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Protein

Surfeit locus protein 6

Gene

SURF6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity).By similarity

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Surfeit locus protein 6
Gene namesi
Name:SURF6
Synonyms:SURF-6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:11478. SURF6.

Subcellular locationi

GO - Cellular componenti

  • granular component Source: UniProtKB
  • nucleolus Source: ProtInc
  • nucleoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36263.

Polymorphism and mutation databases

BioMutaiSURF6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 361361Surfeit locus protein 6PRO_0000220969Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei74 – 741Phosphoserine3 Publications
Modified residuei138 – 1381Phosphoserine3 Publications
Modified residuei229 – 2291Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO75683.
PaxDbiO75683.
PeptideAtlasiO75683.
PRIDEiO75683.

PTM databases

PhosphoSiteiO75683.

Expressioni

Gene expression databases

BgeeiO75683.
CleanExiHS_SURF6.
GenevisibleiO75683. HS.

Organism-specific databases

HPAiHPA023608.

Interactioni

Protein-protein interaction databases

BioGridi112705. 15 interactions.
IntActiO75683. 4 interactions.
MINTiMINT-3001658.

Structurei

3D structure databases

ProteinModelPortaliO75683.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi45 – 495Nuclear localization signalSequence Analysis
Motifi154 – 1585Nuclear localization signalSequence Analysis

Sequence similaritiesi

Belongs to the SURF6 family.Curated

Phylogenomic databases

eggNOGiNOG274744.
GeneTreeiENSGT00390000006980.
HOGENOMiHOG000133097.
HOVERGENiHBG054998.
InParanoidiO75683.
OMAiKFRKREE.
OrthoDBiEOG7HHWTK.
PhylomeDBiO75683.
TreeFamiTF321608.

Family and domain databases

InterProiIPR029190. Rrp14/SURF6_C.
IPR007019. SURF6.
[Graphical view]
PANTHERiPTHR14369. PTHR14369. 1 hit.
PfamiPF04935. SURF6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75683-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLLAKDAY LQSLAKKICS HSAPEQQART RAGKTQGSET AGPPKKKRKK
60 70 80 90 100
TQKKFRKREE KAAEHKAKSL GEKSPAASGA RRPEAAKEEA AWASSSAGNP
110 120 130 140 150
ADGLATEPES VFALDVLRQR LHEKIQEARG QGSAKELSPA ALEKRRRRKQ
160 170 180 190 200
ERDRKKRKRK ELRAKEKARK AEEATEAQEV VEATPEGACT EPREPPGLIF
210 220 230 240 250
NKVEVSEDEP ASKAQRRKEK RQRVKGNLTP LTGRNYRQLL ERLQARQSRL
260 270 280 290 300
DELRGQDEGK AQELEAKMKW TNLLYKAEGV KIRDDERLLQ EALKRKEKRR
310 320 330 340 350
AQRQRRWEKR TAGVVEKMQQ RQDRRRQNLR RKKAARAERR LLRARKKGRI
360
LPQDLERAGL V
Length:361
Mass (Da):41,450
Last modified:June 6, 2002 - v3
Checksum:i34F63992E3E82797
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61A → T in CAA12054 (PubMed:11891058).Curated
Sequence conflicti102 – 1021D → N in AAD56587 (PubMed:10675619).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti163 – 1631R → W.
Corresponds to variant rs886090 [ dbSNP | Ensembl ].
VAR_014532
Natural varianti175 – 1751T → M.
Corresponds to variant rs886089 [ dbSNP | Ensembl ].
VAR_014533
Natural varianti193 – 1931R → Q.
Corresponds to variant rs34657219 [ dbSNP | Ensembl ].
VAR_052199
Natural varianti201 – 2011N → H.
Corresponds to variant rs35316446 [ dbSNP | Ensembl ].
VAR_052200
Natural varianti311 – 3111T → M.
Corresponds to variant rs1800867 [ dbSNP | Ensembl ].
VAR_014534

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF186772 Genomic DNA. Translation: AAD56587.1.
AL158826 Genomic DNA. Translation: CAI12825.1.
CH471090 Genomic DNA. Translation: EAW88055.1.
BC003001 mRNA. Translation: AAH03001.1.
BC006197 mRNA. Translation: AAH06197.1.
BC014878 mRNA. Translation: AAH14878.1.
AJ224639 Genomic DNA. Translation: CAA12054.1.
CCDSiCCDS6962.1.
RefSeqiNP_001265871.1. NM_001278942.1.
NP_006744.2. NM_006753.5.
UniGeneiHs.274430.

Genome annotation databases

EnsembliENST00000372022; ENSP00000361092; ENSG00000148296.
ENST00000629980; ENSP00000485909; ENSG00000281309.
GeneIDi6838.
KEGGihsa:6838.
UCSCiuc004cdb.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF186772 Genomic DNA. Translation: AAD56587.1.
AL158826 Genomic DNA. Translation: CAI12825.1.
CH471090 Genomic DNA. Translation: EAW88055.1.
BC003001 mRNA. Translation: AAH03001.1.
BC006197 mRNA. Translation: AAH06197.1.
BC014878 mRNA. Translation: AAH14878.1.
AJ224639 Genomic DNA. Translation: CAA12054.1.
CCDSiCCDS6962.1.
RefSeqiNP_001265871.1. NM_001278942.1.
NP_006744.2. NM_006753.5.
UniGeneiHs.274430.

3D structure databases

ProteinModelPortaliO75683.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112705. 15 interactions.
IntActiO75683. 4 interactions.
MINTiMINT-3001658.

PTM databases

PhosphoSiteiO75683.

Polymorphism and mutation databases

BioMutaiSURF6.

Proteomic databases

MaxQBiO75683.
PaxDbiO75683.
PeptideAtlasiO75683.
PRIDEiO75683.

Protocols and materials databases

DNASUi6838.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372022; ENSP00000361092; ENSG00000148296.
ENST00000629980; ENSP00000485909; ENSG00000281309.
GeneIDi6838.
KEGGihsa:6838.
UCSCiuc004cdb.4. human.

Organism-specific databases

CTDi6838.
GeneCardsiGC09M136197.
HGNCiHGNC:11478. SURF6.
HPAiHPA023608.
MIMi185642. gene.
neXtProtiNX_O75683.
PharmGKBiPA36263.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG274744.
GeneTreeiENSGT00390000006980.
HOGENOMiHOG000133097.
HOVERGENiHBG054998.
InParanoidiO75683.
OMAiKFRKREE.
OrthoDBiEOG7HHWTK.
PhylomeDBiO75683.
TreeFamiTF321608.

Miscellaneous databases

ChiTaRSiSURF6. human.
GeneWikiiSURF6.
GenomeRNAii6838.
NextBioi26697.
PROiO75683.
SOURCEiSearch...

Gene expression databases

BgeeiO75683.
CleanExiHS_SURF6.
GenevisibleiO75683. HS.

Family and domain databases

InterProiIPR029190. Rrp14/SURF6_C.
IPR007019. SURF6.
[Graphical view]
PANTHERiPTHR14369. PTHR14369. 1 hit.
PfamiPF04935. SURF6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and genomic analysis of the human surf-6 gene: a member of the Surfeit locus."
    Magoulas C., Fried M.
    Gene 243:115-123(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Lymph.
  5. "The human homologue of the mouse Surf5 gene encodes multiple alternatively spliced transcripts."
    Angiolillo A., Russo G., Porcellini A., Smaldone S., D'Alessandro F., Pietropaolo C.
    Gene 284:169-178(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-31.
  6. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
    Yu L.R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.
    J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74 AND SER-138, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74 AND THR-229, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSURF6_HUMAN
AccessioniPrimary (citable) accession number: O75683
Secondary accession number(s): Q5T8U1
, Q9BRK9, Q9BTZ5, Q9UK24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 6, 2002
Last modified: June 24, 2015
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.