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Protein

Ret finger protein-like 1

Gene

RFPL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri40 – 8243RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ret finger protein-like 1
Alternative name(s):
RING finger protein 78
Gene namesi
Name:RFPL1
Synonyms:RFPL1L, RNF78
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:9977. RFPL1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34346.

Polymorphism and mutation databases

BioMutaiRFPL1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317Ret finger protein-like 1PRO_0000056030Add
BLAST

Proteomic databases

PaxDbiO75677.
PRIDEiO75677.

PTM databases

iPTMnetiO75677.

Expressioni

Tissue specificityi

Seems to be expressed in prostate and less abundantly in adult brain, fetal liver, and fetal kidney.

Gene expression databases

BgeeiO75677.
CleanExiHS_RFPL1.
GenevisibleiO75677. HS.

Interactioni

Protein-protein interaction databases

BioGridi111920. 1 interaction.
STRINGi9606.ENSP00000346342.

Structurei

3D structure databases

ProteinModelPortaliO75677.
SMRiO75677. Positions 30-103, 122-304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini107 – 301195B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri40 – 8243RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00760000118993.
HOGENOMiHOG000230861.
HOVERGENiHBG061854.
InParanoidiO75677.
OMAiCATSIEC.
OrthoDBiEOG7CVPZS.
PhylomeDBiO75677.
TreeFamiTF317532.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR022723. RDM_domain_RFPL.
IPR003877. SPRY_dom.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF11002. RDM. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75677-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRLSLVTTN RLSPHGNFLP LCTFPLAVDM AALFQEASSC PVCSDYLEKP
60 70 80 90 100
MSLECGCAVC FKCINSLQKE PHGEDLLCCC CSMVSQKNKI RPSWQLERLA
110 120 130 140 150
SHIKELEPKL KKILQMNPRM RKFQVDMTLD ADTANNFLLI SDDLRSVRSG
160 170 180 190 200
CITQNRQDLA ERFDVSICIL GSPRFTCGRH YWEVDVGTST EWDLGVCRES
210 220 230 240 250
VHRKGRIHLT TERGFWTVSL RDGSRLSAST VPLTFLFVDR KLQRVGIFLD
260 270 280 290 300
MGMQNVSFFD AEGGSHVYTF RSVSAEEPLH LFFAPPSPPN GDKSVLSICP
310
VINPGTTDAP VHPGEAK
Length:317
Mass (Da):35,491
Last modified:March 15, 2005 - v2
Checksum:i75FDDED7BF51B8CA
GO

Sequence cautioni

The sequence CAA09043.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAA09044.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti289 – 2891P → S in CAG30448 (PubMed:15461802).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti94 – 941W → R.
Corresponds to variant rs16987627 [ dbSNP | Ensembl ].
VAR_039572
Natural varianti127 – 1271M → T.3 Publications
Corresponds to variant rs3804076 [ dbSNP | Ensembl ].
VAR_020115
Natural varianti139 – 1391Missing .3 Publications
VAR_039573

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010228 mRNA. Translation: CAA09043.1. Different initiation.
AJ010229 mRNA. Translation: CAA09044.1. Different initiation.
CR456562 mRNA. Translation: CAG30448.1.
BC104768 mRNA. No translation available.
CCDSiCCDS13857.2.
RefSeqiNP_066306.2. NM_021026.2.
XP_011528600.1. XM_011530298.1.
XP_011528601.1. XM_011530299.1.
XP_011528602.1. XM_011530300.1.
UniGeneiHs.648249.

Genome annotation databases

EnsembliENST00000354373; ENSP00000346342; ENSG00000128250.
GeneIDi5988.
KEGGihsa:5988.
UCSCiuc003afn.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010228 mRNA. Translation: CAA09043.1. Different initiation.
AJ010229 mRNA. Translation: CAA09044.1. Different initiation.
CR456562 mRNA. Translation: CAG30448.1.
BC104768 mRNA. No translation available.
CCDSiCCDS13857.2.
RefSeqiNP_066306.2. NM_021026.2.
XP_011528600.1. XM_011530298.1.
XP_011528601.1. XM_011530299.1.
XP_011528602.1. XM_011530300.1.
UniGeneiHs.648249.

3D structure databases

ProteinModelPortaliO75677.
SMRiO75677. Positions 30-103, 122-304.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111920. 1 interaction.
STRINGi9606.ENSP00000346342.

PTM databases

iPTMnetiO75677.

Polymorphism and mutation databases

BioMutaiRFPL1.

Proteomic databases

PaxDbiO75677.
PRIDEiO75677.

Protocols and materials databases

DNASUi5988.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354373; ENSP00000346342; ENSG00000128250.
GeneIDi5988.
KEGGihsa:5988.
UCSCiuc003afn.3. human.

Organism-specific databases

CTDi5988.
GeneCardsiRFPL1.
HGNCiHGNC:9977. RFPL1.
MIMi605968. gene.
neXtProtiNX_O75677.
PharmGKBiPA34346.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00760000118993.
HOGENOMiHOG000230861.
HOVERGENiHBG061854.
InParanoidiO75677.
OMAiCATSIEC.
OrthoDBiEOG7CVPZS.
PhylomeDBiO75677.
TreeFamiTF317532.

Miscellaneous databases

GenomeRNAii5988.
PROiO75677.
SOURCEiSearch...

Gene expression databases

BgeeiO75677.
CleanExiHS_RFPL1.
GenevisibleiO75677. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR022723. RDM_domain_RFPL.
IPR003877. SPRY_dom.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF11002. RDM. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Duplications on human chromosome 22 reveal a novel Ret finger protein-like gene family with sense and endogenous antisense transcripts."
    Seroussi E., Kedra D., Pan H.-Q., Peyrad M., Schwartz C., Scambler P., Donnai D., Roe B.A., Dumanski J.P.
    Genome Res. 9:803-814(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS THR-127 AND LEU-139 DEL.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS THR-127 AND LEU-139 DEL.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 22-317, VARIANTS THR-127 AND LEU-139 DEL.
    Tissue: Brain.

Entry informationi

Entry nameiRFPL1_HUMAN
AccessioniPrimary (citable) accession number: O75677
Secondary accession number(s): Q6IC06, Q9UJ97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 15, 2005
Last modified: June 8, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.