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O75694 (NU155_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nuclear pore complex protein Nup155
Alternative name(s):
155 kDa nucleoporin
Nucleoporin Nup155
Gene names
Name:NUP155
Synonyms:KIAA0791
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1391 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Essential component of nuclear pore complex. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport By similarity.

Subunit structure

Interacts with GLE1. Able to form a heterotrimer with GLE1 and NUPL2 in vitro. Forms a complex with NUP53, NUP93, NUP205 and lamin B. Ref.7 Ref.8

Subcellular location

Nucleusnuclear pore complex By similarity. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side By similarity. Note: In mitosis, assumes a diffuse cytoplasmic distribution probably as a monomer, before reversing back into a punctate nuclear surface localization at the end of mitosis By similarity.

Tissue specificity

Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Post-translational modification

Phosphorylated. Phosphorylation and dephosphorylation may be important for the function of NUP155 and may play a role in the reversible disassembly of the nuclear pore complex during mitosis By similarity.

Disulfide-linked to NUP62. The the inner channel of the NPC has a different redox environment from the cytoplasm and allows the formation of interchain disulfide bonds between some nucleoporins, the significant increase of these linkages upon oxidative stress reduces the permeability of the NPC By similarity.

Sequence similarities

Belongs to the non-repetitive/WGA-negative nucleoporin family.

Sequence caution

The sequence AAD52966.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence BAA34511.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Biological processmRNA transport
Protein transport
Translocation
Transport
   Cellular componentMembrane
Nuclear pore complex
Nucleus
   Coding sequence diversityAlternative splicing
   PTMDisulfide bond
Glycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processatrial cardiac muscle cell action potential

Inferred from electronic annotation. Source: Ensembl

carbohydrate metabolic process

Traceable author statement. Source: Reactome

cytokine-mediated signaling pathway

Traceable author statement. Source: Reactome

glucose transport

Traceable author statement. Source: Reactome

hexose transport

Traceable author statement. Source: Reactome

mRNA export from nucleus

Inferred from electronic annotation. Source: Ensembl

mitotic cell cycle

Traceable author statement. Source: Reactome

mitotic nuclear envelope disassembly

Traceable author statement. Source: Reactome

nuclear envelope organization

Inferred from direct assay PubMed 19070573. Source: MGI

protein import into nucleus

Inferred from electronic annotation. Source: Ensembl

regulation of glucose transport

Traceable author statement. Source: Reactome

small molecule metabolic process

Traceable author statement. Source: Reactome

transmembrane transport

Traceable author statement. Source: Reactome

viral process

Traceable author statement. Source: Reactome

   Cellular_componentnuclear envelope

Inferred from direct assay PubMed 19070573. Source: MGI

nuclear membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

nuclear pore

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionstructural constituent of nuclear pore

Inferred from electronic annotation. Source: InterPro

transporter activity

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O75694-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O75694-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-59: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13911391Nuclear pore complex protein Nup155
PRO_0000204844

Regions

Compositional bias585 – 65571Pro-rich

Amino acid modifications

Glycosylation5261O-linked (GlcNAc) By similarity

Natural variations

Alternative sequence1 – 5959Missing in isoform 2.
VSP_014437

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 7F07A103AFF7EE1D

FASTA1,391155,199
        10         20         30         40         50         60 
MPSSLLGAAM PASTSAAALQ EALENAGRLI DRQLQEDRMY PDLSELLMVS APNNPTVSGM 

        70         80         90        100        110        120 
SDMDYPLQGP GLLSVPNLPE ISSIRRVPLP PELVEQFGHM QCNCMMGVFP PISRAWLTID 

       130        140        150        160        170        180 
SDIFMWNYED GGDLAYFDGL SETILAVGLV KPKAGIFQPH VRHLLVLATP VDIVILGLSY 

       190        200        210        220        230        240 
ANLQTGSGVL NDSLSGGMQL LPDPLYSLPT DNTYLLTITS TDNGRIFLAG KDGCLYEVAY 

       250        260        270        280        290        300 
QAEAGWFSQR CRKINHSKSS LSFLVPSLLQ FTFSEDDPIL QIAIDNSRNI LYTRSEKGVI 

       310        320        330        340        350        360 
QVYDLGQDGQ GMSRVASVSQ NAIVSAAGNI ARTIDRSVFK PIVQIAVIEN SESLDCQLLA 

       370        380        390        400        410        420 
VTHAGVRLYF STCPFRQPLA RPNTLTLVHV RLPPGFSASS TVEKPSKVHR ALYSKGILLM 

       430        440        450        460        470        480 
AASENEDNDI LWCVNHDTFP FQKPMMETQM TAGVDGHSWA LSAIDELKVD KIITPLNKDH 

       490        500        510        520        530        540 
IPITDSPVVV QQHMLPPKKF VLLSAQGSLM FHKLRPVDQL RHLLVSNVGG DGEEIERFFK 

       550        560        570        580        590        600 
LHQEDQACAT CLILACSTAA CDREVSAWAT RAFFRYGGEA QMRFPTTLPP PSNVGPILGS 

       610        620        630        640        650        660 
PVYSSSPVPS GSPYPNPSFL GTPSHGIQPP AMSTPVCALG NPATQATNMS CVTGPEIVYS 

       670        680        690        700        710        720 
GKHNGICIYF SRIMGNIWDA SLVVERIFKS GNREITAIES SVPCQLLESV LQELKGLQEF 

       730        740        750        760        770        780 
LDRNSQFAGG PLGNPNTTAK VQQRLIGFMR PENGNPQQMQ QELQRKFHEA QLSEKISLQA 

       790        800        810        820        830        840 
IQQLVRKSYQ ALALWKLLCE HQFTIIVAEL QKELQEQLKI TTFKDLVIRD KELTGALIAS 

       850        860        870        880        890        900 
LINCYIRDNA AVDGISLHLQ DICPLLYSTD DAICSKANEL LQRSRQVQNK TEKERMLRES 

       910        920        930        940        950        960 
LKEYQKISNQ VDLSNVCAQY RQVRFYEGVV ELSLTAAEKK DPQGLGLHFY KHGEPEEDIV 

       970        980        990       1000       1010       1020 
GLQAFQERLN SYKCITDTLQ ELVNQSKAAP QSPSVPKKPG PPVLSSDPNM LSNEEAGHHF 

      1030       1040       1050       1060       1070       1080 
EQMLKLSQRS KDELFSIALY NWLIQVDLAD KLLQVASPFL EPHLVRMAKV DQNRVRYMDL 

      1090       1100       1110       1120       1130       1140 
LWRYYEKNRS FSNAARVLSR LADMHSTEIS LQQRLEYIAR AILSAKSSTA ISSIAADGEF 

      1150       1160       1170       1180       1190       1200 
LHELEEKMEV ARIQLQIQET LQRQYSHHSS VQDAVSQLDS ELMDITKLYG EFADPFKLAE 

      1210       1220       1230       1240       1250       1260 
CKLAIIHCAG YSDPILVQTL WQDIIEKELS DSVTLSSSDR MHALSLKIVL LGKIYAGTPR 

      1270       1280       1290       1300       1310       1320 
FFPLDFIVQF LEQQVCTLNW DVGFVIQTMN EIGVPLPRLL EVYDQLFKSR DPFWNRMKKP 

      1330       1340       1350       1360       1370       1380 
LHLLDCIHVL LIRYVENPSQ VLNCERRRFT NLCLDAVCGY LVELQSMSSS VAVQAITGNF 

      1390 
KSLQAKLERL H 

« Hide

Isoform 2 [UniParc].

Checksum: D84A93B75A3F66A6
Show »

FASTA1,332149,016

References

« Hide 'large scale' references
[1]"Localization of a human nucleoporin 155 gene (NUP155) to the 5p13 region and cloning of its cDNA."
Zhang X., Yang H., Corydon M.J., Pedersen S., Korenberg J.R., Chen X.N., Laporte J., Gregersen N., Niebuhr E., Liu G., Bolund L.
Genomics 57:144-151(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Testis.
[2]"Genomic organization, transcript variants and comparative analysis of the human nucleoporin 155 (NUP155) gene."
Zhang X., Yang H., Yu J., Chen C., Zhang G., Bao J., Du Y., Kibukawa M., Li Z., Wang J., Hu S., Dong W., Wang J., Gregersen N., Niebuhr E., Bolund L.
Gene 288:9-18(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[4]Ohara O., Suyama M., Nagase T., Ishikawa K., Kikuno R.
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Testis.
[6]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 728-1391.
Tissue: Testis.
[7]"The mRNA export factor human Gle1 interacts with the nuclear pore complex protein Nup155."
Rayala H.J., Kendirgi F., Barry D.M., Majerus P.W., Wente S.R.
Mol. Cell. Proteomics 3:145-155(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH GLE1.
[8]"Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex."
Hawryluk-Gara L.A., Shibuya E.K., Wozniak R.W.
Mol. Biol. Cell 16:2382-2394(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN A COMPLEX WITH LAMIN B; NUP53; NUP93 AND NUP205.
[9]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[12]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ007558 mRNA. Translation: CAA07553.1.
AF165926 Genomic DNA. Translation: AAD52966.1. Sequence problems.
AB018334 mRNA. Translation: BAA34511.2. Different initiation.
BC039257 mRNA. Translation: AAH39257.1.
AL117585 mRNA. Translation: CAB56007.1.
CCDSCCDS3921.1. [O75694-1]
CCDS43310.1. [O75694-2]
PIRT17317.
RefSeqNP_004289.1. NM_004298.3. [O75694-2]
NP_705618.1. NM_153485.2. [O75694-1]
UniGeneHs.547696.

3D structure databases

ProteinModelPortalO75694.
SMRO75694. Positions 89-590, 871-1311.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114990. 21 interactions.
IntActO75694. 16 interactions.
MINTMINT-1200468.
STRING9606.ENSP00000231498.

PTM databases

PhosphoSiteO75694.

Proteomic databases

MaxQBO75694.
PaxDbO75694.
PRIDEO75694.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000231498; ENSP00000231498; ENSG00000113569. [O75694-1]
ENST00000381843; ENSP00000371265; ENSG00000113569. [O75694-2]
GeneID9631.
KEGGhsa:9631.
UCSCuc003jkt.1. human. [O75694-1]

Organism-specific databases

CTD9631.
GeneCardsGC05M037327.
HGNCHGNC:8063. NUP155.
HPAHPA037774.
HPA037775.
MIM606694. gene.
neXtProtNX_O75694.
Orphanet334. Familial atrial fibrillation.
PharmGKBPA31849.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5308.
HOGENOMHOG000043927.
HOVERGENHBG052680.
InParanoidO75694.
KOK14312.
OMAAPQSMQV.
OrthoDBEOG7JQBMH.
PhylomeDBO75694.
TreeFamTF105951.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
REACT_115566. Cell Cycle.
REACT_116125. Disease.
REACT_15518. Transmembrane transport of small molecules.
REACT_21300. Mitotic M-M/G1 phases.
REACT_6900. Immune System.

Gene expression databases

ArrayExpressO75694.
BgeeO75694.
CleanExHS_NUP155.
GenevestigatorO75694.

Family and domain databases

InterProIPR007187. Nucleoporin_Nup133/Nup155_C.
IPR014908. Nucleoporin_Nup133/Nup155_N.
IPR004870. Nucleoporin_Nup155.
[Graphical view]
PANTHERPTHR10350. PTHR10350. 1 hit.
PfamPF03177. Nucleoporin_C. 1 hit.
PF08801. Nucleoporin_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiNUP155.
GenomeRNAi9631.
NextBio36143.
PROO75694.
SOURCESearch...

Entry information

Entry nameNU155_HUMAN
AccessionPrimary (citable) accession number: O75694
Secondary accession number(s): Q9UBE9, Q9UFL5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM