O75683 (SURF6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Surfeit locus protein 6

Gene names

Name:	SURF6
Synonyms:	SURF-6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly By similarity.
Subcellular location	Nucleus › nucleoplasm By similarity. Nucleus › nucleolus By similarity. Note: Granular component of the nucleolus By similarity.
Sequence similarities	Belongs to the SURF6 family.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Ligand	DNA-binding RNA-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ribosome biogenesis Inferred from electronic annotation. Source: Compara
Cellular_component	granular component Inferred from sequence or structural similarity. Source: UniProtKB nucleoplasm part Inferred from electronic annotation. Source: Compara
Molecular_function	DNA binding Inferred from sequence or structural similarity. Source: UniProtKB RNA binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 361	361	Surfeit locus protein 6		PRO_0000220969
Regions
	Motif	45 – 49	5	Nuclear localization signal Potential
	Motif	154 – 158	5	Nuclear localization signal Potential
Amino acid modifications
	Modified residue	74	1	Phosphoserine Ref.6 Ref.7 Ref.8
	Modified residue	138	1	Phosphoserine Ref.7 Ref.9 Ref.10
	Modified residue	229	1	Phosphothreonine Ref.8
Natural variations
	Natural variant	163	1	R → W. Corresponds to variant rs886090 [ dbSNP | Ensembl ].		VAR_014532
	Natural variant	175	1	T → M. Corresponds to variant rs886089 [ dbSNP | Ensembl ].		VAR_014533
	Natural variant	193	1	R → Q. Corresponds to variant rs34657219 [ dbSNP | Ensembl ].		VAR_052199
	Natural variant	201	1	N → H. Corresponds to variant rs35316446 [ dbSNP | Ensembl ].		VAR_052200
	Natural variant	311	1	T → M. Corresponds to variant rs1800867 [ dbSNP | Ensembl ].		VAR_014534
Experimental info
	Sequence conflict	6	1	A → T in CAA12054. Ref.5
	Sequence conflict	102	1	D → N in AAD56587. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O75683 [UniParc]. Last modified June 6, 2002. Version 3. Checksum: 34F63992E3E82797	FASTA	361	41,450
	10 20 30 40 50 60 MASLLAKDAY LQSLAKKICS HSAPEQQART RAGKTQGSET AGPPKKKRKK TQKKFRKREE 70 80 90 100 110 120 KAAEHKAKSL GEKSPAASGA RRPEAAKEEA AWASSSAGNP ADGLATEPES VFALDVLRQR 130 140 150 160 170 180 LHEKIQEARG QGSAKELSPA ALEKRRRRKQ ERDRKKRKRK ELRAKEKARK AEEATEAQEV 190 200 210 220 230 240 VEATPEGACT EPREPPGLIF NKVEVSEDEP ASKAQRRKEK RQRVKGNLTP LTGRNYRQLL 250 260 270 280 290 300 ERLQARQSRL DELRGQDEGK AQELEAKMKW TNLLYKAEGV KIRDDERLLQ EALKRKEKRR 310 320 330 340 350 360 AQRQRRWEKR TAGVVEKMQQ RQDRRRQNLR RKKAARAERR LLRARKKGRI LPQDLERAGL V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and genomic analysis of the human surf-6 gene: a member of the Surfeit locus." Magoulas C., Fried M. Gene 243:115-123(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung and Lymph.
[5]	"The human homologue of the mouse Surf5 gene encodes multiple alternatively spliced transcripts." Angiolillo A., Russo G., Porcellini A., Smaldone S., D'Alessandro F., Pietropaolo C. Gene 284:169-178(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-31.
[6]	"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74 AND SER-138, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74 AND THR-229, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF186772 Genomic DNA. Translation: AAD56587.1. AL158826 Genomic DNA. Translation: CAI12825.1. CH471090 Genomic DNA. Translation: EAW88055.1. BC003001 mRNA. Translation: AAH03001.1. BC006197 mRNA. Translation: AAH06197.1. BC014878 mRNA. Translation: AAH14878.1. AJ224639 Genomic DNA. Translation: CAA12054.1.
IPI	IPI00026606.
RefSeq	NP_006744.2. NM_006753.4.
UniGene	Hs.274430.
3D structure databases
ProteinModelPortal	O75683.
ModBase	Search...
Protein-protein interaction databases
IntAct	O75683. 3 interactions.
STRING	9606.ENSP00000361092.
PTM databases
PhosphoSite	O75683.
Proteomic databases
PaxDb	O75683.
PeptideAtlas	O75683.
PRIDE	O75683.
Protocols and materials databases
DNASU	6838.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000372022; ENSP00000361092; ENSG00000148296. ENST00000561828; ENSP00000457813; ENSG00000261306.
GeneID	6838.
KEGG	hsa:6838.
UCSC	uc004cdb.4. human.
Organism-specific databases
CTD	6838.
GeneCards	GC09M136197.
HGNC	HGNC:11478. SURF6.
HPA	HPA023608.
MIM	185642. gene.
neXtProt	NX_O75683.
PharmGKB	PA36263.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG274744.
HOGENOM	HOG000133097.
HOVERGEN	HBG054998.
InParanoid	O75683.
OMA	EPPGLIF.
OrthoDB	EOG4J9N0X.
PhylomeDB	O75683.
Gene expression databases
Bgee	O75683.
CleanEx	HS_SURF6.
Genevestigator	O75683.
GermOnline	ENSG00000148296. Homo sapiens.
Family and domain databases
InterPro	IPR007019. Surf6. [Graphical view]
PANTHER	PTHR14369. PTHR14369. 1 hit.
Pfam	PF04935. SURF6. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SURF6. human.
GenomeRNAi	6838.
NextBio	26697.
SOURCE	Search...

Entry information

Entry name

SURF6_HUMAN

Accession

Primary (citable) accession number: O75683
Secondary accession number(s): Q5T8U1 , Q9BRK9, Q9BTZ5, Q9UK24

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	June 6, 2002
Last modified:	April 3, 2013
This is version 103 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.