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O75607

- NPM3_HUMAN

UniProt

O75607 - NPM3_HUMAN

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Protein
Nucleoplasmin-3
Gene
NPM3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May act as a chaperone.

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. rRNA processing Source: Ensembl
  2. rRNA transcription Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoplasmin-3
Gene namesi
Name:NPM3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:7931. NPM3.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleolus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31733.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 178177Nucleoplasmin-3
PRO_0000219489Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine6 Publications
Modified residuei13 – 131Phosphoserine2 Publications
Modified residuei16 – 161Phosphoserine1 Publication
Modified residuei147 – 1471Phosphoserine1 Publication
Modified residuei151 – 1511Phosphoserine1 Publication
Modified residuei158 – 1581Phosphoserine1 Publication

Post-translational modificationi

Phosphorylated Reviewed prediction.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO75607.
PaxDbiO75607.
PeptideAtlasiO75607.
PRIDEiO75607.

PTM databases

PhosphoSiteiO75607.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiO75607.
CleanExiHS_NPM3.
GenevestigatoriO75607.

Organism-specific databases

HPAiHPA036295.
HPA036296.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
tatP046082EBI-721544,EBI-6164389From a different organism.

Protein-protein interaction databases

BioGridi115640. 13 interactions.
IntActiO75607. 3 interactions.
MINTiMINT-1426791.
STRINGi9606.ENSP00000359128.

Structurei

3D structure databases

ProteinModelPortaliO75607.
SMRiO75607. Positions 37-137.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2 – 109Ala-rich
Compositional biasi145 – 16420Asp/Glu-rich (highly acidic)
Add
BLAST
Compositional biasi148 – 1569Poly-Glu

Sequence similaritiesi

Belongs to the nucleoplasmin family.

Phylogenomic databases

eggNOGiNOG87795.
HOGENOMiHOG000030911.
HOVERGENiHBG045601.
InParanoidiO75607.
KOiK11278.
OMAiANLRLSC.
OrthoDBiEOG79W97G.
PhylomeDBiO75607.
TreeFamiTF327704.

Family and domain databases

Gene3Di2.60.120.340. 1 hit.
InterProiIPR004301. Nucleoplasmin.
IPR024057. Nucleoplasmin_core_dom.
[Graphical view]
PANTHERiPTHR22747. PTHR22747. 1 hit.
SUPFAMiSSF69203. SSF69203. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75607-1 [UniParc]FASTAAdd to Basket

« Hide

MAAGTAAALA FLSQESRTRA GGVGGLRVPA PVTMDSFFFG CELSGHTRSF    50
TFKVEEEDDA EHVLALTMLC LTEGAKDECN VVEVVARNHD HQEIAVPVAN 100
LKLSCQPMLS LDDFQLQPPV TFRLKSGSGP VRITGRHQIV TMSNDVSEEE 150
SEEEEEDSDE EEVELCPILP AKKQGGRP 178
Length:178
Mass (Da):19,344
Last modified:January 23, 2007 - v3
Checksum:i8C899DE8C3CD61FA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161S → N.
Corresponds to variant rs34376117 [ dbSNP | Ensembl ].
VAR_050410
Natural varianti80 – 801N → I.1 Publication
Corresponds to variant rs2735420 [ dbSNP | Ensembl ].
VAR_050411

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti61 – 622EH → DD in AAD51496. 1 Publication
Sequence conflicti83 – 831E → K in AAD51496. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY049737 mRNA. Translation: AAL12172.1.
AF081280 mRNA. Translation: AAC31609.1.
AF079325 Genomic DNA. Translation: AAD51496.1.
BC041067 mRNA. Translation: AAH41067.1.
BC054868 mRNA. Translation: AAH54868.1.
CCDSiCCDS7519.1.
RefSeqiNP_008924.1. NM_006993.2.
UniGeneiHs.90691.

Genome annotation databases

EnsembliENST00000370110; ENSP00000359128; ENSG00000107833.
GeneIDi10360.
KEGGihsa:10360.
UCSCiuc001ktt.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY049737 mRNA. Translation: AAL12172.1 .
AF081280 mRNA. Translation: AAC31609.1 .
AF079325 Genomic DNA. Translation: AAD51496.1 .
BC041067 mRNA. Translation: AAH41067.1 .
BC054868 mRNA. Translation: AAH54868.1 .
CCDSi CCDS7519.1.
RefSeqi NP_008924.1. NM_006993.2.
UniGenei Hs.90691.

3D structure databases

ProteinModelPortali O75607.
SMRi O75607. Positions 37-137.
ModBasei Search...

Protein-protein interaction databases

BioGridi 115640. 13 interactions.
IntActi O75607. 3 interactions.
MINTi MINT-1426791.
STRINGi 9606.ENSP00000359128.

PTM databases

PhosphoSitei O75607.

Proteomic databases

MaxQBi O75607.
PaxDbi O75607.
PeptideAtlasi O75607.
PRIDEi O75607.

Protocols and materials databases

DNASUi 10360.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000370110 ; ENSP00000359128 ; ENSG00000107833 .
GeneIDi 10360.
KEGGi hsa:10360.
UCSCi uc001ktt.3. human.

Organism-specific databases

CTDi 10360.
GeneCardsi GC10M103532.
HGNCi HGNC:7931. NPM3.
HPAi HPA036295.
HPA036296.
MIMi 606456. gene.
neXtProti NX_O75607.
PharmGKBi PA31733.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG87795.
HOGENOMi HOG000030911.
HOVERGENi HBG045601.
InParanoidi O75607.
KOi K11278.
OMAi ANLRLSC.
OrthoDBi EOG79W97G.
PhylomeDBi O75607.
TreeFami TF327704.

Miscellaneous databases

GeneWikii NPM3.
GenomeRNAii 10360.
NextBioi 39273.
PROi O75607.
SOURCEi Search...

Gene expression databases

Bgeei O75607.
CleanExi HS_NPM3.
Genevestigatori O75607.

Family and domain databases

Gene3Di 2.60.120.340. 1 hit.
InterProi IPR004301. Nucleoplasmin.
IPR024057. Nucleoplasmin_core_dom.
[Graphical view ]
PANTHERi PTHR22747. PTHR22747. 1 hit.
SUPFAMi SSF69203. SSF69203. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, expression and nuclear localization of human NPM3, a member of the nucleophosmin/nucleoplasmin family of nuclear chaperones."
    Shackleford G.M., Ganguly A., MacArthur C.A.
    BMC Genomics 2:8-8(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. Hu G.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Retinoic acid induces differential expression of FGF8 isoforms in LNCaP cells."
    Brondani V., Albrecht G., Hamy F.
    Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-80.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  5. Bienvenut W.V.
    Submitted (JUL-2005) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-17, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: B-cell lymphoma.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-147; SER-151 AND SER-158, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13 AND SER-16, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNPM3_HUMAN
AccessioniPrimary (citable) accession number: O75607
Secondary accession number(s): Q9UNY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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