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Protein

Left-right determination factor 1

Gene

LEFTY1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Required for left-right axis determination as a regulator of LEFTY2 and NODAL.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Enzyme and pathway databases

ReactomeiREACT_111057. Signaling by NODAL.
REACT_111059. Regulation of signaling by NODAL.

Names & Taxonomyi

Protein namesi
Recommended name:
Left-right determination factor 1
Alternative name(s):
Left-right determination factor B
Protein lefty-1
Protein lefty-B
Gene namesi
Name:LEFTY1
Synonyms:LEFTB, LEFTYB
ORF Names:UNQ278/PRO317
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:6552. LEFTY1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30332.

Polymorphism and mutation databases

BioMutaiLEFTY1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Propeptidei22 – 7655Or 135Sequence AnalysisPRO_0000033810Add
BLAST
Chaini77 – 366290Left-right determination factor 1PRO_0000033811Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi251 ↔ 264By similarity
Disulfide bondi263 ↔ 316By similarity
Disulfide bondi293 ↔ 351By similarity
Disulfide bondi297 ↔ 353By similarity

Post-translational modificationi

The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO75610.
PRIDEiO75610.

Miscellaneous databases

PMAP-CutDBO75610.

Expressioni

Gene expression databases

BgeeiO75610.
CleanExiHS_LEFTY1.
ExpressionAtlasiO75610. baseline.
GenevisibleiO75610. HS.

Organism-specific databases

HPAiHPA047883.
HPA056210.

Interactioni

Protein-protein interaction databases

BioGridi115881. 3 interactions.
STRINGi9606.ENSP00000272134.

Structurei

3D structure databases

ProteinModelPortaliO75610.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG266606.
GeneTreeiENSGT00390000010056.
HOGENOMiHOG000113317.
HOVERGENiHBG074429.
InParanoidiO75610.
KOiK04668.
OMAiYQAFRCA.
OrthoDBiEOG71VST0.
PhylomeDBiO75610.
TreeFamiTF106462.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR003942. LRDF.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PIRSFiPIRSF037402. TGFb4. 1 hit.
PRINTSiPR01427. TGFBETA4.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75610-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPLWLCWAL WVLPLASPGA ALTGEQLLGS LLRQLQLKEV PTLDRADMEE
60 70 80 90 100
LVIPTHVRAQ YVALLQRSHG DRSRGKRFSQ SFREVAGRFL ALEASTHLLV
110 120 130 140 150
FGMEQRLPPN SELVQAVLRL FQEPVPKAAL HRHGRLSPRS ARARVTVEWL
160 170 180 190 200
RVRDDGSNRT SLIDSRLVSV HESGWKAFDV TEAVNFWQQL SRPRQPLLLQ
210 220 230 240 250
VSVQREHLGP LASGAHKLVR FASQGAPAGL GEPQLELHTL DLGDYGAQGD
260 270 280 290 300
CDPEAPMTEG TRCCRQEMYI DLQGMKWAEN WVLEPPGFLA YECVGTCRQP
310 320 330 340 350
PEALAFKWPF LGPRQCIASE TDSLPMIVSI KEGGRTRPQV VSLPNMRVQK
360
CSCASDGALV PRRLQP
Length:366
Mass (Da):40,880
Last modified:November 1, 1998 - v1
Checksum:iBCF900C71ED9AA2A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti57 – 571V → M.
Corresponds to variant rs35273824 [ dbSNP | Ensembl ].
VAR_052567
Natural varianti92 – 921L → S.2 Publications
Corresponds to variant rs145431393 [ dbSNP | Ensembl ].
VAR_070888
Natural varianti142 – 1421R → Q.2 Publications
Corresponds to variant rs191758097 [ dbSNP | Ensembl ].
VAR_070889
Natural varianti322 – 3221D → A.
Corresponds to variant rs360057 [ dbSNP | Ensembl ].
VAR_024231

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081507
, AF081504, AF081505, AF081506 Genomic DNA. Translation: AAC33967.1.
AF081512 mRNA. Translation: AAD48144.1.
AY358873 mRNA. Translation: AAQ89232.1.
AK313115 mRNA. Translation: BAG35937.1.
AK222714 mRNA. Translation: BAD96434.1.
AL117348 Genomic DNA. Translation: CAI21799.1.
BC027883 mRNA. Translation: AAH27883.1.
CCDSiCCDS1548.1.
RefSeqiNP_066277.1. NM_020997.3.
UniGeneiHs.656214.

Genome annotation databases

EnsembliENST00000272134; ENSP00000272134; ENSG00000243709.
GeneIDi10637.
KEGGihsa:10637.
UCSCiuc001hpo.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081507
, AF081504, AF081505, AF081506 Genomic DNA. Translation: AAC33967.1.
AF081512 mRNA. Translation: AAD48144.1.
AY358873 mRNA. Translation: AAQ89232.1.
AK313115 mRNA. Translation: BAG35937.1.
AK222714 mRNA. Translation: BAD96434.1.
AL117348 Genomic DNA. Translation: CAI21799.1.
BC027883 mRNA. Translation: AAH27883.1.
CCDSiCCDS1548.1.
RefSeqiNP_066277.1. NM_020997.3.
UniGeneiHs.656214.

3D structure databases

ProteinModelPortaliO75610.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115881. 3 interactions.
STRINGi9606.ENSP00000272134.

Polymorphism and mutation databases

BioMutaiLEFTY1.

Proteomic databases

PaxDbiO75610.
PRIDEiO75610.

Protocols and materials databases

DNASUi10637.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272134; ENSP00000272134; ENSG00000243709.
GeneIDi10637.
KEGGihsa:10637.
UCSCiuc001hpo.3. human.

Organism-specific databases

CTDi10637.
GeneCardsiGC01M226073.
HGNCiHGNC:6552. LEFTY1.
HPAiHPA047883.
HPA056210.
MIMi603037. gene.
neXtProtiNX_O75610.
PharmGKBiPA30332.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG266606.
GeneTreeiENSGT00390000010056.
HOGENOMiHOG000113317.
HOVERGENiHBG074429.
InParanoidiO75610.
KOiK04668.
OMAiYQAFRCA.
OrthoDBiEOG71VST0.
PhylomeDBiO75610.
TreeFamiTF106462.

Enzyme and pathway databases

ReactomeiREACT_111057. Signaling by NODAL.
REACT_111059. Regulation of signaling by NODAL.

Miscellaneous databases

ChiTaRSiLEFTY1. human.
GenomeRNAii10637.
NextBioi35467717.
PMAP-CutDBO75610.
PROiO75610.
SOURCEiSearch...

Gene expression databases

BgeeiO75610.
CleanExiHS_LEFTY1.
ExpressionAtlasiO75610. baseline.
GenevisibleiO75610. HS.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR003942. LRDF.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PIRSFiPIRSF037402. TGFb4. 1 hit.
PRINTSiPR01427. TGFBETA4.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development."
    Kosaki K., Bassi M.T., Kosaki R., Lewin M., Belmont J., Schauer G., Casey B.
    Am. J. Hum. Genet. 64:712-721(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Teratocarcinoma.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS SER-92 AND GLN-142.
    Tissue: Colon.
  4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS SER-92 AND GLN-142.
    Tissue: Colon.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas and Spleen.

Entry informationi

Entry nameiLFTY1_HUMAN
AccessioniPrimary (citable) accession number: O75610
Secondary accession number(s): B2R7U0, Q53H67, Q5TE94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1998
Last modified: July 22, 2015
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.