Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nucleoplasmin-3

Gene

NPM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May act as a chaperone.

GO - Molecular functioni

  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoplasmin-3
Gene namesi
Name:NPM3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:7931. NPM3.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10360.
OpenTargetsiENSG00000107833.
PharmGKBiPA31733.

Polymorphism and mutation databases

BioMutaiNPM3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00002194892 – 178Nucleoplasmin-3Add BLAST177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei13PhosphoserineCombined sources1
Modified residuei16PhosphoserineCombined sources1
Modified residuei27Omega-N-methylarginineCombined sources1
Modified residuei147PhosphoserineCombined sources1
Modified residuei151PhosphoserineCombined sources1
Modified residuei158PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated.Curated

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiO75607.
MaxQBiO75607.
PaxDbiO75607.
PeptideAtlasiO75607.
PRIDEiO75607.
TopDownProteomicsiO75607.

PTM databases

iPTMnetiO75607.
PhosphoSitePlusiO75607.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000107833.
CleanExiHS_NPM3.
GenevisibleiO75607. HS.

Organism-specific databases

HPAiHPA036295.
HPA036296.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi115640. 28 interactors.
IntActiO75607. 12 interactors.
MINTiMINT-1426791.
STRINGi9606.ENSP00000359128.

Structurei

3D structure databases

ProteinModelPortaliO75607.
SMRiO75607.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 10Ala-rich9
Compositional biasi145 – 164Asp/Glu-rich (highly acidic)Add BLAST20
Compositional biasi148 – 156Poly-Glu9

Sequence similaritiesi

Belongs to the nucleoplasmin family.Curated

Phylogenomic databases

eggNOGiENOG410IZ8K. Eukaryota.
ENOG41120H8. LUCA.
GeneTreeiENSGT00440000034554.
HOGENOMiHOG000030911.
HOVERGENiHBG045601.
InParanoidiO75607.
KOiK11278.
OMAiVPFYTFQ.
OrthoDBiEOG091G0MSK.
PhylomeDBiO75607.
TreeFamiTF327704.

Family and domain databases

InterProiView protein in InterPro
IPR004301. Nucleoplasmin.
IPR024057. Nucleoplasmin_core_dom.
PANTHERiPTHR22747. PTHR22747. 1 hit.
PfamiView protein in Pfam
PF03066. Nucleoplasmin. 1 hit.
SUPFAMiSSF69203. SSF69203. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75607-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGTAAALA FLSQESRTRA GGVGGLRVPA PVTMDSFFFG CELSGHTRSF
60 70 80 90 100
TFKVEEEDDA EHVLALTMLC LTEGAKDECN VVEVVARNHD HQEIAVPVAN
110 120 130 140 150
LKLSCQPMLS LDDFQLQPPV TFRLKSGSGP VRITGRHQIV TMSNDVSEEE
160 170
SEEEEEDSDE EEVELCPILP AKKQGGRP
Length:178
Mass (Da):19,344
Last modified:January 23, 2007 - v3
Checksum:i8C899DE8C3CD61FA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti61 – 62EH → DD in AAD51496 (Ref. 3) Curated2
Sequence conflicti83E → K in AAD51496 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05041016S → N. Corresponds to variant dbSNP:rs34376117Ensembl.1
Natural variantiVAR_05041180N → I1 PublicationCorresponds to variant dbSNP:rs2735420Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY049737 mRNA. Translation: AAL12172.1.
AF081280 mRNA. Translation: AAC31609.1.
AF079325 Genomic DNA. Translation: AAD51496.1.
BC041067 mRNA. Translation: AAH41067.1.
BC054868 mRNA. Translation: AAH54868.1.
CCDSiCCDS7519.1.
RefSeqiNP_008924.1. NM_006993.2.
UniGeneiHs.90691.

Genome annotation databases

EnsembliENST00000370110; ENSP00000359128; ENSG00000107833.
GeneIDi10360.
KEGGihsa:10360.
UCSCiuc001ktt.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNPM3_HUMAN
AccessioniPrimary (citable) accession number: O75607
Secondary accession number(s): Q9UNY6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 139 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families