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Protein

GTP-binding protein REM 1

Gene

REM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Promotes endothelial cell sprouting and actin cytoskeletal reorganization. May be involved in angiogenesis. May function in Ca2+ signaling.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi87 – 94GTPBy similarity8
Nucleotide bindingi195 – 198GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calmodulin-binding, GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein REM 1
Alternative name(s):
GTPase-regulating endothelial cell sprouting
Rad and Gem-like GTP-binding protein 1
Gene namesi
Name:REM1
Synonyms:GES, REM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15922. REM1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi94T → N: No endothelial cell sprouting. 1 Publication1

Organism-specific databases

DisGeNETi28954.
OpenTargetsiENSG00000088320.
PharmGKBiPA34324.

Polymorphism and mutation databases

BioMutaiREM1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001224811 – 298GTP-binding protein REM 1Add BLAST298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei51PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO75628.
PeptideAtlasiO75628.
PRIDEiO75628.

PTM databases

iPTMnetiO75628.
PhosphoSitePlusiO75628.

Expressioni

Tissue specificityi

Most highly expressed in the endothelial lining of the blood vessels in uterus and heart. Lower levels found in spleen, lymph node, kidney and testis. Also found in cells with secretory function such as the islets of Langerhans, lobule/duct epithelium in the breast, bile duct epithelium in the liver, surface epithelium in the endometrial glands of the uterus, colon mucosa and acinar cells in the pancreas and the prostate.

Gene expression databases

BgeeiENSG00000088320.
CleanExiHS_REM1.
GenevisibleiO75628. HS.

Organism-specific databases

HPAiHPA049821.

Interactioni

Subunit structurei

In vitro, interacts with calmodulin in a calcium-dependent manner.

Protein-protein interaction databases

BioGridi118781. 6 interactors.
STRINGi9606.ENSP00000201979.

Structurei

Secondary structure

1298
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi80 – 86Combined sources7
Helixi93 – 101Combined sources9
Beta strandi112 – 123Combined sources12
Beta strandi126 – 133Combined sources8
Helixi145 – 149Combined sources5
Turni150 – 152Combined sources3
Beta strandi155 – 162Combined sources8
Helixi166 – 181Combined sources16
Beta strandi190 – 195Combined sources6
Turni200 – 202Combined sources3
Helixi207 – 217Combined sources11
Beta strandi219 – 223Combined sources5
Turni226 – 229Combined sources4
Helixi232 – 247Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NZJX-ray2.50A/B/C/D79-251[»]
ProteinModelPortaliO75628.
SMRiO75628.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75628.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni268 – 287Calmodulin-bindingBy similarityAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi241 – 288Arg-richAdd BLAST48

Sequence similaritiesi

Belongs to the small GTPase superfamily. RGK family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133672.
HOGENOMiHOG000246961.
HOVERGENiHBG104899.
InParanoidiO75628.
KOiK07847.
OMAiKSWSQES.
OrthoDBiEOG091G0OCN.
PhylomeDBiO75628.
TreeFamiTF314379.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR017358. Small_GTPase_GEM/REM/Rad.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PIRSFiPIRSF038017. GTP-binding_GEM. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75628-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLNTEQEAK TPLHRRASTP LPLSPRGHQP GRLSTVPSTQ SQHPRLGQSA
60 70 80 90 100
SLNPPTQKPS PAPDDWSSES SDSEGSWEAL YRVVLLGDPG VGKTSLASLF
110 120 130 140 150
AGKQERDLHE QLGEDVYERT LTVDGEDTTL VVVDTWEAEK LDKSWSQESC
160 170 180 190 200
LQGGSAYVIV YSIADRGSFE SASELRIQLR RTHQADHVPI ILVGNKADLA
210 220 230 240 250
RCREVSVEEG RACAVVFDCK FIETSATLQH NVAELFEGVV RQLRLRRRDS
260 270 280 290
AAKEPPAPRR PASLAQRARR FLARLTARSA RRRALKARSK SCHNLAVL
Length:298
Mass (Da):32,947
Last modified:November 7, 2003 - v2
Checksum:iE7CCE776FFD42CD7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti209E → V in AAC33132 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04949828H → R.2 PublicationsCorresponds to variant rs1006459dbSNPEnsembl.1
Natural variantiVAR_06123245R → W.Corresponds to variant rs59730832dbSNPEnsembl.1
Natural variantiVAR_04949959P → A.Corresponds to variant rs2233829dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF084465 mRNA. Translation: AAC33132.1.
AF152863 mRNA. Translation: AAF74212.1.
BT020078 mRNA. Translation: AAV38881.1.
BT020079 mRNA. Translation: AAV38882.1.
AK313060 mRNA. Translation: BAG35890.1.
AL121751 Genomic DNA. Translation: CAB90274.1.
CH471077 Genomic DNA. Translation: EAW76439.1.
CH471077 Genomic DNA. Translation: EAW76440.1.
CH471077 Genomic DNA. Translation: EAW76442.1.
BC039813 mRNA. Translation: AAH39813.1.
CCDSiCCDS13181.1.
RefSeqiNP_054731.2. NM_014012.5.
UniGeneiHs.247729.

Genome annotation databases

EnsembliENST00000201979; ENSP00000201979; ENSG00000088320.
GeneIDi28954.
KEGGihsa:28954.
UCSCiuc002wwa.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF084465 mRNA. Translation: AAC33132.1.
AF152863 mRNA. Translation: AAF74212.1.
BT020078 mRNA. Translation: AAV38881.1.
BT020079 mRNA. Translation: AAV38882.1.
AK313060 mRNA. Translation: BAG35890.1.
AL121751 Genomic DNA. Translation: CAB90274.1.
CH471077 Genomic DNA. Translation: EAW76439.1.
CH471077 Genomic DNA. Translation: EAW76440.1.
CH471077 Genomic DNA. Translation: EAW76442.1.
BC039813 mRNA. Translation: AAH39813.1.
CCDSiCCDS13181.1.
RefSeqiNP_054731.2. NM_014012.5.
UniGeneiHs.247729.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NZJX-ray2.50A/B/C/D79-251[»]
ProteinModelPortaliO75628.
SMRiO75628.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118781. 6 interactors.
STRINGi9606.ENSP00000201979.

PTM databases

iPTMnetiO75628.
PhosphoSitePlusiO75628.

Polymorphism and mutation databases

BioMutaiREM1.

Proteomic databases

PaxDbiO75628.
PeptideAtlasiO75628.
PRIDEiO75628.

Protocols and materials databases

DNASUi28954.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000201979; ENSP00000201979; ENSG00000088320.
GeneIDi28954.
KEGGihsa:28954.
UCSCiuc002wwa.5. human.

Organism-specific databases

CTDi28954.
DisGeNETi28954.
GeneCardsiREM1.
HGNCiHGNC:15922. REM1.
HPAiHPA049821.
MIMi610388. gene.
neXtProtiNX_O75628.
OpenTargetsiENSG00000088320.
PharmGKBiPA34324.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133672.
HOGENOMiHOG000246961.
HOVERGENiHBG104899.
InParanoidiO75628.
KOiK07847.
OMAiKSWSQES.
OrthoDBiEOG091G0OCN.
PhylomeDBiO75628.
TreeFamiTF314379.

Miscellaneous databases

EvolutionaryTraceiO75628.
GenomeRNAii28954.
PROiO75628.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000088320.
CleanExiHS_REM1.
GenevisibleiO75628. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR017358. Small_GTPase_GEM/REM/Rad.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PIRSFiPIRSF038017. GTP-binding_GEM. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiREM1_HUMAN
AccessioniPrimary (citable) accession number: O75628
Secondary accession number(s): E1P5L1
, Q5TZR7, Q5TZR8, Q9NP57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: November 7, 2003
Last modified: November 30, 2016
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.