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O75683 (SURF6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Surfeit locus protein 6
Gene names
Name:SURF6
Synonyms:SURF-6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly By similarity.

Subcellular location

Nucleusnucleoplasm By similarity. Nucleusnucleolus By similarity. Note: Granular component of the nucleolus By similarity.

Sequence similarities

Belongs to the SURF6 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 361361Surfeit locus protein 6
PRO_0000220969

Regions

Motif45 – 495Nuclear localization signal Potential
Motif154 – 1585Nuclear localization signal Potential

Amino acid modifications

Modified residue741Phosphoserine Ref.6 Ref.7 Ref.8
Modified residue1381Phosphoserine Ref.7 Ref.10 Ref.11
Modified residue2291Phosphothreonine Ref.8

Natural variations

Natural variant1631R → W.
Corresponds to variant rs886090 [ dbSNP | Ensembl ].
VAR_014532
Natural variant1751T → M.
Corresponds to variant rs886089 [ dbSNP | Ensembl ].
VAR_014533
Natural variant1931R → Q.
Corresponds to variant rs34657219 [ dbSNP | Ensembl ].
VAR_052199
Natural variant2011N → H.
Corresponds to variant rs35316446 [ dbSNP | Ensembl ].
VAR_052200
Natural variant3111T → M.
Corresponds to variant rs1800867 [ dbSNP | Ensembl ].
VAR_014534

Experimental info

Sequence conflict61A → T in CAA12054. Ref.5
Sequence conflict1021D → N in AAD56587. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O75683 [UniParc].

Last modified June 6, 2002. Version 3.
Checksum: 34F63992E3E82797

FASTA36141,450
        10         20         30         40         50         60 
MASLLAKDAY LQSLAKKICS HSAPEQQART RAGKTQGSET AGPPKKKRKK TQKKFRKREE 

        70         80         90        100        110        120 
KAAEHKAKSL GEKSPAASGA RRPEAAKEEA AWASSSAGNP ADGLATEPES VFALDVLRQR 

       130        140        150        160        170        180 
LHEKIQEARG QGSAKELSPA ALEKRRRRKQ ERDRKKRKRK ELRAKEKARK AEEATEAQEV 

       190        200        210        220        230        240 
VEATPEGACT EPREPPGLIF NKVEVSEDEP ASKAQRRKEK RQRVKGNLTP LTGRNYRQLL 

       250        260        270        280        290        300 
ERLQARQSRL DELRGQDEGK AQELEAKMKW TNLLYKAEGV KIRDDERLLQ EALKRKEKRR 

       310        320        330        340        350        360 
AQRQRRWEKR TAGVVEKMQQ RQDRRRQNLR RKKAARAERR LLRARKKGRI LPQDLERAGL 


V 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and genomic analysis of the human surf-6 gene: a member of the Surfeit locus."
Magoulas C., Fried M.
Gene 243:115-123(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung and Lymph.
[5]"The human homologue of the mouse Surf5 gene encodes multiple alternatively spliced transcripts."
Angiolillo A., Russo G., Porcellini A., Smaldone S., D'Alessandro F., Pietropaolo C.
Gene 284:169-178(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-31.
[6]"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
Yu L.R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.
J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74 AND SER-138, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74 AND THR-229, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[11]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF186772 Genomic DNA. Translation: AAD56587.1.
AL158826 Genomic DNA. Translation: CAI12825.1.
CH471090 Genomic DNA. Translation: EAW88055.1.
BC003001 mRNA. Translation: AAH03001.1.
BC006197 mRNA. Translation: AAH06197.1.
BC014878 mRNA. Translation: AAH14878.1.
AJ224639 Genomic DNA. Translation: CAA12054.1.
CCDSCCDS6962.1.
RefSeqNP_001265871.1. NM_001278942.1.
NP_006744.2. NM_006753.5.
UniGeneHs.274430.

3D structure databases

ProteinModelPortalO75683.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112705. 3 interactions.
IntActO75683. 3 interactions.
MINTMINT-3001658.
STRING9606.ENSP00000361092.

PTM databases

PhosphoSiteO75683.

Proteomic databases

MaxQBO75683.
PaxDbO75683.
PeptideAtlasO75683.
PRIDEO75683.

Protocols and materials databases

DNASU6838.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000372022; ENSP00000361092; ENSG00000148296.
ENST00000561828; ENSP00000457813; ENSG00000261306.
GeneID6838.
KEGGhsa:6838.
UCSCuc004cdb.4. human.

Organism-specific databases

CTD6838.
GeneCardsGC09M136197.
HGNCHGNC:11478. SURF6.
HPAHPA023608.
MIM185642. gene.
neXtProtNX_O75683.
PharmGKBPA36263.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG274744.
HOGENOMHOG000133097.
HOVERGENHBG054998.
InParanoidO75683.
OMAKFRKREE.
OrthoDBEOG7HHWTK.
PhylomeDBO75683.
TreeFamTF321608.

Gene expression databases

BgeeO75683.
CleanExHS_SURF6.
GenevestigatorO75683.

Family and domain databases

InterProIPR029190. Rrp14/SURF6_C.
IPR007019. SURF6.
[Graphical view]
PANTHERPTHR14369. PTHR14369. 1 hit.
PfamPF04935. SURF6. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSURF6. human.
GeneWikiSURF6.
GenomeRNAi6838.
NextBio26697.
PROO75683.
SOURCESearch...

Entry information

Entry nameSURF6_HUMAN
AccessionPrimary (citable) accession number: O75683
Secondary accession number(s): Q5T8U1 expand/collapse secondary AC list , Q9BRK9, Q9BTZ5, Q9UK24
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 6, 2002
Last modified: July 9, 2014
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM