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O75691 (UTP20_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Small subunit processome component 20 homolog
Alternative name(s):
Down-regulated in metastasis protein
Novel nucleolar protein 73
Short name=NNP73
Protein Key-1A6
Gene names
Name:UTP20
Synonyms:DRIM
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length2785 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in 18S pre-rRNA processing. Associates with U3 snoRNA. Ref.8

Subunit structure

Interacts with FBL and PPP1R26. Ref.6 Ref.8

Subcellular location

Nucleusnucleolus. Note: Colocalizes with NCL in the nucleolus. Ref.4 Ref.5 Ref.7

Tissue specificity

Expressed in appendix, brain, colon, fetal liver, heart, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus. Ref.1

Sequence similarities

Belongs to the UTP20 family.

Contains 2 HEAT repeats.

Sequence caution

The sequence AAG35208.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Biological processrRNA processing
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   DomainCoiled coil
Repeat
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processendonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Inferred from sequence or structural similarity PubMed 17652137. Source: UniProtKB

endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Inferred from sequence or structural similarity PubMed 15590835. Source: UniProtKB

endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Inferred from sequence or structural similarity PubMed 17652137. Source: UniProtKB

negative regulation of cell proliferation

Traceable author statement Ref.1. Source: ProtInc

rRNA processing

Inferred from mutant phenotype Ref.8. Source: UniProtKB

   Cellular_component90S preribosome

Inferred from sequence or structural similarity PubMed 12150911. Source: UniProtKB

cytoplasm

Inferred from sequence or structural similarity PubMed 17652137. Source: UniProtKB

nucleolus

Inferred from direct assay Ref.7. Source: UniProtKB

nucleoplasm

Inferred from sequence or structural similarity PubMed 17652137. Source: UniProtKB

preribosome, small subunit precursor

Inferred from sequence or structural similarity PubMed 17652137. Source: UniProtKB

small-subunit processome

Inferred from sequence or structural similarity PubMed 15590835. Source: UniProtKB

   Molecular_functionpoly(A) RNA binding

Inferred from direct assay PubMed 22658674PubMed 22681889. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PPP1R26Q5T8A74EBI-356062,EBI-308500

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 27852785Small subunit processome component 20 homolog
PRO_0000080011

Regions

Repeat165 – 20238HEAT 1
Repeat1841 – 187838HEAT 2
Region2744 – 277532Nuclear localization signal
Region2744 – 276118Nucleolar localization signal
Coiled coil2688 – 276578 Potential
Compositional bias1319 – 13246Poly-Lys

Amino acid modifications

Modified residue7881Phosphoserine Ref.9
Modified residue17411Phosphothreonine Ref.9 Ref.10 Ref.12 Ref.15
Modified residue26011Phosphoserine Ref.13 Ref.15

Natural variations

Natural variant1201M → T.
Corresponds to variant rs2290723 [ dbSNP | Ensembl ].
VAR_055135
Natural variant5021S → C.
Corresponds to variant rs4764643 [ dbSNP | Ensembl ].
VAR_022162
Natural variant16451K → I in a breast cancer sample; somatic mutation. Ref.16
VAR_036274
Natural variant18821L → Q. Ref.1
Corresponds to variant rs10082778 [ dbSNP | Ensembl ].
VAR_055136
Natural variant24521I → F in a breast cancer sample; somatic mutation. Ref.16
VAR_036275
Natural variant26121E → Q.
Corresponds to variant rs1061436 [ dbSNP | Ensembl ].
VAR_022163

Experimental info

Mutagenesis2744 – 27463KKK → AAA: Inhibits nucleolar but not nuclear localization. Ref.7
Mutagenesis27441K → A: Does not decrease nucleolar localization. Ref.7
Mutagenesis27451K → A: Does not decrease nucleolar localization. Ref.7
Mutagenesis27461K → A: Decreases nucleolar localization. Ref.7
Mutagenesis2748 – 27492KK → AA: Inhibits nucleolar but not nuclear localization. Ref.7
Mutagenesis27481K → A: Does not decrease nucleolar localization. Ref.7
Mutagenesis27491K → A: Decreases nucleolar localization. Ref.7
Mutagenesis27511K → A: Does not decrease nucleolar localization. Ref.7
Mutagenesis27531K → A: Does not decrease nucleolar localization. Ref.7
Mutagenesis2757 – 27604KKRK → AAAA: Inhibits nucleolar localization and decreases nuclear localization. Ref.7
Mutagenesis27571K → A: Does not decrease nucleolar localization. Ref.7
Mutagenesis27581K → A: Does not decrease nucleolar localization. Ref.7
Mutagenesis27601K → A: Does not decrease nucleolar localization. Ref.7
Sequence conflict15051A → P in CAA07243. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O75691 [UniParc].

Last modified May 18, 2010. Version 3.
Checksum: 0CE63611C8440E0D

FASTA2,785318,385
        10         20         30         40         50         60 
MKTKPVSHKT ENTYRFLTFA ERLGNVNIDI IHRIDRTASY EEEVETYFFE GLLKWRELNL 

        70         80         90        100        110        120 
TEHFGKFYKE VIDKCQSFNQ LVYHQNEIVQ SLKTHLQVKN SFAYQPLLDL VVQLARDLQM 

       130        140        150        160        170        180 
DFYPHFPEFF LTITSILETQ DTELLEWAFT SLSYLYKYLW RLMVKDMSSI YSMYSTLLAH 

       190        200        210        220        230        240 
KKLHIRNFAA ESFTFLMRKV SDKNALFNLM FLDLDKHPEK VEGVGQLLFE MCKGVRNMFH 

       250        260        270        280        290        300 
SCTGQAVKLI LRKLGPVTET ETQLPWMLIG ETLKNMVKST VSYISKEHFG TFFECLQESL 

       310        320        330        340        350        360 
LDLHTKVTKT NCCESSEQIK RLLETYLILV KHGSGTKIPT PADVCKVLSQ TLQVASLSTS 

       370        380        390        400        410        420 
CWETLLDVIS ALILGENVSL PETLIKETIE KIFESRFEKR LIFSFSEVMF AMKQFEQLFL 

       430        440        450        460        470        480 
PSFLSYIVNC FLIDDAVVKD EALAILAKLI LNKAAPPTAG SMAIEKYPLV FSPQMVGFYI 

       490        500        510        520        530        540 
KQKKTRSKGR NEQFPVLDHL LSIIKLPPNK DTTYLSQSWA ALVVLPHIRP LEKEKVIPLV 

       550        560        570        580        590        600 
TGFIEALFMT VDKGSFGKGN LFVLCQAVNT LLSLEESSEL LHLVPVERVK NLVLTFPLEP 

       610        620        630        640        650        660 
SVLLLTDLYY QRLALCGCKG PLSQEALMEL FPKLQANIST GVSKIRLLTI RILNHFDVQL 

       670        680        690        700        710        720 
PESMEDDGLS ERQSVFAILR QAELVPATVN DYREKLLHLR KLRHDVVQTA VPDGPLQEVP 

       730        740        750        760        770        780 
LRYLLGMLYI NFSALWDPVI ELISSHAHEM ENKQFWKVYY EHLEKAATHA EKELQNDMTD 

       790        800        810        820        830        840 
EKSVGDESWE QTQEGDVGAL YHEQLALKTD CQERLDHTNF RFLLWRALTK FPERVEPRSR 

       850        860        870        880        890        900 
ELSPLFLRFI NNEYYPADLQ VAPTQDLRRK GKGMVAEEIE EEPAAGDDEE LEEEAVPQDE 

       910        920        930        940        950        960 
SSQKKKTRRA AAKQLIAHLQ VFSKFSNPRA LYLESKLYEL YLQLLLHQDQ MVQKITLDCI 

       970        980        990       1000       1010       1020 
MTYKHPHVLP YRENLQRLLE DRSFKEEIVH FSISEDNAVV KTAHRADLFP ILMRILYGRM 

      1030       1040       1050       1060       1070       1080 
KNKTGSKTQG KSASGTRMAI VLRFLAGTQP EEIQIFLDLL FEPVRHFKNG ECHSAVIQAV 

      1090       1100       1110       1120       1130       1140 
EDLDLSKVLP LGRQHGILNS LEIVLKNISH LISAYLPKIL QILLCMTATV SHILDQREKI 

      1150       1160       1170       1180       1190       1200 
QLRFINPLKN LRRLGIKMVT DIFLDWESYQ FRTEEIDAVF HGAVWPQISR LGSESQYSPT 

      1210       1220       1230       1240       1250       1260 
PLLKLISIWS RNARYFPLLA KQKPGHPECD ILTNVFAILS AKNLSDATAS IVMDIVDDLL 

      1270       1280       1290       1300       1310       1320 
NLPDFEPTET VLNLLVTGCV YPGIAENIGE SITIGGRLIL PHVPAILQYL SKTTISAEKV 

      1330       1340       1350       1360       1370       1380 
KKKKNRAQVS KELGILSKIS KFMKDKEQSS VLITLLLPFL HRGNIAEDTE VDILVTVQNL 

      1390       1400       1410       1420       1430       1440 
LKHCVDPTSF LKPIAKLFSV IKNKLSRKLL CTVFETLSDF ESGLKYITDV VKLNAFDQRH 

      1450       1460       1470       1480       1490       1500 
LDDINFDVRF ETFQTITSYI KEMQIVDVNY LIPVMHNCFY NLELGDMSLS DNASMCLMSI 

      1510       1520       1530       1540       1550       1560 
IKKLAALNVT EKDYREIIHR SLLEKLRKGL KSQTESIQQD YTTILSCLIQ TFPNQLEFKD 

      1570       1580       1590       1600       1610       1620 
LVQLTHYHDP EMDFFENMKH IQIHRRARAL KKLAKQLMEG KVVLSSKSLQ NYIMPYAMTP 

      1630       1640       1650       1660       1670       1680 
IFDEKMLKHE NITTAATEII GAICKHLSWS AYMYYLKHFI HVLQTGQINQ KLGVSLLVIV 

      1690       1700       1710       1720       1730       1740 
LEAFHFDHKT LEEQMGKIEN EENAIEAIEL PEPEAMELER VDEEEKEYTC KSLSDNGQPG 

      1750       1760       1770       1780       1790       1800 
TPDPADSGGT SAKESECITK PVSFLPQNKE EIERTIKNIQ GTITGDILPR LHKCLASTTK 

      1810       1820       1830       1840       1850       1860 
REEEHKLVKS KVVNDEEVVR VPLAFAMVKL MQSLPQEVME ANLPSILLKV CALLKNRAQE 

      1870       1880       1890       1900       1910       1920 
IRDIARSTLA KIIEDLGVHF LLYVLKELQT TLVRGYQVHV LTFTVHMLLQ GLTNKLQVGD 

      1930       1940       1950       1960       1970       1980 
LDSCLDIMIE IFNHELFGAV AEEKEVKQIL SKVMEARRSK SYDSYEILGK FVGKDQVTKL 

      1990       2000       2010       2020       2030       2040 
ILPLKEILQN TTSLKLARKV HETLRRITVG LIVNQEMTAE SILLLSYGLI SENLPLLTEK 

      2050       2060       2070       2080       2090       2100 
EKNPVAPAPD PRLPPQSCLL LPPTPVRGGQ KAVVSRKTNM HIFIESGLRL LHLSLKTSKI 

      2110       2120       2130       2140       2150       2160 
KSSGECVLEM LDPFVSLLID CLGSMDVKVI TGALQCLIWV LRFPLPSIET KAEQLTKHLF 

      2170       2180       2190       2200       2210       2220 
LLLKDYAKLG AARGQNFHLV VNCFKCVTIL VKKVKSYQIT EKQLQVLLAY AEEDIYDTSR 

      2230       2240       2250       2260       2270       2280 
QATAFGLLKA ILSRKLLVPE IDEVMRKVSK LAVSAQSEPA RVQCRQVFLK YILDYPLGDK 

      2290       2300       2310       2320       2330       2340 
LRPNLEFMLA QLNYEHETGR ESTLEMIAYL FDTFPQGLLH ENCGMFFIPL CLMTINDDSA 

      2350       2360       2370       2380       2390       2400 
TCKKMASMTI KSLLGKISLE KKDWLFDMVT TWFGAKKRLN RQLAALICGL FVESEGVDFE 

      2410       2420       2430       2440       2450       2460 
KRLGTVLPVI EKEIDPENFK DIMEETEEKA ADRLLFSFLT LITKLIKECN IIQFTKPAET 

      2470       2480       2490       2500       2510       2520 
LSKIWSHVHS HLRHPHNWVW LTAAQIFGLL FASCQPEELI QKWNTKKTKK HLPEPVAIKF 

      2530       2540       2550       2560       2570       2580 
LASDLDQKMK SISLASCHQL HSKFLDQSLG EQVVKNLLFA AKVLYLLELY CEDKQSKIKE 

      2590       2600       2610       2620       2630       2640 
DLEEQEALED GVACADEKAE SDGEEKEEVK EELGRPATLL WLIQKLSRIA KLEAAYSPRN 

      2650       2660       2670       2680       2690       2700 
PLKRTCIFKF LGAVAMDLGI DKVKPYLPMI IAPLFRELNS TYSEQDPLLK NLSQEIIELL 

      2710       2720       2730       2740       2750       2760 
KKLVGLESFS LAFASVQKQA NEKRALRKKR KALEFVTNPD IAAKKKMKKH KNKSEAKKRK 

      2770       2780 
IEFLRPGYKA KRQKSHSLKD LAMVE 

« Hide

References

« Hide 'large scale' references
[1]"Differential gene expression in mammary carcinoma cell lines: identification of DRIM, a new gene down-regulated in metastasis."
Schwirzke M., Gnirke A., Bork P., Tarin D., Weidle U.H.
Anticancer Res. 18:1409-1421(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT GLN-1882.
[2]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Key-1A6."
Ke Y., Hagiwara K., Zhao H., Ning T., Su X.L., Mcmenamin H., Lu G.R., Wang B., Harris C.C.
Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1883-2785.
[4]"Directed proteomic analysis of the human nucleolus."
Andersen J.S., Lyon C.E., Fox A.H., Leung A.K.L., Lam Y.W., Steen H., Mann M., Lamond A.I.
Curr. Biol. 12:1-11(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
[5]"Functional proteomic analysis of human nucleolus."
Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J.
Mol. Biol. Cell 13:4100-4109(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"KIAA0649, a 1A6/DRIM-interacting protein with the oncogenic potential."
Yang L., Zhao J., Lu W., Li Y., Du X., Ning T., Lu G., Ke Y.
Biochem. Biophys. Res. Commun. 334:884-890(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PPP1R26.
[7]"Mapping nucleolar localization sequences of 1A6/DRIM."
Liu J., Du X., Ke Y.
FEBS Lett. 580:1405-1410(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF 2744-LYS--LYS-2746; LYS-2744; LYS-2745; LYS-2746; 2748-LYS-LYS-2749; LYS-2748; LYS-2749; LYS-2751; LYS-2753; 2757-LYS--LYS-2760; LYS-2757; LYS-2758 AND LYS-2760.
[8]"Human 1A6/DRIM, the homolog of yeast Utp20, functions in the 18S rRNA processing."
Wang Y., Liu J., Zhao H., Lue W., Zhao J., Yang L., Li N., Du X., Ke Y.
Biochim. Biophys. Acta 1773:863-868(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH FBL.
[9]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-788 AND THR-1741, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1741, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[11]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1741, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[13]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2601, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[14]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[15]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1741 AND SER-2601, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[16]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] ILE-1645 AND PHE-2452.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ006778 mRNA. Translation: CAA07243.1.
AC063948 Genomic DNA. No translation available.
AC063951 Genomic DNA. No translation available.
AF072718 mRNA. Translation: AAG35208.1. Different initiation.
RefSeqNP_055318.2. NM_014503.2.
UniGeneHs.295732.

3D structure databases

ProteinModelPortalO75691.
SMRO75691. Positions 128-158, 1522-1551, 1823-1876, 2111-2136, 2256-2315, 2383-2410, 2465-2490, 2687-2712.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid118152. 12 interactions.
IntActO75691. 2 interactions.
MINTMINT-1163597.
STRING9606.ENSP00000261637.

PTM databases

PhosphoSiteO75691.

2D gel databases

SWISS-2DPAGEO75691.

Proteomic databases

PaxDbO75691.
PRIDEO75691.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000261637; ENSP00000261637; ENSG00000120800.
GeneID27340.
KEGGhsa:27340.
UCSCuc001tia.1. human.

Organism-specific databases

CTD27340.
GeneCardsGC12P101673.
H-InvDBHIX0010919.
HGNCHGNC:17897. UTP20.
MIM612822. gene.
neXtProtNX_O75691.
PharmGKBPA143485666.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG296791.
HOGENOMHOG000168315.
HOVERGENHBG094143.
InParanoidO75691.
KOK14772.
OMAWLFDMVT.
OrthoDBEOG7MWGVX.
PhylomeDBO75691.
TreeFamTF105652.

Gene expression databases

BgeeO75691.
CleanExHS_UTP20.
GenevestigatorO75691.

Family and domain databases

Gene3D1.25.10.10. 5 hits.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR011430. DRIM.
[Graphical view]
PfamPF07539. DRIM. 1 hit.
[Graphical view]
SUPFAMSSF48371. SSF48371. 12 hits.
ProtoNetSearch...

Other

GeneWikiUTP20.
GenomeRNAi27340.
NextBio50408.
PROO75691.
SOURCESearch...

Entry information

Entry nameUTP20_HUMAN
AccessionPrimary (citable) accession number: O75691
Secondary accession number(s): Q9H3H4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: May 18, 2010
Last modified: April 16, 2014
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM