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O75610

- LFTY1_HUMAN

UniProt

O75610 - LFTY1_HUMAN

Protein

Left-right determination factor 1

Gene

LEFTY1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Required for left-right axis determination as a regulator of LEFTY2 and NODAL.

    GO - Biological processi

    1. cell growth Source: InterPro
    2. determination of left/right symmetry Source: BHF-UCL
    3. heart morphogenesis Source: BHF-UCL
    4. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    5. transforming growth factor beta receptor signaling pathway Source: ProtInc

    Keywords - Molecular functioni

    Cytokine, Developmental protein, Growth factor

    Enzyme and pathway databases

    ReactomeiREACT_111059. Regulation of signaling by NODAL.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Left-right determination factor 1
    Alternative name(s):
    Left-right determination factor B
    Protein lefty-1
    Protein lefty-B
    Gene namesi
    Name:LEFTY1
    Synonyms:LEFTB, LEFTYB
    ORF Names:UNQ278/PRO317
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:6552. LEFTY1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30332.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Propeptidei22 – 7655Or 135Sequence AnalysisPRO_0000033810Add
    BLAST
    Chaini77 – 366290Left-right determination factor 1PRO_0000033811Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi251 ↔ 264By similarity
    Disulfide bondi263 ↔ 316By similarity
    Disulfide bondi293 ↔ 351By similarity
    Disulfide bondi297 ↔ 353By similarity

    Post-translational modificationi

    The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO75610.
    PRIDEiO75610.

    Miscellaneous databases

    PMAP-CutDBO75610.

    Expressioni

    Gene expression databases

    BgeeiO75610.
    CleanExiHS_LEFTY1.
    GenevestigatoriO75610.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000272134.

    Structurei

    3D structure databases

    ProteinModelPortaliO75610.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG266606.
    HOGENOMiHOG000113317.
    HOVERGENiHBG074429.
    InParanoidiO75610.
    KOiK04668.
    OMAiVEGMVIP.
    OrthoDBiEOG71VST0.
    PhylomeDBiO75610.
    TreeFamiTF106462.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR003942. LRDF.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view]
    PANTHERiPTHR11848. PTHR11848. 1 hit.
    PfamiPF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037402. TGFb4. 1 hit.
    PRINTSiPR01427. TGFBETA4.
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O75610-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQPLWLCWAL WVLPLASPGA ALTGEQLLGS LLRQLQLKEV PTLDRADMEE    50
    LVIPTHVRAQ YVALLQRSHG DRSRGKRFSQ SFREVAGRFL ALEASTHLLV 100
    FGMEQRLPPN SELVQAVLRL FQEPVPKAAL HRHGRLSPRS ARARVTVEWL 150
    RVRDDGSNRT SLIDSRLVSV HESGWKAFDV TEAVNFWQQL SRPRQPLLLQ 200
    VSVQREHLGP LASGAHKLVR FASQGAPAGL GEPQLELHTL DLGDYGAQGD 250
    CDPEAPMTEG TRCCRQEMYI DLQGMKWAEN WVLEPPGFLA YECVGTCRQP 300
    PEALAFKWPF LGPRQCIASE TDSLPMIVSI KEGGRTRPQV VSLPNMRVQK 350
    CSCASDGALV PRRLQP 366
    Length:366
    Mass (Da):40,880
    Last modified:November 1, 1998 - v1
    Checksum:iBCF900C71ED9AA2A
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti57 – 571V → M.
    Corresponds to variant rs35273824 [ dbSNP | Ensembl ].
    VAR_052567
    Natural varianti92 – 921L → S.2 Publications
    Corresponds to variant rs145431393 [ dbSNP | Ensembl ].
    VAR_070888
    Natural varianti142 – 1421R → Q.2 Publications
    Corresponds to variant rs191758097 [ dbSNP | Ensembl ].
    VAR_070889
    Natural varianti322 – 3221D → A.
    Corresponds to variant rs360057 [ dbSNP | Ensembl ].
    VAR_024231

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF081507
    , AF081504, AF081505, AF081506 Genomic DNA. Translation: AAC33967.1.
    AF081512 mRNA. Translation: AAD48144.1.
    AY358873 mRNA. Translation: AAQ89232.1.
    AK313115 mRNA. Translation: BAG35937.1.
    AK222714 mRNA. Translation: BAD96434.1.
    AL117348 Genomic DNA. Translation: CAI21799.1.
    BC027883 mRNA. Translation: AAH27883.1.
    CCDSiCCDS1548.1.
    RefSeqiNP_066277.1. NM_020997.3.
    UniGeneiHs.656214.

    Genome annotation databases

    EnsembliENST00000272134; ENSP00000272134; ENSG00000243709.
    GeneIDi10637.
    KEGGihsa:10637.
    UCSCiuc001hpo.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF081507
    , AF081504 , AF081505 , AF081506 Genomic DNA. Translation: AAC33967.1 .
    AF081512 mRNA. Translation: AAD48144.1 .
    AY358873 mRNA. Translation: AAQ89232.1 .
    AK313115 mRNA. Translation: BAG35937.1 .
    AK222714 mRNA. Translation: BAD96434.1 .
    AL117348 Genomic DNA. Translation: CAI21799.1 .
    BC027883 mRNA. Translation: AAH27883.1 .
    CCDSi CCDS1548.1.
    RefSeqi NP_066277.1. NM_020997.3.
    UniGenei Hs.656214.

    3D structure databases

    ProteinModelPortali O75610.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000272134.

    Proteomic databases

    PaxDbi O75610.
    PRIDEi O75610.

    Protocols and materials databases

    DNASUi 10637.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000272134 ; ENSP00000272134 ; ENSG00000243709 .
    GeneIDi 10637.
    KEGGi hsa:10637.
    UCSCi uc001hpo.3. human.

    Organism-specific databases

    CTDi 10637.
    GeneCardsi GC01M226073.
    HGNCi HGNC:6552. LEFTY1.
    MIMi 603037. gene.
    neXtProti NX_O75610.
    PharmGKBi PA30332.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG266606.
    HOGENOMi HOG000113317.
    HOVERGENi HBG074429.
    InParanoidi O75610.
    KOi K04668.
    OMAi VEGMVIP.
    OrthoDBi EOG71VST0.
    PhylomeDBi O75610.
    TreeFami TF106462.

    Enzyme and pathway databases

    Reactomei REACT_111059. Regulation of signaling by NODAL.

    Miscellaneous databases

    ChiTaRSi LEFTY1. human.
    GenomeRNAii 10637.
    NextBioi 35467717.
    PMAP-CutDB O75610.
    PROi O75610.
    SOURCEi Search...

    Gene expression databases

    Bgeei O75610.
    CleanExi HS_LEFTY1.
    Genevestigatori O75610.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR003942. LRDF.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view ]
    PANTHERi PTHR11848. PTHR11848. 1 hit.
    Pfami PF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037402. TGFb4. 1 hit.
    PRINTSi PR01427. TGFBETA4.
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development."
      Kosaki K., Bassi M.T., Kosaki R., Lewin M., Belmont J., Schauer G., Casey B.
      Am. J. Hum. Genet. 64:712-721(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Tissue: Teratocarcinoma.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS SER-92 AND GLN-142.
      Tissue: Colon.
    4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS SER-92 AND GLN-142.
      Tissue: Colon.
    5. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pancreas and Spleen.

    Entry informationi

    Entry nameiLFTY1_HUMAN
    AccessioniPrimary (citable) accession number: O75610
    Secondary accession number(s): B2R7U0, Q53H67, Q5TE94
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 127 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3