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Protein

Ret finger protein-like 2

Gene

RFPL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri101 – 143RING-type; degenerateAdd BLAST43

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ret finger protein-like 2
Alternative name(s):
RING finger protein 79
Gene namesi
Name:RFPL2
Synonyms:RNF79
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000128253.13
HGNCiHGNC:9979 RFPL2
MIMi605969 gene
neXtProtiNX_O75678

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000128253
PharmGKBiPA34348

Polymorphism and mutation databases

BioMutaiRFPL2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000560311 – 378Ret finger protein-like 2Add BLAST378

Proteomic databases

PaxDbiO75678
PRIDEiO75678
ProteomicsDBi50152
50153 [O75678-2]
50154 [O75678-3]

Expressioni

Tissue specificityi

Seems to be expressed in prostate and less abundantly in adult brain, fetal liver, and fetal kidney.

Gene expression databases

BgeeiENSG00000128253
CleanExiHS_RFPL2
ExpressionAtlasiO75678 baseline and differential
GenevisibleiO75678 HS

Organism-specific databases

HPAiHPA048320
HPA072380

Interactioni

Protein-protein interaction databases

BioGridi115962, 15 interactors
STRINGi9606.ENSP00000383096

Structurei

3D structure databases

ProteinModelPortaliO75678
SMRiO75678
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini168 – 362B30.2/SPRYPROSITE-ProRule annotationAdd BLAST195

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri101 – 143RING-type; degenerateAdd BLAST43

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG4111G04 LUCA
GeneTreeiENSGT00760000118993
HOGENOMiHOG000230861
HOVERGENiHBG061854
InParanoidiO75678
OMAiRICLCAV
OrthoDBiEOG091G0G5I
PhylomeDBiO75678
TreeFamiTF317532

Family and domain databases

CDDicd15821 SPRY_PRY_RFPL, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR022723 RDM_domain_RFPL
IPR038908 RFPL
IPR037960 SPRY/PRY_RFPL
IPR003877 SPRY_dom
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR25462 PTHR25462, 1 hit
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF11002 RDM, 1 hit
PF00622 SPRY, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00589 PRY, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75678-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVAELGFPE TAVSQSRICL CAVLCGHWDF ADMMVIRSLS LIRLEGVEGR
60 70 80 90 100
DPVGGGNLTN KRPSCAPSPQ DLSAQWKQLE DRGASSRRVD MAALFQEASS
110 120 130 140 150
CPVCSDYLEK PMSLECGCAV CLKCINSLQK EPHGEDLLCC CSSMVSRKNK
160 170 180 190 200
IRRNRQLERL ASHIKELEPK LKKILQMNPR MRKFQVDMTL DANTANNFLL
210 220 230 240 250
ISDDLRSVRS GRIRQNRQDL AERFDVSVCI LGSPRFTCGR HCWEVDVGTS
260 270 280 290 300
TEWDLGVCRE SVHRKGRIQL TTELGFWTVS LRDGGRLSAT TVPLTFLFVD
310 320 330 340 350
RKLQRVGIFL DMGMQNVSFF DAESGSHVYT FRSVSAEEPL RPFLAPSVPP
360 370
NGDQGVLSIC PLMNSGTTDA PVRPGEAK
Note: No experimental confirmation available.
Length:378
Mass (Da):42,077
Last modified:July 5, 2005 - v3
Checksum:i670B38CDE6509BA4
GO
Isoform 2 (identifier: O75678-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: Missing.

Show »
Length:288
Mass (Da):32,278
Checksum:i1DCD5E89AFB0A7C6
GO
Isoform 3 (identifier: O75678-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: Missing.
     62-88: RPSCAPSPQDLSAQWKQLEDRGASSRR → MKRLSLVTTNRLSPHGNFFTLCTFPLA

Show »
Length:317
Mass (Da):35,540
Checksum:i8EBAE75BEECAC43F
GO

Sequence cautioni

The sequence CAA09045 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060534119A → T. Corresponds to variant dbSNP:rs8135276Ensembl.1
Natural variantiVAR_060535141C → Y2 PublicationsCorresponds to variant dbSNP:rs136478Ensembl.1
Natural variantiVAR_060536215Q → H. Corresponds to variant dbSNP:rs56240743Ensembl.1
Natural variantiVAR_060537290T → S2 PublicationsCorresponds to variant dbSNP:rs136472Ensembl.1
Natural variantiVAR_060538324S → G2 PublicationsCorresponds to variant dbSNP:rs136470Ensembl.1
Natural variantiVAR_060539341R → C2 PublicationsCorresponds to variant dbSNP:rs136468Ensembl.1
Natural variantiVAR_060540348V → I2 PublicationsCorresponds to variant dbSNP:rs136467Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0142671 – 90Missing in isoform 2. 2 PublicationsAdd BLAST90
Alternative sequenceiVSP_0383261 – 61Missing in isoform 3. 2 PublicationsAdd BLAST61
Alternative sequenceiVSP_03832762 – 88RPSCA…ASSRR → MKRLSLVTTNRLSPHGNFFT LCTFPLA in isoform 3. 2 PublicationsAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010231 mRNA Translation: CAA09045.1 Different initiation.
AK055999 mRNA No translation available.
CR456563 mRNA Translation: CAG30449.1
AL008723 Genomic DNA No translation available.
BC051910 mRNA Translation: AAH51910.1
BC069827 mRNA Translation: AAH69827.2
CCDSiCCDS43009.2 [O75678-1]
CCDS46694.1 [O75678-3]
RefSeqiNP_001091997.2, NM_001098527.2 [O75678-1]
NP_001153017.1, NM_001159545.1 [O75678-2]
NP_001153018.1, NM_001159546.1 [O75678-2]
NP_006596.2, NM_006605.3 [O75678-3]
XP_011528134.1, XM_011529832.1 [O75678-1]
XP_016884024.1, XM_017028535.1 [O75678-2]
XP_016884025.1, XM_017028536.1 [O75678-2]
UniGeneiHs.157427

Genome annotation databases

EnsembliENST00000248980; ENSP00000248980; ENSG00000128253 [O75678-3]
ENST00000248983; ENSP00000248983; ENSG00000128253 [O75678-1]
ENST00000400237; ENSP00000383096; ENSG00000128253 [O75678-1]
GeneIDi10739
KEGGihsa:10739
UCSCiuc003amg.4 human [O75678-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRFPL2_HUMAN
AccessioniPrimary (citable) accession number: O75678
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: July 5, 2005
Last modified: June 20, 2018
This is version 161 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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