O75638 (CTAG2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cancer/testis antigen 2
Short name=CT2

Alternative name(s):
Autoimmunogenic cancer/testis antigen NY-ESO-2
Cancer/testis antigen 6.2
Short name=CT6.2
L antigen family member 1
Short name=LAGE-1

Gene names

Name:	CTAG2
Synonyms:	ESO2, LAGE1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	210 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Tissue specificity	Testis and very low level in placenta and in some uterus samples. Observed in 25-50% of tumor samples of melanomas, non-small-cell lung carcinomas, bladder, prostate and head and neck cancers.
Sequence similarities	Belongs to the CTAG family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	centrosome Inferred from direct assay. Source: LIFEdb
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform LAGE-1B (identifier: O75638-1)

Also known as: LAGE-1L;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform LAGE-1A (identifier: O75638-2)

Also known as: LAGE-1S;

The sequence of this isoform differs from the canonical sequence as follows:
     135-210: MSVRDQDREG...FNVMFSAPHI → IRLTAADHRQ...LAQAPSGQRR

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 210	210	Cancer/testis antigen 2		PRO_0000218923
Regions
	Compositional bias	5 – 79	75	Gly-rich
	Compositional bias	183 – 188	6	Poly-Pro
Natural variations
	Alternative sequence	135 – 210	76	MSVRD…SAPHI → IRLTAADHRQLQLSISSCLQ QLSLLMWITQCFLPVFLAQA PSGQRR in isoform LAGE-1A.		VSP_004301
	Natural variant	6	1	Q → R. Ref.1 Ref.4 Ref.6 Corresponds to variant rs34402964 [ dbSNP | Ensembl ].		VAR_007855
	Natural variant	89	1	Q → E. Ref.1 Ref.4 Ref.6 Corresponds to variant rs17328091 [ dbSNP | Ensembl ].		VAR_007856
	Natural variant	99	1	P → A. Corresponds to variant rs5987003 [ dbSNP | Ensembl ].		VAR_057512
Experimental info
	Sequence conflict	138	1	R → W in CAA11117. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform LAGE-1B (LAGE-1L) [UniParc]. Last modified May 18, 2010. Version 2. Checksum: 1DD0B1829735B60A	FASTA	210	21,061
	10 20 30 40 50 60 MQAEGQGTGG STGDADGPGG PGIPDGPGGN AGGPGEAGAT GGRGPRGAGA ARASGPRGGA 70 80 90 100 110 120 PRGPHGGAAS AQDGRCPCGA RRPDSRLLQL HITMPFSSPM EAELVRRILS RDAAPLPRPG 130 140 150 160 170 180 AVLKDFTVSG NLLFMSVRDQ DREGAGRMRV VGWGLGSASP EGQKARDLRT PKHKVSEQRP 190 200 210 GTPGPPPPEG AQGDGCRGVA FNVMFSAPHI
	Isoform LAGE-1A (LAGE-1S) [UniParc]. Checksum: 9077FAF953543A25	FASTA	180	18,237
	10 20 30 40 50 60 MQAEGQGTGG STGDADGPGG PGIPDGPGGN AGGPGEAGAT GGRGPRGAGA ARASGPRGGA 70 80 90 100 110 120 PRGPHGGAAS AQDGRCPCGA RRPDSRLLQL HITMPFSSPM EAELVRRILS RDAAPLPRPG 130 140 150 160 170 180 AVLKDFTVSG NLLFIRLTAA DHRQLQLSIS SCLQQLSLLM WITQCFLPVF LAQAPSGQRR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"LAGE-1, a new gene with tumor specificity." Lethe B.G., Lucas S., Michaux L., De Smet C., Godelaine D., Serrano A., De Plaen E., Boon T. Int. J. Cancer 76:903-908(1998) [PubMed: 9626360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS LAGE-1A AND LAGE-1B), VARIANTS ARG-6 AND GLU-89. Tissue: Melanoma.
[2]	"Interleukin-2-induced, melanoma-specific T cells recognize CAMEL, an unexpected translation product of LAGE-1." Aarnoudse C.A., Van den Doel P.B., Heemskerk B., Schrier P.I. Int. J. Cancer 82:442-448(1999) [PubMed: 10399963] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LAGE-1A AND LAGE-1B). Tissue: Melanoma.
[3]	"Multiple pathogenic and benign genomic rearrangements occur at a 35 kb duplication involving the NEMO and LAGE2 genes." Aradhya S., Bardaro T., Galgoczy P., Yamagata T., Esposito T., Patlan H., Ciccodicola A., Kenwrick S., Platzer M., D'Urso M., Nelson D.L. Hum. Mol. Genet. 10:2557-2567(2001) [PubMed: 11709543] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Identification and expression analysis of novel LAGE-1 alleles with single nucleotide polymorphisms in cancer patients." Shao Y., Sun Z.-Y., Sun S.-W., Zhao Y., Sin W.Y., Yuan Y.-H., Simpson A.J.G., Old L.J., Sang X.-T., Mao Y.-L., Xie Y., Huang J.-F., Zhao H.-T. J. Cancer Res. Clin. Oncol. 134:495-502(2008) [PubMed: 17899192] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LAGE-1A), VARIANTS ARG-6 AND GLU-89. Tissue: Hepatoma and Stomach cancer.
[5]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS LAGE-1A AND LAGE-1B), VARIANTS ARG-6 AND GLU-89. Tissue: Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ223093 Genomic DNA. Translation: CAA11117.1. AJ223093 Genomic DNA. Translation: CAA11116.1. AJ223040 mRNA. Translation: CAA11043.1. AJ223041 mRNA. Translation: CAA11044.1. AJ012834 mRNA. Translation: CAA10194.1. AJ012835 mRNA. Translation: CAA10196.1. AF277315 Genomic DNA. Translation: AAL27015.1. AY679088 mRNA. Translation: AAV98584.1. AY679089 mRNA. Translation: AAV98585.1. BC002833 mRNA. Translation: AAH02833.1. BC113998 mRNA. Translation: AAI13999.1. BC128045 mRNA. Translation: AAI28046.1.
IPI	IPI00218262. IPI00294635.
RefSeq	NP_066274.1. NM_020994.3. NP_758965.1. NM_172377.3.
UniGene	Hs.87225.
3D structure databases
ProteinModelPortal	O75638.
ModBase	Search...
Protein-protein interaction databases
STRING	O75638.
Proteomic databases
PRIDE	O75638.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000247306; ENSP00000247306; ENSG00000126890.
GeneID	30848.
KEGG	hsa:30848.
Organism-specific databases
CTD	30848.
GeneCards	GC0XM153880.
HGNC	HGNC:2492. CTAG2.
MIM	300396. gene.
neXtProt	NX_O75638.
PharmGKB	PA26994.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00410000025802.
OMA	CEARRPD.
OrthoDB	EOG4QRH5Q.
Gene expression databases
ArrayExpress	O75638.
Bgee	O75638.
CleanEx	HS_CTAG2.
Genevestigator	O75638.
GermOnline	ENSG00000126890. Homo sapiens.
Family and domain databases
InterPro	IPR015419. EKC/KEOPS_Pcc1. [Graphical view]
Pfam	PF09341. Pcc1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

CTAG2_HUMAN

Accession

Primary (citable) accession number: O75638
Secondary accession number(s): O75637 , Q0VIL6, Q14CD6, Q2Z1N4, Q9BU80, Q9UJ89, Q9Y479

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 18, 2010
Last modified:	January 25, 2012
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.