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O75610

- LFTY1_HUMAN

UniProt

O75610 - LFTY1_HUMAN

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Protein

Left-right determination factor 1

Gene
LEFTY1, LEFTB, LEFTYB, UNQ278/PRO317
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Required for left-right axis determination as a regulator of LEFTY2 and NODAL.

GO - Biological processi

  1. cell growth Source: InterPro
  2. determination of left/right symmetry Source: BHF-UCL
  3. heart morphogenesis Source: BHF-UCL
  4. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  5. transforming growth factor beta receptor signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Enzyme and pathway databases

ReactomeiREACT_111059. Regulation of signaling by NODAL.

Names & Taxonomyi

Protein namesi
Recommended name:
Left-right determination factor 1
Alternative name(s):
Left-right determination factor B
Protein lefty-1
Protein lefty-B
Gene namesi
Name:LEFTY1
Synonyms:LEFTB, LEFTYB
ORF Names:UNQ278/PRO317
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:6552. LEFTY1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30332.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Propeptidei22 – 7655Or 135 Reviewed predictionPRO_0000033810Add
BLAST
Chaini77 – 366290Left-right determination factor 1PRO_0000033811Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi158 – 1581N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi251 ↔ 264 By similarity
Disulfide bondi263 ↔ 316 By similarity
Disulfide bondi293 ↔ 351 By similarity
Disulfide bondi297 ↔ 353 By similarity

Post-translational modificationi

The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO75610.
PRIDEiO75610.

Miscellaneous databases

PMAP-CutDBO75610.

Expressioni

Gene expression databases

BgeeiO75610.
CleanExiHS_LEFTY1.
GenevestigatoriO75610.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000272134.

Structurei

3D structure databases

ProteinModelPortaliO75610.

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG266606.
HOGENOMiHOG000113317.
HOVERGENiHBG074429.
InParanoidiO75610.
KOiK04668.
OMAiVEGMVIP.
OrthoDBiEOG71VST0.
PhylomeDBiO75610.
TreeFamiTF106462.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR003942. LRDF.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PIRSFiPIRSF037402. TGFb4. 1 hit.
PRINTSiPR01427. TGFBETA4.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75610-1 [UniParc]FASTAAdd to Basket

« Hide

MQPLWLCWAL WVLPLASPGA ALTGEQLLGS LLRQLQLKEV PTLDRADMEE    50
LVIPTHVRAQ YVALLQRSHG DRSRGKRFSQ SFREVAGRFL ALEASTHLLV 100
FGMEQRLPPN SELVQAVLRL FQEPVPKAAL HRHGRLSPRS ARARVTVEWL 150
RVRDDGSNRT SLIDSRLVSV HESGWKAFDV TEAVNFWQQL SRPRQPLLLQ 200
VSVQREHLGP LASGAHKLVR FASQGAPAGL GEPQLELHTL DLGDYGAQGD 250
CDPEAPMTEG TRCCRQEMYI DLQGMKWAEN WVLEPPGFLA YECVGTCRQP 300
PEALAFKWPF LGPRQCIASE TDSLPMIVSI KEGGRTRPQV VSLPNMRVQK 350
CSCASDGALV PRRLQP 366
Length:366
Mass (Da):40,880
Last modified:November 1, 1998 - v1
Checksum:iBCF900C71ED9AA2A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti57 – 571V → M.
Corresponds to variant rs35273824 [ dbSNP | Ensembl ].
VAR_052567
Natural varianti92 – 921L → S.2 Publications
Corresponds to variant rs145431393 [ dbSNP | Ensembl ].
VAR_070888
Natural varianti142 – 1421R → Q.2 Publications
Corresponds to variant rs191758097 [ dbSNP | Ensembl ].
VAR_070889
Natural varianti322 – 3221D → A.
Corresponds to variant rs360057 [ dbSNP | Ensembl ].
VAR_024231

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF081507
, AF081504, AF081505, AF081506 Genomic DNA. Translation: AAC33967.1.
AF081512 mRNA. Translation: AAD48144.1.
AY358873 mRNA. Translation: AAQ89232.1.
AK313115 mRNA. Translation: BAG35937.1.
AK222714 mRNA. Translation: BAD96434.1.
AL117348 Genomic DNA. Translation: CAI21799.1.
BC027883 mRNA. Translation: AAH27883.1.
CCDSiCCDS1548.1.
RefSeqiNP_066277.1. NM_020997.3.
UniGeneiHs.656214.

Genome annotation databases

EnsembliENST00000272134; ENSP00000272134; ENSG00000243709.
GeneIDi10637.
KEGGihsa:10637.
UCSCiuc001hpo.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF081507
, AF081504 , AF081505 , AF081506 Genomic DNA. Translation: AAC33967.1 .
AF081512 mRNA. Translation: AAD48144.1 .
AY358873 mRNA. Translation: AAQ89232.1 .
AK313115 mRNA. Translation: BAG35937.1 .
AK222714 mRNA. Translation: BAD96434.1 .
AL117348 Genomic DNA. Translation: CAI21799.1 .
BC027883 mRNA. Translation: AAH27883.1 .
CCDSi CCDS1548.1.
RefSeqi NP_066277.1. NM_020997.3.
UniGenei Hs.656214.

3D structure databases

ProteinModelPortali O75610.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000272134.

Proteomic databases

PaxDbi O75610.
PRIDEi O75610.

Protocols and materials databases

DNASUi 10637.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000272134 ; ENSP00000272134 ; ENSG00000243709 .
GeneIDi 10637.
KEGGi hsa:10637.
UCSCi uc001hpo.3. human.

Organism-specific databases

CTDi 10637.
GeneCardsi GC01M226073.
HGNCi HGNC:6552. LEFTY1.
MIMi 603037. gene.
neXtProti NX_O75610.
PharmGKBi PA30332.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG266606.
HOGENOMi HOG000113317.
HOVERGENi HBG074429.
InParanoidi O75610.
KOi K04668.
OMAi VEGMVIP.
OrthoDBi EOG71VST0.
PhylomeDBi O75610.
TreeFami TF106462.

Enzyme and pathway databases

Reactomei REACT_111059. Regulation of signaling by NODAL.

Miscellaneous databases

ChiTaRSi LEFTY1. human.
GenomeRNAii 10637.
NextBioi 35467717.
PMAP-CutDB O75610.
PROi O75610.
SOURCEi Search...

Gene expression databases

Bgeei O75610.
CleanExi HS_LEFTY1.
Genevestigatori O75610.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR003942. LRDF.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view ]
PANTHERi PTHR11848. PTHR11848. 1 hit.
Pfami PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view ]
PIRSFi PIRSF037402. TGFb4. 1 hit.
PRINTSi PR01427. TGFBETA4.
SMARTi SM00204. TGFB. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development."
    Kosaki K., Bassi M.T., Kosaki R., Lewin M., Belmont J., Schauer G., Casey B.
    Am. J. Hum. Genet. 64:712-721(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Teratocarcinoma.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS SER-92 AND GLN-142.
    Tissue: Colon.
  4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS SER-92 AND GLN-142.
    Tissue: Colon.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas and Spleen.

Entry informationi

Entry nameiLFTY1_HUMAN
AccessioniPrimary (citable) accession number: O75610
Secondary accession number(s): B2R7U0, Q53H67, Q5TE94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1998
Last modified: September 3, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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