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Protein

Carboxylic ester hydrolase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • lipase activity Source: UniProtKB

GO - Biological processi

  • cell differentiation Source: UniProtKB
  • cell growth Source: UniProtKB
  • cholesterol catabolic process Source: UniProtKB
  • fat-soluble vitamin catabolic process Source: UniProtKB
  • intestinal cholesterol absorption Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotation

Protein family/group databases

ESTHERihuman-CEL. Cholesterol_esterase.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxylic ester hydrolaseUniRule annotation (EC:3.1.1.-UniRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB
  • Golgi apparatus Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiO75612.
PRIDEiO75612.

PTM databases

iPTMnetiO75612.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000361151.

Structurei

3D structure databases

ProteinModelPortaliO75612.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 522517COesteraseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the type-B carboxylesterase/lipase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1516. Eukaryota.
COG2272. LUCA.
HOGENOMiHOG000091866.
HOVERGENiHBG008839.
KOiK12298.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

O75612-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AKLGAVYTEG GFVEGVNKKL GLLGDSVDIF KGIPFAAPTK ALENPQPHPG
60 70 80 90 100
WQGTLKAKNF KKRCLQATIT QDSTYGDEDC LYLNIWVPQG RKQVSRDLPV
110 120 130 140 150
MIWIYGGAFL MGSGHGANFL NNYLYDGEEI ATRGNVIVVT FNYRVGPLGF
160 170 180 190 200
LSTGDANLPG NYGLRDQHMA IAWVKRNIAA FGGDPNNITL FGESAGGASV
210 220 230 240 250
SLQTLSPYNK GLIRRAISQS GVALSPWVIQ KNPLFWAKKV AEKVGCPVGD
260 270 280 290 300
AARMAQCLKV TDPRALTLAY KVPLAGLEYP MLHYVGFVPV IDGDFIPADP
310 320 330 340 350
INLYANAADI DYIAGTNNMD GHIFASIDMP AINKGNKKVT EEDFYKLVSE
360 370 380 390 400
FTITKGLRGA KTTFDVYTES WAQDPSQENK KKTVVDFETD VLFLVPTEIA
410 420 430 440 450
LAQHRANAKS AKTYAYLFSH PSRMPVYPKW VGADHADDIQ YVFGKPFATP
460 470 480 490 500
TGYRPQDRTV SKAMIAYWTN FAKTGDPNMG DSAVPTHWEP YTTENSGYLE
510 520 530 540 550
ITKKMGSSSM KRSLRTNFLR YWTLTYLALP TVTDQEATPV PPTGDSEATP
560 570 580 590 600
VPPTGDSETA PVPPTGDSGA PPVPPTGDSG APPVPPTGDS EAAPVPPTGD
610
SKEAQMPAVI RF
Length:612
Mass (Da):66,363
Last modified:November 1, 1998 - v1
Checksum:iA5E9092D19390B26
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081673 mRNA. Translation: AAC71012.1.
RefSeqiNP_001798.2. NM_001807.4.
UniGeneiHs.533258.

Genome annotation databases

GeneIDi1056.
KEGGihsa:1056.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081673 mRNA. Translation: AAC71012.1.
RefSeqiNP_001798.2. NM_001807.4.
UniGeneiHs.533258.

3D structure databases

ProteinModelPortaliO75612.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000361151.

Protein family/group databases

ESTHERihuman-CEL. Cholesterol_esterase.

PTM databases

iPTMnetiO75612.

Proteomic databases

PaxDbiO75612.
PRIDEiO75612.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1056.
KEGGihsa:1056.

Organism-specific databases

CTDi1056.

Phylogenomic databases

eggNOGiKOG1516. Eukaryota.
COG2272. LUCA.
HOGENOMiHOG000091866.
HOVERGENiHBG008839.
KOiK12298.

Miscellaneous databases

GenomeRNAii1056.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of the oncofetal isoform of the human pancreatic bile salt-dependent lipase."
    Pasqualini E., Caillol N., Panicot L., Mas E., Lloubes R., Lombardo D.
    J. Biol. Chem. 273:28208-28218(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: PancreasImported.

Entry informationi

Entry nameiO75612_HUMAN
AccessioniPrimary (citable) accession number: O75612
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.