Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ret finger protein-like 2

Gene

RFPL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri101 – 14343RING-type; degenerateAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ret finger protein-like 2
Alternative name(s):
RING finger protein 79
Gene namesi
Name:RFPL2
Synonyms:RNF79
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:9979. RFPL2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34348.

Polymorphism and mutation databases

BioMutaiRFPL2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 378378Ret finger protein-like 2PRO_0000056031Add
BLAST

Proteomic databases

PaxDbiO75678.
PRIDEiO75678.

Expressioni

Tissue specificityi

Seems to be expressed in prostate and less abundantly in adult brain, fetal liver, and fetal kidney.

Gene expression databases

BgeeiO75678.
CleanExiHS_RFPL2.
ExpressionAtlasiO75678. baseline and differential.
GenevisibleiO75678. HS.

Interactioni

Protein-protein interaction databases

BioGridi115962. 14 interactions.
STRINGi9606.ENSP00000383096.

Structurei

3D structure databases

ProteinModelPortaliO75678.
SMRiO75678. Positions 91-164, 183-364.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini168 – 362195B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri101 – 14343RING-type; degenerateAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00760000118993.
HOGENOMiHOG000230861.
HOVERGENiHBG061854.
InParanoidiO75678.
OMAiRICLCAV.
OrthoDBiEOG7CVPZS.
PhylomeDBiO75678.
TreeFamiTF317532.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR022723. RDM_domain_RFPL.
IPR003877. SPRY_dom.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF11002. RDM. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75678-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVAELGFPE TAVSQSRICL CAVLCGHWDF ADMMVIRSLS LIRLEGVEGR
60 70 80 90 100
DPVGGGNLTN KRPSCAPSPQ DLSAQWKQLE DRGASSRRVD MAALFQEASS
110 120 130 140 150
CPVCSDYLEK PMSLECGCAV CLKCINSLQK EPHGEDLLCC CSSMVSRKNK
160 170 180 190 200
IRRNRQLERL ASHIKELEPK LKKILQMNPR MRKFQVDMTL DANTANNFLL
210 220 230 240 250
ISDDLRSVRS GRIRQNRQDL AERFDVSVCI LGSPRFTCGR HCWEVDVGTS
260 270 280 290 300
TEWDLGVCRE SVHRKGRIQL TTELGFWTVS LRDGGRLSAT TVPLTFLFVD
310 320 330 340 350
RKLQRVGIFL DMGMQNVSFF DAESGSHVYT FRSVSAEEPL RPFLAPSVPP
360 370
NGDQGVLSIC PLMNSGTTDA PVRPGEAK
Note: No experimental confirmation available.
Length:378
Mass (Da):42,077
Last modified:July 5, 2005 - v3
Checksum:i670B38CDE6509BA4
GO
Isoform 2 (identifier: O75678-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: Missing.

Show »
Length:288
Mass (Da):32,278
Checksum:i1DCD5E89AFB0A7C6
GO
Isoform 3 (identifier: O75678-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: Missing.
     62-88: RPSCAPSPQDLSAQWKQLEDRGASSRR → MKRLSLVTTNRLSPHGNFFTLCTFPLA

Show »
Length:317
Mass (Da):35,540
Checksum:i8EBAE75BEECAC43F
GO

Sequence cautioni

The sequence CAA09045.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti119 – 1191A → T.
Corresponds to variant rs8135276 [ dbSNP | Ensembl ].
VAR_060534
Natural varianti141 – 1411C → Y.2 Publications
Corresponds to variant rs136478 [ dbSNP | Ensembl ].
VAR_060535
Natural varianti215 – 2151Q → H.
Corresponds to variant rs56240743 [ dbSNP | Ensembl ].
VAR_060536
Natural varianti290 – 2901T → S.2 Publications
Corresponds to variant rs136472 [ dbSNP | Ensembl ].
VAR_060537
Natural varianti324 – 3241S → G.2 Publications
Corresponds to variant rs136470 [ dbSNP | Ensembl ].
VAR_060538
Natural varianti341 – 3411R → C.2 Publications
Corresponds to variant rs136468 [ dbSNP | Ensembl ].
VAR_060539
Natural varianti348 – 3481V → I.2 Publications
Corresponds to variant rs136467 [ dbSNP | Ensembl ].
VAR_060540

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9090Missing in isoform 2. 2 PublicationsVSP_014267Add
BLAST
Alternative sequencei1 – 6161Missing in isoform 3. 2 PublicationsVSP_038326Add
BLAST
Alternative sequencei62 – 8827RPSCA…ASSRR → MKRLSLVTTNRLSPHGNFFT LCTFPLA in isoform 3. 2 PublicationsVSP_038327Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010231 mRNA. Translation: CAA09045.1. Different initiation.
AK055999 mRNA. No translation available.
CR456563 mRNA. Translation: CAG30449.1.
AL008723 Genomic DNA. Translation: CAB51756.2.
BC051910 mRNA. Translation: AAH51910.1.
BC069827 mRNA. Translation: AAH69827.2.
CCDSiCCDS43009.2. [O75678-1]
CCDS46694.1. [O75678-3]
RefSeqiNP_001091997.2. NM_001098527.2. [O75678-1]
NP_001153017.1. NM_001159545.1. [O75678-2]
NP_001153018.1. NM_001159546.1. [O75678-2]
NP_006596.2. NM_006605.3. [O75678-3]
XP_005261367.1. XM_005261310.1. [O75678-2]
XP_011528134.1. XM_011529832.1. [O75678-1]
UniGeneiHs.157427.

Genome annotation databases

EnsembliENST00000248980; ENSP00000248980; ENSG00000128253. [O75678-3]
ENST00000248983; ENSP00000248983; ENSG00000128253. [O75678-1]
ENST00000400237; ENSP00000383096; ENSG00000128253. [O75678-1]
GeneIDi10739.
KEGGihsa:10739.
UCSCiuc003amg.4. human. [O75678-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010231 mRNA. Translation: CAA09045.1. Different initiation.
AK055999 mRNA. No translation available.
CR456563 mRNA. Translation: CAG30449.1.
AL008723 Genomic DNA. Translation: CAB51756.2.
BC051910 mRNA. Translation: AAH51910.1.
BC069827 mRNA. Translation: AAH69827.2.
CCDSiCCDS43009.2. [O75678-1]
CCDS46694.1. [O75678-3]
RefSeqiNP_001091997.2. NM_001098527.2. [O75678-1]
NP_001153017.1. NM_001159545.1. [O75678-2]
NP_001153018.1. NM_001159546.1. [O75678-2]
NP_006596.2. NM_006605.3. [O75678-3]
XP_005261367.1. XM_005261310.1. [O75678-2]
XP_011528134.1. XM_011529832.1. [O75678-1]
UniGeneiHs.157427.

3D structure databases

ProteinModelPortaliO75678.
SMRiO75678. Positions 91-164, 183-364.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115962. 14 interactions.
STRINGi9606.ENSP00000383096.

Polymorphism and mutation databases

BioMutaiRFPL2.

Proteomic databases

PaxDbiO75678.
PRIDEiO75678.

Protocols and materials databases

DNASUi10739.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000248980; ENSP00000248980; ENSG00000128253. [O75678-3]
ENST00000248983; ENSP00000248983; ENSG00000128253. [O75678-1]
ENST00000400237; ENSP00000383096; ENSG00000128253. [O75678-1]
GeneIDi10739.
KEGGihsa:10739.
UCSCiuc003amg.4. human. [O75678-1]

Organism-specific databases

CTDi10739.
GeneCardsiRFPL2.
HGNCiHGNC:9979. RFPL2.
MIMi605969. gene.
neXtProtiNX_O75678.
PharmGKBiPA34348.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00760000118993.
HOGENOMiHOG000230861.
HOVERGENiHBG061854.
InParanoidiO75678.
OMAiRICLCAV.
OrthoDBiEOG7CVPZS.
PhylomeDBiO75678.
TreeFamiTF317532.

Miscellaneous databases

GenomeRNAii10739.
NextBioi40776.
PROiO75678.
SOURCEiSearch...

Gene expression databases

BgeeiO75678.
CleanExiHS_RFPL2.
ExpressionAtlasiO75678. baseline and differential.
GenevisibleiO75678. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR022723. RDM_domain_RFPL.
IPR003877. SPRY_dom.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF11002. RDM. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Duplications on human chromosome 22 reveal a novel Ret finger protein-like gene family with sense and endogenous antisense transcripts."
    Seroussi E., Kedra D., Pan H.-Q., Peyrad M., Schwartz C., Scambler P., Donnai D., Roe B.A., Dumanski J.P.
    Genome Res. 9:803-814(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANTS TYR-141; SER-290; GLY-324; CYS-341 AND ILE-348.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS TYR-141; SER-290; GLY-324; CYS-341 AND ILE-348.
  4. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Brain.

Entry informationi

Entry nameiRFPL2_HUMAN
AccessioniPrimary (citable) accession number: O75678
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: July 5, 2005
Last modified: May 11, 2016
This is version 149 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.