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Protein

Surfeit locus protein 6

Gene

SURF6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity).By similarity

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding, RNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000148296-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Surfeit locus protein 6
Gene namesi
Name:SURF6
Synonyms:SURF-6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:11478. SURF6.

Subcellular locationi

GO - Cellular componenti

  • cytosolic large ribosomal subunit Source: GO_Central
  • granular component Source: UniProtKB
  • nucleolus Source: ProtInc
  • nucleoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6838.
OpenTargetsiENSG00000148296.
ENSG00000281309.
PharmGKBiPA36263.

Polymorphism and mutation databases

BioMutaiSURF6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002209691 – 361Surfeit locus protein 6Add BLAST361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei74PhosphoserineCombined sources1
Modified residuei138PhosphoserineCombined sources1
Modified residuei229PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO75683.
MaxQBiO75683.
PaxDbiO75683.
PeptideAtlasiO75683.
PRIDEiO75683.

PTM databases

iPTMnetiO75683.
PhosphoSitePlusiO75683.

Expressioni

Gene expression databases

BgeeiENSG00000148296.
CleanExiHS_SURF6.
GenevisibleiO75683. HS.

Organism-specific databases

HPAiHPA023608.
HPA074622.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CSNK2A1P684002EBI-2691252,EBI-347804

Protein-protein interaction databases

BioGridi112705. 25 interactors.
IntActiO75683. 6 interactors.
MINTiMINT-3001658.
STRINGi9606.ENSP00000361092.

Structurei

3D structure databases

ProteinModelPortaliO75683.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi45 – 49Nuclear localization signalSequence analysis5
Motifi154 – 158Nuclear localization signalSequence analysis5

Sequence similaritiesi

Belongs to the SURF6 family.Curated

Phylogenomic databases

eggNOGiKOG2885. Eukaryota.
ENOG4111G0Y. LUCA.
GeneTreeiENSGT00390000006980.
HOGENOMiHOG000133097.
HOVERGENiHBG054998.
InParanoidiO75683.
OMAiKFRKREE.
OrthoDBiEOG091G0O75.
PhylomeDBiO75683.
TreeFamiTF321608.

Family and domain databases

InterProiIPR029190. Rrp14/SURF6_C.
IPR007019. SURF6.
[Graphical view]
PANTHERiPTHR14369. PTHR14369. 1 hit.
PfamiPF04935. SURF6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75683-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLLAKDAY LQSLAKKICS HSAPEQQART RAGKTQGSET AGPPKKKRKK
60 70 80 90 100
TQKKFRKREE KAAEHKAKSL GEKSPAASGA RRPEAAKEEA AWASSSAGNP
110 120 130 140 150
ADGLATEPES VFALDVLRQR LHEKIQEARG QGSAKELSPA ALEKRRRRKQ
160 170 180 190 200
ERDRKKRKRK ELRAKEKARK AEEATEAQEV VEATPEGACT EPREPPGLIF
210 220 230 240 250
NKVEVSEDEP ASKAQRRKEK RQRVKGNLTP LTGRNYRQLL ERLQARQSRL
260 270 280 290 300
DELRGQDEGK AQELEAKMKW TNLLYKAEGV KIRDDERLLQ EALKRKEKRR
310 320 330 340 350
AQRQRRWEKR TAGVVEKMQQ RQDRRRQNLR RKKAARAERR LLRARKKGRI
360
LPQDLERAGL V
Length:361
Mass (Da):41,450
Last modified:June 6, 2002 - v3
Checksum:i34F63992E3E82797
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6A → T in CAA12054 (PubMed:11891058).Curated1
Sequence conflicti102D → N in AAD56587 (PubMed:10675619).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014532163R → W.Corresponds to variant rs886090dbSNPEnsembl.1
Natural variantiVAR_014533175T → M.Corresponds to variant rs886089dbSNPEnsembl.1
Natural variantiVAR_052199193R → Q.Corresponds to variant rs34657219dbSNPEnsembl.1
Natural variantiVAR_052200201N → H.Corresponds to variant rs35316446dbSNPEnsembl.1
Natural variantiVAR_014534311T → M.Corresponds to variant rs1800867dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF186772 Genomic DNA. Translation: AAD56587.1.
AL158826 Genomic DNA. Translation: CAI12825.1.
CH471090 Genomic DNA. Translation: EAW88055.1.
BC003001 mRNA. Translation: AAH03001.1.
BC006197 mRNA. Translation: AAH06197.1.
BC014878 mRNA. Translation: AAH14878.1.
AJ224639 Genomic DNA. Translation: CAA12054.1.
CCDSiCCDS6962.1.
RefSeqiNP_001265871.1. NM_001278942.1.
NP_006744.2. NM_006753.5.
UniGeneiHs.274430.

Genome annotation databases

EnsembliENST00000372022; ENSP00000361092; ENSG00000148296.
ENST00000629980; ENSP00000485909; ENSG00000281309.
GeneIDi6838.
KEGGihsa:6838.
UCSCiuc004cdb.6. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF186772 Genomic DNA. Translation: AAD56587.1.
AL158826 Genomic DNA. Translation: CAI12825.1.
CH471090 Genomic DNA. Translation: EAW88055.1.
BC003001 mRNA. Translation: AAH03001.1.
BC006197 mRNA. Translation: AAH06197.1.
BC014878 mRNA. Translation: AAH14878.1.
AJ224639 Genomic DNA. Translation: CAA12054.1.
CCDSiCCDS6962.1.
RefSeqiNP_001265871.1. NM_001278942.1.
NP_006744.2. NM_006753.5.
UniGeneiHs.274430.

3D structure databases

ProteinModelPortaliO75683.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112705. 25 interactors.
IntActiO75683. 6 interactors.
MINTiMINT-3001658.
STRINGi9606.ENSP00000361092.

PTM databases

iPTMnetiO75683.
PhosphoSitePlusiO75683.

Polymorphism and mutation databases

BioMutaiSURF6.

Proteomic databases

EPDiO75683.
MaxQBiO75683.
PaxDbiO75683.
PeptideAtlasiO75683.
PRIDEiO75683.

Protocols and materials databases

DNASUi6838.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372022; ENSP00000361092; ENSG00000148296.
ENST00000629980; ENSP00000485909; ENSG00000281309.
GeneIDi6838.
KEGGihsa:6838.
UCSCiuc004cdb.6. human.

Organism-specific databases

CTDi6838.
DisGeNETi6838.
GeneCardsiSURF6.
HGNCiHGNC:11478. SURF6.
HPAiHPA023608.
HPA074622.
MIMi185642. gene.
neXtProtiNX_O75683.
OpenTargetsiENSG00000148296.
ENSG00000281309.
PharmGKBiPA36263.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2885. Eukaryota.
ENOG4111G0Y. LUCA.
GeneTreeiENSGT00390000006980.
HOGENOMiHOG000133097.
HOVERGENiHBG054998.
InParanoidiO75683.
OMAiKFRKREE.
OrthoDBiEOG091G0O75.
PhylomeDBiO75683.
TreeFamiTF321608.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000148296-MONOMER.

Miscellaneous databases

ChiTaRSiSURF6. human.
GeneWikiiSURF6.
GenomeRNAii6838.
PROiO75683.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000148296.
CleanExiHS_SURF6.
GenevisibleiO75683. HS.

Family and domain databases

InterProiIPR029190. Rrp14/SURF6_C.
IPR007019. SURF6.
[Graphical view]
PANTHERiPTHR14369. PTHR14369. 1 hit.
PfamiPF04935. SURF6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSURF6_HUMAN
AccessioniPrimary (citable) accession number: O75683
Secondary accession number(s): Q5T8U1
, Q9BRK9, Q9BTZ5, Q9UK24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 6, 2002
Last modified: November 30, 2016
This is version 138 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.