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Protein

GTP-binding protein REM 1

Gene

REM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes endothelial cell sprouting and actin cytoskeletal reorganization. May be involved in angiogenesis. May function in Ca2+ signaling.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi87 – 94GTPBy similarity8
Nucleotide bindingi195 – 198GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein REM 1
Alternative name(s):
GTPase-regulating endothelial cell sprouting
Rad and Gem-like GTP-binding protein 1
Gene namesi
Name:REM1
Synonyms:GES, REM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000088320.3
HGNCiHGNC:15922 REM1
MIMi610388 gene
neXtProtiNX_O75628

Subcellular locationi

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi94T → N: No endothelial cell sprouting. 1 Publication1

Organism-specific databases

DisGeNETi28954
OpenTargetsiENSG00000088320
PharmGKBiPA34324

Polymorphism and mutation databases

BioMutaiREM1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001224811 – 298GTP-binding protein REM 1Add BLAST298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei51PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO75628
PaxDbiO75628
PeptideAtlasiO75628
PRIDEiO75628

PTM databases

iPTMnetiO75628
PhosphoSitePlusiO75628

Expressioni

Tissue specificityi

Most highly expressed in the endothelial lining of the blood vessels in uterus and heart. Lower levels found in spleen, lymph node, kidney and testis. Also found in cells with secretory function such as the islets of Langerhans, lobule/duct epithelium in the breast, bile duct epithelium in the liver, surface epithelium in the endometrial glands of the uterus, colon mucosa and acinar cells in the pancreas and the prostate.

Gene expression databases

BgeeiENSG00000088320
CleanExiHS_REM1
GenevisibleiO75628 HS

Organism-specific databases

HPAiHPA049821

Interactioni

Subunit structurei

In vitro, interacts with calmodulin in a calcium-dependent manner.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi118781, 6 interactors
STRINGi9606.ENSP00000201979

Structurei

Secondary structure

1298
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi80 – 86Combined sources7
Helixi93 – 101Combined sources9
Beta strandi112 – 123Combined sources12
Beta strandi126 – 133Combined sources8
Helixi145 – 149Combined sources5
Turni150 – 152Combined sources3
Beta strandi155 – 162Combined sources8
Helixi166 – 181Combined sources16
Beta strandi190 – 195Combined sources6
Turni200 – 202Combined sources3
Helixi207 – 217Combined sources11
Beta strandi219 – 223Combined sources5
Turni226 – 229Combined sources4
Helixi232 – 247Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NZJX-ray2.50A/B/C/D79-251[»]
ProteinModelPortaliO75628
SMRiO75628
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75628

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni268 – 287Calmodulin-bindingBy similarityAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi241 – 288Arg-richAdd BLAST48

Sequence similaritiesi

Belongs to the small GTPase superfamily. RGK family.Curated

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133672
HOGENOMiHOG000246961
HOVERGENiHBG104899
InParanoidiO75628
KOiK07847
OMAiKLDESWS
OrthoDBiEOG091G0OCN
PhylomeDBiO75628
TreeFamiTF314379

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR017358 RGK
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
PIRSFiPIRSF038017 GTP-binding_GEM, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequencei

Sequence statusi: Complete.

O75628-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLNTEQEAK TPLHRRASTP LPLSPRGHQP GRLSTVPSTQ SQHPRLGQSA
60 70 80 90 100
SLNPPTQKPS PAPDDWSSES SDSEGSWEAL YRVVLLGDPG VGKTSLASLF
110 120 130 140 150
AGKQERDLHE QLGEDVYERT LTVDGEDTTL VVVDTWEAEK LDKSWSQESC
160 170 180 190 200
LQGGSAYVIV YSIADRGSFE SASELRIQLR RTHQADHVPI ILVGNKADLA
210 220 230 240 250
RCREVSVEEG RACAVVFDCK FIETSATLQH NVAELFEGVV RQLRLRRRDS
260 270 280 290
AAKEPPAPRR PASLAQRARR FLARLTARSA RRRALKARSK SCHNLAVL
Length:298
Mass (Da):32,947
Last modified:November 7, 2003 - v2
Checksum:iE7CCE776FFD42CD7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti209E → V in AAC33132 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04949828H → R2 PublicationsCorresponds to variant dbSNP:rs1006459Ensembl.1
Natural variantiVAR_06123245R → W. Corresponds to variant dbSNP:rs59730832Ensembl.1
Natural variantiVAR_04949959P → A. Corresponds to variant dbSNP:rs2233829Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF084465 mRNA Translation: AAC33132.1
AF152863 mRNA Translation: AAF74212.1
BT020078 mRNA Translation: AAV38881.1
BT020079 mRNA Translation: AAV38882.1
AK313060 mRNA Translation: BAG35890.1
AL121751 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76439.1
CH471077 Genomic DNA Translation: EAW76440.1
CH471077 Genomic DNA Translation: EAW76442.1
BC039813 mRNA Translation: AAH39813.1
CCDSiCCDS13181.1
RefSeqiNP_054731.2, NM_014012.5
UniGeneiHs.247729

Genome annotation databases

EnsembliENST00000201979; ENSP00000201979; ENSG00000088320
GeneIDi28954
KEGGihsa:28954
UCSCiuc002wwa.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiREM1_HUMAN
AccessioniPrimary (citable) accession number: O75628
Secondary accession number(s): E1P5L1
, Q5TZR7, Q5TZR8, Q9NP57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: November 7, 2003
Last modified: May 23, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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