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Protein

TOM1-like protein 1

Gene

TOM1L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions (By similarity).By similarity

GO - Molecular functioni

  1. clathrin binding Source: UniProtKB
  2. protein kinase activator activity Source: Ensembl
  3. protein kinase binding Source: UniProtKB
  4. ubiquitin binding Source: HGNC

GO - Biological processi

  1. activation of protein kinase activity Source: UniProtKB
  2. intracellular protein transport Source: InterPro
  3. negative regulation of mitosis Source: UniProtKB
  4. positive regulation of protein autophosphorylation Source: UniProtKB
  5. signal transduction Source: UniProtKB
  6. ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: HGNC
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
TOM1-like protein 1
Alternative name(s):
Src-activating and signaling molecule protein
Target of Myb-like protein 1
Gene namesi
Name:TOM1L1
Synonyms:SRCASM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:11983. TOM1L1.

Subcellular locationi

Golgi apparatusGolgi stack. Endosome membrane Curated. Cytoplasm By similarity. Membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Note: A small proportion is membrane-associated.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytosol Source: HGNC
  3. endosome Source: UniProtKB
  4. endosome membrane Source: UniProtKB-SubCell
  5. extracellular vesicular exosome Source: UniProtKB
  6. Golgi stack Source: UniProtKB-SubCell
  7. intracellular Source: InterPro
  8. lysosome Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36667.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 476476TOM1-like protein 1PRO_0000072566Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei314 – 3141Phosphoserine1 Publication
Modified residuei321 – 3211Phosphoserine2 Publications
Modified residuei323 – 3231Phosphoserine5 Publications
Modified residuei460 – 4601PhosphotyrosineBy similarity

Post-translational modificationi

Phosphorylated on tyrosines by FYN and LYN.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO75674.
PaxDbiO75674.
PRIDEiO75674.

PTM databases

PhosphoSiteiO75674.

Expressioni

Gene expression databases

BgeeiO75674.
CleanExiHS_TOM1L1.
ExpressionAtlasiO75674. baseline and differential.
GenevestigatoriO75674.

Organism-specific databases

HPAiHPA022916.

Interactioni

Subunit structurei

Interacts with FYN, GRB2 and PIK3R1 when phosphorylated. Interacts with LYN.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CLTCQ006104EBI-712991,EBI-354967
EGFRP005336EBI-712991,EBI-297353
GRB2P629932EBI-712991,EBI-401755
TOLLIPQ9H0E23EBI-712991,EBI-74615
TOM1O607842EBI-712991,EBI-74634
VAV2P527352EBI-712991,EBI-297549

Protein-protein interaction databases

BioGridi115352. 52 interactions.
IntActiO75674. 30 interactions.
MINTiMINT-1213299.
STRINGi9606.ENSP00000408958.

Structurei

Secondary structure

1
476
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi10 – 123Combined sources
Helixi14 – 229Combined sources
Helixi32 – 4413Combined sources
Helixi48 – 6013Combined sources
Helixi66 – 8217Combined sources
Helixi85 – 917Combined sources
Helixi94 – 974Combined sources
Turni98 – 1014Combined sources
Helixi102 – 1054Combined sources
Helixi107 – 1093Combined sources
Helixi113 – 12715Combined sources
Beta strandi131 – 1333Combined sources
Helixi137 – 14812Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3RRUX-ray3.00A/B9-150[»]
ProteinModelPortaliO75674.
SMRiO75674. Positions 9-149, 200-288.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 154133VHSPROSITE-ProRule annotationAdd
BLAST
Domaini200 – 28889GATPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni392 – 3954Interaction with GRB2By similarity
Regioni442 – 4454Interaction with PIK3R1By similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi421 – 4255SH3-bindingBy similarity
Motifi460 – 4634SH2-bindingBy similarity

Sequence similaritiesi

Belongs to the TOM1 family.Curated
Contains 1 GAT domain.PROSITE-ProRule annotation
Contains 1 VHS domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiNOG321220.
GeneTreeiENSGT00700000104139.
HOGENOMiHOG000285970.
HOVERGENiHBG025068.
InParanoidiO75674.
OMAiYKTSREM.
OrthoDBiEOG75B859.
PhylomeDBiO75674.
TreeFamiTF314105.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiIPR008942. ENTH_VHS.
IPR004152. GAT_dom.
IPR014645. TOM1.
IPR027428. TOM1L1.
IPR002014. VHS.
IPR018205. VHS_subgr.
[Graphical view]
PANTHERiPTHR13856:SF28. PTHR13856:SF28. 1 hit.
PfamiPF03127. GAT. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view]
PIRSFiPIRSF036948. TOM1. 1 hit.
SMARTiSM00288. VHS. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
PROSITEiPS50909. GAT. 1 hit.
PS50179. VHS. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75674-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFGKSHRDP YATSVGHLIE KATFAGVQTE DWGQFMHICD IINTTQDGPK
60 70 80 90 100
DAVKALKKRI SKNYNHKEIQ LTLSLIDMCV QNCGPSFQSL IVKKEFVKEN
110 120 130 140 150
LVKLLNPRYN LPLDIQNRIL NFIKTWSQGF PGGVDVSEVK EVYLDLVKKG
160 170 180 190 200
VQFPPSEAEA ETARQETAQI SSNPPTSVPT APALSSVIAP KNSTVTLVPE
210 220 230 240 250
QIGKLHSELD MVKMNVRVMS AILMENTPGS ENHEDIELLQ KLYKTGREMQ
260 270 280 290 300
ERIMDLLVVV ENEDVTVELI QVNEDLNNAI LGYERFTRNQ QRILEQNKNQ
310 320 330 340 350
KEATNTTSEP SAPSQDLLDL SPSPRMPRAT LGELNTMNNQ LSGLNFSLPS
360 370 380 390 400
SDVTNNLKPS LHPQMNLLAL ENTEIPPFAQ RTSQNLTSSH AYDNFLEHSN
410 420 430 440 450
SVFLQPVSLQ TIAAAPSNQS LPPLPSNHPA MTKSDLQPPN YYEVMEFDPL
460 470
APAVTTEAIY EEIDAHQHKG AQNDGD
Length:476
Mass (Da):52,989
Last modified:November 25, 2008 - v2
Checksum:i47ED5FA1F40144C0
GO
Isoform 2 (identifier: O75674-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     345-346: NF → SK
     347-476: Missing.

Note: No experimental confirmation available.

Show »
Length:346
Mass (Da):38,713
Checksum:i414DC8AEA1AB415F
GO
Isoform 3 (identifier: O75674-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: Missing.

Note: No experimental confirmation available.

Show »
Length:399
Mass (Da):44,334
Checksum:iF1E782419B262E59
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti48 – 481G → A in CAA08993 (PubMed:10329004).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti108 – 1081R → S.
Corresponds to variant rs16955377 [ dbSNP | Ensembl ].
VAR_047469

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7777Missing in isoform 3. 1 PublicationVSP_057424Add
BLAST
Alternative sequencei345 – 3462NF → SK in isoform 2. 1 PublicationVSP_056852
Alternative sequencei347 – 476130Missing in isoform 2. 1 PublicationVSP_056853Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010071 mRNA. Translation: CAA08993.1.
AK315039 mRNA. Translation: BAG37522.1.
AK315907 mRNA. Translation: BAH14278.1.
AK223125 mRNA. Translation: BAD96845.1.
AC007485 Genomic DNA. No translation available.
AC090824 Genomic DNA. No translation available.
KC877665 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94551.1.
CH471109 Genomic DNA. Translation: EAW94553.1.
BC029396 mRNA. Translation: AAH29396.1.
CCDSiCCDS11582.1. [O75674-1]
RefSeqiNP_005477.2. NM_005486.2. [O75674-1]
XP_005256971.1. XM_005256914.2.
XP_005256972.1. XM_005256915.2.
XP_006721693.1. XM_006721630.1.
UniGeneiHs.153504.

Genome annotation databases

EnsembliENST00000348161; ENSP00000343901; ENSG00000141198. [O75674-3]
ENST00000536554; ENSP00000443099; ENSG00000141198. [O75674-3]
ENST00000570371; ENSP00000458553; ENSG00000141198. [O75674-2]
ENST00000575333; ENSP00000458918; ENSG00000141198. [O75674-2]
ENST00000575882; ENSP00000460823; ENSG00000141198. [O75674-1]
GeneIDi10040.
KEGGihsa:10040.
UCSCiuc002iuc.3. human.
uc002iud.2. human. [O75674-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010071 mRNA. Translation: CAA08993.1.
AK315039 mRNA. Translation: BAG37522.1.
AK315907 mRNA. Translation: BAH14278.1.
AK223125 mRNA. Translation: BAD96845.1.
AC007485 Genomic DNA. No translation available.
AC090824 Genomic DNA. No translation available.
KC877665 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94551.1.
CH471109 Genomic DNA. Translation: EAW94553.1.
BC029396 mRNA. Translation: AAH29396.1.
CCDSiCCDS11582.1. [O75674-1]
RefSeqiNP_005477.2. NM_005486.2. [O75674-1]
XP_005256971.1. XM_005256914.2.
XP_005256972.1. XM_005256915.2.
XP_006721693.1. XM_006721630.1.
UniGeneiHs.153504.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3RRUX-ray3.00A/B9-150[»]
ProteinModelPortaliO75674.
SMRiO75674. Positions 9-149, 200-288.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115352. 52 interactions.
IntActiO75674. 30 interactions.
MINTiMINT-1213299.
STRINGi9606.ENSP00000408958.

PTM databases

PhosphoSiteiO75674.

Proteomic databases

MaxQBiO75674.
PaxDbiO75674.
PRIDEiO75674.

Protocols and materials databases

DNASUi10040.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000348161; ENSP00000343901; ENSG00000141198. [O75674-3]
ENST00000536554; ENSP00000443099; ENSG00000141198. [O75674-3]
ENST00000570371; ENSP00000458553; ENSG00000141198. [O75674-2]
ENST00000575333; ENSP00000458918; ENSG00000141198. [O75674-2]
ENST00000575882; ENSP00000460823; ENSG00000141198. [O75674-1]
GeneIDi10040.
KEGGihsa:10040.
UCSCiuc002iuc.3. human.
uc002iud.2. human. [O75674-1]

Organism-specific databases

CTDi10040.
GeneCardsiGC17P052978.
H-InvDBHIX0014000.
HGNCiHGNC:11983. TOM1L1.
HPAiHPA022916.
MIMi604701. gene.
neXtProtiNX_O75674.
PharmGKBiPA36667.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG321220.
GeneTreeiENSGT00700000104139.
HOGENOMiHOG000285970.
HOVERGENiHBG025068.
InParanoidiO75674.
OMAiYKTSREM.
OrthoDBiEOG75B859.
PhylomeDBiO75674.
TreeFamiTF314105.

Miscellaneous databases

ChiTaRSiTOM1L1. human.
GeneWikiiTOM1L1.
GenomeRNAii10040.
NextBioi35480718.
PROiO75674.
SOURCEiSearch...

Gene expression databases

BgeeiO75674.
CleanExiHS_TOM1L1.
ExpressionAtlasiO75674. baseline and differential.
GenevestigatoriO75674.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiIPR008942. ENTH_VHS.
IPR004152. GAT_dom.
IPR014645. TOM1.
IPR027428. TOM1L1.
IPR002014. VHS.
IPR018205. VHS_subgr.
[Graphical view]
PANTHERiPTHR13856:SF28. PTHR13856:SF28. 1 hit.
PfamiPF03127. GAT. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view]
PIRSFiPIRSF036948. TOM1. 1 hit.
SMARTiSM00288. VHS. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
PROSITEiPS50909. GAT. 1 hit.
PS50179. VHS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM."
    Seroussi E., Kedra D., Kost-Alimova M., Sandberg-Nordqvist A.-C., Fransson I., Jacobs J.F.M., Fu Y., Pan H.-Q., Roe B.A., Imreh S., Dumanski J.P.
    Genomics 57:380-388(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Adrenal gland and Trachea.
  3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney.
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Kidney.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-314 AND SER-323, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-323, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321 AND SER-323, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-323, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321 AND SER-323, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  13. "X-ray crystal structure of the VHS domain of human TOM1-like protein, Northeast structural genomics consortium target HR3050E."
    Northeast structural genomics consortium (NESG)
    Submitted (JUN-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 9-150.

Entry informationi

Entry nameiTM1L1_HUMAN
AccessioniPrimary (citable) accession number: O75674
Secondary accession number(s): B7Z9E2, Q53G06, Q8N749
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 25, 2008
Last modified: March 4, 2015
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.