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Protein

Ret finger protein-like 3

Gene

RFPL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

(Microbial infection) Stimulates the activity of Human Immunodeficiency Virus 1/HIV-1 pre-integration complex.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri40 – 82RING-typePROSITE-ProRule annotationAdd BLAST43

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ret finger protein-like 3
Gene namesi
Name:RFPL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000128276.10
HGNCiHGNC:9980 RFPL3
MIMi605970 gene
neXtProtiNX_O75679

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000128276
PharmGKBiPA34349

Polymorphism and mutation databases

BioMutaiRFPL3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000560321 – 317Ret finger protein-like 3Add BLAST317

Proteomic databases

PaxDbiO75679
PeptideAtlasiO75679
PRIDEiO75679
ProteomicsDBi50155

PTM databases

iPTMnetiO75679
PhosphoSitePlusiO75679

Expressioni

Tissue specificityi

Expressed during neurogenesis in differentiating human embryonic stem cells and in the developing human neocortex.1 Publication

Gene expression databases

BgeeiENSG00000128276
CleanExiHS_RFPL3
GenevisibleiO75679 HS

Organism-specific databases

HPAiHPA048320
HPA072380

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi115961, 8 interactors
IntActiO75679, 8 interactors
STRINGi9606.ENSP00000249007

Structurei

3D structure databases

ProteinModelPortaliO75679
SMRiO75679
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini107 – 301B30.2/SPRYPROSITE-ProRule annotationAdd BLAST195

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri40 – 82RING-typePROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG4111G04 LUCA
GeneTreeiENSGT00760000118993
HOGENOMiHOG000230861
HOVERGENiHBG061854
InParanoidiO75679
OMAiRFDMSIC
OrthoDBiEOG091G0G5I
PhylomeDBiO75679
TreeFamiTF317532

Family and domain databases

CDDicd15821 SPRY_PRY_RFPL, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR022723 RDM_domain_RFPL
IPR038908 RFPL
IPR037960 SPRY/PRY_RFPL
IPR003877 SPRY_dom
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR25462 PTHR25462, 1 hit
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF11002 RDM, 1 hit
PF00622 SPRY, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00589 PRY, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75679-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKRLSLVTTN RLSPQGNFLP LCTFPLAVDM AALFQEASSC PVCSDYLEKP
60 70 80 90 100
MSLECGCTVC LKCINSLQKE PHGEDLLCCC CSMVSQRNKI RPNRQLERLV
110 120 130 140 150
SHIKELEPKL KKILQMNPRM RKFQVDMTLD ADTANNFLLI SDDLRSVRSG
160 170 180 190 200
LITQNRQDLA ERFDVSVCIL GSPRFTCGRH YWEVDVGTST EWDLGVCRES
210 220 230 240 250
VHCKGKIQLT TELGFWTVSL RDGSRLSAST VPLTFLLVDR KLQRVGIFLD
260 270 280 290 300
MGMQNVSFFD AESGSHVYTF RSVSAEEPLR PFLAPSIPPN GDQGVLSICP
310
LMNSGTTDAP VRPGEAK
Length:317
Mass (Da):35,386
Last modified:March 15, 2005 - v2
Checksum:i6C27D4829924D2FB
GO
Isoform 2 (identifier: O75679-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.

Note: No experimental confirmation available.
Show »
Length:288
Mass (Da):32,171
Checksum:iE1FB99D29C010E3E
GO

Sequence cautioni

The sequence CAA09046 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05209183M → T. Corresponds to variant dbSNP:rs16987625Ensembl.1
Natural variantiVAR_052092110L → M1 PublicationCorresponds to variant dbSNP:rs9621427Ensembl.1
Natural variantiVAR_052093126D → N. Corresponds to variant dbSNP:rs9619258Ensembl.1
Natural variantiVAR_059814181Y → C. Corresponds to variant dbSNP:rs5749408Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0456511 – 29Missing in isoform 2. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010232 mRNA Translation: CAA09046.1 Different initiation.
CR456564 mRNA Translation: CAG30450.1
AL021937 Genomic DNA No translation available.
BC031689 mRNA Translation: AAH31689.1
BC069753 mRNA Translation: AAH69753.2
CCDSiCCDS13904.1 [O75679-2]
CCDS43011.1 [O75679-1]
RefSeqiNP_001092005.1, NM_001098535.1 [O75679-1]
NP_006595.1, NM_006604.2 [O75679-2]
UniGeneiHs.558455

Genome annotation databases

EnsembliENST00000249007; ENSP00000249007; ENSG00000128276 [O75679-1]
ENST00000397468; ENSP00000380609; ENSG00000128276 [O75679-2]
GeneIDi10738
KEGGihsa:10738
UCSCiuc003amj.3 human [O75679-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRFPL3_HUMAN
AccessioniPrimary (citable) accession number: O75679
Secondary accession number(s): A2A279
, Q6IC03, Q6IC04, Q6NSX3, Q8N5R4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 15, 2005
Last modified: June 20, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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