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O75683

- SURF6_HUMAN

UniProt

O75683 - SURF6_HUMAN

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Protein

Surfeit locus protein 6

Gene
SURF6, SURF-6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly By similarity.

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. poly(A) RNA binding Source: UniProtKB
  3. RNA binding Source: UniProtKB

GO - Biological processi

  1. ribosome biogenesis Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

DNA-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Surfeit locus protein 6
Gene namesi
Name:SURF6
Synonyms:SURF-6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:11478. SURF6.

Subcellular locationi

Nucleusnucleoplasm By similarity. Nucleusnucleolus By similarity
Note: Granular component of the nucleolus By similarity.

GO - Cellular componenti

  1. granular component Source: UniProtKB
  2. nucleolus Source: ProtInc
  3. nucleoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36263.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 361361Surfeit locus protein 6PRO_0000220969Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei74 – 741Phosphoserine3 Publications
Modified residuei138 – 1381Phosphoserine3 Publications
Modified residuei229 – 2291Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO75683.
PaxDbiO75683.
PeptideAtlasiO75683.
PRIDEiO75683.

PTM databases

PhosphoSiteiO75683.

Expressioni

Gene expression databases

BgeeiO75683.
CleanExiHS_SURF6.
GenevestigatoriO75683.

Organism-specific databases

HPAiHPA023608.

Interactioni

Protein-protein interaction databases

BioGridi112705. 4 interactions.
IntActiO75683. 3 interactions.
MINTiMINT-3001658.
STRINGi9606.ENSP00000361092.

Structurei

3D structure databases

ProteinModelPortaliO75683.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi45 – 495Nuclear localization signal Reviewed prediction
Motifi154 – 1585Nuclear localization signal Reviewed prediction

Sequence similaritiesi

Belongs to the SURF6 family.

Phylogenomic databases

eggNOGiNOG274744.
HOGENOMiHOG000133097.
HOVERGENiHBG054998.
InParanoidiO75683.
OMAiKFRKREE.
OrthoDBiEOG7HHWTK.
PhylomeDBiO75683.
TreeFamiTF321608.

Family and domain databases

InterProiIPR029190. Rrp14/SURF6_C.
IPR007019. SURF6.
[Graphical view]
PANTHERiPTHR14369. PTHR14369. 1 hit.
PfamiPF04935. SURF6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75683-1 [UniParc]FASTAAdd to Basket

« Hide

MASLLAKDAY LQSLAKKICS HSAPEQQART RAGKTQGSET AGPPKKKRKK    50
TQKKFRKREE KAAEHKAKSL GEKSPAASGA RRPEAAKEEA AWASSSAGNP 100
ADGLATEPES VFALDVLRQR LHEKIQEARG QGSAKELSPA ALEKRRRRKQ 150
ERDRKKRKRK ELRAKEKARK AEEATEAQEV VEATPEGACT EPREPPGLIF 200
NKVEVSEDEP ASKAQRRKEK RQRVKGNLTP LTGRNYRQLL ERLQARQSRL 250
DELRGQDEGK AQELEAKMKW TNLLYKAEGV KIRDDERLLQ EALKRKEKRR 300
AQRQRRWEKR TAGVVEKMQQ RQDRRRQNLR RKKAARAERR LLRARKKGRI 350
LPQDLERAGL V 361
Length:361
Mass (Da):41,450
Last modified:June 6, 2002 - v3
Checksum:i34F63992E3E82797
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti163 – 1631R → W.
Corresponds to variant rs886090 [ dbSNP | Ensembl ].
VAR_014532
Natural varianti175 – 1751T → M.
Corresponds to variant rs886089 [ dbSNP | Ensembl ].
VAR_014533
Natural varianti193 – 1931R → Q.
Corresponds to variant rs34657219 [ dbSNP | Ensembl ].
VAR_052199
Natural varianti201 – 2011N → H.
Corresponds to variant rs35316446 [ dbSNP | Ensembl ].
VAR_052200
Natural varianti311 – 3111T → M.
Corresponds to variant rs1800867 [ dbSNP | Ensembl ].
VAR_014534

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61A → T in CAA12054. 1 Publication
Sequence conflicti102 – 1021D → N in AAD56587. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF186772 Genomic DNA. Translation: AAD56587.1.
AL158826 Genomic DNA. Translation: CAI12825.1.
CH471090 Genomic DNA. Translation: EAW88055.1.
BC003001 mRNA. Translation: AAH03001.1.
BC006197 mRNA. Translation: AAH06197.1.
BC014878 mRNA. Translation: AAH14878.1.
AJ224639 Genomic DNA. Translation: CAA12054.1.
CCDSiCCDS6962.1.
RefSeqiNP_001265871.1. NM_001278942.1.
NP_006744.2. NM_006753.5.
UniGeneiHs.274430.

Genome annotation databases

EnsembliENST00000372022; ENSP00000361092; ENSG00000148296.
ENST00000561828; ENSP00000457813; ENSG00000261306.
GeneIDi6838.
KEGGihsa:6838.
UCSCiuc004cdb.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF186772 Genomic DNA. Translation: AAD56587.1 .
AL158826 Genomic DNA. Translation: CAI12825.1 .
CH471090 Genomic DNA. Translation: EAW88055.1 .
BC003001 mRNA. Translation: AAH03001.1 .
BC006197 mRNA. Translation: AAH06197.1 .
BC014878 mRNA. Translation: AAH14878.1 .
AJ224639 Genomic DNA. Translation: CAA12054.1 .
CCDSi CCDS6962.1.
RefSeqi NP_001265871.1. NM_001278942.1.
NP_006744.2. NM_006753.5.
UniGenei Hs.274430.

3D structure databases

ProteinModelPortali O75683.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112705. 4 interactions.
IntActi O75683. 3 interactions.
MINTi MINT-3001658.
STRINGi 9606.ENSP00000361092.

PTM databases

PhosphoSitei O75683.

Proteomic databases

MaxQBi O75683.
PaxDbi O75683.
PeptideAtlasi O75683.
PRIDEi O75683.

Protocols and materials databases

DNASUi 6838.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000372022 ; ENSP00000361092 ; ENSG00000148296 .
ENST00000561828 ; ENSP00000457813 ; ENSG00000261306 .
GeneIDi 6838.
KEGGi hsa:6838.
UCSCi uc004cdb.4. human.

Organism-specific databases

CTDi 6838.
GeneCardsi GC09M136197.
HGNCi HGNC:11478. SURF6.
HPAi HPA023608.
MIMi 185642. gene.
neXtProti NX_O75683.
PharmGKBi PA36263.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG274744.
HOGENOMi HOG000133097.
HOVERGENi HBG054998.
InParanoidi O75683.
OMAi KFRKREE.
OrthoDBi EOG7HHWTK.
PhylomeDBi O75683.
TreeFami TF321608.

Miscellaneous databases

ChiTaRSi SURF6. human.
GeneWikii SURF6.
GenomeRNAii 6838.
NextBioi 26697.
PROi O75683.
SOURCEi Search...

Gene expression databases

Bgeei O75683.
CleanExi HS_SURF6.
Genevestigatori O75683.

Family and domain databases

InterProi IPR029190. Rrp14/SURF6_C.
IPR007019. SURF6.
[Graphical view ]
PANTHERi PTHR14369. PTHR14369. 1 hit.
Pfami PF04935. SURF6. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and genomic analysis of the human surf-6 gene: a member of the Surfeit locus."
    Magoulas C., Fried M.
    Gene 243:115-123(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Lymph.
  5. "The human homologue of the mouse Surf5 gene encodes multiple alternatively spliced transcripts."
    Angiolillo A., Russo G., Porcellini A., Smaldone S., D'Alessandro F., Pietropaolo C.
    Gene 284:169-178(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-31.
  6. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
    Yu L.R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.
    J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74 AND SER-138, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74 AND THR-229, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSURF6_HUMAN
AccessioniPrimary (citable) accession number: O75683
Secondary accession number(s): Q5T8U1
, Q9BRK9, Q9BTZ5, Q9UK24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 6, 2002
Last modified: September 3, 2014
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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