Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O75629

- CREG1_HUMAN

UniProt

O75629 - CREG1_HUMAN

Protein

Protein CREG1

Gene

CREG1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R.2 Publications

    GO - Molecular functioni

    1. FMN binding Source: InterPro
    2. oxidoreductase activity Source: InterPro
    3. transcription corepressor activity Source: ProtInc

    GO - Biological processi

    1. cell proliferation Source: ProtInc
    2. multicellular organismal development Source: ProtInc
    3. regulation of growth Source: UniProtKB-KW
    4. regulation of transcription from RNA polymerase II promoter Source: ProtInc

    Keywords - Biological processi

    Growth regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein CREG1
    Alternative name(s):
    Cellular repressor of E1A-stimulated genes 1
    Gene namesi
    Name:CREG1
    Synonyms:CREG
    ORF Names:UNQ727/PRO1409
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:2351. CREG1.

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. transcription factor complex Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26869.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 31311 PublicationAdd
    BLAST
    Chaini32 – 220189Protein CREG1PRO_0000006203Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi160 – 1601N-linked (GlcNAc...)2 Publications
    Glycosylationi193 – 1931N-linked (GlcNAc...)2 Publications
    Glycosylationi216 – 2161N-linked (GlcNAc...)2 Publications

    Post-translational modificationi

    N-glycosylated.2 Publications

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiO75629.
    PaxDbiO75629.
    PeptideAtlasiO75629.
    PRIDEiO75629.

    Expressioni

    Gene expression databases

    BgeeiO75629.
    CleanExiHS_CREG1.
    GenevestigatoriO75629.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with IGF2R; the interaction is dependent on glycosylation.2 Publications

    Protein-protein interaction databases

    BioGridi114332. 6 interactions.
    IntActiO75629. 2 interactions.
    STRINGi9606.ENSP00000359540.

    Structurei

    Secondary structure

    1
    220
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi55 – 6511
    Beta strandi67 – 748
    Helixi78 – 803
    Beta strandi84 – 907
    Beta strandi104 – 1074
    Helixi112 – 1198
    Beta strandi122 – 1287
    Helixi129 – 1313
    Helixi134 – 1385
    Beta strandi149 – 15810
    Helixi161 – 1633
    Helixi164 – 17411
    Helixi176 – 1805
    Helixi183 – 1853
    Beta strandi188 – 20013
    Beta strandi202 – 2054
    Helixi211 – 2166

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1XHNX-ray1.95A/B/C/D49-220[»]
    ProteinModelPortaliO75629.
    SMRiO75629. Positions 49-218.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO75629.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CREG family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG294476.
    HOGENOMiHOG000239875.
    HOVERGENiHBG051115.
    InParanoidiO75629.
    OMAiKVNETEM.
    OrthoDBiEOG7ZWD33.
    PhylomeDBiO75629.
    TreeFamiTF324680.

    Family and domain databases

    Gene3Di2.30.110.10. 1 hit.
    InterProiIPR014631. CREG.
    IPR012349. Split_barrel_FMN-bd.
    [Graphical view]
    PIRSFiPIRSF036911. CREG. 1 hit.
    SUPFAMiSSF50475. SSF50475. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O75629-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGLSRGSAR ALLAALLAST LLALLVSPAR GRGGRDHGDW DEASRLPPLP    50
    PREDAARVAR FVTHVSDWGA LATISTLEAV RGRPFADVLS LSDGPPGAGS 100
    GVPYFYLSPL QLSVSNLQEN PYATLTMTLA QTNFCKKHGF DPQSPLCVHI 150
    MLSGTVTKVN ETEMDIAKHS LFIRHPEMKT WPSSHNWFFA KLNITNIWVL 200
    DYFGGPKIVT PEEYYNVTVQ 220
    Length:220
    Mass (Da):24,075
    Last modified:November 1, 1998 - v1
    Checksum:i0DB95A1E4149CD7C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti52 – 598Missing in BAC04550. (PubMed:16710414)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF084523 mRNA. Translation: AAC34861.1.
    AY359071 mRNA. Translation: AAQ89430.1.
    AK095456 mRNA. Translation: BAC04550.1.
    AK315497 mRNA. Translation: BAG37881.1.
    AL031733 Genomic DNA. Translation: CAB42866.1.
    CH471067 Genomic DNA. Translation: EAW90795.1.
    BC006786 mRNA. Translation: AAH06786.1.
    BC008628 mRNA. Translation: AAH08628.1.
    CCDSiCCDS1262.1.
    RefSeqiNP_003842.1. NM_003851.2.
    UniGeneiHs.5710.

    Genome annotation databases

    EnsembliENST00000370509; ENSP00000359540; ENSG00000143162.
    GeneIDi8804.
    KEGGihsa:8804.
    UCSCiuc001gel.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF084523 mRNA. Translation: AAC34861.1 .
    AY359071 mRNA. Translation: AAQ89430.1 .
    AK095456 mRNA. Translation: BAC04550.1 .
    AK315497 mRNA. Translation: BAG37881.1 .
    AL031733 Genomic DNA. Translation: CAB42866.1 .
    CH471067 Genomic DNA. Translation: EAW90795.1 .
    BC006786 mRNA. Translation: AAH06786.1 .
    BC008628 mRNA. Translation: AAH08628.1 .
    CCDSi CCDS1262.1.
    RefSeqi NP_003842.1. NM_003851.2.
    UniGenei Hs.5710.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1XHN X-ray 1.95 A/B/C/D 49-220 [» ]
    ProteinModelPortali O75629.
    SMRi O75629. Positions 49-218.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114332. 6 interactions.
    IntActi O75629. 2 interactions.
    STRINGi 9606.ENSP00000359540.

    Proteomic databases

    MaxQBi O75629.
    PaxDbi O75629.
    PeptideAtlasi O75629.
    PRIDEi O75629.

    Protocols and materials databases

    DNASUi 8804.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000370509 ; ENSP00000359540 ; ENSG00000143162 .
    GeneIDi 8804.
    KEGGi hsa:8804.
    UCSCi uc001gel.3. human.

    Organism-specific databases

    CTDi 8804.
    GeneCardsi GC01M167498.
    HGNCi HGNC:2351. CREG1.
    neXtProti NX_O75629.
    PharmGKBi PA26869.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG294476.
    HOGENOMi HOG000239875.
    HOVERGENi HBG051115.
    InParanoidi O75629.
    OMAi KVNETEM.
    OrthoDBi EOG7ZWD33.
    PhylomeDBi O75629.
    TreeFami TF324680.

    Miscellaneous databases

    EvolutionaryTracei O75629.
    GeneWikii CREG1.
    GenomeRNAii 8804.
    NextBioi 33024.
    PROi O75629.

    Gene expression databases

    Bgeei O75629.
    CleanExi HS_CREG1.
    Genevestigatori O75629.

    Family and domain databases

    Gene3Di 2.30.110.10. 1 hit.
    InterProi IPR014631. CREG.
    IPR012349. Split_barrel_FMN-bd.
    [Graphical view ]
    PIRSFi PIRSF036911. CREG. 1 hit.
    SUPFAMi SSF50475. SSF50475. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A cellular repressor of E1A-stimulated genes that inhibits activation by E2F."
      Veal E., Eisenstein M., Tseng Z.H., Gill G.
      Mol. Cell. Biol. 18:5032-5041(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Tongue.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lymph and Placenta.
    7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 32-46.
    8. "The secreted glycoprotein CREG enhances differentiation of NTERA-2 human embryonal carcinoma cells."
      Veal E., Groisman R., Eisenstein M., Gill G.
      Oncogene 19:2120-2128(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, GLYCOSYLATION.
    9. "The secreted glycoprotein CREG inhibits cell growth dependent on the mannose-6-phosphate/insulin-like growth factor II receptor."
      Di Bacco A., Gill G.
      Oncogene 22:5436-5445(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH IGF2R, FUNCTION.
    10. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-160; ASN-193 AND ASN-216.
      Tissue: Liver.
    11. "The crystal structure of CREG, a secreted glycoprotein involved in cellular growth and differentiation."
      Sacher M., Di Bacco A., Lunin V.V., Ye Z., Wagner J., Gill G., Cygler M.
      Proc. Natl. Acad. Sci. U.S.A. 102:18326-18331(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 49-220, SUBUNIT.

    Entry informationi

    Entry nameiCREG1_HUMAN
    AccessioniPrimary (citable) accession number: O75629
    Secondary accession number(s): B2RDD4, Q8N9A3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 15, 2005
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3