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O75674

- TM1L1_HUMAN

UniProt

O75674 - TM1L1_HUMAN

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Protein
TOM1-like protein 1
Gene
TOM1L1, SRCASM
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions By similarity.

GO - Molecular functioni

  1. clathrin binding Source: UniProtKB
  2. protein binding Source: UniProtKB
  3. protein kinase activator activity Source: Ensembl
  4. protein kinase binding Source: UniProtKB
  5. ubiquitin binding Source: HGNC

GO - Biological processi

  1. activation of protein kinase activity Source: UniProtKB
  2. intracellular protein transport Source: InterPro
  3. negative regulation of mitosis Source: UniProtKB
  4. positive regulation of protein autophosphorylation Source: UniProtKB
  5. signal transduction Source: UniProtKB
  6. ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: HGNC
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
TOM1-like protein 1
Alternative name(s):
Src-activating and signaling molecule protein
Target of Myb-like protein 1
Gene namesi
Name:TOM1L1
Synonyms:SRCASM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:11983. TOM1L1.

Subcellular locationi

Golgi apparatusGolgi stack. Endosome membrane Reviewed prediction. Cytoplasm By similarity. Membrane; Peripheral membrane protein; Cytoplasmic side By similarity
Note: A small proportion is membrane-associated By similarity.

GO - Cellular componenti

  1. Golgi stack Source: UniProtKB-SubCell
  2. cytoplasm Source: UniProtKB
  3. cytosol Source: HGNC
  4. endosome Source: UniProtKB
  5. endosome membrane Source: UniProtKB-SubCell
  6. extracellular vesicular exosome Source: UniProt
  7. lysosome Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36667.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 476476TOM1-like protein 1
PRO_0000072566Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei314 – 3141Phosphoserine1 Publication
Modified residuei321 – 3211Phosphoserine1 Publication
Modified residuei323 – 3231Phosphoserine4 Publications
Modified residuei460 – 4601Phosphotyrosine By similarity

Post-translational modificationi

Phosphorylated on tyrosines by FYN and LYN By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO75674.
PaxDbiO75674.
PRIDEiO75674.

PTM databases

PhosphoSiteiO75674.

Expressioni

Gene expression databases

ArrayExpressiO75674.
BgeeiO75674.
CleanExiHS_TOM1L1.
GenevestigatoriO75674.

Organism-specific databases

HPAiHPA022916.

Interactioni

Subunit structurei

Interacts with FYN, GRB2 and PIK3R1 when phosphorylated By similarity. Interacts with LYN By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
CLTCQ006104EBI-712991,EBI-354967
EGFRP005336EBI-712991,EBI-297353
GRB2P629932EBI-712991,EBI-401755
TOLLIPQ9H0E23EBI-712991,EBI-74615
TOM1O607842EBI-712991,EBI-74634
VAV2P527352EBI-712991,EBI-297549

Protein-protein interaction databases

BioGridi115352. 52 interactions.
IntActiO75674. 30 interactions.
MINTiMINT-1213299.
STRINGi9606.ENSP00000408958.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi10 – 123
Helixi14 – 229
Helixi32 – 4413
Helixi48 – 6013
Helixi66 – 8217
Helixi85 – 917
Helixi94 – 974
Turni98 – 1014
Helixi102 – 1054
Helixi107 – 1093
Helixi113 – 12715
Beta strandi131 – 1333
Helixi137 – 14812

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3RRUX-ray3.00A/B9-150[»]
ProteinModelPortaliO75674.
SMRiO75674. Positions 9-149, 200-288.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 154133VHS
Add
BLAST
Domaini200 – 28889GAT
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni392 – 3954Interaction with GRB2 By similarity
Regioni442 – 4454Interaction with PIK3R1 By similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi421 – 4255SH3-binding By similarity
Motifi460 – 4634SH2-binding By similarity

Sequence similaritiesi

Belongs to the TOM1 family.
Contains 1 GAT domain.
Contains 1 VHS domain.

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiNOG321220.
HOGENOMiHOG000285970.
HOVERGENiHBG025068.
InParanoidiO75674.
OMAiVTTEAIY.
OrthoDBiEOG75B859.
PhylomeDBiO75674.
TreeFamiTF314105.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiIPR008942. ENTH_VHS.
IPR004152. GAT.
IPR014645. TOM1.
IPR027428. TOM1L1.
IPR002014. VHS.
IPR018205. VHS_subgr.
[Graphical view]
PANTHERiPTHR13856:SF28. PTHR13856:SF28. 1 hit.
PfamiPF03127. GAT. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view]
PIRSFiPIRSF036948. TOM1. 1 hit.
SMARTiSM00288. VHS. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
PROSITEiPS50909. GAT. 1 hit.
PS50179. VHS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75674-1 [UniParc]FASTAAdd to Basket

« Hide

MAFGKSHRDP YATSVGHLIE KATFAGVQTE DWGQFMHICD IINTTQDGPK    50
DAVKALKKRI SKNYNHKEIQ LTLSLIDMCV QNCGPSFQSL IVKKEFVKEN 100
LVKLLNPRYN LPLDIQNRIL NFIKTWSQGF PGGVDVSEVK EVYLDLVKKG 150
VQFPPSEAEA ETARQETAQI SSNPPTSVPT APALSSVIAP KNSTVTLVPE 200
QIGKLHSELD MVKMNVRVMS AILMENTPGS ENHEDIELLQ KLYKTGREMQ 250
ERIMDLLVVV ENEDVTVELI QVNEDLNNAI LGYERFTRNQ QRILEQNKNQ 300
KEATNTTSEP SAPSQDLLDL SPSPRMPRAT LGELNTMNNQ LSGLNFSLPS 350
SDVTNNLKPS LHPQMNLLAL ENTEIPPFAQ RTSQNLTSSH AYDNFLEHSN 400
SVFLQPVSLQ TIAAAPSNQS LPPLPSNHPA MTKSDLQPPN YYEVMEFDPL 450
APAVTTEAIY EEIDAHQHKG AQNDGD 476
Length:476
Mass (Da):52,989
Last modified:November 25, 2008 - v2
Checksum:i47ED5FA1F40144C0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti108 – 1081R → S.
Corresponds to variant rs16955377 [ dbSNP | Ensembl ].
VAR_047469

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti48 – 481G → A in CAA08993. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ010071 mRNA. Translation: CAA08993.1.
AK315039 mRNA. Translation: BAG37522.1.
AK223125 mRNA. Translation: BAD96845.1.
CH471109 Genomic DNA. Translation: EAW94553.1.
CCDSiCCDS11582.1.
RefSeqiNP_005477.2. NM_005486.2.
UniGeneiHs.153504.

Genome annotation databases

EnsembliENST00000575882; ENSP00000460823; ENSG00000141198.
GeneIDi10040.
KEGGihsa:10040.
UCSCiuc002iud.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ010071 mRNA. Translation: CAA08993.1 .
AK315039 mRNA. Translation: BAG37522.1 .
AK223125 mRNA. Translation: BAD96845.1 .
CH471109 Genomic DNA. Translation: EAW94553.1 .
CCDSi CCDS11582.1.
RefSeqi NP_005477.2. NM_005486.2.
UniGenei Hs.153504.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3RRU X-ray 3.00 A/B 9-150 [» ]
ProteinModelPortali O75674.
SMRi O75674. Positions 9-149, 200-288.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115352. 52 interactions.
IntActi O75674. 30 interactions.
MINTi MINT-1213299.
STRINGi 9606.ENSP00000408958.

PTM databases

PhosphoSitei O75674.

Proteomic databases

MaxQBi O75674.
PaxDbi O75674.
PRIDEi O75674.

Protocols and materials databases

DNASUi 10040.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000575882 ; ENSP00000460823 ; ENSG00000141198 .
GeneIDi 10040.
KEGGi hsa:10040.
UCSCi uc002iud.2. human.

Organism-specific databases

CTDi 10040.
GeneCardsi GC17P052978.
H-InvDB HIX0014000.
HGNCi HGNC:11983. TOM1L1.
HPAi HPA022916.
MIMi 604701. gene.
neXtProti NX_O75674.
PharmGKBi PA36667.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG321220.
HOGENOMi HOG000285970.
HOVERGENi HBG025068.
InParanoidi O75674.
OMAi VTTEAIY.
OrthoDBi EOG75B859.
PhylomeDBi O75674.
TreeFami TF314105.

Miscellaneous databases

ChiTaRSi TOM1L1. human.
GeneWikii TOM1L1.
GenomeRNAii 10040.
NextBioi 37921.
PROi O75674.
SOURCEi Search...

Gene expression databases

ArrayExpressi O75674.
Bgeei O75674.
CleanExi HS_TOM1L1.
Genevestigatori O75674.

Family and domain databases

Gene3Di 1.25.40.90. 1 hit.
InterProi IPR008942. ENTH_VHS.
IPR004152. GAT.
IPR014645. TOM1.
IPR027428. TOM1L1.
IPR002014. VHS.
IPR018205. VHS_subgr.
[Graphical view ]
PANTHERi PTHR13856:SF28. PTHR13856:SF28. 1 hit.
Pfami PF03127. GAT. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view ]
PIRSFi PIRSF036948. TOM1. 1 hit.
SMARTi SM00288. VHS. 1 hit.
[Graphical view ]
SUPFAMi SSF48464. SSF48464. 1 hit.
PROSITEi PS50909. GAT. 1 hit.
PS50179. VHS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM."
    Seroussi E., Kedra D., Kost-Alimova M., Sandberg-Nordqvist A.-C., Fransson I., Jacobs J.F.M., Fu Y., Pan H.-Q., Roe B.A., Imreh S., Dumanski J.P.
    Genomics 57:380-388(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Trachea.
  3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-314 AND SER-323, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-323, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321 AND SER-323, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-323, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "X-ray crystal structure of the VHS domain of human TOM1-like protein, Northeast structural genomics consortium target HR3050E."
    Northeast structural genomics consortium (NESG)
    Submitted (JUN-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 9-150.

Entry informationi

Entry nameiTM1L1_HUMAN
AccessioniPrimary (citable) accession number: O75674
Secondary accession number(s): Q53G06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 25, 2008
Last modified: September 3, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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