Da):155,199
Last modified:November 1, 1998 - v1
Checksum:i7F07A103AFF7EE1D
GO
Isoform 2 (identifier: O75694-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-59: Missing.

Note: No experimental confirmation available.

Show »
Length:1,332
Mass (Da):149,016
Checksum:iD84A93B75A3F66A6
GO

Sequence cautioni

The sequence AAD52966.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence BAA34511.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti391 – 3911R → H in ATFB15; fails to accumulate at various foci of the nuclear envelope and is diffusely distributed in the cytoplasm; shows significantly reduced permeability of the nuclear envelope compared to wild-type. 1 Publication
VAR_071762

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5959Missing in isoform 2. 1 PublicationVSP_014437Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007558 mRNA. Translation: CAA07553.1.
AF165926 Genomic DNA. Translation: AAD52966.1. Sequence problems.
AB018334 mRNA. Translation: BAA34511.2. Different initiation.
BC039257 mRNA. Translation: AAH39257.1.
AL117585 mRNA. Translation: CAB56007.1.
CCDSiCCDS3921.1. [O75694-1]
CCDS43310.1. [O75694-2]
PIRiT17317.
RefSeqiNP_004289.1. NM_004298.3. [O75694-2]
NP_705618.1. NM_153485.2. [O75694-1]
UniGeneiHs.547696.

Genome annotation databases

EnsembliENST00000231498; ENSP00000231498; ENSG00000113569. [O75694-1]
ENST00000381843; ENSP00000371265; ENSG00000113569. [O75694-2]
GeneIDi9631.
KEGGihsa:9631.
UCSCiuc003jkt.1. human. [O75694-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007558 mRNA. Translation: CAA07553.1 .
AF165926 Genomic DNA. Translation: AAD52966.1 . Sequence problems.
AB018334 mRNA. Translation: BAA34511.2 . Different initiation.
BC039257 mRNA. Translation: AAH39257.1 .
AL117585 mRNA. Translation: CAB56007.1 .
CCDSi CCDS3921.1. [O75694-1 ]
CCDS43310.1. [O75694-2 ]
PIRi T17317.
RefSeqi NP_004289.1. NM_004298.3. [O75694-2 ]
NP_705618.1. NM_153485.2. [O75694-1 ]
UniGenei Hs.547696.

3D structure databases

ProteinModelPortali O75694.
SMRi O75694. Positions 89-590, 871-1311.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114990. 25 interactions.
IntActi O75694. 16 interactions.
MINTi MINT-1200468.
STRINGi 9606.ENSP00000231498.

PTM databases

PhosphoSitei O75694.

Proteomic databases

MaxQBi O75694.
PaxDbi O75694.
PRIDEi O75694.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000231498 ; ENSP00000231498 ; ENSG00000113569 . [O75694-1 ]
ENST00000381843 ; ENSP00000371265 ; ENSG00000113569 . [O75694-2 ]
GeneIDi 9631.
KEGGi hsa:9631.
UCSCi uc003jkt.1. human. [O75694-1 ]

Organism-specific databases

CTDi 9631.
GeneCardsi GC05M037327.
HGNCi HGNC:8063. NUP155.
HPAi HPA037774.
HPA037775.
MIMi 606694. gene.
615770. phenotype.
neXtProti NX_O75694.
Orphaneti 334. Familial atrial fibrillation.
PharmGKBi PA31849.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5308.
GeneTreei ENSGT00390000016532.
HOGENOMi HOG000043927.
HOVERGENi HBG052680.
InParanoidi O75694.
KOi K14312.
OMAi APQSMQV.
OrthoDBi EOG7JQBMH.
PhylomeDBi O75694.
TreeFami TF105951.

Enzyme and pathway databases

Reactomei REACT_115831. ISG15 antiviral mechanism.
REACT_163931. Nuclear Pore Complex (NPC) Disassembly.
REACT_267668. Transcriptional regulation by small RNAs.
REACT_6190. Rev-mediated nuclear export of HIV RNA.
REACT_6354. Viral Messenger RNA Synthesis.
REACT_6804. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_7991. Vpr-mediated nuclear import of PICs.
REACT_9395. Nuclear import of Rev protein.

Miscellaneous databases

GeneWikii NUP155.
GenomeRNAii 9631.
NextBioi 36143.
PROi O75694.
SOURCEi Search...

Gene expression databases

Bgeei O75694.
CleanExi HS_NUP155.
ExpressionAtlasi O75694. baseline and differential.
Genevestigatori O75694.

Family and domain databases

InterProi IPR007187. Nucleoporin_Nup133/Nup155_C.
IPR014908. Nucleoporin_Nup133/Nup155_N.
IPR004870. Nucleoporin_Nup155.
[Graphical view ]
PANTHERi PTHR10350. PTHR10350. 1 hit.
Pfami PF03177. Nucleoporin_C. 1 hit.
PF08801. Nucleoporin_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Localization of a human nucleoporin 155 gene (NUP155) to the 5p13 region and cloning of its cDNA."
    Zhang X., Yang H., Corydon M.J., Pedersen S., Korenberg J.R., Chen X.N., Laporte J., Gregersen N., Niebuhr E., Liu G., Bolund L.
    Genomics 57:144-151(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. "Genomic organization, transcript variants and comparative analysis of the human nucleoporin 155 (NUP155) gene."
    Zhang X., Yang H., Yu J., Chen C., Zhang G., Bao J., Du Y., Kibukawa M., Li Z., Wang J., Hu S., Dong W., Wang J., Gregersen N., Niebuhr E., Bolund L.
    Gene 288:9-18(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  4. Ohara O., Suyama M., Nagase T., Ishikawa K., Kikuno R.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 728-1391.
    Tissue: Testis.
  7. "The mRNA export factor human Gle1 interacts with the nuclear pore complex protein Nup155."
    Rayala H.J., Kendirgi F., Barry D.M., Majerus P.W., Wente S.R.
    Mol. Cell. Proteomics 3:145-155(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GLE1.
  8. "Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex."
    Hawryluk-Gara L.A., Shibuya E.K., Wozniak R.W.
    Mol. Biol. Cell 16:2382-2394(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH LAMIN B; NUP53; NUP93 AND NUP205.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Mutation in nuclear pore component NUP155 leads to atrial fibrillation and early sudden cardiac death."
    Zhang X., Chen S., Yoo S., Chakrabarti S., Zhang T., Ke T., Oberti C., Yong S.L., Fang F., Li L., de la Fuente R., Wang L., Chen Q., Wang Q.K.
    Cell 135:1017-1027(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN ATFB15, VARIANT ATFB15 HIS-391.

Entry informationi

Entry nameiNU155_HUMAN
AccessioniPrimary (citable) accession number: O75694
Secondary accession number(s): Q9UBE9, Q9UFL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: November 26, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3