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O75694

- NU155_HUMAN

UniProt

O75694 - NU155_HUMAN

Protein

Nuclear pore complex protein Nup155

Gene

NUP155

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Essential component of nuclear pore complex. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport By similarity.By similarity

    GO - Molecular functioni

    1. structural constituent of nuclear pore Source: InterPro
    2. transporter activity Source: ProtInc

    GO - Biological processi

    1. atrial cardiac muscle cell action potential Source: Ensembl
    2. carbohydrate metabolic process Source: Reactome
    3. cytokine-mediated signaling pathway Source: Reactome
    4. glucose transport Source: Reactome
    5. hexose transport Source: Reactome
    6. mitotic cell cycle Source: Reactome
    7. mitotic nuclear envelope disassembly Source: Reactome
    8. mRNA export from nucleus Source: Ensembl
    9. nuclear envelope organization Source: MGI
    10. protein import into nucleus Source: Ensembl
    11. regulation of glucose transport Source: Reactome
    12. small molecule metabolic process Source: Reactome
    13. transmembrane transport Source: Reactome
    14. viral process Source: Reactome

    Keywords - Biological processi

    mRNA transport, Protein transport, Translocation, Transport

    Enzyme and pathway databases

    ReactomeiREACT_115831. ISG15 antiviral mechanism.
    REACT_163931. Nuclear Pore Complex (NPC) Disassembly.
    REACT_6190. Rev-mediated nuclear export of HIV RNA.
    REACT_6804. Regulation of Glucokinase by Glucokinase Regulatory Protein.
    REACT_7991. Vpr-mediated nuclear import of PICs.
    REACT_9395. Nuclear import of Rev protein.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nuclear pore complex protein Nup155
    Alternative name(s):
    155 kDa nucleoporin
    Nucleoporin Nup155
    Gene namesi
    Name:NUP155
    Synonyms:KIAA0791
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:8063. NUP155.

    Subcellular locationi

    Nucleusnuclear pore complex By similarity. Nucleus membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Nucleus membrane By similarity; Peripheral membrane protein By similarity; Nucleoplasmic side By similarity
    Note: In mitosis, assumes a diffuse cytoplasmic distribution probably as a monomer, before reversing back into a punctate nuclear surface localization at the end of mitosis.By similarity

    GO - Cellular componenti

    1. membrane Source: UniProtKB
    2. nuclear envelope Source: MGI
    3. nuclear membrane Source: UniProtKB-SubCell
    4. nuclear pore Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Nuclear pore complex, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti334. Familial atrial fibrillation.
    PharmGKBiPA31849.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13911391Nuclear pore complex protein Nup155PRO_0000204844Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi526 – 5261O-linked (GlcNAc)By similarity

    Post-translational modificationi

    Phosphorylated. Phosphorylation and dephosphorylation may be important for the function of NUP155 and may play a role in the reversible disassembly of the nuclear pore complex during mitosis By similarity.By similarity
    Disulfide-linked to NUP62. The the inner channel of the NPC has a different redox environment from the cytoplasm and allows the formation of interchain disulfide bonds between some nucleoporins, the significant increase of these linkages upon oxidative stress reduces the permeability of the NPC By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiO75694.
    PaxDbiO75694.
    PRIDEiO75694.

    PTM databases

    PhosphoSiteiO75694.

    Expressioni

    Tissue specificityi

    Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

    Gene expression databases

    ArrayExpressiO75694.
    BgeeiO75694.
    CleanExiHS_NUP155.
    GenevestigatoriO75694.

    Organism-specific databases

    HPAiHPA037774.
    HPA037775.

    Interactioni

    Subunit structurei

    Interacts with GLE1. Able to form a heterotrimer with GLE1 and NUPL2 in vitro. Forms a complex with NUP53, NUP93, NUP205 and lamin B.2 Publications

    Protein-protein interaction databases

    BioGridi114990. 22 interactions.
    IntActiO75694. 16 interactions.
    MINTiMINT-1200468.
    STRINGi9606.ENSP00000231498.

    Structurei

    3D structure databases

    ProteinModelPortaliO75694.
    SMRiO75694. Positions 89-590, 871-1311.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi585 – 65571Pro-richAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG5308.
    HOGENOMiHOG000043927.
    HOVERGENiHBG052680.
    InParanoidiO75694.
    KOiK14312.
    OMAiAPQSMQV.
    OrthoDBiEOG7JQBMH.
    PhylomeDBiO75694.
    TreeFamiTF105951.

    Family and domain databases

    InterProiIPR007187. Nucleoporin_Nup133/Nup155_C.
    IPR014908. Nucleoporin_Nup133/Nup155_N.
    IPR004870. Nucleoporin_Nup155.
    [Graphical view]
    PANTHERiPTHR10350. PTHR10350. 1 hit.
    PfamiPF03177. Nucleoporin_C. 1 hit.
    PF08801. Nucleoporin_N. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O75694-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPSSLLGAAM PASTSAAALQ EALENAGRLI DRQLQEDRMY PDLSELLMVS     50
    APNNPTVSGM SDMDYPLQGP GLLSVPNLPE ISSIRRVPLP PELVEQFGHM 100
    QCNCMMGVFP PISRAWLTID SDIFMWNYED GGDLAYFDGL SETILAVGLV 150
    KPKAGIFQPH VRHLLVLATP VDIVILGLSY ANLQTGSGVL NDSLSGGMQL 200
    LPDPLYSLPT DNTYLLTITS TDNGRIFLAG KDGCLYEVAY QAEAGWFSQR 250
    CRKINHSKSS LSFLVPSLLQ FTFSEDDPIL QIAIDNSRNI LYTRSEKGVI 300
    QVYDLGQDGQ GMSRVASVSQ NAIVSAAGNI ARTIDRSVFK PIVQIAVIEN 350
    SESLDCQLLA VTHAGVRLYF STCPFRQPLA RPNTLTLVHV RLPPGFSASS 400
    TVEKPSKVHR ALYSKGILLM AASENEDNDI LWCVNHDTFP FQKPMMETQM 450
    TAGVDGHSWA LSAIDELKVD KIITPLNKDH IPITDSPVVV QQHMLPPKKF 500
    VLLSAQGSLM FHKLRPVDQL RHLLVSNVGG DGEEIERFFK LHQEDQACAT 550
    CLILACSTAA CDREVSAWAT RAFFRYGGEA QMRFPTTLPP PSNVGPILGS 600
    PVYSSSPVPS GSPYPNPSFL GTPSHGIQPP AMSTPVCALG NPATQATNMS 650
    CVTGPEIVYS GKHNGICIYF SRIMGNIWDA SLVVERIFKS GNREITAIES 700
    SVPCQLLESV LQELKGLQEF LDRNSQFAGG PLGNPNTTAK VQQRLIGFMR 750
    PENGNPQQMQ QELQRKFHEA QLSEKISLQA IQQLVRKSYQ ALALWKLLCE 800
    HQFTIIVAEL QKELQEQLKI TTFKDLVIRD KELTGALIAS LINCYIRDNA 850
    AVDGISLHLQ DICPLLYSTD DAICSKANEL LQRSRQVQNK TEKERMLRES 900
    LKEYQKISNQ VDLSNVCAQY RQVRFYEGVV ELSLTAAEKK DPQGLGLHFY 950
    KHGEPEEDIV GLQAFQERLN SYKCITDTLQ ELVNQSKAAP QSPSVPKKPG 1000
    PPVLSSDPNM LSNEEAGHHF EQMLKLSQRS KDELFSIALY NWLIQVDLAD 1050
    KLLQVASPFL EPHLVRMAKV DQNRVRYMDL LWRYYEKNRS FSNAARVLSR 1100
    LADMHSTEIS LQQRLEYIAR AILSAKSSTA ISSIAADGEF LHELEEKMEV 1150
    ARIQLQIQET LQRQYSHHSS VQDAVSQLDS ELMDITKLYG EFADPFKLAE 1200
    CKLAIIHCAG YSDPILVQTL WQDIIEKELS DSVTLSSSDR MHALSLKIVL 1250
    LGKIYAGTPR FFPLDFIVQF LEQQVCTLNW DVGFVIQTMN EIGVPLPRLL 1300
    EVYDQLFKSR DPFWNRMKKP LHLLDCIHVL LIRYVENPSQ VLNCERRRFT 1350
    NLCLDAVCGY LVELQSMSSS VAVQAITGNF KSLQAKLERL H 1391
    Length:1,391
    Mass (Da):155,199
    Last modified:November 1, 1998 - v1
    Checksum:i7F07A103AFF7EE1D
    GO
    Isoform 2 (identifier: O75694-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-59: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,332
    Mass (Da):149,016
    Checksum:iD84A93B75A3F66A6
    GO

    Sequence cautioni

    The sequence BAA34511.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence AAD52966.1 differs from that shown. Reason: Erroneous gene model prediction.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 5959Missing in isoform 2. 1 PublicationVSP_014437Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ007558 mRNA. Translation: CAA07553.1.
    AF165926 Genomic DNA. Translation: AAD52966.1. Sequence problems.
    AB018334 mRNA. Translation: BAA34511.2. Different initiation.
    BC039257 mRNA. Translation: AAH39257.1.
    AL117585 mRNA. Translation: CAB56007.1.
    CCDSiCCDS3921.1. [O75694-1]
    CCDS43310.1. [O75694-2]
    PIRiT17317.
    RefSeqiNP_004289.1. NM_004298.3. [O75694-2]
    NP_705618.1. NM_153485.2. [O75694-1]
    UniGeneiHs.547696.

    Genome annotation databases

    EnsembliENST00000231498; ENSP00000231498; ENSG00000113569. [O75694-1]
    ENST00000381843; ENSP00000371265; ENSG00000113569. [O75694-2]
    GeneIDi9631.
    KEGGihsa:9631.
    UCSCiuc003jkt.1. human. [O75694-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ007558 mRNA. Translation: CAA07553.1 .
    AF165926 Genomic DNA. Translation: AAD52966.1 . Sequence problems.
    AB018334 mRNA. Translation: BAA34511.2 . Different initiation.
    BC039257 mRNA. Translation: AAH39257.1 .
    AL117585 mRNA. Translation: CAB56007.1 .
    CCDSi CCDS3921.1. [O75694-1 ]
    CCDS43310.1. [O75694-2 ]
    PIRi T17317.
    RefSeqi NP_004289.1. NM_004298.3. [O75694-2 ]
    NP_705618.1. NM_153485.2. [O75694-1 ]
    UniGenei Hs.547696.

    3D structure databases

    ProteinModelPortali O75694.
    SMRi O75694. Positions 89-590, 871-1311.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114990. 22 interactions.
    IntActi O75694. 16 interactions.
    MINTi MINT-1200468.
    STRINGi 9606.ENSP00000231498.

    PTM databases

    PhosphoSitei O75694.

    Proteomic databases

    MaxQBi O75694.
    PaxDbi O75694.
    PRIDEi O75694.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000231498 ; ENSP00000231498 ; ENSG00000113569 . [O75694-1 ]
    ENST00000381843 ; ENSP00000371265 ; ENSG00000113569 . [O75694-2 ]
    GeneIDi 9631.
    KEGGi hsa:9631.
    UCSCi uc003jkt.1. human. [O75694-1 ]

    Organism-specific databases

    CTDi 9631.
    GeneCardsi GC05M037327.
    HGNCi HGNC:8063. NUP155.
    HPAi HPA037774.
    HPA037775.
    MIMi 606694. gene.
    neXtProti NX_O75694.
    Orphaneti 334. Familial atrial fibrillation.
    PharmGKBi PA31849.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5308.
    HOGENOMi HOG000043927.
    HOVERGENi HBG052680.
    InParanoidi O75694.
    KOi K14312.
    OMAi APQSMQV.
    OrthoDBi EOG7JQBMH.
    PhylomeDBi O75694.
    TreeFami TF105951.

    Enzyme and pathway databases

    Reactomei REACT_115831. ISG15 antiviral mechanism.
    REACT_163931. Nuclear Pore Complex (NPC) Disassembly.
    REACT_6190. Rev-mediated nuclear export of HIV RNA.
    REACT_6804. Regulation of Glucokinase by Glucokinase Regulatory Protein.
    REACT_7991. Vpr-mediated nuclear import of PICs.
    REACT_9395. Nuclear import of Rev protein.

    Miscellaneous databases

    GeneWikii NUP155.
    GenomeRNAii 9631.
    NextBioi 36143.
    PROi O75694.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75694.
    Bgeei O75694.
    CleanExi HS_NUP155.
    Genevestigatori O75694.

    Family and domain databases

    InterProi IPR007187. Nucleoporin_Nup133/Nup155_C.
    IPR014908. Nucleoporin_Nup133/Nup155_N.
    IPR004870. Nucleoporin_Nup155.
    [Graphical view ]
    PANTHERi PTHR10350. PTHR10350. 1 hit.
    Pfami PF03177. Nucleoporin_C. 1 hit.
    PF08801. Nucleoporin_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Localization of a human nucleoporin 155 gene (NUP155) to the 5p13 region and cloning of its cDNA."
      Zhang X., Yang H., Corydon M.J., Pedersen S., Korenberg J.R., Chen X.N., Laporte J., Gregersen N., Niebuhr E., Liu G., Bolund L.
      Genomics 57:144-151(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Testis.
    2. "Genomic organization, transcript variants and comparative analysis of the human nucleoporin 155 (NUP155) gene."
      Zhang X., Yang H., Yu J., Chen C., Zhang G., Bao J., Du Y., Kibukawa M., Li Z., Wang J., Hu S., Dong W., Wang J., Gregersen N., Niebuhr E., Bolund L.
      Gene 288:9-18(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    4. Ohara O., Suyama M., Nagase T., Ishikawa K., Kikuno R.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 728-1391.
      Tissue: Testis.
    7. "The mRNA export factor human Gle1 interacts with the nuclear pore complex protein Nup155."
      Rayala H.J., Kendirgi F., Barry D.M., Majerus P.W., Wente S.R.
      Mol. Cell. Proteomics 3:145-155(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GLE1.
    8. "Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex."
      Hawryluk-Gara L.A., Shibuya E.K., Wozniak R.W.
      Mol. Biol. Cell 16:2382-2394(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN A COMPLEX WITH LAMIN B; NUP53; NUP93 AND NUP205.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiNU155_HUMAN
    AccessioniPrimary (citable) accession number: O75694
    Secondary accession number(s): Q9UBE9, Q9UFL5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 127 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3