Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

TOM1-like protein 1

Gene

TOM1L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions (By similarity).By similarity

GO - Molecular functioni

  • clathrin binding Source: UniProtKB
  • protein kinase activator activity Source: InterPro
  • protein kinase binding Source: UniProtKB
  • ubiquitin binding Source: HGNC

GO - Biological processi

  • activation of protein kinase activity Source: UniProtKB
  • intracellular protein transport Source: InterPro
  • negative regulation of mitotic nuclear division Source: UniProtKB
  • positive regulation of protein autophosphorylation Source: UniProtKB
  • signal transduction Source: UniProtKB
  • ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: HGNC
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000141198-MONOMER.
SIGNORiO75674.

Names & Taxonomyi

Protein namesi
Recommended name:
TOM1-like protein 1
Alternative name(s):
Src-activating and signaling molecule protein
Target of Myb-like protein 1
Gene namesi
Name:TOM1L1
Synonyms:SRCASM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:11983. TOM1L1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: HGNC
  • endosome Source: UniProtKB
  • endosome membrane Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • Golgi stack Source: UniProtKB-SubCell
  • lysosome Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10040.
OpenTargetsiENSG00000141198.
PharmGKBiPA36667.

Polymorphism and mutation databases

BioMutaiTOM1L1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000725661 – 476TOM1-like protein 1Add BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei171PhosphoserineBy similarity1
Modified residuei314PhosphoserineCombined sources1
Modified residuei321PhosphoserineCombined sources1
Modified residuei323PhosphoserineCombined sources1
Modified residuei460PhosphotyrosineBy similarity1

Post-translational modificationi

Phosphorylated on tyrosines by FYN and LYN.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO75674.
PaxDbiO75674.
PeptideAtlasiO75674.
PRIDEiO75674.

PTM databases

iPTMnetiO75674.
PhosphoSitePlusiO75674.

Expressioni

Gene expression databases

BgeeiENSG00000141198.
CleanExiHS_TOM1L1.
ExpressionAtlasiO75674. baseline and differential.
GenevisibleiO75674. HS.

Organism-specific databases

HPAiHPA022916.

Interactioni

Subunit structurei

Interacts with FYN, GRB2 and PIK3R1 when phosphorylated. Interacts with LYN.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CLTCQ006104EBI-712991,EBI-354967
EGFRP005336EBI-712991,EBI-297353
GRB2P629932EBI-712991,EBI-401755
TOLLIPQ9H0E23EBI-712991,EBI-74615
TOM1O607842EBI-712991,EBI-74634
VAV2P527352EBI-712991,EBI-297549

GO - Molecular functioni

  • clathrin binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • ubiquitin binding Source: HGNC

Protein-protein interaction databases

BioGridi115352. 58 interactors.
IntActiO75674. 32 interactors.
MINTiMINT-1213299.
STRINGi9606.ENSP00000460823.

Structurei

Secondary structure

1476
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 12Combined sources3
Helixi14 – 22Combined sources9
Helixi32 – 44Combined sources13
Helixi48 – 60Combined sources13
Helixi66 – 82Combined sources17
Helixi85 – 91Combined sources7
Helixi94 – 97Combined sources4
Turni98 – 101Combined sources4
Helixi102 – 105Combined sources4
Helixi107 – 109Combined sources3
Helixi113 – 127Combined sources15
Beta strandi131 – 133Combined sources3
Helixi137 – 148Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RRUX-ray3.00A/B9-150[»]
ProteinModelPortaliO75674.
SMRiO75674.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 154VHSPROSITE-ProRule annotationAdd BLAST133
Domaini200 – 288GATPROSITE-ProRule annotationAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni392 – 395Interaction with GRB2By similarity4
Regioni442 – 445Interaction with PIK3R1By similarity4

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi421 – 425SH3-bindingBy similarity5
Motifi460 – 463SH2-bindingBy similarity4

Sequence similaritiesi

Belongs to the TOM1 family.Curated
Contains 1 GAT domain.PROSITE-ProRule annotation
Contains 1 VHS domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiKOG1087. Eukaryota.
ENOG410Y26G. LUCA.
GeneTreeiENSGT00860000133703.
HOGENOMiHOG000285970.
HOVERGENiHBG025068.
InParanoidiO75674.
OMAiTMNNQLS.
OrthoDBiEOG091G08M1.
PhylomeDBiO75674.
TreeFamiTF314105.

Family and domain databases

Gene3Di1.20.58.160. 1 hit.
1.25.40.90. 1 hit.
InterProiIPR008942. ENTH_VHS.
IPR004152. GAT_dom.
IPR014645. TOM1.
IPR027428. TOM1L1.
IPR002014. VHS_dom.
[Graphical view]
PANTHERiPTHR13856:SF28. PTHR13856:SF28. 2 hits.
PfamiPF03127. GAT. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view]
PIRSFiPIRSF036948. TOM1. 1 hit.
SMARTiSM00288. VHS. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
PROSITEiPS50909. GAT. 1 hit.
PS50179. VHS. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75674-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFGKSHRDP YATSVGHLIE KATFAGVQTE DWGQFMHICD IINTTQDGPK
60 70 80 90 100
DAVKALKKRI SKNYNHKEIQ LTLSLIDMCV QNCGPSFQSL IVKKEFVKEN
110 120 130 140 150
LVKLLNPRYN LPLDIQNRIL NFIKTWSQGF PGGVDVSEVK EVYLDLVKKG
160 170 180 190 200
VQFPPSEAEA ETARQETAQI SSNPPTSVPT APALSSVIAP KNSTVTLVPE
210 220 230 240 250
QIGKLHSELD MVKMNVRVMS AILMENTPGS ENHEDIELLQ KLYKTGREMQ
260 270 280 290 300
ERIMDLLVVV ENEDVTVELI QVNEDLNNAI LGYERFTRNQ QRILEQNKNQ
310 320 330 340 350
KEATNTTSEP SAPSQDLLDL SPSPRMPRAT LGELNTMNNQ LSGLNFSLPS
360 370 380 390 400
SDVTNNLKPS LHPQMNLLAL ENTEIPPFAQ RTSQNLTSSH AYDNFLEHSN
410 420 430 440 450
SVFLQPVSLQ TIAAAPSNQS LPPLPSNHPA MTKSDLQPPN YYEVMEFDPL
460 470
APAVTTEAIY EEIDAHQHKG AQNDGD
Length:476
Mass (Da):52,989
Last modified:November 25, 2008 - v2
Checksum:i47ED5FA1F40144C0
GO
Isoform 2 (identifier: O75674-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     345-346: NF → SK
     347-476: Missing.

Note: No experimental confirmation available.
Show »
Length:346
Mass (Da):38,713
Checksum:i414DC8AEA1AB415F
GO
Isoform 3 (identifier: O75674-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: Missing.

Note: No experimental confirmation available.
Show »
Length:399
Mass (Da):44,334
Checksum:iF1E782419B262E59
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48G → A in CAA08993 (PubMed:10329004).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047469108R → S.Corresponds to variant rs16955377dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0574241 – 77Missing in isoform 3. 1 PublicationAdd BLAST77
Alternative sequenceiVSP_056852345 – 346NF → SK in isoform 2. 1 Publication2
Alternative sequenceiVSP_056853347 – 476Missing in isoform 2. 1 PublicationAdd BLAST130

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010071 mRNA. Translation: CAA08993.1.
AK315039 mRNA. Translation: BAG37522.1.
AK315907 mRNA. Translation: BAH14278.1.
AK223125 mRNA. Translation: BAD96845.1.
AC007485 Genomic DNA. No translation available.
AC090824 Genomic DNA. No translation available.
KC877665 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94551.1.
CH471109 Genomic DNA. Translation: EAW94553.1.
BC029396 mRNA. Translation: AAH29396.1.
CCDSiCCDS11582.1. [O75674-1]
CCDS82160.1. [O75674-2]
CCDS82161.1. [O75674-3]
RefSeqiNP_001308102.1. NM_001321173.1. [O75674-2]
NP_001308103.1. NM_001321174.1. [O75674-3]
NP_001308104.1. NM_001321175.1. [O75674-3]
NP_001308105.1. NM_001321176.1. [O75674-3]
NP_005477.2. NM_005486.2. [O75674-1]
XP_016879491.1. XM_017024002.1. [O75674-3]
UniGeneiHs.153504.

Genome annotation databases

EnsembliENST00000348161; ENSP00000343901; ENSG00000141198. [O75674-3]
ENST00000536554; ENSP00000443099; ENSG00000141198. [O75674-3]
ENST00000570371; ENSP00000458553; ENSG00000141198. [O75674-2]
ENST00000575333; ENSP00000458918; ENSG00000141198. [O75674-2]
ENST00000575882; ENSP00000460823; ENSG00000141198. [O75674-1]
GeneIDi10040.
KEGGihsa:10040.
UCSCiuc002iuc.4. human. [O75674-1]
uc010dbz.3. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010071 mRNA. Translation: CAA08993.1.
AK315039 mRNA. Translation: BAG37522.1.
AK315907 mRNA. Translation: BAH14278.1.
AK223125 mRNA. Translation: BAD96845.1.
AC007485 Genomic DNA. No translation available.
AC090824 Genomic DNA. No translation available.
KC877665 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94551.1.
CH471109 Genomic DNA. Translation: EAW94553.1.
BC029396 mRNA. Translation: AAH29396.1.
CCDSiCCDS11582.1. [O75674-1]
CCDS82160.1. [O75674-2]
CCDS82161.1. [O75674-3]
RefSeqiNP_001308102.1. NM_001321173.1. [O75674-2]
NP_001308103.1. NM_001321174.1. [O75674-3]
NP_001308104.1. NM_001321175.1. [O75674-3]
NP_001308105.1. NM_001321176.1. [O75674-3]
NP_005477.2. NM_005486.2. [O75674-1]
XP_016879491.1. XM_017024002.1. [O75674-3]
UniGeneiHs.153504.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RRUX-ray3.00A/B9-150[»]
ProteinModelPortaliO75674.
SMRiO75674.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115352. 58 interactors.
IntActiO75674. 32 interactors.
MINTiMINT-1213299.
STRINGi9606.ENSP00000460823.

PTM databases

iPTMnetiO75674.
PhosphoSitePlusiO75674.

Polymorphism and mutation databases

BioMutaiTOM1L1.

Proteomic databases

MaxQBiO75674.
PaxDbiO75674.
PeptideAtlasiO75674.
PRIDEiO75674.

Protocols and materials databases

DNASUi10040.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000348161; ENSP00000343901; ENSG00000141198. [O75674-3]
ENST00000536554; ENSP00000443099; ENSG00000141198. [O75674-3]
ENST00000570371; ENSP00000458553; ENSG00000141198. [O75674-2]
ENST00000575333; ENSP00000458918; ENSG00000141198. [O75674-2]
ENST00000575882; ENSP00000460823; ENSG00000141198. [O75674-1]
GeneIDi10040.
KEGGihsa:10040.
UCSCiuc002iuc.4. human. [O75674-1]
uc010dbz.3. human.

Organism-specific databases

CTDi10040.
DisGeNETi10040.
GeneCardsiTOM1L1.
H-InvDBHIX0014000.
HGNCiHGNC:11983. TOM1L1.
HPAiHPA022916.
MIMi604701. gene.
neXtProtiNX_O75674.
OpenTargetsiENSG00000141198.
PharmGKBiPA36667.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1087. Eukaryota.
ENOG410Y26G. LUCA.
GeneTreeiENSGT00860000133703.
HOGENOMiHOG000285970.
HOVERGENiHBG025068.
InParanoidiO75674.
OMAiTMNNQLS.
OrthoDBiEOG091G08M1.
PhylomeDBiO75674.
TreeFamiTF314105.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000141198-MONOMER.
SIGNORiO75674.

Miscellaneous databases

ChiTaRSiTOM1L1. human.
GeneWikiiTOM1L1.
GenomeRNAii10040.
PROiO75674.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000141198.
CleanExiHS_TOM1L1.
ExpressionAtlasiO75674. baseline and differential.
GenevisibleiO75674. HS.

Family and domain databases

Gene3Di1.20.58.160. 1 hit.
1.25.40.90. 1 hit.
InterProiIPR008942. ENTH_VHS.
IPR004152. GAT_dom.
IPR014645. TOM1.
IPR027428. TOM1L1.
IPR002014. VHS_dom.
[Graphical view]
PANTHERiPTHR13856:SF28. PTHR13856:SF28. 2 hits.
PfamiPF03127. GAT. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view]
PIRSFiPIRSF036948. TOM1. 1 hit.
SMARTiSM00288. VHS. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
PROSITEiPS50909. GAT. 1 hit.
PS50179. VHS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM1L1_HUMAN
AccessioniPrimary (citable) accession number: O75674
Secondary accession number(s): B7Z9E2, Q53G06, Q8N749
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 25, 2008
Last modified: November 30, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.