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Protein

Ret finger protein-like 2

Gene

RFPL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri101 – 143RING-type; degenerateAdd BLAST43

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ret finger protein-like 2
Alternative name(s):
RING finger protein 79
Gene namesi
Name:RFPL2
Synonyms:RNF79
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000128253.13.
HGNCiHGNC:9979. RFPL2.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000128253.
PharmGKBiPA34348.

Polymorphism and mutation databases

BioMutaiRFPL2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000560311 – 378Ret finger protein-like 2Add BLAST378

Proteomic databases

PaxDbiO75678.
PRIDEiO75678.

Expressioni

Tissue specificityi

Seems to be expressed in prostate and less abundantly in adult brain, fetal liver, and fetal kidney.

Gene expression databases

BgeeiENSG00000128253.
CleanExiHS_RFPL2.
ExpressionAtlasiO75678. baseline and differential.
GenevisibleiO75678. HS.

Organism-specific databases

HPAiHPA048320.
HPA072380.

Interactioni

Protein-protein interaction databases

BioGridi115962. 15 interactors.
STRINGi9606.ENSP00000383096.

Structurei

3D structure databases

ProteinModelPortaliO75678.
SMRiO75678.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini168 – 362B30.2/SPRYPROSITE-ProRule annotationAdd BLAST195

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri101 – 143RING-type; degenerateAdd BLAST43

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00760000118993.
HOGENOMiHOG000230861.
HOVERGENiHBG061854.
InParanoidiO75678.
OMAiRICLCAV.
OrthoDBiEOG091G0G5I.
PhylomeDBiO75678.
TreeFamiTF317532.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR001870. B30.2/SPRY.
IPR003879. Butyrophylin_SPRY.
IPR013320. ConA-like_dom_sf.
IPR006574. PRY.
IPR022723. RDM_domain_RFPL.
IPR003877. SPRY_dom.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF13765. PRY. 1 hit.
PF11002. RDM. 1 hit.
PF00622. SPRY. 1 hit.
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiView protein in SMART
SM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiView protein in PROSITE
PS50188. B302_SPRY. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75678-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVAELGFPE TAVSQSRICL CAVLCGHWDF ADMMVIRSLS LIRLEGVEGR
60 70 80 90 100
DPVGGGNLTN KRPSCAPSPQ DLSAQWKQLE DRGASSRRVD MAALFQEASS
110 120 130 140 150
CPVCSDYLEK PMSLECGCAV CLKCINSLQK EPHGEDLLCC CSSMVSRKNK
160 170 180 190 200
IRRNRQLERL ASHIKELEPK LKKILQMNPR MRKFQVDMTL DANTANNFLL
210 220 230 240 250
ISDDLRSVRS GRIRQNRQDL AERFDVSVCI LGSPRFTCGR HCWEVDVGTS
260 270 280 290 300
TEWDLGVCRE SVHRKGRIQL TTELGFWTVS LRDGGRLSAT TVPLTFLFVD
310 320 330 340 350
RKLQRVGIFL DMGMQNVSFF DAESGSHVYT FRSVSAEEPL RPFLAPSVPP
360 370
NGDQGVLSIC PLMNSGTTDA PVRPGEAK
Note: No experimental confirmation available.
Length:378
Mass (Da):42,077
Last modified:July 5, 2005 - v3
Checksum:i670B38CDE6509BA4
GO
Isoform 2 (identifier: O75678-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: Missing.

Show »
Length:288
Mass (Da):32,278
Checksum:i1DCD5E89AFB0A7C6
GO
Isoform 3 (identifier: O75678-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: Missing.
     62-88: RPSCAPSPQDLSAQWKQLEDRGASSRR → MKRLSLVTTNRLSPHGNFFTLCTFPLA

Show »
Length:317
Mass (Da):35,540
Checksum:i8EBAE75BEECAC43F
GO

Sequence cautioni

The sequence CAA09045 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060534119A → T. Corresponds to variant dbSNP:rs8135276Ensembl.1
Natural variantiVAR_060535141C → Y2 PublicationsCorresponds to variant dbSNP:rs136478Ensembl.1
Natural variantiVAR_060536215Q → H. Corresponds to variant dbSNP:rs56240743Ensembl.1
Natural variantiVAR_060537290T → S2 PublicationsCorresponds to variant dbSNP:rs136472Ensembl.1
Natural variantiVAR_060538324S → G2 PublicationsCorresponds to variant dbSNP:rs136470Ensembl.1
Natural variantiVAR_060539341R → C2 PublicationsCorresponds to variant dbSNP:rs136468Ensembl.1
Natural variantiVAR_060540348V → I2 PublicationsCorresponds to variant dbSNP:rs136467Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0142671 – 90Missing in isoform 2. 2 PublicationsAdd BLAST90
Alternative sequenceiVSP_0383261 – 61Missing in isoform 3. 2 PublicationsAdd BLAST61
Alternative sequenceiVSP_03832762 – 88RPSCA…ASSRR → MKRLSLVTTNRLSPHGNFFT LCTFPLA in isoform 3. 2 PublicationsAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010231 mRNA. Translation: CAA09045.1. Different initiation.
AK055999 mRNA. No translation available.
CR456563 mRNA. Translation: CAG30449.1.
AL008723 Genomic DNA. Translation: CAB51756.2.
BC051910 mRNA. Translation: AAH51910.1.
BC069827 mRNA. Translation: AAH69827.2.
CCDSiCCDS43009.2. [O75678-1]
CCDS46694.1. [O75678-3]
RefSeqiNP_001091997.2. NM_001098527.2. [O75678-1]
NP_001153017.1. NM_001159545.1. [O75678-2]
NP_001153018.1. NM_001159546.1. [O75678-2]
NP_006596.2. NM_006605.3. [O75678-3]
XP_011528134.1. XM_011529832.1. [O75678-1]
XP_016884024.1. XM_017028535.1. [O75678-2]
XP_016884025.1. XM_017028536.1. [O75678-2]
UniGeneiHs.157427.

Genome annotation databases

EnsembliENST00000248980; ENSP00000248980; ENSG00000128253. [O75678-3]
ENST00000248983; ENSP00000248983; ENSG00000128253. [O75678-1]
ENST00000400237; ENSP00000383096; ENSG00000128253. [O75678-1]
GeneIDi10739.
KEGGihsa:10739.
UCSCiuc003amg.4. human. [O75678-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRFPL2_HUMAN
AccessioniPrimary (citable) accession number: O75678
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: July 5, 2005
Last modified: November 22, 2017
This is version 158 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot