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O75628

- REM1_HUMAN

UniProt

O75628 - REM1_HUMAN

Protein

GTP-binding protein REM 1

Gene

REM1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (07 Nov 2003)
      Previous versions | rss
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    Functioni

    Promotes endothelial cell sprouting and actin cytoskeletal reorganization. May be involved in angiogenesis. May function in Ca2+ signaling.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi87 – 948GTPBy similarity
    Nucleotide bindingi195 – 1984GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. GTP catabolic process Source: InterPro
    2. small GTPase mediated signal transduction Source: InterPro

    Keywords - Ligandi

    Calmodulin-binding, GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP-binding protein REM 1
    Alternative name(s):
    GTPase-regulating endothelial cell sprouting
    Rad and Gem-like GTP-binding protein 1
    Gene namesi
    Name:REM1
    Synonyms:GES, REM
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:15922. REM1.

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: InterPro

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi94 – 941T → N: No endothelial cell sprouting. 1 Publication

    Organism-specific databases

    PharmGKBiPA34324.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 298298GTP-binding protein REM 1PRO_0000122481Add
    BLAST

    Proteomic databases

    PaxDbiO75628.
    PRIDEiO75628.

    PTM databases

    PhosphoSiteiO75628.

    Expressioni

    Tissue specificityi

    Most highly expressed in the endothelial lining of the blood vessels in uterus and heart. Lower levels found in spleen, lymph node, kidney and testis. Also found in cells with secretory function such as the islets of Langerhans, lobule/duct epithelium in the breast, bile duct epithelium in the liver, surface epithelium in the endometrial glands of the uterus, colon mucosa and acinar cells in the pancreas and the prostate.

    Gene expression databases

    BgeeiO75628.
    CleanExiHS_REM1.
    GenevestigatoriO75628.

    Organism-specific databases

    HPAiHPA049821.

    Interactioni

    Subunit structurei

    In vitro, interacts with calmodulin in a calcium-dependent manner.

    Protein-protein interaction databases

    BioGridi118781. 6 interactions.
    STRINGi9606.ENSP00000201979.

    Structurei

    Secondary structure

    1
    298
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi80 – 867
    Helixi93 – 1019
    Beta strandi112 – 12312
    Beta strandi126 – 1338
    Helixi145 – 1495
    Turni150 – 1523
    Beta strandi155 – 1628
    Helixi166 – 18116
    Beta strandi190 – 1956
    Turni200 – 2023
    Helixi207 – 21711
    Beta strandi219 – 2235
    Turni226 – 2294
    Helixi232 – 24716

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2NZJX-ray2.50A/B/C/D79-251[»]
    ProteinModelPortaliO75628.
    SMRiO75628. Positions 79-247.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO75628.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni268 – 28720Calmodulin-bindingBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi241 – 28848Arg-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. RGK family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000246961.
    HOVERGENiHBG104899.
    InParanoidiO75628.
    KOiK07847.
    OMAiKLDESWS.
    OrthoDBiEOG7Q8CP8.
    PhylomeDBiO75628.
    TreeFamiTF314379.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR017358. Small_GTPase_GEM/REM/Rad.
    IPR020849. Small_GTPase_Ras.
    [Graphical view]
    PANTHERiPTHR24070. PTHR24070. 1 hit.
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038017. GTP-binding_GEM. 1 hit.
    PRINTSiPR00449. RASTRNSFRMNG.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51421. RAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O75628-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLNTEQEAK TPLHRRASTP LPLSPRGHQP GRLSTVPSTQ SQHPRLGQSA    50
    SLNPPTQKPS PAPDDWSSES SDSEGSWEAL YRVVLLGDPG VGKTSLASLF 100
    AGKQERDLHE QLGEDVYERT LTVDGEDTTL VVVDTWEAEK LDKSWSQESC 150
    LQGGSAYVIV YSIADRGSFE SASELRIQLR RTHQADHVPI ILVGNKADLA 200
    RCREVSVEEG RACAVVFDCK FIETSATLQH NVAELFEGVV RQLRLRRRDS 250
    AAKEPPAPRR PASLAQRARR FLARLTARSA RRRALKARSK SCHNLAVL 298
    Length:298
    Mass (Da):32,947
    Last modified:November 7, 2003 - v2
    Checksum:iE7CCE776FFD42CD7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti209 – 2091E → V in AAC33132. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti28 – 281H → R.2 Publications
    Corresponds to variant rs1006459 [ dbSNP | Ensembl ].
    VAR_049498
    Natural varianti45 – 451R → W.
    Corresponds to variant rs59730832 [ dbSNP | Ensembl ].
    VAR_061232
    Natural varianti59 – 591P → A.
    Corresponds to variant rs2233829 [ dbSNP | Ensembl ].
    VAR_049499

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF084465 mRNA. Translation: AAC33132.1.
    AF152863 mRNA. Translation: AAF74212.1.
    BT020078 mRNA. Translation: AAV38881.1.
    BT020079 mRNA. Translation: AAV38882.1.
    AK313060 mRNA. Translation: BAG35890.1.
    AL121751 Genomic DNA. Translation: CAB90274.1.
    CH471077 Genomic DNA. Translation: EAW76439.1.
    CH471077 Genomic DNA. Translation: EAW76440.1.
    CH471077 Genomic DNA. Translation: EAW76442.1.
    BC039813 mRNA. Translation: AAH39813.1.
    CCDSiCCDS13181.1.
    RefSeqiNP_054731.2. NM_014012.5.
    UniGeneiHs.247729.

    Genome annotation databases

    EnsembliENST00000201979; ENSP00000201979; ENSG00000088320.
    GeneIDi28954.
    KEGGihsa:28954.
    UCSCiuc002wwa.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF084465 mRNA. Translation: AAC33132.1 .
    AF152863 mRNA. Translation: AAF74212.1 .
    BT020078 mRNA. Translation: AAV38881.1 .
    BT020079 mRNA. Translation: AAV38882.1 .
    AK313060 mRNA. Translation: BAG35890.1 .
    AL121751 Genomic DNA. Translation: CAB90274.1 .
    CH471077 Genomic DNA. Translation: EAW76439.1 .
    CH471077 Genomic DNA. Translation: EAW76440.1 .
    CH471077 Genomic DNA. Translation: EAW76442.1 .
    BC039813 mRNA. Translation: AAH39813.1 .
    CCDSi CCDS13181.1.
    RefSeqi NP_054731.2. NM_014012.5.
    UniGenei Hs.247729.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2NZJ X-ray 2.50 A/B/C/D 79-251 [» ]
    ProteinModelPortali O75628.
    SMRi O75628. Positions 79-247.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118781. 6 interactions.
    STRINGi 9606.ENSP00000201979.

    PTM databases

    PhosphoSitei O75628.

    Proteomic databases

    PaxDbi O75628.
    PRIDEi O75628.

    Protocols and materials databases

    DNASUi 28954.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000201979 ; ENSP00000201979 ; ENSG00000088320 .
    GeneIDi 28954.
    KEGGi hsa:28954.
    UCSCi uc002wwa.3. human.

    Organism-specific databases

    CTDi 28954.
    GeneCardsi GC20P030063.
    HGNCi HGNC:15922. REM1.
    HPAi HPA049821.
    MIMi 610388. gene.
    neXtProti NX_O75628.
    PharmGKBi PA34324.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000246961.
    HOVERGENi HBG104899.
    InParanoidi O75628.
    KOi K07847.
    OMAi KLDESWS.
    OrthoDBi EOG7Q8CP8.
    PhylomeDBi O75628.
    TreeFami TF314379.

    Miscellaneous databases

    EvolutionaryTracei O75628.
    GenomeRNAii 28954.
    NextBioi 51769.
    PROi O75628.
    SOURCEi Search...

    Gene expression databases

    Bgeei O75628.
    CleanExi HS_REM1.
    Genevestigatori O75628.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR017358. Small_GTPase_GEM/REM/Rad.
    IPR020849. Small_GTPase_Ras.
    [Graphical view ]
    PANTHERi PTHR24070. PTHR24070. 1 hit.
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038017. GTP-binding_GEM. 1 hit.
    PRINTSi PR00449. RASTRNSFRMNG.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51421. RAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the human Rem gene."
      Finlin B.S., Andres D.A.
      Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Ges, a human GTPase of the Rad/Gem/Kir family, promotes endothelial cell sprouting and cytoskeleton reorganization."
      Pan J.Y., Fieles W.E., White A.M., Egerton M.M., Silberstein D.S.
      J. Cell Biol. 149:1107-1116(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], MUTAGENESIS OF THR-94.
      Tissue: Lymph node.
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-28.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-28.
      Tissue: Caudate nucleus.
    5. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiREM1_HUMAN
    AccessioniPrimary (citable) accession number: O75628
    Secondary accession number(s): E1P5L1
    , Q5TZR7, Q5TZR8, Q9NP57
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 7, 2003
    Last sequence update: November 7, 2003
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3