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O75629

- CREG1_HUMAN

UniProt

O75629 - CREG1_HUMAN

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Protein
Protein CREG1
Gene
CREG1, CREG, UNQ727/PRO1409
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R.2 Publications

GO - Molecular functioni

  1. FMN binding Source: InterPro
  2. oxidoreductase activity Source: InterPro
  3. transcription corepressor activity Source: ProtInc

GO - Biological processi

  1. cell proliferation Source: ProtInc
  2. multicellular organismal development Source: ProtInc
  3. regulation of growth Source: UniProtKB-KW
  4. regulation of transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Growth regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CREG1
Alternative name(s):
Cellular repressor of E1A-stimulated genes 1
Gene namesi
Name:CREG1
Synonyms:CREG
ORF Names:UNQ727/PRO1409
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:2351. CREG1.

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26869.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 31311 Publication
Add
BLAST
Chaini32 – 220189Protein CREG1
PRO_0000006203Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi160 – 1601N-linked (GlcNAc...)1 Publication
Glycosylationi193 – 1931N-linked (GlcNAc...)1 Publication
Glycosylationi216 – 2161N-linked (GlcNAc...)1 Publication

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO75629.
PaxDbiO75629.
PeptideAtlasiO75629.
PRIDEiO75629.

Expressioni

Gene expression databases

BgeeiO75629.
CleanExiHS_CREG1.
GenevestigatoriO75629.

Interactioni

Subunit structurei

Homodimer. Interacts with IGF2R; the interaction is dependent on glycosylation.2 Publications

Protein-protein interaction databases

BioGridi114332. 6 interactions.
IntActiO75629. 2 interactions.
STRINGi9606.ENSP00000359540.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi55 – 6511
Beta strandi67 – 748
Helixi78 – 803
Beta strandi84 – 907
Beta strandi104 – 1074
Helixi112 – 1198
Beta strandi122 – 1287
Helixi129 – 1313
Helixi134 – 1385
Beta strandi149 – 15810
Helixi161 – 1633
Helixi164 – 17411
Helixi176 – 1805
Helixi183 – 1853
Beta strandi188 – 20013
Beta strandi202 – 2054
Helixi211 – 2166

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XHNX-ray1.95A/B/C/D49-220[»]
ProteinModelPortaliO75629.
SMRiO75629. Positions 49-218.

Miscellaneous databases

EvolutionaryTraceiO75629.

Family & Domainsi

Sequence similaritiesi

Belongs to the CREG family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG294476.
HOGENOMiHOG000239875.
HOVERGENiHBG051115.
InParanoidiO75629.
OMAiKVNETEM.
OrthoDBiEOG7ZWD33.
PhylomeDBiO75629.
TreeFamiTF324680.

Family and domain databases

Gene3Di2.30.110.10. 1 hit.
InterProiIPR014631. CREG.
IPR012349. Split_barrel_FMN-bd.
[Graphical view]
PIRSFiPIRSF036911. CREG. 1 hit.
SUPFAMiSSF50475. SSF50475. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75629-1 [UniParc]FASTAAdd to Basket

« Hide

MAGLSRGSAR ALLAALLAST LLALLVSPAR GRGGRDHGDW DEASRLPPLP    50
PREDAARVAR FVTHVSDWGA LATISTLEAV RGRPFADVLS LSDGPPGAGS 100
GVPYFYLSPL QLSVSNLQEN PYATLTMTLA QTNFCKKHGF DPQSPLCVHI 150
MLSGTVTKVN ETEMDIAKHS LFIRHPEMKT WPSSHNWFFA KLNITNIWVL 200
DYFGGPKIVT PEEYYNVTVQ 220
Length:220
Mass (Da):24,075
Last modified:November 1, 1998 - v1
Checksum:i0DB95A1E4149CD7C
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti52 – 598Missing in BAC04550. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF084523 mRNA. Translation: AAC34861.1.
AY359071 mRNA. Translation: AAQ89430.1.
AK095456 mRNA. Translation: BAC04550.1.
AK315497 mRNA. Translation: BAG37881.1.
AL031733 Genomic DNA. Translation: CAB42866.1.
CH471067 Genomic DNA. Translation: EAW90795.1.
BC006786 mRNA. Translation: AAH06786.1.
BC008628 mRNA. Translation: AAH08628.1.
CCDSiCCDS1262.1.
RefSeqiNP_003842.1. NM_003851.2.
UniGeneiHs.5710.

Genome annotation databases

EnsembliENST00000370509; ENSP00000359540; ENSG00000143162.
GeneIDi8804.
KEGGihsa:8804.
UCSCiuc001gel.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF084523 mRNA. Translation: AAC34861.1 .
AY359071 mRNA. Translation: AAQ89430.1 .
AK095456 mRNA. Translation: BAC04550.1 .
AK315497 mRNA. Translation: BAG37881.1 .
AL031733 Genomic DNA. Translation: CAB42866.1 .
CH471067 Genomic DNA. Translation: EAW90795.1 .
BC006786 mRNA. Translation: AAH06786.1 .
BC008628 mRNA. Translation: AAH08628.1 .
CCDSi CCDS1262.1.
RefSeqi NP_003842.1. NM_003851.2.
UniGenei Hs.5710.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1XHN X-ray 1.95 A/B/C/D 49-220 [» ]
ProteinModelPortali O75629.
SMRi O75629. Positions 49-218.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114332. 6 interactions.
IntActi O75629. 2 interactions.
STRINGi 9606.ENSP00000359540.

Proteomic databases

MaxQBi O75629.
PaxDbi O75629.
PeptideAtlasi O75629.
PRIDEi O75629.

Protocols and materials databases

DNASUi 8804.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000370509 ; ENSP00000359540 ; ENSG00000143162 .
GeneIDi 8804.
KEGGi hsa:8804.
UCSCi uc001gel.3. human.

Organism-specific databases

CTDi 8804.
GeneCardsi GC01M167498.
HGNCi HGNC:2351. CREG1.
neXtProti NX_O75629.
PharmGKBi PA26869.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG294476.
HOGENOMi HOG000239875.
HOVERGENi HBG051115.
InParanoidi O75629.
OMAi KVNETEM.
OrthoDBi EOG7ZWD33.
PhylomeDBi O75629.
TreeFami TF324680.

Miscellaneous databases

EvolutionaryTracei O75629.
GeneWikii CREG1.
GenomeRNAii 8804.
NextBioi 33024.
PROi O75629.

Gene expression databases

Bgeei O75629.
CleanExi HS_CREG1.
Genevestigatori O75629.

Family and domain databases

Gene3Di 2.30.110.10. 1 hit.
InterProi IPR014631. CREG.
IPR012349. Split_barrel_FMN-bd.
[Graphical view ]
PIRSFi PIRSF036911. CREG. 1 hit.
SUPFAMi SSF50475. SSF50475. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A cellular repressor of E1A-stimulated genes that inhibits activation by E2F."
    Veal E., Eisenstein M., Tseng Z.H., Gill G.
    Mol. Cell. Biol. 18:5032-5041(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tongue.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymph and Placenta.
  7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 32-46.
  8. "The secreted glycoprotein CREG enhances differentiation of NTERA-2 human embryonal carcinoma cells."
    Veal E., Groisman R., Eisenstein M., Gill G.
    Oncogene 19:2120-2128(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, GLYCOSYLATION.
  9. "The secreted glycoprotein CREG inhibits cell growth dependent on the mannose-6-phosphate/insulin-like growth factor II receptor."
    Di Bacco A., Gill G.
    Oncogene 22:5436-5445(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH IGF2R, FUNCTION.
  10. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-160; ASN-193 AND ASN-216.
    Tissue: Liver.
  11. "The crystal structure of CREG, a secreted glycoprotein involved in cellular growth and differentiation."
    Sacher M., Di Bacco A., Lunin V.V., Ye Z., Wagner J., Gill G., Cygler M.
    Proc. Natl. Acad. Sci. U.S.A. 102:18326-18331(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 49-220, SUBUNIT.

Entry informationi

Entry nameiCREG1_HUMAN
AccessioniPrimary (citable) accession number: O75629
Secondary accession number(s): B2RDD4, Q8N9A3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: November 1, 1998
Last modified: September 3, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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