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O75628

- REM1_HUMAN

UniProt

O75628 - REM1_HUMAN

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Protein

GTP-binding protein REM 1

Gene

REM1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Promotes endothelial cell sprouting and actin cytoskeletal reorganization. May be involved in angiogenesis. May function in Ca2+ signaling.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi87 – 948GTPBy similarity
Nucleotide bindingi195 – 1984GTPBy similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. GTP catabolic process Source: InterPro
  2. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calmodulin-binding, GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein REM 1
Alternative name(s):
GTPase-regulating endothelial cell sprouting
Rad and Gem-like GTP-binding protein 1
Gene namesi
Name:REM1
Synonyms:GES, REM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:15922. REM1.

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi94 – 941T → N: No endothelial cell sprouting. 1 Publication

Organism-specific databases

PharmGKBiPA34324.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298GTP-binding protein REM 1PRO_0000122481Add
BLAST

Proteomic databases

PaxDbiO75628.
PRIDEiO75628.

PTM databases

PhosphoSiteiO75628.

Expressioni

Tissue specificityi

Most highly expressed in the endothelial lining of the blood vessels in uterus and heart. Lower levels found in spleen, lymph node, kidney and testis. Also found in cells with secretory function such as the islets of Langerhans, lobule/duct epithelium in the breast, bile duct epithelium in the liver, surface epithelium in the endometrial glands of the uterus, colon mucosa and acinar cells in the pancreas and the prostate.

Gene expression databases

BgeeiO75628.
CleanExiHS_REM1.
GenevestigatoriO75628.

Organism-specific databases

HPAiHPA049821.

Interactioni

Subunit structurei

In vitro, interacts with calmodulin in a calcium-dependent manner.

Protein-protein interaction databases

BioGridi118781. 6 interactions.
STRINGi9606.ENSP00000201979.

Structurei

Secondary structure

1
298
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi80 – 867
Helixi93 – 1019
Beta strandi112 – 12312
Beta strandi126 – 1338
Helixi145 – 1495
Turni150 – 1523
Beta strandi155 – 1628
Helixi166 – 18116
Beta strandi190 – 1956
Turni200 – 2023
Helixi207 – 21711
Beta strandi219 – 2235
Turni226 – 2294
Helixi232 – 24716

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2NZJX-ray2.50A/B/C/D79-251[»]
ProteinModelPortaliO75628.
SMRiO75628. Positions 79-247.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75628.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni268 – 28720Calmodulin-bindingBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi241 – 28848Arg-richAdd
BLAST

Sequence similaritiesi

Belongs to the small GTPase superfamily. RGK family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000118909.
HOGENOMiHOG000246961.
HOVERGENiHBG104899.
InParanoidiO75628.
KOiK07847.
OMAiKLDESWS.
OrthoDBiEOG7Q8CP8.
PhylomeDBiO75628.
TreeFamiTF314379.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR017358. Small_GTPase_GEM/REM/Rad.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PIRSFiPIRSF038017. GTP-binding_GEM. 1 hit.
PRINTSiPR00449. RASTRNSFRMNG.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75628-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLNTEQEAK TPLHRRASTP LPLSPRGHQP GRLSTVPSTQ SQHPRLGQSA
60 70 80 90 100
SLNPPTQKPS PAPDDWSSES SDSEGSWEAL YRVVLLGDPG VGKTSLASLF
110 120 130 140 150
AGKQERDLHE QLGEDVYERT LTVDGEDTTL VVVDTWEAEK LDKSWSQESC
160 170 180 190 200
LQGGSAYVIV YSIADRGSFE SASELRIQLR RTHQADHVPI ILVGNKADLA
210 220 230 240 250
RCREVSVEEG RACAVVFDCK FIETSATLQH NVAELFEGVV RQLRLRRRDS
260 270 280 290
AAKEPPAPRR PASLAQRARR FLARLTARSA RRRALKARSK SCHNLAVL
Length:298
Mass (Da):32,947
Last modified:November 7, 2003 - v2
Checksum:iE7CCE776FFD42CD7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti209 – 2091E → V in AAC33132. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti28 – 281H → R.2 Publications
Corresponds to variant rs1006459 [ dbSNP | Ensembl ].
VAR_049498
Natural varianti45 – 451R → W.
Corresponds to variant rs59730832 [ dbSNP | Ensembl ].
VAR_061232
Natural varianti59 – 591P → A.
Corresponds to variant rs2233829 [ dbSNP | Ensembl ].
VAR_049499

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF084465 mRNA. Translation: AAC33132.1.
AF152863 mRNA. Translation: AAF74212.1.
BT020078 mRNA. Translation: AAV38881.1.
BT020079 mRNA. Translation: AAV38882.1.
AK313060 mRNA. Translation: BAG35890.1.
AL121751 Genomic DNA. Translation: CAB90274.1.
CH471077 Genomic DNA. Translation: EAW76439.1.
CH471077 Genomic DNA. Translation: EAW76440.1.
CH471077 Genomic DNA. Translation: EAW76442.1.
BC039813 mRNA. Translation: AAH39813.1.
CCDSiCCDS13181.1.
RefSeqiNP_054731.2. NM_014012.5.
UniGeneiHs.247729.

Genome annotation databases

EnsembliENST00000201979; ENSP00000201979; ENSG00000088320.
GeneIDi28954.
KEGGihsa:28954.
UCSCiuc002wwa.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF084465 mRNA. Translation: AAC33132.1 .
AF152863 mRNA. Translation: AAF74212.1 .
BT020078 mRNA. Translation: AAV38881.1 .
BT020079 mRNA. Translation: AAV38882.1 .
AK313060 mRNA. Translation: BAG35890.1 .
AL121751 Genomic DNA. Translation: CAB90274.1 .
CH471077 Genomic DNA. Translation: EAW76439.1 .
CH471077 Genomic DNA. Translation: EAW76440.1 .
CH471077 Genomic DNA. Translation: EAW76442.1 .
BC039813 mRNA. Translation: AAH39813.1 .
CCDSi CCDS13181.1.
RefSeqi NP_054731.2. NM_014012.5.
UniGenei Hs.247729.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2NZJ X-ray 2.50 A/B/C/D 79-251 [» ]
ProteinModelPortali O75628.
SMRi O75628. Positions 79-247.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118781. 6 interactions.
STRINGi 9606.ENSP00000201979.

PTM databases

PhosphoSitei O75628.

Proteomic databases

PaxDbi O75628.
PRIDEi O75628.

Protocols and materials databases

DNASUi 28954.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000201979 ; ENSP00000201979 ; ENSG00000088320 .
GeneIDi 28954.
KEGGi hsa:28954.
UCSCi uc002wwa.3. human.

Organism-specific databases

CTDi 28954.
GeneCardsi GC20P030063.
HGNCi HGNC:15922. REM1.
HPAi HPA049821.
MIMi 610388. gene.
neXtProti NX_O75628.
PharmGKBi PA34324.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00760000118909.
HOGENOMi HOG000246961.
HOVERGENi HBG104899.
InParanoidi O75628.
KOi K07847.
OMAi KLDESWS.
OrthoDBi EOG7Q8CP8.
PhylomeDBi O75628.
TreeFami TF314379.

Miscellaneous databases

EvolutionaryTracei O75628.
GenomeRNAii 28954.
NextBioi 51769.
PROi O75628.
SOURCEi Search...

Gene expression databases

Bgeei O75628.
CleanExi HS_REM1.
Genevestigatori O75628.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR017358. Small_GTPase_GEM/REM/Rad.
IPR020849. Small_GTPase_Ras.
[Graphical view ]
PANTHERi PTHR24070. PTHR24070. 1 hit.
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PIRSFi PIRSF038017. GTP-binding_GEM. 1 hit.
PRINTSi PR00449. RASTRNSFRMNG.
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51421. RAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the human Rem gene."
    Finlin B.S., Andres D.A.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Ges, a human GTPase of the Rad/Gem/Kir family, promotes endothelial cell sprouting and cytoskeleton reorganization."
    Pan J.Y., Fieles W.E., White A.M., Egerton M.M., Silberstein D.S.
    J. Cell Biol. 149:1107-1116(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], MUTAGENESIS OF THR-94.
    Tissue: Lymph node.
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-28.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-28.
    Tissue: Caudate nucleus.
  5. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiREM1_HUMAN
AccessioniPrimary (citable) accession number: O75628
Secondary accession number(s): E1P5L1
, Q5TZR7, Q5TZR8, Q9NP57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: November 7, 2003
Last modified: October 29, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3