LEFTY1

Functionⁱ

Required for left-right axis determination as a regulator of LEFTY2 and NODAL.

GO - Molecular functionⁱ

cytokine activity Source: GO_Central
growth factor activity Source: UniProtKB-KW
transforming growth factor beta receptor binding Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

BMP signaling pathway Source: GO_Central
cell development Source: GO_Central
cell growth Source: InterPro
determination of left/right symmetry Source: BHF-UCL
heart morphogenesis Source: BHF-UCL
negative regulation of transcription by RNA polymerase II Source: BHF-UCL
positive regulation of pathway-restricted SMAD protein phosphorylation Source: GO_Central
regulation of apoptotic process Source: GO_Central
regulation of MAPK cascade Source: GO_Central
SMAD protein signal transduction Source: GO_Central
transforming growth factor beta receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 10053005

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cytokine, Developmental protein, Growth factor

Molecular function

Cytokine, Developmental protein, Growth factor

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1181150. Signaling by NODAL. R-HSA-1433617. Regulation of signaling by NODAL.
SIGNORⁱ	O75610.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Left-right determination factor 1 Alternative name(s): Left-right determination factor B Protein lefty-1 Protein lefty-B
Gene namesⁱ	Name:LEFTY1 Synonyms:LEFTB, LEFTYB ORF Names:UNQ278/PRO317
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000243709.1.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6552. LEFTY1.
MIMⁱ	603037. gene.
neXtProtⁱ	NX_O75610.

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10637.
Open Targets More...OpenTargetsⁱ	ENSG00000243709.
PharmGKBⁱ	PA30332.

Polymorphism and mutation databases

BioMutaⁱ	LEFTY1.

BioMutaⁱ

LEFTY1.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 21	Sequence analysisAdd BLAST	21
PropeptideⁱPRO_0000033810	22 – 76	Or 135Sequence analysisAdd BLAST	55
ChainⁱPRO_0000033811	77 – 366	Left-right determination factor 1Add BLAST	290

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	158	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	251 ↔ 264	By similarity
Disulfide bondⁱ	263 ↔ 316	By similarity
Disulfide bondⁱ	293 ↔ 351	By similarity
Disulfide bondⁱ	297 ↔ 353	By similarity

Post-translational modificationⁱ

The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	O75610.
PaxDbⁱ	O75610.
PeptideAtlas More...PeptideAtlasⁱ	O75610.
PRIDEⁱ	O75610.

PTM databases

iPTMnetⁱ	O75610.
PhosphoSitePlusⁱ	O75610.

Miscellaneous databases

PMAP-CutDBⁱ	O75610.

PMAP-CutDBⁱ

O75610.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000243709.
CleanExⁱ	HS_LEFTY1.
ExpressionAtlasⁱ	O75610. baseline and differential.
Genevisibleⁱ	O75610. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA047883. HPA056210.

HPAⁱ

HPA047883.
HPA056210.

Interactionⁱ

GO - Molecular functionⁱ

cytokine activity Source: GO_Central
growth factor activity Source: UniProtKB-KW
transforming growth factor beta receptor binding Source: GO_Central

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	115881. 2 interactors.
STRINGⁱ	9606.ENSP00000272134.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O75610.
SMRⁱ	O75610.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the TGF-beta family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG3900. Eukaryota. ENOG410XT8Z. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000010056.
HOGENOMⁱ	HOG000113317.
HOVERGENⁱ	HBG074429.
InParanoidⁱ	O75610.
KEGG Orthology (KO) More...KOⁱ	K04668.
OMAⁱ	MAIPTHV.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09EN.
PhylomeDBⁱ	O75610.
TreeFamⁱ	TF106462.

Family and domain databases

Gene3Dⁱ	2.10.90.10. 1 hit.
InterProⁱ	View protein in InterPro IPR029034. Cystine-knot_cytokine. IPR003942. LRDF. IPR001839. TGF-b_C. IPR001111. TGF-b_propeptide. IPR015615. TGF-beta-rel. IPR017948. TGFb_CS.
PANTHERⁱ	PTHR11848. PTHR11848. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00019. TGF_beta. 1 hit. PF00688. TGFb_propeptide. 1 hit.
PIRSFⁱ	PIRSF037402. TGFb4. 1 hit.
PRINTSⁱ	PR01427. TGFBETA4.
SMARTⁱ	View protein in SMART SM00204. TGFB. 1 hit.
SUPFAMⁱ	SSF57501. SSF57501. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00250. TGF_BETA_1. 1 hit. PS51362. TGF_BETA_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

O75610-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MQPLWLCWAL WVLPLASPGA ALTGEQLLGS LLRQLQLKEV PTLDRADMEE 
        60         70         80         90        100
LVIPTHVRAQ YVALLQRSHG DRSRGKRFSQ SFREVAGRFL ALEASTHLLV 
       110        120        130        140        150
FGMEQRLPPN SELVQAVLRL FQEPVPKAAL HRHGRLSPRS ARARVTVEWL 
       160        170        180        190        200
RVRDDGSNRT SLIDSRLVSV HESGWKAFDV TEAVNFWQQL SRPRQPLLLQ 
       210        220        230        240        250
VSVQREHLGP LASGAHKLVR FASQGAPAGL GEPQLELHTL DLGDYGAQGD 
       260        270        280        290        300
CDPEAPMTEG TRCCRQEMYI DLQGMKWAEN WVLEPPGFLA YECVGTCRQP 
       310        320        330        340        350
PEALAFKWPF LGPRQCIASE TDSLPMIVSI KEGGRTRPQV VSLPNMRVQK 
       360 
CSCASDGALV PRRLQP

Length:366

Mass (Da):40,880

Last modified:November 1, 1998 - v1

Checksum:ⁱBCF900C71ED9AA2A

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_052567	57	V → M. Corresponds to variant dbSNP:rs35273824Ensembl.	1
Natural variantⁱVAR_070888	92	L → S2 PublicationsCorresponds to variant dbSNP:rs145431393Ensembl.	1
Natural variantⁱVAR_070889	142	R → Q2 PublicationsCorresponds to variant dbSNP:rs191758097Ensembl.	1
Natural variantⁱVAR_024231	322	D → A. Corresponds to variant dbSNP:rs360057Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF081507 , AF081504, AF081505, AF081506 Genomic DNA. Translation: AAC33967.1. AF081512 mRNA. Translation: AAD48144.1. AY358873 mRNA. Translation: AAQ89232.1. AK313115 mRNA. Translation: BAG35937.1. AK222714 mRNA. Translation: BAD96434.1. AL117348 Genomic DNA. No translation available. BC027883 mRNA. Translation: AAH27883.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1548.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_066277.1. NM_020997.3.
UniGeneⁱ	Hs.656214.

Genome annotation databases

Ensemblⁱ	ENST00000272134; ENSP00000272134; ENSG00000243709.
GeneIDⁱ	10637.
KEGGⁱ	hsa:10637.
UCSC genome browser More...UCSCⁱ	uc001hpo.3. human.

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
O75610	O00292 A0A024R3P5 H2Q183 A0A2I3SR52 A0A2J8K9D0 H2N3J7 F6VUD5 G7MEF3 G3REB4 G3QEZ4 +21	Homo sapiens (Human) Pan troglodytes (Chimpanzee) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Macaca mulatta (Rhesus macaque) Gorilla gorilla gorilla (Western lowland gorilla) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Macaca nemestrina (Pig-tailed macaque) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) And more	366	UniRef90_O00292	Cluster: Left-right determination factor 2	32

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
O75610	O00292 A0A024R3P5 H2Q183 A0A2K5N170 G7MEF3 A0A0D9RUU8 A0A2K5YB52 G3REB4 G3QEZ4 A0A2K6AGJ9 +136	Homo sapiens (Human) Pan troglodytes (Chimpanzee) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Macaca mulatta (Rhesus macaque) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Mandrillus leucophaeus (Drill) (Papio leucophaeus) Gorilla gorilla gorilla (Western lowland gorilla) Papio anubis (Olive baboon) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) And more	366	UniRef50_O00292	Cluster: Left-right determination factor 2	147

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF081507 , AF081504, AF081505, AF081506 Genomic DNA. Translation: AAC33967.1. AF081512 mRNA. Translation: AAD48144.1. AY358873 mRNA. Translation: AAQ89232.1. AK313115 mRNA. Translation: BAG35937.1. AK222714 mRNA. Translation: BAD96434.1. AL117348 Genomic DNA. No translation available. BC027883 mRNA. Translation: AAH27883.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1548.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_066277.1. NM_020997.3.
UniGeneⁱ	Hs.656214.

3D structure databases

ProteinModelPortalⁱ	O75610.
SMRⁱ	O75610.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115881. 2 interactors.
STRINGⁱ	9606.ENSP00000272134.

PTM databases

iPTMnetⁱ	O75610.
PhosphoSitePlusⁱ	O75610.

Polymorphism and mutation databases

BioMutaⁱ	LEFTY1.

BioMutaⁱ

LEFTY1.

Proteomic databases

EPDⁱ	O75610.
PaxDbⁱ	O75610.
PeptideAtlas More...PeptideAtlasⁱ	O75610.
PRIDEⁱ	O75610.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10637.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000272134; ENSP00000272134; ENSG00000243709.
GeneIDⁱ	10637.
KEGGⁱ	hsa:10637.
UCSC genome browser More...UCSCⁱ	uc001hpo.3. human.

Organism-specific databases

CTDⁱ	10637.
DisGeNET More...DisGeNETⁱ	10637.
EuPathDBⁱ	HostDB:ENSG00000243709.1.
GeneCardsⁱ	LEFTY1.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6552. LEFTY1.
Human Protein Atlas More...HPAⁱ	HPA047883. HPA056210.
MIMⁱ	603037. gene.
neXtProtⁱ	NX_O75610.
Open Targets More...OpenTargetsⁱ	ENSG00000243709.
PharmGKBⁱ	PA30332.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3900. Eukaryota. ENOG410XT8Z. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000010056.
HOGENOMⁱ	HOG000113317.
HOVERGENⁱ	HBG074429.
InParanoidⁱ	O75610.
KEGG Orthology (KO) More...KOⁱ	K04668.
OMAⁱ	MAIPTHV.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09EN.
PhylomeDBⁱ	O75610.
TreeFamⁱ	TF106462.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1181150. Signaling by NODAL. R-HSA-1433617. Regulation of signaling by NODAL.
SIGNORⁱ	O75610.

Miscellaneous databases

ChiTaRSⁱ	LEFTY1. human.
GenomeRNAiⁱ	10637.
PMAP-CutDBⁱ	O75610.
Protein Ontology More...PROⁱ	PR:O75610.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000243709.
CleanExⁱ	HS_LEFTY1.
ExpressionAtlasⁱ	O75610. baseline and differential.
Genevisibleⁱ	O75610. HS.

Family and domain databases

Gene3Dⁱ	2.10.90.10. 1 hit.
InterProⁱ	View protein in InterPro IPR029034. Cystine-knot_cytokine. IPR003942. LRDF. IPR001839. TGF-b_C. IPR001111. TGF-b_propeptide. IPR015615. TGF-beta-rel. IPR017948. TGFb_CS.
PANTHERⁱ	PTHR11848. PTHR11848. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00019. TGF_beta. 1 hit. PF00688. TGFb_propeptide. 1 hit.
PIRSFⁱ	PIRSF037402. TGFb4. 1 hit.
PRINTSⁱ	PR01427. TGFBETA4.
SMARTⁱ	View protein in SMART SM00204. TGFB. 1 hit.
SUPFAMⁱ	SSF57501. SSF57501. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00250. TGF_BETA_1. 1 hit. PS51362. TGF_BETA_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LFTY1_HUMAN
Accessionⁱ	O75610Primary (citable) accession number: O75610 Secondary accession number(s): B2R7U0, Q53H67, Q5TE94
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
	Last sequence update:	November 1, 1998
	Last modified:	March 28, 2018
	This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O75610 (LFTY1_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Left-right determination factor 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ