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Protein

Cancer/testis antigen 2

Gene

CTAG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Cancer/testis antigen 2
Short name:
CT2
Alternative name(s):
Autoimmunogenic cancer/testis antigen NY-ESO-2
Cancer/testis antigen 6.2
Short name:
CT6.2
L antigen family member 1
Short name:
LAGE-1
Gene namesi
Name:CTAG2
Synonyms:ESO2, LAGE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:2492. CTAG2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26994.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210Cancer/testis antigen 2PRO_0000218923Add
BLAST

Proteomic databases

MaxQBiO75638.
PaxDbiO75638.
PeptideAtlasiO75638.
PRIDEiO75638.

PTM databases

iPTMnetiO75638.
PhosphoSiteiO75638.

Expressioni

Tissue specificityi

Testis and very low level in placenta and in some uterus samples. Observed in 25-50% of tumor samples of melanomas, non-small-cell lung carcinomas, bladder, prostate and head and neck cancers.

Gene expression databases

BgeeiENSG00000126890.
CleanExiHS_CTAG2.
GenevisibleiO75638. HS.

Organism-specific databases

HPAiHPA071467.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TRIP6Q156543EBI-10188927,EBI-742327
UBQLN1Q9UMX0-23EBI-10188927,EBI-10173939

Protein-protein interaction databases

BioGridi119058. 3 interactions.
IntActiO75638. 3 interactions.
MINTiMINT-4726249.

Structurei

3D structure databases

ProteinModelPortaliO75638.
SMRiO75638. Positions 88-140.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi5 – 7975Gly-richAdd
BLAST
Compositional biasi183 – 1886Poly-Pro

Sequence similaritiesi

Belongs to the CTAG/PCC1 family.Curated

Phylogenomic databases

eggNOGiENOG410JKWD. Eukaryota.
ENOG4111CUS. LUCA.
InParanoidiO75638.
OrthoDBiEOG091G0LGL.
PhylomeDBiO75638.
TreeFamiTF337064.

Family and domain databases

InterProiIPR015419. CTAG/Pcc1.
[Graphical view]
PfamiPF09341. Pcc1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform LAGE-1B (identifier: O75638-1) [UniParc]FASTAAdd to basket
Also known as: LAGE-1L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQAEGQGTGG STGDADGPGG PGIPDGPGGN AGGPGEAGAT GGRGPRGAGA
60 70 80 90 100
ARASGPRGGA PRGPHGGAAS AQDGRCPCGA RRPDSRLLQL HITMPFSSPM
110 120 130 140 150
EAELVRRILS RDAAPLPRPG AVLKDFTVSG NLLFMSVRDQ DREGAGRMRV
160 170 180 190 200
VGWGLGSASP EGQKARDLRT PKHKVSEQRP GTPGPPPPEG AQGDGCRGVA
210
FNVMFSAPHI
Length:210
Mass (Da):21,061
Last modified:May 18, 2010 - v2
Checksum:i1DD0B1829735B60A
GO
Isoform LAGE-1A (identifier: O75638-2) [UniParc]FASTAAdd to basket
Also known as: LAGE-1S

The sequence of this isoform differs from the canonical sequence as follows:
     135-210: MSVRDQDREG...FNVMFSAPHI → IRLTAADHRQ...LAQAPSGQRR

Show »
Length:180
Mass (Da):18,237
Checksum:i9077FAF953543A25
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti138 – 1381R → W in CAA11117 (PubMed:9626360).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61Q → R.3 Publications
Corresponds to variant rs34402964 [ dbSNP | Ensembl ].
VAR_007855
Natural varianti89 – 891Q → E.3 Publications
Corresponds to variant rs17328091 [ dbSNP | Ensembl ].
VAR_007856
Natural varianti99 – 991P → A.
Corresponds to variant rs5987003 [ dbSNP | Ensembl ].
VAR_057512

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei135 – 21076MSVRD…SAPHI → IRLTAADHRQLQLSISSCLQ QLSLLMWITQCFLPVFLAQA PSGQRR in isoform LAGE-1A. 4 PublicationsVSP_004301Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223093 Genomic DNA. Translation: CAA11117.1.
AJ223093 Genomic DNA. Translation: CAA11116.1.
AJ223040 mRNA. Translation: CAA11043.1.
AJ223041 mRNA. Translation: CAA11044.1.
AJ012834 mRNA. Translation: CAA10194.1.
AJ012835 mRNA. Translation: CAA10196.1.
AF277315 Genomic DNA. Translation: AAL27015.1.
AY679088 mRNA. Translation: AAV98584.1.
AY679089 mRNA. Translation: AAV98585.1.
BC002833 mRNA. Translation: AAH02833.1.
BC113998 mRNA. Translation: AAI13999.1.
BC128045 mRNA. Translation: AAI28046.1.
CCDSiCCDS14759.1. [O75638-1]
CCDS35455.1. [O75638-2]
RefSeqiNP_066274.2. NM_020994.4.
NP_758965.2. NM_172377.4.
UniGeneiHs.713312.
Hs.87225.

Genome annotation databases

EnsembliENST00000247306; ENSP00000247306; ENSG00000126890.
ENST00000369585; ENSP00000358598; ENSG00000126890.
GeneIDi30848.
KEGGihsa:30848.
UCSCiuc004fmh.3. human. [O75638-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223093 Genomic DNA. Translation: CAA11117.1.
AJ223093 Genomic DNA. Translation: CAA11116.1.
AJ223040 mRNA. Translation: CAA11043.1.
AJ223041 mRNA. Translation: CAA11044.1.
AJ012834 mRNA. Translation: CAA10194.1.
AJ012835 mRNA. Translation: CAA10196.1.
AF277315 Genomic DNA. Translation: AAL27015.1.
AY679088 mRNA. Translation: AAV98584.1.
AY679089 mRNA. Translation: AAV98585.1.
BC002833 mRNA. Translation: AAH02833.1.
BC113998 mRNA. Translation: AAI13999.1.
BC128045 mRNA. Translation: AAI28046.1.
CCDSiCCDS14759.1. [O75638-1]
CCDS35455.1. [O75638-2]
RefSeqiNP_066274.2. NM_020994.4.
NP_758965.2. NM_172377.4.
UniGeneiHs.713312.
Hs.87225.

3D structure databases

ProteinModelPortaliO75638.
SMRiO75638. Positions 88-140.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119058. 3 interactions.
IntActiO75638. 3 interactions.
MINTiMINT-4726249.

PTM databases

iPTMnetiO75638.
PhosphoSiteiO75638.

Proteomic databases

MaxQBiO75638.
PaxDbiO75638.
PeptideAtlasiO75638.
PRIDEiO75638.

Protocols and materials databases

DNASUi30848.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000247306; ENSP00000247306; ENSG00000126890.
ENST00000369585; ENSP00000358598; ENSG00000126890.
GeneIDi30848.
KEGGihsa:30848.
UCSCiuc004fmh.3. human. [O75638-1]

Organism-specific databases

CTDi30848.
GeneCardsiCTAG2.
HGNCiHGNC:2492. CTAG2.
HPAiHPA071467.
MIMi300396. gene.
neXtProtiNX_O75638.
PharmGKBiPA26994.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JKWD. Eukaryota.
ENOG4111CUS. LUCA.
InParanoidiO75638.
OrthoDBiEOG091G0LGL.
PhylomeDBiO75638.
TreeFamiTF337064.

Miscellaneous databases

GenomeRNAii30848.
PROiO75638.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126890.
CleanExiHS_CTAG2.
GenevisibleiO75638. HS.

Family and domain databases

InterProiIPR015419. CTAG/Pcc1.
[Graphical view]
PfamiPF09341. Pcc1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCTAG2_HUMAN
AccessioniPrimary (citable) accession number: O75638
Secondary accession number(s): O75637
, Q0VIL6, Q14CD6, Q2Z1N4, Q9BU80, Q9UJ89, Q9Y479
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 18, 2010
Last modified: September 7, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.