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O75683

- SURF6_HUMAN

UniProt

O75683 - SURF6_HUMAN

Protein

Surfeit locus protein 6

Gene

SURF6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 3 (06 Jun 2002)
      Previous versions | rss
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    Functioni

    Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. poly(A) RNA binding Source: UniProtKB
    3. RNA binding Source: UniProtKB

    GO - Biological processi

    1. ribosome biogenesis Source: Ensembl

    Keywords - Ligandi

    DNA-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Surfeit locus protein 6
    Gene namesi
    Name:SURF6
    Synonyms:SURF-6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:11478. SURF6.

    Subcellular locationi

    Nucleusnucleoplasm By similarity. Nucleusnucleolus By similarity
    Note: Granular component of the nucleolus.By similarity

    GO - Cellular componenti

    1. granular component Source: UniProtKB
    2. nucleolus Source: ProtInc
    3. nucleoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36263.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 361361Surfeit locus protein 6PRO_0000220969Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei74 – 741Phosphoserine3 Publications
    Modified residuei138 – 1381Phosphoserine3 Publications
    Modified residuei229 – 2291Phosphothreonine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO75683.
    PaxDbiO75683.
    PeptideAtlasiO75683.
    PRIDEiO75683.

    PTM databases

    PhosphoSiteiO75683.

    Expressioni

    Gene expression databases

    BgeeiO75683.
    CleanExiHS_SURF6.
    GenevestigatoriO75683.

    Organism-specific databases

    HPAiHPA023608.

    Interactioni

    Protein-protein interaction databases

    BioGridi112705. 4 interactions.
    IntActiO75683. 3 interactions.
    MINTiMINT-3001658.
    STRINGi9606.ENSP00000361092.

    Structurei

    3D structure databases

    ProteinModelPortaliO75683.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi45 – 495Nuclear localization signalSequence Analysis
    Motifi154 – 1585Nuclear localization signalSequence Analysis

    Sequence similaritiesi

    Belongs to the SURF6 family.Curated

    Phylogenomic databases

    eggNOGiNOG274744.
    HOGENOMiHOG000133097.
    HOVERGENiHBG054998.
    InParanoidiO75683.
    OMAiKFRKREE.
    OrthoDBiEOG7HHWTK.
    PhylomeDBiO75683.
    TreeFamiTF321608.

    Family and domain databases

    InterProiIPR029190. Rrp14/SURF6_C.
    IPR007019. SURF6.
    [Graphical view]
    PANTHERiPTHR14369. PTHR14369. 1 hit.
    PfamiPF04935. SURF6. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O75683-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASLLAKDAY LQSLAKKICS HSAPEQQART RAGKTQGSET AGPPKKKRKK    50
    TQKKFRKREE KAAEHKAKSL GEKSPAASGA RRPEAAKEEA AWASSSAGNP 100
    ADGLATEPES VFALDVLRQR LHEKIQEARG QGSAKELSPA ALEKRRRRKQ 150
    ERDRKKRKRK ELRAKEKARK AEEATEAQEV VEATPEGACT EPREPPGLIF 200
    NKVEVSEDEP ASKAQRRKEK RQRVKGNLTP LTGRNYRQLL ERLQARQSRL 250
    DELRGQDEGK AQELEAKMKW TNLLYKAEGV KIRDDERLLQ EALKRKEKRR 300
    AQRQRRWEKR TAGVVEKMQQ RQDRRRQNLR RKKAARAERR LLRARKKGRI 350
    LPQDLERAGL V 361
    Length:361
    Mass (Da):41,450
    Last modified:June 6, 2002 - v3
    Checksum:i34F63992E3E82797
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti6 – 61A → T in CAA12054. (PubMed:11891058)Curated
    Sequence conflicti102 – 1021D → N in AAD56587. (PubMed:10675619)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti163 – 1631R → W.
    Corresponds to variant rs886090 [ dbSNP | Ensembl ].
    VAR_014532
    Natural varianti175 – 1751T → M.
    Corresponds to variant rs886089 [ dbSNP | Ensembl ].
    VAR_014533
    Natural varianti193 – 1931R → Q.
    Corresponds to variant rs34657219 [ dbSNP | Ensembl ].
    VAR_052199
    Natural varianti201 – 2011N → H.
    Corresponds to variant rs35316446 [ dbSNP | Ensembl ].
    VAR_052200
    Natural varianti311 – 3111T → M.
    Corresponds to variant rs1800867 [ dbSNP | Ensembl ].
    VAR_014534

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF186772 Genomic DNA. Translation: AAD56587.1.
    AL158826 Genomic DNA. Translation: CAI12825.1.
    CH471090 Genomic DNA. Translation: EAW88055.1.
    BC003001 mRNA. Translation: AAH03001.1.
    BC006197 mRNA. Translation: AAH06197.1.
    BC014878 mRNA. Translation: AAH14878.1.
    AJ224639 Genomic DNA. Translation: CAA12054.1.
    CCDSiCCDS6962.1.
    RefSeqiNP_001265871.1. NM_001278942.1.
    NP_006744.2. NM_006753.5.
    UniGeneiHs.274430.

    Genome annotation databases

    EnsembliENST00000372022; ENSP00000361092; ENSG00000148296.
    GeneIDi6838.
    KEGGihsa:6838.
    UCSCiuc004cdb.4. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF186772 Genomic DNA. Translation: AAD56587.1 .
    AL158826 Genomic DNA. Translation: CAI12825.1 .
    CH471090 Genomic DNA. Translation: EAW88055.1 .
    BC003001 mRNA. Translation: AAH03001.1 .
    BC006197 mRNA. Translation: AAH06197.1 .
    BC014878 mRNA. Translation: AAH14878.1 .
    AJ224639 Genomic DNA. Translation: CAA12054.1 .
    CCDSi CCDS6962.1.
    RefSeqi NP_001265871.1. NM_001278942.1.
    NP_006744.2. NM_006753.5.
    UniGenei Hs.274430.

    3D structure databases

    ProteinModelPortali O75683.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112705. 4 interactions.
    IntActi O75683. 3 interactions.
    MINTi MINT-3001658.
    STRINGi 9606.ENSP00000361092.

    PTM databases

    PhosphoSitei O75683.

    Proteomic databases

    MaxQBi O75683.
    PaxDbi O75683.
    PeptideAtlasi O75683.
    PRIDEi O75683.

    Protocols and materials databases

    DNASUi 6838.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000372022 ; ENSP00000361092 ; ENSG00000148296 .
    GeneIDi 6838.
    KEGGi hsa:6838.
    UCSCi uc004cdb.4. human.

    Organism-specific databases

    CTDi 6838.
    GeneCardsi GC09M136197.
    HGNCi HGNC:11478. SURF6.
    HPAi HPA023608.
    MIMi 185642. gene.
    neXtProti NX_O75683.
    PharmGKBi PA36263.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG274744.
    HOGENOMi HOG000133097.
    HOVERGENi HBG054998.
    InParanoidi O75683.
    OMAi KFRKREE.
    OrthoDBi EOG7HHWTK.
    PhylomeDBi O75683.
    TreeFami TF321608.

    Miscellaneous databases

    ChiTaRSi SURF6. human.
    GeneWikii SURF6.
    GenomeRNAii 6838.
    NextBioi 26697.
    PROi O75683.
    SOURCEi Search...

    Gene expression databases

    Bgeei O75683.
    CleanExi HS_SURF6.
    Genevestigatori O75683.

    Family and domain databases

    InterProi IPR029190. Rrp14/SURF6_C.
    IPR007019. SURF6.
    [Graphical view ]
    PANTHERi PTHR14369. PTHR14369. 1 hit.
    Pfami PF04935. SURF6. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and genomic analysis of the human surf-6 gene: a member of the Surfeit locus."
      Magoulas C., Fried M.
      Gene 243:115-123(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung and Lymph.
    5. "The human homologue of the mouse Surf5 gene encodes multiple alternatively spliced transcripts."
      Angiolillo A., Russo G., Porcellini A., Smaldone S., D'Alessandro F., Pietropaolo C.
      Gene 284:169-178(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-31.
    6. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
      Yu L.R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.
      J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74 AND SER-138, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74 AND THR-229, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSURF6_HUMAN
    AccessioniPrimary (citable) accession number: O75683
    Secondary accession number(s): Q5T8U1
    , Q9BRK9, Q9BTZ5, Q9UK24
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: June 6, 2002
    Last modified: October 1, 2014
    This is version 116 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3