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O75674

- TM1L1_HUMAN

UniProt

O75674 - TM1L1_HUMAN

Protein

TOM1-like protein 1

Gene

TOM1L1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions By similarity.By similarity

    GO - Molecular functioni

    1. clathrin binding Source: UniProtKB
    2. protein binding Source: UniProtKB
    3. protein kinase activator activity Source: Ensembl
    4. protein kinase binding Source: UniProtKB
    5. ubiquitin binding Source: HGNC

    GO - Biological processi

    1. activation of protein kinase activity Source: UniProtKB
    2. intracellular protein transport Source: InterPro
    3. negative regulation of mitosis Source: UniProtKB
    4. positive regulation of protein autophosphorylation Source: UniProtKB
    5. signal transduction Source: UniProtKB
    6. ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: HGNC

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    TOM1-like protein 1
    Alternative name(s):
    Src-activating and signaling molecule protein
    Target of Myb-like protein 1
    Gene namesi
    Name:TOM1L1
    Synonyms:SRCASM
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:11983. TOM1L1.

    Subcellular locationi

    Golgi apparatusGolgi stack. Endosome membrane Curated. Cytoplasm By similarity. Membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
    Note: A small proportion is membrane-associated.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytosol Source: HGNC
    3. endosome Source: UniProtKB
    4. endosome membrane Source: UniProtKB-SubCell
    5. extracellular vesicular exosome Source: UniProt
    6. Golgi stack Source: UniProtKB-SubCell
    7. lysosome Source: ProtInc

    Keywords - Cellular componenti

    Cytoplasm, Endosome, Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36667.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 476476TOM1-like protein 1PRO_0000072566Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei314 – 3141Phosphoserine1 Publication
    Modified residuei321 – 3211Phosphoserine1 Publication
    Modified residuei323 – 3231Phosphoserine4 Publications
    Modified residuei460 – 4601PhosphotyrosineBy similarity

    Post-translational modificationi

    Phosphorylated on tyrosines by FYN and LYN.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO75674.
    PaxDbiO75674.
    PRIDEiO75674.

    PTM databases

    PhosphoSiteiO75674.

    Expressioni

    Gene expression databases

    ArrayExpressiO75674.
    BgeeiO75674.
    CleanExiHS_TOM1L1.
    GenevestigatoriO75674.

    Organism-specific databases

    HPAiHPA022916.

    Interactioni

    Subunit structurei

    Interacts with FYN, GRB2 and PIK3R1 when phosphorylated. Interacts with LYN.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CLTCQ006104EBI-712991,EBI-354967
    EGFRP005336EBI-712991,EBI-297353
    GRB2P629932EBI-712991,EBI-401755
    TOLLIPQ9H0E23EBI-712991,EBI-74615
    TOM1O607842EBI-712991,EBI-74634
    VAV2P527352EBI-712991,EBI-297549

    Protein-protein interaction databases

    BioGridi115352. 52 interactions.
    IntActiO75674. 30 interactions.
    MINTiMINT-1213299.
    STRINGi9606.ENSP00000408958.

    Structurei

    Secondary structure

    1
    476
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi10 – 123
    Helixi14 – 229
    Helixi32 – 4413
    Helixi48 – 6013
    Helixi66 – 8217
    Helixi85 – 917
    Helixi94 – 974
    Turni98 – 1014
    Helixi102 – 1054
    Helixi107 – 1093
    Helixi113 – 12715
    Beta strandi131 – 1333
    Helixi137 – 14812

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3RRUX-ray3.00A/B9-150[»]
    ProteinModelPortaliO75674.
    SMRiO75674. Positions 9-149, 200-288.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 154133VHSPROSITE-ProRule annotationAdd
    BLAST
    Domaini200 – 28889GATPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni392 – 3954Interaction with GRB2By similarity
    Regioni442 – 4454Interaction with PIK3R1By similarity

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi421 – 4255SH3-bindingBy similarity
    Motifi460 – 4634SH2-bindingBy similarity

    Sequence similaritiesi

    Belongs to the TOM1 family.Curated
    Contains 1 GAT domain.PROSITE-ProRule annotation
    Contains 1 VHS domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3-binding

    Phylogenomic databases

    eggNOGiNOG321220.
    HOGENOMiHOG000285970.
    HOVERGENiHBG025068.
    InParanoidiO75674.
    OMAiVTTEAIY.
    OrthoDBiEOG75B859.
    PhylomeDBiO75674.
    TreeFamiTF314105.

    Family and domain databases

    Gene3Di1.25.40.90. 1 hit.
    InterProiIPR008942. ENTH_VHS.
    IPR004152. GAT.
    IPR014645. TOM1.
    IPR027428. TOM1L1.
    IPR002014. VHS.
    IPR018205. VHS_subgr.
    [Graphical view]
    PANTHERiPTHR13856:SF28. PTHR13856:SF28. 1 hit.
    PfamiPF03127. GAT. 1 hit.
    PF00790. VHS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036948. TOM1. 1 hit.
    SMARTiSM00288. VHS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48464. SSF48464. 1 hit.
    PROSITEiPS50909. GAT. 1 hit.
    PS50179. VHS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O75674-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFGKSHRDP YATSVGHLIE KATFAGVQTE DWGQFMHICD IINTTQDGPK    50
    DAVKALKKRI SKNYNHKEIQ LTLSLIDMCV QNCGPSFQSL IVKKEFVKEN 100
    LVKLLNPRYN LPLDIQNRIL NFIKTWSQGF PGGVDVSEVK EVYLDLVKKG 150
    VQFPPSEAEA ETARQETAQI SSNPPTSVPT APALSSVIAP KNSTVTLVPE 200
    QIGKLHSELD MVKMNVRVMS AILMENTPGS ENHEDIELLQ KLYKTGREMQ 250
    ERIMDLLVVV ENEDVTVELI QVNEDLNNAI LGYERFTRNQ QRILEQNKNQ 300
    KEATNTTSEP SAPSQDLLDL SPSPRMPRAT LGELNTMNNQ LSGLNFSLPS 350
    SDVTNNLKPS LHPQMNLLAL ENTEIPPFAQ RTSQNLTSSH AYDNFLEHSN 400
    SVFLQPVSLQ TIAAAPSNQS LPPLPSNHPA MTKSDLQPPN YYEVMEFDPL 450
    APAVTTEAIY EEIDAHQHKG AQNDGD 476
    Length:476
    Mass (Da):52,989
    Last modified:November 25, 2008 - v2
    Checksum:i47ED5FA1F40144C0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti48 – 481G → A in CAA08993. (PubMed:10329004)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti108 – 1081R → S.
    Corresponds to variant rs16955377 [ dbSNP | Ensembl ].
    VAR_047469

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ010071 mRNA. Translation: CAA08993.1.
    AK315039 mRNA. Translation: BAG37522.1.
    AK223125 mRNA. Translation: BAD96845.1.
    CH471109 Genomic DNA. Translation: EAW94553.1.
    CCDSiCCDS11582.1.
    RefSeqiNP_005477.2. NM_005486.2.
    UniGeneiHs.153504.

    Genome annotation databases

    EnsembliENST00000575882; ENSP00000460823; ENSG00000141198.
    GeneIDi10040.
    KEGGihsa:10040.
    UCSCiuc002iud.2. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ010071 mRNA. Translation: CAA08993.1 .
    AK315039 mRNA. Translation: BAG37522.1 .
    AK223125 mRNA. Translation: BAD96845.1 .
    CH471109 Genomic DNA. Translation: EAW94553.1 .
    CCDSi CCDS11582.1.
    RefSeqi NP_005477.2. NM_005486.2.
    UniGenei Hs.153504.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3RRU X-ray 3.00 A/B 9-150 [» ]
    ProteinModelPortali O75674.
    SMRi O75674. Positions 9-149, 200-288.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115352. 52 interactions.
    IntActi O75674. 30 interactions.
    MINTi MINT-1213299.
    STRINGi 9606.ENSP00000408958.

    PTM databases

    PhosphoSitei O75674.

    Proteomic databases

    MaxQBi O75674.
    PaxDbi O75674.
    PRIDEi O75674.

    Protocols and materials databases

    DNASUi 10040.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000575882 ; ENSP00000460823 ; ENSG00000141198 .
    GeneIDi 10040.
    KEGGi hsa:10040.
    UCSCi uc002iud.2. human.

    Organism-specific databases

    CTDi 10040.
    GeneCardsi GC17P052978.
    H-InvDB HIX0014000.
    HGNCi HGNC:11983. TOM1L1.
    HPAi HPA022916.
    MIMi 604701. gene.
    neXtProti NX_O75674.
    PharmGKBi PA36667.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG321220.
    HOGENOMi HOG000285970.
    HOVERGENi HBG025068.
    InParanoidi O75674.
    OMAi VTTEAIY.
    OrthoDBi EOG75B859.
    PhylomeDBi O75674.
    TreeFami TF314105.

    Miscellaneous databases

    ChiTaRSi TOM1L1. human.
    GeneWikii TOM1L1.
    GenomeRNAii 10040.
    NextBioi 37921.
    PROi O75674.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75674.
    Bgeei O75674.
    CleanExi HS_TOM1L1.
    Genevestigatori O75674.

    Family and domain databases

    Gene3Di 1.25.40.90. 1 hit.
    InterProi IPR008942. ENTH_VHS.
    IPR004152. GAT.
    IPR014645. TOM1.
    IPR027428. TOM1L1.
    IPR002014. VHS.
    IPR018205. VHS_subgr.
    [Graphical view ]
    PANTHERi PTHR13856:SF28. PTHR13856:SF28. 1 hit.
    Pfami PF03127. GAT. 1 hit.
    PF00790. VHS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036948. TOM1. 1 hit.
    SMARTi SM00288. VHS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48464. SSF48464. 1 hit.
    PROSITEi PS50909. GAT. 1 hit.
    PS50179. VHS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM."
      Seroussi E., Kedra D., Kost-Alimova M., Sandberg-Nordqvist A.-C., Fransson I., Jacobs J.F.M., Fu Y., Pan H.-Q., Roe B.A., Imreh S., Dumanski J.P.
      Genomics 57:380-388(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Trachea.
    3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-314 AND SER-323, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-323, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321 AND SER-323, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-323, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "X-ray crystal structure of the VHS domain of human TOM1-like protein, Northeast structural genomics consortium target HR3050E."
      Northeast structural genomics consortium (NESG)
      Submitted (JUN-2011) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 9-150.

    Entry informationi

    Entry nameiTM1L1_HUMAN
    AccessioniPrimary (citable) accession number: O75674
    Secondary accession number(s): Q53G06
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 15, 2002
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3