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Protein

Protein CREG1

Gene

CREG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R.2 Publications

GO - Molecular functioni

  • FMN binding Source: InterPro
  • oxidoreductase activity Source: InterPro
  • transcription corepressor activity Source: ProtInc

GO - Biological processi

  • cell proliferation Source: ProtInc
  • multicellular organism development Source: ProtInc
  • regulation of growth Source: UniProtKB-KW
  • regulation of transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Growth regulation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143162-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CREG1
Alternative name(s):
Cellular repressor of E1A-stimulated genes 1
Gene namesi
Name:CREG1
Synonyms:CREG
ORF Names:UNQ727/PRO1409
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:2351. CREG1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
  • transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi8804.
OpenTargetsiENSG00000143162.
PharmGKBiPA26869.

Polymorphism and mutation databases

BioMutaiCREG1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 311 PublicationAdd BLAST31
ChainiPRO_000000620332 – 220Protein CREG1Add BLAST189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi160N-linked (GlcNAc...)1 Publication1
Glycosylationi193N-linked (GlcNAc...)1 Publication1
Glycosylationi216N-linked (GlcNAc...)1 Publication1

Post-translational modificationi

N-glycosylated.2 Publications

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiO75629.
MaxQBiO75629.
PaxDbiO75629.
PeptideAtlasiO75629.
PRIDEiO75629.

PTM databases

iPTMnetiO75629.
PhosphoSitePlusiO75629.

Expressioni

Gene expression databases

BgeeiENSG00000143162.
CleanExiHS_CREG1.
GenevisibleiO75629. HS.

Organism-specific databases

HPAiHPA056390.

Interactioni

Subunit structurei

Homodimer. Interacts with IGF2R; the interaction is dependent on glycosylation.2 Publications

Protein-protein interaction databases

BioGridi114332. 10 interactors.
IntActiO75629. 2 interactors.
STRINGi9606.ENSP00000359540.

Structurei

Secondary structure

1220
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi55 – 65Combined sources11
Beta strandi67 – 74Combined sources8
Helixi78 – 80Combined sources3
Beta strandi84 – 90Combined sources7
Beta strandi104 – 107Combined sources4
Helixi112 – 119Combined sources8
Beta strandi122 – 128Combined sources7
Helixi129 – 131Combined sources3
Helixi134 – 138Combined sources5
Beta strandi149 – 158Combined sources10
Helixi161 – 163Combined sources3
Helixi164 – 174Combined sources11
Helixi176 – 180Combined sources5
Helixi183 – 185Combined sources3
Beta strandi188 – 200Combined sources13
Beta strandi202 – 205Combined sources4
Helixi211 – 216Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XHNX-ray1.95A/B/C/D49-220[»]
ProteinModelPortaliO75629.
SMRiO75629.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75629.

Family & Domainsi

Sequence similaritiesi

Belongs to the CREG family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3374. Eukaryota.
ENOG4111WS9. LUCA.
GeneTreeiENSGT00390000005914.
HOGENOMiHOG000239875.
HOVERGENiHBG051115.
InParanoidiO75629.
OMAiKVNETEM.
OrthoDBiEOG091G14BY.
PhylomeDBiO75629.
TreeFamiTF324680.

Family and domain databases

Gene3Di2.30.110.10. 1 hit.
InterProiIPR014631. CREG.
IPR012349. Split_barrel_FMN-bd.
[Graphical view]
PIRSFiPIRSF036911. CREG. 1 hit.
SUPFAMiSSF50475. SSF50475. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75629-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLSRGSAR ALLAALLAST LLALLVSPAR GRGGRDHGDW DEASRLPPLP
60 70 80 90 100
PREDAARVAR FVTHVSDWGA LATISTLEAV RGRPFADVLS LSDGPPGAGS
110 120 130 140 150
GVPYFYLSPL QLSVSNLQEN PYATLTMTLA QTNFCKKHGF DPQSPLCVHI
160 170 180 190 200
MLSGTVTKVN ETEMDIAKHS LFIRHPEMKT WPSSHNWFFA KLNITNIWVL
210 220
DYFGGPKIVT PEEYYNVTVQ
Length:220
Mass (Da):24,075
Last modified:November 1, 1998 - v1
Checksum:i0DB95A1E4149CD7C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52 – 59Missing in BAC04550 (PubMed:16710414).Curated8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF084523 mRNA. Translation: AAC34861.1.
AY359071 mRNA. Translation: AAQ89430.1.
AK095456 mRNA. Translation: BAC04550.1.
AK315497 mRNA. Translation: BAG37881.1.
AL031733 Genomic DNA. Translation: CAB42866.1.
CH471067 Genomic DNA. Translation: EAW90795.1.
BC006786 mRNA. Translation: AAH06786.1.
BC008628 mRNA. Translation: AAH08628.1.
CCDSiCCDS1262.1.
RefSeqiNP_003842.1. NM_003851.2.
UniGeneiHs.5710.

Genome annotation databases

EnsembliENST00000370509; ENSP00000359540; ENSG00000143162.
GeneIDi8804.
KEGGihsa:8804.
UCSCiuc001gel.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF084523 mRNA. Translation: AAC34861.1.
AY359071 mRNA. Translation: AAQ89430.1.
AK095456 mRNA. Translation: BAC04550.1.
AK315497 mRNA. Translation: BAG37881.1.
AL031733 Genomic DNA. Translation: CAB42866.1.
CH471067 Genomic DNA. Translation: EAW90795.1.
BC006786 mRNA. Translation: AAH06786.1.
BC008628 mRNA. Translation: AAH08628.1.
CCDSiCCDS1262.1.
RefSeqiNP_003842.1. NM_003851.2.
UniGeneiHs.5710.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XHNX-ray1.95A/B/C/D49-220[»]
ProteinModelPortaliO75629.
SMRiO75629.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114332. 10 interactors.
IntActiO75629. 2 interactors.
STRINGi9606.ENSP00000359540.

PTM databases

iPTMnetiO75629.
PhosphoSitePlusiO75629.

Polymorphism and mutation databases

BioMutaiCREG1.

Proteomic databases

EPDiO75629.
MaxQBiO75629.
PaxDbiO75629.
PeptideAtlasiO75629.
PRIDEiO75629.

Protocols and materials databases

DNASUi8804.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370509; ENSP00000359540; ENSG00000143162.
GeneIDi8804.
KEGGihsa:8804.
UCSCiuc001gel.4. human.

Organism-specific databases

CTDi8804.
DisGeNETi8804.
GeneCardsiCREG1.
HGNCiHGNC:2351. CREG1.
HPAiHPA056390.
neXtProtiNX_O75629.
OpenTargetsiENSG00000143162.
PharmGKBiPA26869.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3374. Eukaryota.
ENOG4111WS9. LUCA.
GeneTreeiENSGT00390000005914.
HOGENOMiHOG000239875.
HOVERGENiHBG051115.
InParanoidiO75629.
OMAiKVNETEM.
OrthoDBiEOG091G14BY.
PhylomeDBiO75629.
TreeFamiTF324680.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143162-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

EvolutionaryTraceiO75629.
GeneWikiiCREG1.
GenomeRNAii8804.
PROiO75629.

Gene expression databases

BgeeiENSG00000143162.
CleanExiHS_CREG1.
GenevisibleiO75629. HS.

Family and domain databases

Gene3Di2.30.110.10. 1 hit.
InterProiIPR014631. CREG.
IPR012349. Split_barrel_FMN-bd.
[Graphical view]
PIRSFiPIRSF036911. CREG. 1 hit.
SUPFAMiSSF50475. SSF50475. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCREG1_HUMAN
AccessioniPrimary (citable) accession number: O75629
Secondary accession number(s): B2RDD4, Q8N9A3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.