Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Uroplakin-3a

Gene

UPK3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Uroplakin-3a
Short name:
UP3a
Alternative name(s):
Uroplakin III
Short name:
UPIII
Gene namesi
Name:UPK3A
Synonyms:UPK3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:12580. UPK3A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 207189LumenalSequence analysisAdd
BLAST
Transmembranei208 – 23528HelicalSequence analysisAdd
BLAST
Topological domaini236 – 28752CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Involvement in diseasei

Mutations in UPK3A have been detected in patients with renal adyplasia suggesting a possible involvement of this gene in kidney and urinary tract anomalies.

Keywords - Diseasei

Disease mutation

Organism-specific databases

MalaCardsiUPK3A.
Orphaneti93100. Unilateral renal agenesis.
PharmGKBiPA37212.

Polymorphism and mutation databases

BioMutaiUPK3A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818By similarityAdd
BLAST
Chaini19 – 287269Uroplakin-3aPRO_0000022637Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence analysis
Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence analysis
Glycosylationi170 – 1701N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO75631.
PeptideAtlasiO75631.
PRIDEiO75631.

PTM databases

iPTMnetiO75631.
PhosphoSiteiO75631.

Expressioni

Tissue specificityi

Expressed in ureter.1 Publication

Gene expression databases

BgeeiO75631.
CleanExiHS_UPK3A.
GenevisibleiO75631. HS.

Organism-specific databases

HPAiHPA018407.
HPA018415.

Interactioni

Subunit structurei

Heterodimer with uroplakin-1B (UPK1B).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
SGTAO437653EBI-10188907,EBI-347996

Protein-protein interaction databases

BioGridi113226. 2 interactions.
IntActiO75631. 1 interaction.
STRINGi9606.ENSP00000216211.

Structurei

3D structure databases

ProteinModelPortaliO75631.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uroplakin-3 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE9T. Eukaryota.
ENOG41123W4. LUCA.
GeneTreeiENSGT00510000048620.
HOGENOMiHOG000143412.
HOVERGENiHBG058769.
InParanoidiO75631.
KOiK19520.
OMAiETTHDSQ.
OrthoDBiEOG7J9VQC.
PhylomeDBiO75631.
TreeFamiTF336628.

Family and domain databases

InterProiIPR024831. Uroplakin-3.
IPR024825. Uroplakin-3a.
[Graphical view]
PANTHERiPTHR15446. PTHR15446. 1 hit.
PTHR15446:SF17. PTHR15446:SF17. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75631-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPPLWALLAL GCLRFGSAVN LQPQLASVTF ATNNPTLTTV ALEKPLCMFD
60 70 80 90 100
SKEALTGTHE VYLYVLVDSA ISRNASVQDS TNTPLGSTFL QTEGGRTGPY
110 120 130 140 150
KAVAFDLIPC SDLPSLDAIG DVSKASQILN AYLVRVGANG TCLWDPNFQG
160 170 180 190 200
LCNAPLSAAT EYRFKYVLVN MSTGLVEDQT LWSDPIRTNQ LTPYSTIDTW
210 220 230 240 250
PGRRSGGMIV ITSILGSLPF FLLVGFAGAI ALSLVDMGSS DGETTHDSQI
260 270 280
TQEAVPKSLG ASESSYTSVN RGPPLDRAEV YSSKLQD
Length:287
Mass (Da):30,670
Last modified:October 11, 2004 - v3
Checksum:i2A14B21746FDBD25
GO
Isoform 2 (identifier: O75631-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     70-191: AISRNASVQD...WSDPIRTNQL → V

Show »
Length:166
Mass (Da):17,672
Checksum:i9D03D8AFADEA55B6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti236 – 2361D → A in BAA31460 (PubMed:9818021).Curated
Sequence conflicti236 – 2361D → A in BAA25678 (PubMed:9818021).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti91 – 911Q → L.
Corresponds to variant rs6006979 [ dbSNP | Ensembl ].
VAR_044399
Natural varianti154 – 1541A → P.1 Publication
Corresponds to variant rs1057353 [ dbSNP | Ensembl ].
VAR_020158
Natural varianti202 – 2021G → D Found in a patient with unilateral multicystic kidney disease; unknown pathological significance. 1 Publication
Corresponds to variant rs121918187 [ dbSNP | Ensembl ].
VAR_044400
Natural varianti273 – 2731P → L Found in patients with renal adysplasia; unknown pathological significance; normal targeting to the cell surface. 1 Publication
Corresponds to variant rs121918186 [ dbSNP | Ensembl ].
VAR_044401

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei70 – 191122AISRN…RTNQL → V in isoform 2. 1 PublicationVSP_030004Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085808 mRNA. Translation: AAC34888.1.
AB010637 mRNA. Translation: BAA31460.1.
AB010116 mRNA. Translation: BAA25678.1.
CR456608 mRNA. Translation: CAG30494.1.
AL008718 Genomic DNA. Translation: CAI17948.1.
AL008718 Genomic DNA. Translation: CAQ08673.1.
BC069544 mRNA. Translation: AAH69544.1.
BC108900 mRNA. Translation: AAI08901.1.
CCDSiCCDS14064.1. [O75631-1]
CCDS54539.1. [O75631-2]
RefSeqiNP_001161046.1. NM_001167574.1. [O75631-2]
NP_008884.1. NM_006953.3. [O75631-1]
UniGeneiHs.632787.

Genome annotation databases

EnsembliENST00000216211; ENSP00000216211; ENSG00000100373. [O75631-1]
ENST00000396082; ENSP00000379391; ENSG00000100373. [O75631-2]
GeneIDi7380.
KEGGihsa:7380.
UCSCiuc003bfy.4. human. [O75631-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085808 mRNA. Translation: AAC34888.1.
AB010637 mRNA. Translation: BAA31460.1.
AB010116 mRNA. Translation: BAA25678.1.
CR456608 mRNA. Translation: CAG30494.1.
AL008718 Genomic DNA. Translation: CAI17948.1.
AL008718 Genomic DNA. Translation: CAQ08673.1.
BC069544 mRNA. Translation: AAH69544.1.
BC108900 mRNA. Translation: AAI08901.1.
CCDSiCCDS14064.1. [O75631-1]
CCDS54539.1. [O75631-2]
RefSeqiNP_001161046.1. NM_001167574.1. [O75631-2]
NP_008884.1. NM_006953.3. [O75631-1]
UniGeneiHs.632787.

3D structure databases

ProteinModelPortaliO75631.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113226. 2 interactions.
IntActiO75631. 1 interaction.
STRINGi9606.ENSP00000216211.

PTM databases

iPTMnetiO75631.
PhosphoSiteiO75631.

Polymorphism and mutation databases

BioMutaiUPK3A.

Proteomic databases

PaxDbiO75631.
PeptideAtlasiO75631.
PRIDEiO75631.

Protocols and materials databases

DNASUi7380.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216211; ENSP00000216211; ENSG00000100373. [O75631-1]
ENST00000396082; ENSP00000379391; ENSG00000100373. [O75631-2]
GeneIDi7380.
KEGGihsa:7380.
UCSCiuc003bfy.4. human. [O75631-1]

Organism-specific databases

CTDi7380.
GeneCardsiUPK3A.
HGNCiHGNC:12580. UPK3A.
HPAiHPA018407.
HPA018415.
MalaCardsiUPK3A.
MIMi611559. gene.
neXtProtiNX_O75631.
Orphaneti93100. Unilateral renal agenesis.
PharmGKBiPA37212.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE9T. Eukaryota.
ENOG41123W4. LUCA.
GeneTreeiENSGT00510000048620.
HOGENOMiHOG000143412.
HOVERGENiHBG058769.
InParanoidiO75631.
KOiK19520.
OMAiETTHDSQ.
OrthoDBiEOG7J9VQC.
PhylomeDBiO75631.
TreeFamiTF336628.

Miscellaneous databases

GeneWikiiUPK3A.
GenomeRNAii7380.
PROiO75631.
SOURCEiSearch...

Gene expression databases

BgeeiO75631.
CleanExiHS_UPK3A.
GenevisibleiO75631. HS.

Family and domain databases

InterProiIPR024831. Uroplakin-3.
IPR024825. Uroplakin-3a.
[Graphical view]
PANTHERiPTHR15446. PTHR15446. 1 hit.
PTHR15446:SF17. PTHR15446:SF17. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Geall K., Hall G., Smith B., Southgate J.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Ureter.
  2. "Expression of uroplakin Ib and uroplakin III genes in tissues and peripheral blood of patients with transitional cell carcinoma."
    Yuasa T., Yoshiki T., Tanaka T., Kim C.J., Isono T., Okada Y.
    Jpn. J. Cancer Res. 89:879-882(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT PRO-154.
    Tissue: Urinary bladder urothelium.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
  6. Cited for: TISSUE SPECIFICITY.
  7. "De novo Uroplakin IIIa heterozygous mutations cause human renal adysplasia leading to severe kidney failure."
    Jenkins D., Bitner-Glindzicz M., Malcolm S., Hu C.-C.A., Allison J., Winyard P.J.D., Gullett A.M., Thomas D.F.M., Belk R.A., Feather S.A., Sun T.-T., Woolf A.S.
    J. Am. Soc. Nephrol. 16:2141-2149(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT LEU-273, POSSIBLE INVOLVEMENT IN KIDNEY AND URINARY TRACT ANOMALIES, CHARACTERIZATION OF VARIANT LEU-273.
  8. Cited for: VARIANT ASP-202, POSSIBLE INVOLVEMENT IN KIDNEY AND URINARY TRACT ANOMALIES.

Entry informationi

Entry nameiUPK3A_HUMAN
AccessioniPrimary (citable) accession number: O75631
Secondary accession number(s): B0QY25
, O60261, Q32N05, Q5TII6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 11, 2004
Last modified: July 6, 2016
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.