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Protein

Caspase-13

Gene

CASP13

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei210 – 2101By similarity
Active sitei258 – 2581By similarity

GO - Molecular functioni

  • cysteine-type endopeptidase activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiC14.017.

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase-13 (EC:3.4.22.-)
Short name:
CASP-13
Alternative name(s):
Evolutionary related interleukin-1-beta-converting enzyme
Short name:
ERICE
Cleaved into the following 2 chains:
Gene namesi
Name:CASP13
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 15

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi258 – 2581C → S: Inactivation. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 289Caspase-13 subunit 1PRO_0000004650
Propeptidei1 – ?Sequence analysisPRO_0000004649
Chaini290 – 37788Caspase-13 subunit 2PRO_0000004651Add
BLAST

Post-translational modificationi

The two subunits are derived from the precursor sequence by an autocatalytic mechanism or by cleavage by Caspase-8.

Keywords - PTMi

Zymogen

Proteomic databases

PaxDbiO75601.
PRIDEiO75601.

Expressioni

Tissue specificityi

Mainly expressed in peripheral blood lymphocytes, spleen and placenta.

Gene expression databases

ExpressionAtlasiO75601. baseline and differential.

Interactioni

Subunit structurei

Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a small and a large subunit.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027820.

Structurei

3D structure databases

ProteinModelPortaliO75601.
SMRiO75601. Positions 124-270, 290-377.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8686CARDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C14A family.Curated
Contains 1 CARD domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
HOVERGENiHBG076981.
InParanoidiO75601.
KOiK04394.
TreeFamiTF102023.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.1460. 1 hit.
InterProiIPR001315. CARD.
IPR029030. Caspase-like_dom.
IPR033139. Caspase_cys_AS.
IPR016129. Caspase_his_AS.
IPR011029. DEATH-like_dom.
IPR002138. Pept_C14_p10.
IPR001309. Pept_C14_p20.
IPR017350. Pept_C14A_CASP1-typ.
IPR015917. Pept_C14A_HD.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
[Graphical view]
PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00114. CARD. 1 hit.
SM00115. CASc. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52129. SSF52129. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: O75601-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEDKHNKNP LKMLESLGKE LISGLLDDFV EKNVLKLEEE EKKKIYDAKL
60 70 80 90 100
QDKARVLVDS IRQKNQEAGQ VFVQTFLNID KNSTSIKAPE ETVAGPDESV
110 120 130 140 150
GSAATLKLCP HEEFLKLCKE RAGEIYPIKE RKDRTRLALI ICNTEFDHMP
160 170 180 190 200
PRNGAALDIL GMKQLLEGLG YTVEVEEKLT ARDMESVLWK FAAREEHKSS
210 220 230 240 250
DSTFLVFMSH GILDGICGTM HSEEEPDVLP YDTIFRTFNN RNCLSLKDKP
260 270 280 290 300
KVIIVQACRG ANRGELWVSD SPPALADSFS QSSENLEEDA VYKTHVEKDF
310 320 330 340 350
IAFCSSTPHN VSWRDIKKGS LFITRLITCF QKYAWCCHLE EVFRKVQQSF
360 370
EKPNVKAQMP TVERLSMTRY FYLFPGN
Length:377
Mass (Da):43,012
Last modified:November 1, 1998 - v1
Checksum:i959A59424DAECBF4
GO
Isoform B (identifier: O75601-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-124: Missing.

Show »
Length:320
Mass (Da):36,924
Checksum:iCCAE7D97B44E7049
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei68 – 12457Missing in isoform B. 1 PublicationVSP_000823Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078533 mRNA. Translation: AAC28380.1.
AF383946 mRNA. Translation: AAK77964.1.
AF383947 mRNA. Translation: AAK77965.1.
RefSeqiNP_788811.1. NM_176638.5. [O75601-1]
UniGeneiBt.16018.

Genome annotation databases

EnsembliENSBTAT00000027820; ENSBTAP00000027820; ENSBTAG00000020884. [O75601-1]
GeneIDi338039.
KEGGibta:338039.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078533 mRNA. Translation: AAC28380.1.
AF383946 mRNA. Translation: AAK77964.1.
AF383947 mRNA. Translation: AAK77965.1.
RefSeqiNP_788811.1. NM_176638.5. [O75601-1]
UniGeneiBt.16018.

3D structure databases

ProteinModelPortaliO75601.
SMRiO75601. Positions 124-270, 290-377.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027820.

Protein family/group databases

MEROPSiC14.017.

Proteomic databases

PaxDbiO75601.
PRIDEiO75601.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000027820; ENSBTAP00000027820; ENSBTAG00000020884. [O75601-1]
GeneIDi338039.
KEGGibta:338039.

Organism-specific databases

CTDi837.

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
HOVERGENiHBG076981.
InParanoidiO75601.
KOiK04394.
TreeFamiTF102023.

Miscellaneous databases

NextBioi20812492.

Gene expression databases

ExpressionAtlasiO75601. baseline and differential.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.1460. 1 hit.
InterProiIPR001315. CARD.
IPR029030. Caspase-like_dom.
IPR033139. Caspase_cys_AS.
IPR016129. Caspase_his_AS.
IPR011029. DEATH-like_dom.
IPR002138. Pept_C14_p10.
IPR001309. Pept_C14_p20.
IPR017350. Pept_C14A_CASP1-typ.
IPR015917. Pept_C14A_HD.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
[Graphical view]
PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00114. CARD. 1 hit.
SM00115. CASc. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52129. SSF52129. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), MUTAGENESIS OF CYS-258.
    Tissue: Fibroblast.
  2. "Evidence that caspase-13 is not a human but a bovine gene."
    Koenig U., Eckhart L., Tschachler E.
    Biochem. Biophys. Res. Commun. 285:1150-1154(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).

Entry informationi

Entry nameiCASPD_BOVIN
AccessioniPrimary (citable) accession number: O75601
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: April 13, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was originally thought to originate from human.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.