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Protein

TIP41-like protein

Gene

TIPRL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.1 Publication

GO - Biological processi

  • DNA damage checkpoint Source: UniProtKB
  • negative regulation of protein phosphatase type 2A activity Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143155-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
TIP41-like protein
Alternative name(s):
Putative MAPK-activating protein PM10
Type 2A-interacting protein
Short name:
TIP
Gene namesi
Name:TIPRL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:30231. TIPRL.

Subcellular locationi

  • Cytoplasm 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi71D → L: Abolishes interaction with PPP2CA, PPP2CB and PPP4C. 1 Publication1
Mutagenesisi79Y → H: Diminishes interaction with PPP2CA. 1 Publication1
Mutagenesisi136I → T: Abolishes interaction with PPP2CA, PPP2CB and PPP4C. 1 Publication1
Mutagenesisi196M → V: Abolishes interaction with PPP2CA, PPP2CB and PPP4C. 1 Publication1
Mutagenesisi198D → N: Abolishes interaction with PPP2CA, PPP2CB and PPP4C. 1 Publication1

Organism-specific databases

DisGeNETi261726.
OpenTargetsiENSG00000143155.
PharmGKBiPA142670811.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003018531 – 272TIP41-like proteinAdd BLAST272

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei106N6-acetyllysineCombined sources1
Modified residuei265PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO75663.
MaxQBiO75663.
PaxDbiO75663.
PeptideAtlasiO75663.
PRIDEiO75663.

PTM databases

iPTMnetiO75663.
PhosphoSitePlusiO75663.

Expressioni

Gene expression databases

BgeeiENSG00000143155.
CleanExiHS_TIPRL.
GenevisibleiO75663. HS.

Organism-specific databases

HPAiHPA027995.
HPA054282.

Interactioni

Subunit structurei

Isoform 1 interacts with PPP2CA. Isoform 2 does not interact with PPP2CA. Interacts with PPP2CB, PPP4C and PPP6C. Interacts with IGBP1; the interaction is dependent on PPP2CA. Associates with a protein phosphatase 2A PP2A(C):alpha-4 complex.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
IGBP1P783182EBI-1054735,EBI-1055954
PPP2CAP677753EBI-1054735,EBI-712311
Ppp2caP633313EBI-1054735,EBI-7050205From a different organism.
PPP4CP605104EBI-1054735,EBI-1046072
PPP6CO007434EBI-1054735,EBI-359751

Protein-protein interaction databases

BioGridi129283. 43 interactors.
IntActiO75663. 12 interactors.
MINTiMINT-7002837.
STRINGi9606.ENSP00000356807.

Structurei

Secondary structure

1272
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi18 – 23Combined sources6
Helixi30 – 39Combined sources10
Beta strandi47 – 49Combined sources3
Beta strandi54 – 59Combined sources6
Beta strandi64 – 67Combined sources4
Helixi69 – 73Combined sources5
Helixi83 – 86Combined sources4
Beta strandi119 – 121Combined sources3
Beta strandi128 – 131Combined sources4
Helixi138 – 142Combined sources5
Beta strandi148 – 158Combined sources11
Turni160 – 163Combined sources4
Beta strandi164 – 175Combined sources12
Beta strandi178 – 189Combined sources12
Turni190 – 192Combined sources3
Beta strandi193 – 206Combined sources14
Beta strandi208 – 220Combined sources13
Helixi221 – 224Combined sources4
Helixi229 – 233Combined sources5
Helixi235 – 238Combined sources4
Helixi239 – 241Combined sources3
Beta strandi244 – 253Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5D9GX-ray2.15A/B16-256[»]
ProteinModelPortaliO75663.
SMRiO75663.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni173 – 272Interaction with PPP2CAAdd BLAST100

Sequence similaritiesi

Belongs to the TIP41 family.Curated

Phylogenomic databases

eggNOGiKOG3224. Eukaryota.
ENOG410XT96. LUCA.
GeneTreeiENSGT00390000006659.
HOGENOMiHOG000213547.
HOVERGENiHBG053157.
InParanoidiO75663.
KOiK17607.
OMAiACAQEWQ.
OrthoDBiEOG091G0II3.
PhylomeDBiO75663.
TreeFamiTF105943.

Family and domain databases

InterProiIPR007303. TIP41-like.
[Graphical view]
PfamiPF04176. TIP41. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75663-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMIHGFQSSH RDFCFGPWKL TASKTHIMKS ADVEKLADEL HMPSLPEMMF
60 70 80 90 100
GDNVLRIQHG SGFGIEFNAT DALRCVNNYQ GMLKVACAEE WQESRTEGEH
110 120 130 140 150
SKEVIKPYDW TYTTDYKGTL LGESLKLKVV PTTDHIDTEK LKAREQIKFF
160 170 180 190 200
EEVLLFEDEL HDHGVSSLSV KIRVMPSSFF LLLRFFLRID GVLIRMNDTR
210 220 230 240 250
LYHEADKTYM LREYTSRESK ISSLMHVPPS LFTEPNEISQ YLPIKEAVCE
260 270
KLIFPERIDP NPADSQKSTQ VE
Length:272
Mass (Da):31,444
Last modified:January 1, 1999 - v2
Checksum:i23B730E0BC27DCEA
GO
Isoform 2 (identifier: O75663-2) [UniParc]FASTAAdd to basket
Also known as: TIP_i2

The sequence of this isoform differs from the canonical sequence as follows:
     173-178: RVMPSS → PGGGHL
     179-272: Missing.

Show »
Length:178
Mass (Da):20,214
Checksum:i8016BC0DF3BF11F5
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027883173 – 178RVMPSS → PGGGHL in isoform 2. 1 Publication6
Alternative sequenceiVSP_027884179 – 272Missing in isoform 2. 1 PublicationAdd BLAST94

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049670 mRNA. Translation: CAB41244.1.
AB097034 mRNA. Translation: BAC77387.1.
AK313520 mRNA. Translation: BAG36300.1.
AL021397 Genomic DNA. Translation: CAA16171.1.
AL021397 Genomic DNA. Translation: CAI22473.1.
CH471067 Genomic DNA. Translation: EAW90821.1.
BC009506 mRNA. Translation: AAH09506.1.
BX648646 Transcribed RNA. Translation: CAI46265.1.
CCDSiCCDS1270.1. [O75663-1]
CCDS30935.1. [O75663-2]
RefSeqiNP_001026970.1. NM_001031800.2. [O75663-2]
NP_690866.1. NM_152902.4. [O75663-1]
UniGeneiHs.209431.

Genome annotation databases

EnsembliENST00000367830; ENSP00000356804; ENSG00000143155. [O75663-2]
ENST00000367833; ENSP00000356807; ENSG00000143155. [O75663-1]
GeneIDi261726.
KEGGihsa:261726.
UCSCiuc001gff.5. human. [O75663-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049670 mRNA. Translation: CAB41244.1.
AB097034 mRNA. Translation: BAC77387.1.
AK313520 mRNA. Translation: BAG36300.1.
AL021397 Genomic DNA. Translation: CAA16171.1.
AL021397 Genomic DNA. Translation: CAI22473.1.
CH471067 Genomic DNA. Translation: EAW90821.1.
BC009506 mRNA. Translation: AAH09506.1.
BX648646 Transcribed RNA. Translation: CAI46265.1.
CCDSiCCDS1270.1. [O75663-1]
CCDS30935.1. [O75663-2]
RefSeqiNP_001026970.1. NM_001031800.2. [O75663-2]
NP_690866.1. NM_152902.4. [O75663-1]
UniGeneiHs.209431.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5D9GX-ray2.15A/B16-256[»]
ProteinModelPortaliO75663.
SMRiO75663.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129283. 43 interactors.
IntActiO75663. 12 interactors.
MINTiMINT-7002837.
STRINGi9606.ENSP00000356807.

PTM databases

iPTMnetiO75663.
PhosphoSitePlusiO75663.

Proteomic databases

EPDiO75663.
MaxQBiO75663.
PaxDbiO75663.
PeptideAtlasiO75663.
PRIDEiO75663.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367830; ENSP00000356804; ENSG00000143155. [O75663-2]
ENST00000367833; ENSP00000356807; ENSG00000143155. [O75663-1]
GeneIDi261726.
KEGGihsa:261726.
UCSCiuc001gff.5. human. [O75663-1]

Organism-specific databases

CTDi261726.
DisGeNETi261726.
GeneCardsiTIPRL.
HGNCiHGNC:30231. TIPRL.
HPAiHPA027995.
HPA054282.
MIMi611807. gene.
neXtProtiNX_O75663.
OpenTargetsiENSG00000143155.
PharmGKBiPA142670811.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3224. Eukaryota.
ENOG410XT96. LUCA.
GeneTreeiENSGT00390000006659.
HOGENOMiHOG000213547.
HOVERGENiHBG053157.
InParanoidiO75663.
KOiK17607.
OMAiACAQEWQ.
OrthoDBiEOG091G0II3.
PhylomeDBiO75663.
TreeFamiTF105943.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143155-MONOMER.

Miscellaneous databases

ChiTaRSiTIPRL. human.
GenomeRNAii261726.
PROiO75663.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143155.
CleanExiHS_TIPRL.
GenevisibleiO75663. HS.

Family and domain databases

InterProiIPR007303. TIP41-like.
[Graphical view]
PfamiPF04176. TIP41. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTIPRL_HUMAN
AccessioniPrimary (citable) accession number: O75663
Secondary accession number(s): B2R8V3, Q5HYB2, Q8IZ86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: January 1, 1999
Last modified: November 30, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.