Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

TOM1-like protein 1

Gene

TOM1L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions (By similarity).By similarity

Caution

GO - Molecular functioni

  • clathrin binding Source: UniProtKB
  • protein kinase activator activity Source: InterPro
  • protein kinase binding Source: UniProtKB
  • SH3 domain binding Source: UniProtKB-KW
  • ubiquitin binding Source: HGNC

GO - Biological processi

  • activation of protein kinase activity Source: UniProtKB
  • intracellular protein transport Source: InterPro
  • negative regulation of mitotic nuclear division Source: UniProtKB
  • positive regulation of protein autophosphorylation Source: UniProtKB
  • signal transduction Source: UniProtKB
  • ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: HGNC

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

SIGNORiO75674

Names & Taxonomyi

Protein namesi
Recommended name:
TOM1-like protein 1
Alternative name(s):
Src-activating and signaling molecule protein
Target of Myb-like protein 1
Gene namesi
Name:TOM1L1
Synonyms:SRCASM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000141198.13
HGNCiHGNC:11983 TOM1L1
MIMi604701 gene
neXtProtiNX_O75674

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10040
OpenTargetsiENSG00000141198
PharmGKBiPA36667

Polymorphism and mutation databases

BioMutaiTOM1L1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000725661 – 476TOM1-like protein 1Add BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei171PhosphoserineBy similarity1
Modified residuei314PhosphoserineCombined sources1
Modified residuei321PhosphoserineCombined sources1
Modified residuei323PhosphoserineCombined sources1
Modified residuei460PhosphotyrosineBy similarity1

Post-translational modificationi

Phosphorylated on tyrosines by FYN and LYN.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO75674
PaxDbiO75674
PeptideAtlasiO75674
PRIDEiO75674

PTM databases

iPTMnetiO75674
PhosphoSitePlusiO75674

Expressioni

Gene expression databases

BgeeiENSG00000141198
CleanExiHS_TOM1L1
ExpressionAtlasiO75674 baseline and differential
GenevisibleiO75674 HS

Organism-specific databases

HPAiHPA022916

Interactioni

Subunit structurei

Interacts with FYN, GRB2 and PIK3R1 when phosphorylated. Interacts with LYN.By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • clathrin binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • SH3 domain binding Source: UniProtKB-KW
  • ubiquitin binding Source: HGNC

Protein-protein interaction databases

BioGridi11535262 interactors.
ELMiO75674
IntActiO75674 34 interactors.
MINTiO75674
STRINGi9606.ENSP00000460823

Structurei

Secondary structure

1476
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 12Combined sources3
Helixi14 – 22Combined sources9
Helixi32 – 44Combined sources13
Helixi48 – 60Combined sources13
Helixi66 – 82Combined sources17
Helixi85 – 91Combined sources7
Helixi94 – 97Combined sources4
Turni98 – 101Combined sources4
Helixi102 – 105Combined sources4
Helixi107 – 109Combined sources3
Helixi113 – 127Combined sources15
Beta strandi131 – 133Combined sources3
Helixi137 – 148Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RRUX-ray3.00A/B9-150[»]
ProteinModelPortaliO75674
SMRiO75674
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 154VHSPROSITE-ProRule annotationAdd BLAST133
Domaini200 – 288GATPROSITE-ProRule annotationAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni392 – 395Interaction with GRB2By similarity4
Regioni442 – 445Interaction with PIK3R1By similarity4

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi421 – 425SH3-bindingBy similarity5
Motifi460 – 463SH2-bindingBy similarity4

Sequence similaritiesi

Belongs to the TOM1 family.Curated

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiKOG1087 Eukaryota
ENOG410Y26G LUCA
GeneTreeiENSGT00870000136415
HOGENOMiHOG000285970
HOVERGENiHBG025068
InParanoidiO75674
OMAiYERFTRN
OrthoDBiEOG091G08M1
PhylomeDBiO75674
TreeFamiTF314105

Family and domain databases

Gene3Di1.20.58.1601 hit
1.25.40.901 hit
InterProiView protein in InterPro
IPR008942 ENTH_VHS
IPR004152 GAT_dom
IPR038425 GAT_sf
IPR014645 TOM1
IPR027428 TOM1L1
IPR002014 VHS_dom
PANTHERiPTHR13856:SF28 PTHR13856:SF28, 1 hit
PfamiView protein in Pfam
PF03127 GAT, 1 hit
PF00790 VHS, 1 hit
PIRSFiPIRSF036948 TOM1, 1 hit
SMARTiView protein in SMART
SM00288 VHS, 1 hit
SUPFAMiSSF48464 SSF48464, 1 hit
PROSITEiView protein in PROSITE
PS50909 GAT, 1 hit
PS50179 VHS, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75674-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFGKSHRDP YATSVGHLIE KATFAGVQTE DWGQFMHICD IINTTQDGPK
60 70 80 90 100
DAVKALKKRI SKNYNHKEIQ LTLSLIDMCV QNCGPSFQSL IVKKEFVKEN
110 120 130 140 150
LVKLLNPRYN LPLDIQNRIL NFIKTWSQGF PGGVDVSEVK EVYLDLVKKG
160 170 180 190 200
VQFPPSEAEA ETARQETAQI SSNPPTSVPT APALSSVIAP KNSTVTLVPE
210 220 230 240 250
QIGKLHSELD MVKMNVRVMS AILMENTPGS ENHEDIELLQ KLYKTGREMQ
260 270 280 290 300
ERIMDLLVVV ENEDVTVELI QVNEDLNNAI LGYERFTRNQ QRILEQNKNQ
310 320 330 340 350
KEATNTTSEP SAPSQDLLDL SPSPRMPRAT LGELNTMNNQ LSGLNFSLPS
360 370 380 390 400
SDVTNNLKPS LHPQMNLLAL ENTEIPPFAQ RTSQNLTSSH AYDNFLEHSN
410 420 430 440 450
SVFLQPVSLQ TIAAAPSNQS LPPLPSNHPA MTKSDLQPPN YYEVMEFDPL
460 470
APAVTTEAIY EEIDAHQHKG AQNDGD
Length:476
Mass (Da):52,989
Last modified:November 25, 2008 - v2
Checksum:i47ED5FA1F40144C0
GO
Isoform 2 (identifier: O75674-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     345-346: NF → SK
     347-476: Missing.

Note: No experimental confirmation available.
Show »
Length:346
Mass (Da):38,713
Checksum:i414DC8AEA1AB415F
GO
Isoform 3 (identifier: O75674-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: Missing.

Note: No experimental confirmation available.
Show »
Length:399
Mass (Da):44,334
Checksum:iF1E782419B262E59
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48G → A in CAA08993 (PubMed:10329004).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047469108R → S. Corresponds to variant dbSNP:rs16955377Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0574241 – 77Missing in isoform 3. 1 PublicationAdd BLAST77
Alternative sequenceiVSP_056852345 – 346NF → SK in isoform 2. 1 Publication2
Alternative sequenceiVSP_056853347 – 476Missing in isoform 2. 1 PublicationAdd BLAST130

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010071 mRNA Translation: CAA08993.1
AK315039 mRNA Translation: BAG37522.1
AK315907 mRNA Translation: BAH14278.1
AK223125 mRNA Translation: BAD96845.1
AC007485 Genomic DNA No translation available.
AC090824 Genomic DNA No translation available.
KC877665 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94551.1
CH471109 Genomic DNA Translation: EAW94553.1
BC029396 mRNA Translation: AAH29396.1
CCDSiCCDS11582.1 [O75674-1]
CCDS82160.1 [O75674-2]
CCDS82161.1 [O75674-3]
RefSeqiNP_001308102.1, NM_001321173.1 [O75674-2]
NP_001308103.1, NM_001321174.1 [O75674-3]
NP_001308104.1, NM_001321175.1 [O75674-3]
NP_001308105.1, NM_001321176.1 [O75674-3]
NP_005477.2, NM_005486.2 [O75674-1]
XP_016879491.1, XM_017024002.1 [O75674-3]
UniGeneiHs.153504

Genome annotation databases

EnsembliENST00000348161; ENSP00000343901; ENSG00000141198 [O75674-3]
ENST00000536554; ENSP00000443099; ENSG00000141198 [O75674-3]
ENST00000570371; ENSP00000458553; ENSG00000141198 [O75674-2]
ENST00000575333; ENSP00000458918; ENSG00000141198 [O75674-2]
ENST00000575882; ENSP00000460823; ENSG00000141198 [O75674-1]
GeneIDi10040
KEGGihsa:10040
UCSCiuc002iuc.4 human [O75674-1]
uc010dbz.3 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTM1L1_HUMAN
AccessioniPrimary (citable) accession number: O75674
Secondary accession number(s): B7Z9E2, Q53G06, Q8N749
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 25, 2008
Last modified: March 28, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome