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O75691

- UTP20_HUMAN

UniProt

O75691 - UTP20_HUMAN

Protein

Small subunit processome component 20 homolog

Gene

UTP20

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    Involved in 18S pre-rRNA processing. Associates with U3 snoRNA.1 Publication

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: UniProtKB
    2. endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: UniProtKB
    3. endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: UniProtKB
    4. negative regulation of cell proliferation Source: ProtInc
    5. rRNA processing Source: UniProtKB

    Keywords - Biological processi

    rRNA processing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Small subunit processome component 20 homolog
    Alternative name(s):
    Down-regulated in metastasis protein
    Novel nucleolar protein 73
    Short name:
    NNP73
    Protein Key-1A6
    Gene namesi
    Name:UTP20
    Synonyms:DRIM
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:17897. UTP20.

    Subcellular locationi

    Nucleusnucleolus 3 Publications
    Note: Colocalizes with NCL in the nucleolus.

    GO - Cellular componenti

    1. 90S preribosome Source: UniProtKB
    2. cytoplasm Source: UniProtKB
    3. nucleolus Source: UniProtKB
    4. nucleoplasm Source: UniProtKB
    5. preribosome, small subunit precursor Source: UniProtKB
    6. small-subunit processome Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi2744 – 27463KKK → AAA: Inhibits nucleolar but not nuclear localization. 1 Publication
    Mutagenesisi2744 – 27441K → A: Does not decrease nucleolar localization. 1 Publication
    Mutagenesisi2745 – 27451K → A: Does not decrease nucleolar localization. 1 Publication
    Mutagenesisi2746 – 27461K → A: Decreases nucleolar localization. 1 Publication
    Mutagenesisi2748 – 27492KK → AA: Inhibits nucleolar but not nuclear localization. 1 Publication
    Mutagenesisi2748 – 27481K → A: Does not decrease nucleolar localization. 1 Publication
    Mutagenesisi2749 – 27491K → A: Decreases nucleolar localization. 1 Publication
    Mutagenesisi2751 – 27511K → A: Does not decrease nucleolar localization. 1 Publication
    Mutagenesisi2753 – 27531K → A: Does not decrease nucleolar localization. 1 Publication
    Mutagenesisi2757 – 27604KKRK → AAAA: Inhibits nucleolar localization and decreases nuclear localization. 1 Publication
    Mutagenesisi2757 – 27571K → A: Does not decrease nucleolar localization. 1 Publication
    Mutagenesisi2758 – 27581K → A: Does not decrease nucleolar localization. 1 Publication
    Mutagenesisi2760 – 27601K → A: Does not decrease nucleolar localization. 1 Publication

    Organism-specific databases

    PharmGKBiPA143485666.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 27852785Small subunit processome component 20 homologPRO_0000080011Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei788 – 7881Phosphoserine1 Publication
    Modified residuei1741 – 17411Phosphothreonine4 Publications
    Modified residuei2601 – 26011Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO75691.
    PaxDbiO75691.
    PRIDEiO75691.

    2D gel databases

    SWISS-2DPAGEO75691.

    PTM databases

    PhosphoSiteiO75691.

    Expressioni

    Tissue specificityi

    Expressed in appendix, brain, colon, fetal liver, heart, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus.1 Publication

    Gene expression databases

    BgeeiO75691.
    CleanExiHS_UTP20.
    GenevestigatoriO75691.

    Interactioni

    Subunit structurei

    Interacts with FBL and PPP1R26.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PPP1R26Q5T8A74EBI-356062,EBI-308500

    Protein-protein interaction databases

    BioGridi118152. 14 interactions.
    IntActiO75691. 2 interactions.
    MINTiMINT-1163597.
    STRINGi9606.ENSP00000261637.

    Structurei

    3D structure databases

    ProteinModelPortaliO75691.
    SMRiO75691. Positions 1231-1256.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati165 – 20238HEAT 1Add
    BLAST
    Repeati1841 – 187838HEAT 2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2744 – 277532Nuclear localization signalAdd
    BLAST
    Regioni2744 – 276118Nucleolar localization signalAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili2688 – 276578Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1319 – 13246Poly-Lys

    Sequence similaritiesi

    Belongs to the UTP20 family.Curated
    Contains 2 HEAT repeats.Curated

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiNOG296791.
    HOGENOMiHOG000168315.
    HOVERGENiHBG094143.
    InParanoidiO75691.
    KOiK14772.
    OMAiWLFDMVT.
    OrthoDBiEOG7MWGVX.
    PhylomeDBiO75691.
    TreeFamiTF105652.

    Family and domain databases

    Gene3Di1.25.10.10. 5 hits.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR011430. DRIM.
    [Graphical view]
    PfamiPF07539. DRIM. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 12 hits.

    Sequencei

    Sequence statusi: Complete.

    O75691-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTKPVSHKT ENTYRFLTFA ERLGNVNIDI IHRIDRTASY EEEVETYFFE     50
    GLLKWRELNL TEHFGKFYKE VIDKCQSFNQ LVYHQNEIVQ SLKTHLQVKN 100
    SFAYQPLLDL VVQLARDLQM DFYPHFPEFF LTITSILETQ DTELLEWAFT 150
    SLSYLYKYLW RLMVKDMSSI YSMYSTLLAH KKLHIRNFAA ESFTFLMRKV 200
    SDKNALFNLM FLDLDKHPEK VEGVGQLLFE MCKGVRNMFH SCTGQAVKLI 250
    LRKLGPVTET ETQLPWMLIG ETLKNMVKST VSYISKEHFG TFFECLQESL 300
    LDLHTKVTKT NCCESSEQIK RLLETYLILV KHGSGTKIPT PADVCKVLSQ 350
    TLQVASLSTS CWETLLDVIS ALILGENVSL PETLIKETIE KIFESRFEKR 400
    LIFSFSEVMF AMKQFEQLFL PSFLSYIVNC FLIDDAVVKD EALAILAKLI 450
    LNKAAPPTAG SMAIEKYPLV FSPQMVGFYI KQKKTRSKGR NEQFPVLDHL 500
    LSIIKLPPNK DTTYLSQSWA ALVVLPHIRP LEKEKVIPLV TGFIEALFMT 550
    VDKGSFGKGN LFVLCQAVNT LLSLEESSEL LHLVPVERVK NLVLTFPLEP 600
    SVLLLTDLYY QRLALCGCKG PLSQEALMEL FPKLQANIST GVSKIRLLTI 650
    RILNHFDVQL PESMEDDGLS ERQSVFAILR QAELVPATVN DYREKLLHLR 700
    KLRHDVVQTA VPDGPLQEVP LRYLLGMLYI NFSALWDPVI ELISSHAHEM 750
    ENKQFWKVYY EHLEKAATHA EKELQNDMTD EKSVGDESWE QTQEGDVGAL 800
    YHEQLALKTD CQERLDHTNF RFLLWRALTK FPERVEPRSR ELSPLFLRFI 850
    NNEYYPADLQ VAPTQDLRRK GKGMVAEEIE EEPAAGDDEE LEEEAVPQDE 900
    SSQKKKTRRA AAKQLIAHLQ VFSKFSNPRA LYLESKLYEL YLQLLLHQDQ 950
    MVQKITLDCI MTYKHPHVLP YRENLQRLLE DRSFKEEIVH FSISEDNAVV 1000
    KTAHRADLFP ILMRILYGRM KNKTGSKTQG KSASGTRMAI VLRFLAGTQP 1050
    EEIQIFLDLL FEPVRHFKNG ECHSAVIQAV EDLDLSKVLP LGRQHGILNS 1100
    LEIVLKNISH LISAYLPKIL QILLCMTATV SHILDQREKI QLRFINPLKN 1150
    LRRLGIKMVT DIFLDWESYQ FRTEEIDAVF HGAVWPQISR LGSESQYSPT 1200
    PLLKLISIWS RNARYFPLLA KQKPGHPECD ILTNVFAILS AKNLSDATAS 1250
    IVMDIVDDLL NLPDFEPTET VLNLLVTGCV YPGIAENIGE SITIGGRLIL 1300
    PHVPAILQYL SKTTISAEKV KKKKNRAQVS KELGILSKIS KFMKDKEQSS 1350
    VLITLLLPFL HRGNIAEDTE VDILVTVQNL LKHCVDPTSF LKPIAKLFSV 1400
    IKNKLSRKLL CTVFETLSDF ESGLKYITDV VKLNAFDQRH LDDINFDVRF 1450
    ETFQTITSYI KEMQIVDVNY LIPVMHNCFY NLELGDMSLS DNASMCLMSI 1500
    IKKLAALNVT EKDYREIIHR SLLEKLRKGL KSQTESIQQD YTTILSCLIQ 1550
    TFPNQLEFKD LVQLTHYHDP EMDFFENMKH IQIHRRARAL KKLAKQLMEG 1600
    KVVLSSKSLQ NYIMPYAMTP IFDEKMLKHE NITTAATEII GAICKHLSWS 1650
    AYMYYLKHFI HVLQTGQINQ KLGVSLLVIV LEAFHFDHKT LEEQMGKIEN 1700
    EENAIEAIEL PEPEAMELER VDEEEKEYTC KSLSDNGQPG TPDPADSGGT 1750
    SAKESECITK PVSFLPQNKE EIERTIKNIQ GTITGDILPR LHKCLASTTK 1800
    REEEHKLVKS KVVNDEEVVR VPLAFAMVKL MQSLPQEVME ANLPSILLKV 1850
    CALLKNRAQE IRDIARSTLA KIIEDLGVHF LLYVLKELQT TLVRGYQVHV 1900
    LTFTVHMLLQ GLTNKLQVGD LDSCLDIMIE IFNHELFGAV AEEKEVKQIL 1950
    SKVMEARRSK SYDSYEILGK FVGKDQVTKL ILPLKEILQN TTSLKLARKV 2000
    HETLRRITVG LIVNQEMTAE SILLLSYGLI SENLPLLTEK EKNPVAPAPD 2050
    PRLPPQSCLL LPPTPVRGGQ KAVVSRKTNM HIFIESGLRL LHLSLKTSKI 2100
    KSSGECVLEM LDPFVSLLID CLGSMDVKVI TGALQCLIWV LRFPLPSIET 2150
    KAEQLTKHLF LLLKDYAKLG AARGQNFHLV VNCFKCVTIL VKKVKSYQIT 2200
    EKQLQVLLAY AEEDIYDTSR QATAFGLLKA ILSRKLLVPE IDEVMRKVSK 2250
    LAVSAQSEPA RVQCRQVFLK YILDYPLGDK LRPNLEFMLA QLNYEHETGR 2300
    ESTLEMIAYL FDTFPQGLLH ENCGMFFIPL CLMTINDDSA TCKKMASMTI 2350
    KSLLGKISLE KKDWLFDMVT TWFGAKKRLN RQLAALICGL FVESEGVDFE 2400
    KRLGTVLPVI EKEIDPENFK DIMEETEEKA ADRLLFSFLT LITKLIKECN 2450
    IIQFTKPAET LSKIWSHVHS HLRHPHNWVW LTAAQIFGLL FASCQPEELI 2500
    QKWNTKKTKK HLPEPVAIKF LASDLDQKMK SISLASCHQL HSKFLDQSLG 2550
    EQVVKNLLFA AKVLYLLELY CEDKQSKIKE DLEEQEALED GVACADEKAE 2600
    SDGEEKEEVK EELGRPATLL WLIQKLSRIA KLEAAYSPRN PLKRTCIFKF 2650
    LGAVAMDLGI DKVKPYLPMI IAPLFRELNS TYSEQDPLLK NLSQEIIELL 2700
    KKLVGLESFS LAFASVQKQA NEKRALRKKR KALEFVTNPD IAAKKKMKKH 2750
    KNKSEAKKRK IEFLRPGYKA KRQKSHSLKD LAMVE 2785
    Length:2,785
    Mass (Da):318,385
    Last modified:May 18, 2010 - v3
    Checksum:i0CE63611C8440E0D
    GO

    Sequence cautioni

    The sequence AAG35208.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1505 – 15051A → P in CAA07243. (PubMed:9673349)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti120 – 1201M → T.
    Corresponds to variant rs2290723 [ dbSNP | Ensembl ].
    VAR_055135
    Natural varianti502 – 5021S → C.
    Corresponds to variant rs4764643 [ dbSNP | Ensembl ].
    VAR_022162
    Natural varianti1645 – 16451K → I in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036274
    Natural varianti1882 – 18821L → Q.1 Publication
    Corresponds to variant rs10082778 [ dbSNP | Ensembl ].
    VAR_055136
    Natural varianti2452 – 24521I → F in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036275
    Natural varianti2612 – 26121E → Q.
    Corresponds to variant rs1061436 [ dbSNP | Ensembl ].
    VAR_022163

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ006778 mRNA. Translation: CAA07243.1.
    AC063948 Genomic DNA. No translation available.
    AC063951 Genomic DNA. No translation available.
    AF072718 mRNA. Translation: AAG35208.1. Different initiation.
    CCDSiCCDS9081.1.
    RefSeqiNP_055318.2. NM_014503.2.
    UniGeneiHs.295732.

    Genome annotation databases

    EnsembliENST00000261637; ENSP00000261637; ENSG00000120800.
    GeneIDi27340.
    KEGGihsa:27340.
    UCSCiuc001tia.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ006778 mRNA. Translation: CAA07243.1 .
    AC063948 Genomic DNA. No translation available.
    AC063951 Genomic DNA. No translation available.
    AF072718 mRNA. Translation: AAG35208.1 . Different initiation.
    CCDSi CCDS9081.1.
    RefSeqi NP_055318.2. NM_014503.2.
    UniGenei Hs.295732.

    3D structure databases

    ProteinModelPortali O75691.
    SMRi O75691. Positions 1231-1256.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118152. 14 interactions.
    IntActi O75691. 2 interactions.
    MINTi MINT-1163597.
    STRINGi 9606.ENSP00000261637.

    PTM databases

    PhosphoSitei O75691.

    2D gel databases

    SWISS-2DPAGE O75691.

    Proteomic databases

    MaxQBi O75691.
    PaxDbi O75691.
    PRIDEi O75691.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000261637 ; ENSP00000261637 ; ENSG00000120800 .
    GeneIDi 27340.
    KEGGi hsa:27340.
    UCSCi uc001tia.1. human.

    Organism-specific databases

    CTDi 27340.
    GeneCardsi GC12P101673.
    H-InvDB HIX0010919.
    HGNCi HGNC:17897. UTP20.
    MIMi 612822. gene.
    neXtProti NX_O75691.
    PharmGKBi PA143485666.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG296791.
    HOGENOMi HOG000168315.
    HOVERGENi HBG094143.
    InParanoidi O75691.
    KOi K14772.
    OMAi WLFDMVT.
    OrthoDBi EOG7MWGVX.
    PhylomeDBi O75691.
    TreeFami TF105652.

    Miscellaneous databases

    GeneWikii UTP20.
    GenomeRNAii 27340.
    NextBioi 50408.
    PROi O75691.
    SOURCEi Search...

    Gene expression databases

    Bgeei O75691.
    CleanExi HS_UTP20.
    Genevestigatori O75691.

    Family and domain databases

    Gene3Di 1.25.10.10. 5 hits.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR011430. DRIM.
    [Graphical view ]
    Pfami PF07539. DRIM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 12 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Differential gene expression in mammary carcinoma cell lines: identification of DRIM, a new gene down-regulated in metastasis."
      Schwirzke M., Gnirke A., Bork P., Tarin D., Weidle U.H.
      Anticancer Res. 18:1409-1421(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT GLN-1882.
    2. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Key-1A6."
      Ke Y., Hagiwara K., Zhao H., Ning T., Su X.L., Mcmenamin H., Lu G.R., Wang B., Harris C.C.
      Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1883-2785.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "KIAA0649, a 1A6/DRIM-interacting protein with the oncogenic potential."
      Yang L., Zhao J., Lu W., Li Y., Du X., Ning T., Lu G., Ke Y.
      Biochem. Biophys. Res. Commun. 334:884-890(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PPP1R26.
    7. "Mapping nucleolar localization sequences of 1A6/DRIM."
      Liu J., Du X., Ke Y.
      FEBS Lett. 580:1405-1410(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF 2744-LYS--LYS-2746; LYS-2744; LYS-2745; LYS-2746; 2748-LYS-LYS-2749; LYS-2748; LYS-2749; LYS-2751; LYS-2753; 2757-LYS--LYS-2760; LYS-2757; LYS-2758 AND LYS-2760.
    8. "Human 1A6/DRIM, the homolog of yeast Utp20, functions in the 18S rRNA processing."
      Wang Y., Liu J., Zhao H., Lue W., Zhao J., Yang L., Li N., Du X., Ke Y.
      Biochim. Biophys. Acta 1773:863-868(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH FBL.
    9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-788 AND THR-1741, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1741, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1741, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2601, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1741 AND SER-2601, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. Cited for: VARIANTS [LARGE SCALE ANALYSIS] ILE-1645 AND PHE-2452.

    Entry informationi

    Entry nameiUTP20_HUMAN
    AccessioniPrimary (citable) accession number: O75691
    Secondary accession number(s): Q9H3H4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 12, 2005
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 111 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3