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O75607 (NPM3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nucleoplasmin-3
Gene names
Name:NPM3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length178 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May act as a chaperone.

Subcellular location

Nucleus Ref.1.

Tissue specificity

Ubiquitous. Ref.1

Post-translational modification

Phosphorylated Potential.

Sequence similarities

Belongs to the nucleoplasmin family.

Ontologies

Keywords
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   Molecular functionChaperone
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processrRNA processing

Inferred from electronic annotation. Source: Ensembl

rRNA transcription

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentnucleolus

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionpoly(A) RNA binding

Inferred from direct assay PubMed 22658674PubMed 22681889. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

tatP046082EBI-721544,EBI-6164389From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.5
Chain2 – 178177Nucleoplasmin-3
PRO_0000219489

Regions

Compositional bias2 – 109Ala-rich
Compositional bias145 – 16420Asp/Glu-rich (highly acidic)
Compositional bias148 – 1569Poly-Glu

Amino acid modifications

Modified residue21N-acetylalanine Ref.5 Ref.7 Ref.8 Ref.10 Ref.11 Ref.12
Modified residue131Phosphoserine Ref.8 Ref.10
Modified residue161Phosphoserine Ref.8
Modified residue1471Phosphoserine Ref.6
Modified residue1511Phosphoserine Ref.6
Modified residue1581Phosphoserine Ref.6

Natural variations

Natural variant161S → N.
Corresponds to variant rs34376117 [ dbSNP | Ensembl ].
VAR_050410
Natural variant801N → I. Ref.3
Corresponds to variant rs2735420 [ dbSNP | Ensembl ].
VAR_050411

Experimental info

Sequence conflict61 – 622EH → DD in AAD51496. Ref.3
Sequence conflict831E → K in AAD51496. Ref.3

Sequences

Sequence LengthMass (Da)Tools
O75607 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 8C899DE8C3CD61FA

FASTA17819,344
        10         20         30         40         50         60 
MAAGTAAALA FLSQESRTRA GGVGGLRVPA PVTMDSFFFG CELSGHTRSF TFKVEEEDDA 

        70         80         90        100        110        120 
EHVLALTMLC LTEGAKDECN VVEVVARNHD HQEIAVPVAN LKLSCQPMLS LDDFQLQPPV 

       130        140        150        160        170 
TFRLKSGSGP VRITGRHQIV TMSNDVSEEE SEEEEEDSDE EEVELCPILP AKKQGGRP 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, expression and nuclear localization of human NPM3, a member of the nucleophosmin/nucleoplasmin family of nuclear chaperones."
Shackleford G.M., Ganguly A., MacArthur C.A.
BMC Genomics 2:8-8(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]Hu G.
Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Retinoic acid induces differential expression of FGF8 isoforms in LNCaP cells."
Brondani V., Albrecht G., Hamy F.
Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-80.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin.
[5]Bienvenut W.V.
Submitted (JUL-2005) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 2-17, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: B-cell lymphoma.
[6]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-147; SER-151 AND SER-158, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13 AND SER-16, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY049737 mRNA. Translation: AAL12172.1.
AF081280 mRNA. Translation: AAC31609.1.
AF079325 Genomic DNA. Translation: AAD51496.1.
BC041067 mRNA. Translation: AAH41067.1.
BC054868 mRNA. Translation: AAH54868.1.
RefSeqNP_008924.1. NM_006993.2.
UniGeneHs.90691.

3D structure databases

ProteinModelPortalO75607.
SMRO75607. Positions 37-137.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115640. 11 interactions.
IntActO75607. 3 interactions.
MINTMINT-1426791.
STRING9606.ENSP00000359128.

PTM databases

PhosphoSiteO75607.

Proteomic databases

PaxDbO75607.
PeptideAtlasO75607.
PRIDEO75607.

Protocols and materials databases

DNASU10360.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000370110; ENSP00000359128; ENSG00000107833.
GeneID10360.
KEGGhsa:10360.
UCSCuc001ktt.3. human.

Organism-specific databases

CTD10360.
GeneCardsGC10M103532.
HGNCHGNC:7931. NPM3.
HPAHPA036295.
HPA036296.
MIM606456. gene.
neXtProtNX_O75607.
PharmGKBPA31733.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG87795.
HOGENOMHOG000030911.
HOVERGENHBG045601.
InParanoidO75607.
KOK11278.
OMACELSSKV.
OrthoDBEOG79W97G.
PhylomeDBO75607.
TreeFamTF327704.

Gene expression databases

BgeeO75607.
CleanExHS_NPM3.
GenevestigatorO75607.

Family and domain databases

Gene3D2.60.120.340. 1 hit.
InterProIPR004301. Nucleoplasmin.
IPR024057. Nucleoplasmin_core_dom.
[Graphical view]
PANTHERPTHR22747. PTHR22747. 1 hit.
SUPFAMSSF69203. SSF69203. 1 hit.
ProtoNetSearch...

Other

GeneWikiNPM3.
GenomeRNAi10360.
NextBio39273.
PROO75607.
SOURCESearch...

Entry information

Entry nameNPM3_HUMAN
AccessionPrimary (citable) accession number: O75607
Secondary accession number(s): Q9UNY6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM