Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O75635

- SPB7_HUMAN

UniProt

O75635 - SPB7_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Serpin B7

Gene

SERPINB7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes via its action as a serpin.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei347 – 3482Reactive bondBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: RefGenome

GO - Biological processi

  1. negative regulation of endopeptidase activity Source: RefGenome
  2. positive regulation of collagen biosynthetic process Source: Ensembl
  3. positive regulation of glomerular mesangial cell proliferation Source: Ensembl
  4. positive regulation of platelet-derived growth factor production Source: Ensembl
  5. positive regulation of transforming growth factor beta1 production Source: Ensembl
  6. regulation of proteolysis Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.012.

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin B7
Alternative name(s):
Megsin
TP55
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:13902. SERPINB7.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Keratoderma, palmoplantar, Nagashima type (PPKN) [MIM:615598]: An autosomal recessive, non-syndromic, diffuse palmoplantar keratosis characterized by well-demarcated diffuse erythematous hyperkeratosis expanding onto the dorsal surfaces of the palms and feet and the Achilles tendon area. Hyperkeratosis is mild and non-progressive.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.

Keywords - Diseasei

Palmoplantar keratoderma

Organism-specific databases

MIMi615598. phenotype.
Orphaneti140966. Palmoplantar keratoderma, Nagashima type.
PharmGKBiPA37825.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 380380Serpin B7PRO_0000094108Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei217 – 2171Phosphoserine1 Publication
Modified residuei223 – 2231Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO75635.
PaxDbiO75635.
PRIDEiO75635.

PTM databases

PhosphoSiteiO75635.

Expressioni

Tissue specificityi

Predominantly expressed in mesangial cells. Expressed in the epidermis of the whole body.1 Publication

Gene expression databases

BgeeiO75635.
CleanExiHS_SERPINB7.
ExpressionAtlasiO75635. baseline and differential.
GenevestigatoriO75635.

Organism-specific databases

HPAiHPA024200.

Interactioni

Protein-protein interaction databases

BioGridi114252. 5 interactions.
STRINGi9606.ENSP00000337212.

Structurei

3D structure databases

ProteinModelPortaliO75635.
SMRiO75635. Positions 3-380.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118789.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiO75635.
KOiK13964.
OMAiYIMLPEN.
OrthoDBiEOG7GN2TH.
PhylomeDBiO75635.
TreeFamiTF352619.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O75635-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASLAAANAE FCFNLFREMD DNQGNGNVFF SSLSLFAALA LVRLGAQDDS
60 70 80 90 100
LSQIDKLLHV NTASGYGNSS NSQSGLQSQL KRVFSDINAS HKDYDLSIVN
110 120 130 140 150
GLFAEKVYGF HKDYIECAEK LYDAKVERVD FTNHLEDTRR NINKWVENET
160 170 180 190 200
HGKIKNVIGE GGISSSAVMV LVNAVYFKGK WQSAFTKSET INCHFKSPKC
210 220 230 240 250
SGKAVAMMHQ ERKFNLSVIE DPSMKILELR YNGGINMYVL LPENDLSEIE
260 270 280 290 300
NKLTFQNLME WTNPRRMTSK YVEVFFPQFK IEKNYEMKQY LRALGLKDIF
310 320 330 340 350
DESKADLSGI ASGGRLYISR MMHKSYIEVT EEGTEATAAT GSNIVEKQLP
360 370 380
QSTLFRADHP FLFVIRKDDI ILFSGKVSCP
Length:380
Mass (Da):42,905
Last modified:November 1, 1998 - v1
Checksum:i9A2CDB6C63CFF605
GO
Isoform 2 (identifier: O75635-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     57-73: Missing.

Note: No experimental confirmation available.

Show »
Length:363
Mass (Da):41,174
Checksum:i9E9C813FC804B165
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti155 – 1551K → E in BAG62480. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti266 – 2661R → Q.
Corresponds to variant rs17782413 [ dbSNP | Ensembl ].
VAR_034512

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei57 – 7317Missing in isoform 2. 1 PublicationVSP_044711Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88575 mRNA. Translation: BAA31232.1.
AF027866 mRNA. Translation: AAC64506.1.
AK300828 mRNA. Translation: BAG62480.1.
AC069356 Genomic DNA. No translation available.
AC072051 Genomic DNA. No translation available.
BC069417 mRNA. Translation: AAH69417.1.
BC069442 mRNA. Translation: AAH69442.1.
BC069547 mRNA. Translation: AAH69547.1.
BC106743 mRNA. Translation: AAI06744.1.
BC106744 mRNA. Translation: AAI06745.1.
CCDSiCCDS11988.1. [O75635-1]
CCDS58633.1. [O75635-2]
RefSeqiNP_001035237.1. NM_001040147.2. [O75635-1]
NP_001248759.1. NM_001261830.1. [O75635-1]
NP_001248760.1. NM_001261831.1. [O75635-2]
NP_003775.1. NM_003784.3. [O75635-1]
XP_006722625.1. XM_006722562.1. [O75635-1]
UniGeneiHs.138202.
Hs.742388.

Genome annotation databases

EnsembliENST00000336429; ENSP00000337212; ENSG00000166396. [O75635-1]
ENST00000398019; ENSP00000381101; ENSG00000166396. [O75635-1]
ENST00000540675; ENSP00000444572; ENSG00000166396. [O75635-2]
ENST00000546027; ENSP00000444861; ENSG00000166396. [O75635-1]
GeneIDi8710.
KEGGihsa:8710.
UCSCiuc002ljl.4. human. [O75635-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88575 mRNA. Translation: BAA31232.1 .
AF027866 mRNA. Translation: AAC64506.1 .
AK300828 mRNA. Translation: BAG62480.1 .
AC069356 Genomic DNA. No translation available.
AC072051 Genomic DNA. No translation available.
BC069417 mRNA. Translation: AAH69417.1 .
BC069442 mRNA. Translation: AAH69442.1 .
BC069547 mRNA. Translation: AAH69547.1 .
BC106743 mRNA. Translation: AAI06744.1 .
BC106744 mRNA. Translation: AAI06745.1 .
CCDSi CCDS11988.1. [O75635-1 ]
CCDS58633.1. [O75635-2 ]
RefSeqi NP_001035237.1. NM_001040147.2. [O75635-1 ]
NP_001248759.1. NM_001261830.1. [O75635-1 ]
NP_001248760.1. NM_001261831.1. [O75635-2 ]
NP_003775.1. NM_003784.3. [O75635-1 ]
XP_006722625.1. XM_006722562.1. [O75635-1 ]
UniGenei Hs.138202.
Hs.742388.

3D structure databases

ProteinModelPortali O75635.
SMRi O75635. Positions 3-380.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114252. 5 interactions.
STRINGi 9606.ENSP00000337212.

Protein family/group databases

MEROPSi I04.012.

PTM databases

PhosphoSitei O75635.

Proteomic databases

MaxQBi O75635.
PaxDbi O75635.
PRIDEi O75635.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000336429 ; ENSP00000337212 ; ENSG00000166396 . [O75635-1 ]
ENST00000398019 ; ENSP00000381101 ; ENSG00000166396 . [O75635-1 ]
ENST00000540675 ; ENSP00000444572 ; ENSG00000166396 . [O75635-2 ]
ENST00000546027 ; ENSP00000444861 ; ENSG00000166396 . [O75635-1 ]
GeneIDi 8710.
KEGGi hsa:8710.
UCSCi uc002ljl.4. human. [O75635-1 ]

Organism-specific databases

CTDi 8710.
GeneCardsi GC18P061394.
HGNCi HGNC:13902. SERPINB7.
HPAi HPA024200.
MIMi 603357. gene.
615598. phenotype.
neXtProti NX_O75635.
Orphaneti 140966. Palmoplantar keratoderma, Nagashima type.
PharmGKBi PA37825.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4826.
GeneTreei ENSGT00760000118789.
HOGENOMi HOG000238519.
HOVERGENi HBG005957.
InParanoidi O75635.
KOi K13964.
OMAi YIMLPEN.
OrthoDBi EOG7GN2TH.
PhylomeDBi O75635.
TreeFami TF352619.

Miscellaneous databases

GeneWikii SERPINB7.
GenomeRNAii 8710.
NextBioi 32665.
PROi O75635.
SOURCEi Search...

Gene expression databases

Bgeei O75635.
CleanExi HS_SERPINB7.
ExpressionAtlasi O75635. baseline and differential.
Genevestigatori O75635.

Family and domain databases

InterProi IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
PROSITEi PS00284. SERPIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "A mesangium-predominant gene, megsin, is a new serpin upregulated in IgA nephropathy."
    Miyata T., Nangaku M., Suzuki D., Inagi R., Uragami K., Sakai H., Okubo K., Kurokawa K.
    J. Clin. Invest. 102:828-836(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Mesangial cell.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-217 AND SER-223, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: TISSUE SPECIFICITY, INVOLVEMENT IN PPKN.

Entry informationi

Entry nameiSPB7_HUMAN
AccessioniPrimary (citable) accession number: O75635
Secondary accession number(s): B4DUW8
, F5GZC0, Q1ED45, Q3KPG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3