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O75626

- PRDM1_HUMAN

UniProt

O75626 - PRDM1_HUMAN

Protein

PR domain zinc finger protein 1

Gene

PRDM1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    Transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri575 – 59723C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri603 – 62523C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri631 – 65323C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri659 – 68123C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. methyltransferase activity Source: UniProtKB-KW
    3. protein binding Source: IntAct
    4. sequence-specific DNA binding Source: Ensembl
    5. sequence-specific DNA binding transcription factor activity Source: ProtInc

    GO - Biological processi

    1. cell fate commitment Source: Ensembl
    2. eye photoreceptor cell development Source: Ensembl
    3. germ cell development Source: Ensembl
    4. maternal placenta development Source: Ensembl
    5. negative regulation of B cell proliferation Source: Ensembl
    6. negative regulation of lipopolysaccharide-mediated signaling pathway Source: Ensembl
    7. negative regulation of transcription from RNA polymerase II promoter Source: ProtInc
    8. positive regulation of B cell differentiation Source: Ensembl
    9. positive regulation of gene expression Source: Ensembl
    10. transcription, DNA-templated Source: UniProtKB-KW
    11. trophoblast giant cell differentiation Source: Ensembl

    Keywords - Molecular functioni

    Methyltransferase, Repressor, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, S-adenosyl-L-methionine, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    PR domain zinc finger protein 1 (EC:2.1.1.-)
    Alternative name(s):
    BLIMP-1
    Beta-interferon gene positive regulatory domain I-binding factor
    PR domain-containing protein 1
    Positive regulatory domain I-binding factor 1
    Short name:
    PRDI-BF1
    Short name:
    PRDI-binding factor 1
    Gene namesi
    Name:PRDM1
    Synonyms:BLIMP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:9346. PRDM1.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33707.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 825825PR domain zinc finger protein 1PRO_0000047757Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki816 – 816Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)

    Post-translational modificationi

    Sumoylation at Lys-816 by PIAS1 augments transcriptional repressor activity, and is critical for plasma cell differentiation.1 Publication

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    PaxDbiO75626.
    PRIDEiO75626.

    PTM databases

    PhosphoSiteiO75626.

    Expressioni

    Gene expression databases

    ArrayExpressiO75626.
    BgeeiO75626.
    CleanExiHS_PRDM1.
    GenevestigatoriO75626.

    Organism-specific databases

    HPAiHPA030033.

    Interactioni

    Subunit structurei

    Interacts with PRMT5.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PIAS1O759252EBI-948789,EBI-629434
    SUMO1P631652EBI-7839538,EBI-80140

    Protein-protein interaction databases

    BioGridi107108. 19 interactions.
    IntActiO75626. 7 interactions.
    MINTiMINT-2857156.
    STRINGi9606.ENSP00000358092.

    Structurei

    Secondary structure

    1
    825
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi51 – 577
    Beta strandi60 – 623
    Helixi78 – 814
    Beta strandi87 – 915
    Beta strandi98 – 1058
    Beta strandi111 – 1133
    Beta strandi119 – 1213
    Turni123 – 1253
    Beta strandi135 – 1406
    Beta strandi143 – 1497
    Helixi158 – 1614
    Turni168 – 1703
    Beta strandi173 – 1786
    Beta strandi181 – 1888
    Beta strandi197 – 2004
    Helixi202 – 2076
    Helixi218 – 2225

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3DALX-ray1.65A/B38-223[»]
    ProteinModelPortaliO75626.
    SMRiO75626. Positions 44-254, 525-705.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO75626.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini84 – 201118SETPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni527 – 57448Interaction with PIAS1Add
    BLAST

    Sequence similaritiesi

    Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation
    Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 SET domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri575 – 59723C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri603 – 62523C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri631 – 65323C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri659 – 68123C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000059670.
    HOVERGENiHBG053670.
    InParanoidiO75626.
    OMAiTGYKTLP.
    OrthoDBiEOG7060Q3.
    PhylomeDBiO75626.
    TreeFamiTF316545.

    Family and domain databases

    Gene3Di3.30.160.60. 5 hits.
    InterProiIPR001214. SET_dom.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    IPR016608. Znf_PRDM1.
    [Graphical view]
    PfamiPF00856. SET. 1 hit.
    [Graphical view]
    PIRSFiPIRSF013212. PRDM1. 1 hit.
    SMARTiSM00317. SET. 1 hit.
    SM00355. ZnF_C2H2. 5 hits.
    [Graphical view]
    PROSITEiPS50280. SET. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O75626-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLDICLEKRV GTTLAAPKCN SSTVRFQGLA EGTKGTMKMD MEDADMTLWT    50
    EAEFEEKCTY IVNDHPWDSG ADGGTSVQAE ASLPRNLLFK YATNSEEVIG 100
    VMSKEYIPKG TRFGPLIGEI YTNDTVPKNA NRKYFWRIYS RGELHHFIDG 150
    FNEEKSNWMR YVNPAHSPRE QNLAACQNGM NIYFYTIKPI PANQELLVWY 200
    CRDFAERLHY PYPGELTMMN LTQTQSSLKQ PSTEKNELCP KNVPKREYSV 250
    KEILKLDSNP SKGKDLYRSN ISPLTSEKDL DDFRRRGSPE MPFYPRVVYP 300
    IRAPLPEDFL KASLAYGIER PTYITRSPIP SSTTPSPSAR SSPDQSLKSS 350
    SPHSSPGNTV SPVGPGSQEH RDSYAYLNAS YGTEGLGSYP GYAPLPHLPP 400
    AFIPSYNAHY PKFLLPPYGM NCNGLSAVSS MNGINNFGLF PRLCPVYSNL 450
    LGGGSLPHPM LNPTSLPSSL PSDGARRLLQ PEHPREVLVP APHSAFSFTG 500
    AAASMKDKAC SPTSGSPTAG TAATAEHVVQ PKATSAAMAA PSSDEAMNLI 550
    KNKRNMTGYK TLPYPLKKQN GKIKYECNVC AKTFGQLSNL KVHLRVHSGE 600
    RPFKCQTCNK GFTQLAHLQK HYLVHTGEKP HECQVCHKRF SSTSNLKTHL 650
    RLHSGEKPYQ CKVCPAKFTQ FVHLKLHKRL HTRERPHKCS QCHKNYIHLC 700
    SLKVHLKGNC AAAPAPGLPL EDLTRINEEI EKFDISDNAD RLEDVEDDIS 750
    VISVVEKEIL AVVRKEKEET GLKVSLQRNM GNGLLSSGCS LYESSDLPLM 800
    KLPPSNPLPL VPVKVKQETV EPMDP 825
    Length:825
    Mass (Da):91,771
    Last modified:May 18, 2010 - v2
    Checksum:i07B389BACCD6172F
    GO
    Isoform 2 (identifier: O75626-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-36: Missing.

    Show »
    Length:789
    Mass (Da):87,991
    Checksum:i6A1FEBEAD309BC7D
    GO
    Isoform 3 (identifier: O75626-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-3: MLD → MEK
         4-137: Missing.

    Show »
    Length:691
    Mass (Da):76,835
    Checksum:i4C5A56D19255FE89
    GO

    Sequence cautioni

    The sequence AAO45623.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti74 – 741G → S.
    Corresponds to variant rs2185379 [ dbSNP | Ensembl ].
    VAR_019983
    Natural varianti203 – 2031D → E.
    Corresponds to variant rs811925 [ dbSNP | Ensembl ].
    VAR_024221

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3636Missing in isoform 2. 1 PublicationVSP_039188Add
    BLAST
    Alternative sequencei1 – 33MLD → MEK in isoform 3. 2 PublicationsVSP_043646
    Alternative sequencei4 – 137134Missing in isoform 3. 2 PublicationsVSP_043647Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF084199 mRNA. Translation: AAC33300.1.
    AY198414 mRNA. Translation: AAO45623.1. Different initiation.
    AY198415 mRNA. Translation: AAO45624.1.
    AL358952, AL022067 Genomic DNA. Translation: CAQ52574.1.
    AL022067 Genomic DNA. Translation: CAI42295.2.
    AL022067, AL358952 Genomic DNA. Translation: CAQ52608.1.
    CH471051 Genomic DNA. Translation: EAW48419.1.
    CH471051 Genomic DNA. Translation: EAW48421.1.
    CH471051 Genomic DNA. Translation: EAW48422.1.
    BC103832 mRNA. Translation: AAI03833.1.
    BC103833 mRNA. Translation: AAI03834.1.
    BC103834 mRNA. Translation: AAI03835.1.
    CCDSiCCDS34505.1. [O75626-3]
    CCDS5054.2. [O75626-1]
    PIRiA39564.
    RefSeqiNP_001189.2. NM_001198.3. [O75626-1]
    NP_878911.1. NM_182907.2. [O75626-3]
    UniGeneiHs.436023.

    Genome annotation databases

    EnsembliENST00000369089; ENSP00000358085; ENSG00000057657. [O75626-3]
    ENST00000369091; ENSP00000358087; ENSG00000057657. [O75626-2]
    ENST00000369096; ENSP00000358092; ENSG00000057657. [O75626-1]
    GeneIDi639.
    KEGGihsa:639.
    UCSCiuc003prd.2. human. [O75626-1]
    uc003pre.3. human. [O75626-3]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF084199 mRNA. Translation: AAC33300.1 .
    AY198414 mRNA. Translation: AAO45623.1 . Different initiation.
    AY198415 mRNA. Translation: AAO45624.1 .
    AL358952 , AL022067 Genomic DNA. Translation: CAQ52574.1 .
    AL022067 Genomic DNA. Translation: CAI42295.2 .
    AL022067 , AL358952 Genomic DNA. Translation: CAQ52608.1 .
    CH471051 Genomic DNA. Translation: EAW48419.1 .
    CH471051 Genomic DNA. Translation: EAW48421.1 .
    CH471051 Genomic DNA. Translation: EAW48422.1 .
    BC103832 mRNA. Translation: AAI03833.1 .
    BC103833 mRNA. Translation: AAI03834.1 .
    BC103834 mRNA. Translation: AAI03835.1 .
    CCDSi CCDS34505.1. [O75626-3 ]
    CCDS5054.2. [O75626-1 ]
    PIRi A39564.
    RefSeqi NP_001189.2. NM_001198.3. [O75626-1 ]
    NP_878911.1. NM_182907.2. [O75626-3 ]
    UniGenei Hs.436023.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3DAL X-ray 1.65 A/B 38-223 [» ]
    ProteinModelPortali O75626.
    SMRi O75626. Positions 44-254, 525-705.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107108. 19 interactions.
    IntActi O75626. 7 interactions.
    MINTi MINT-2857156.
    STRINGi 9606.ENSP00000358092.

    PTM databases

    PhosphoSitei O75626.

    Proteomic databases

    PaxDbi O75626.
    PRIDEi O75626.

    Protocols and materials databases

    DNASUi 639.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000369089 ; ENSP00000358085 ; ENSG00000057657 . [O75626-3 ]
    ENST00000369091 ; ENSP00000358087 ; ENSG00000057657 . [O75626-2 ]
    ENST00000369096 ; ENSP00000358092 ; ENSG00000057657 . [O75626-1 ]
    GeneIDi 639.
    KEGGi hsa:639.
    UCSCi uc003prd.2. human. [O75626-1 ]
    uc003pre.3. human. [O75626-3 ]

    Organism-specific databases

    CTDi 639.
    GeneCardsi GC06P106534.
    H-InvDB HIX0006099.
    HGNCi HGNC:9346. PRDM1.
    HPAi HPA030033.
    MIMi 603423. gene.
    neXtProti NX_O75626.
    PharmGKBi PA33707.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000059670.
    HOVERGENi HBG053670.
    InParanoidi O75626.
    OMAi TGYKTLP.
    OrthoDBi EOG7060Q3.
    PhylomeDBi O75626.
    TreeFami TF316545.

    Miscellaneous databases

    ChiTaRSi PRDM1. human.
    EvolutionaryTracei O75626.
    GeneWikii PRDM1.
    GenomeRNAii 639.
    NextBioi 2590.
    PROi O75626.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75626.
    Bgeei O75626.
    CleanExi HS_PRDM1.
    Genevestigatori O75626.

    Family and domain databases

    Gene3Di 3.30.160.60. 5 hits.
    InterProi IPR001214. SET_dom.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    IPR016608. Znf_PRDM1.
    [Graphical view ]
    Pfami PF00856. SET. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF013212. PRDM1. 1 hit.
    SMARTi SM00317. SET. 1 hit.
    SM00355. ZnF_C2H2. 5 hits.
    [Graphical view ]
    PROSITEi PS50280. SET. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of a novel repressor of beta-interferon gene expression."
      Keller A.D., Maniatis T.
      Genes Dev. 5:868-879(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "Identification of a functionally impaired positive regulatory domain I binding factor 1 transcription repressor in myeloma cell lines."
      Gyory I., Fejer G., Ghosh N., Seto E., Wright K.L.
      J. Immunol. 170:3125-3133(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
    3. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    6. "NANOS3 function in human germ cell development."
      Julaton V.T., Reijo Pera R.A.
      Hum. Mol. Genet. 20:2238-2250(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    7. "SUMOylation of Blimp-1 is critical for plasma cell differentiation."
      Ying H.Y., Su S.T., Hsu P.H., Chang C.C., Lin I.Y., Tseng Y.H., Tsai M.D., Shih H.M., Lin K.I.
      EMBO Rep. 13:631-637(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUMOYLATION AT LYS-816.
    8. "The crystal structure of methyltransferase domain of human PR domain-containing protein 1."
      Structural genomics consortium (SGC)
      Submitted (FEB-2009) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 38-223.

    Entry informationi

    Entry nameiPRDM1_HUMAN
    AccessioniPrimary (citable) accession number: O75626
    Secondary accession number(s): B2REA6, E1P5E0, Q86WM7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 132 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3