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Protein

C-type lectin domain family 3 member A

Gene

CLEC3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Promotes cell adhesion to laminin-332 and fibronectin.

GO - Molecular functioni

  • carbohydrate binding Source: ProtInc

GO - Biological processi

  • skeletal system development Source: ProtInc

Keywordsi

LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 3 member A
Alternative name(s):
C-type lectin superfamily member 1
Cartilage-derived C-type lectin
Gene namesi
Name:CLEC3A
Synonyms:CLECSF1
ORF Names:UNQ700/PRO1345
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:2052. CLEC3A.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi10143.
PharmGKBiPA26578.

Polymorphism and mutation databases

BioMutaiCLEC3A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000001737423 – 197C-type lectin domain family 3 member AAdd BLAST175

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi68 ↔ 78PROSITE-ProRule annotation
Disulfide bondi95 ↔ 191PROSITE-ProRule annotation
Disulfide bondi167 ↔ 183PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO75596.
PeptideAtlasiO75596.
PRIDEiO75596.

PTM databases

iPTMnetiO75596.
PhosphoSitePlusiO75596.

Expressioni

Tissue specificityi

Restricted to cartilage and breast. Also expressed in breast cancers.1 Publication

Gene expression databases

CleanExiHS_CLEC3A.

Organism-specific databases

HPAiHPA051511.

Interactioni

Protein-protein interaction databases

BioGridi115446. 49 interactors.
STRINGi9606.ENSP00000460682.

Structurei

3D structure databases

ProteinModelPortaliO75596.
SMRiO75596.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 192C-type lectinPROSITE-ProRule annotationAdd BLAST119

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
HOGENOMiHOG000060248.
HOVERGENiHBG108270.
InParanoidiO75596.
KOiK17519.
PhylomeDBiO75596.
TreeFamiTF330481.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
PfamiView protein in Pfam
PF00059. Lectin_C. 1 hit.
SMARTiView protein in SMART
SM00034. CLECT. 1 hit.
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiView protein in PROSITE
PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75596-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKNGLVICI LVITLLLDQT TSHTSRLKAR KHSKRRVRDK DGDLKTQIEK
60 70 80 90 100
LWTEVNALKE IQALQTVCLR GTKVHKKCYL ASEGLKHFHE ANEDCISKGG
110 120 130 140 150
ILVIPRNSDE INALQDYGKR SLPGVNDFWL GINDMVTEGK FVDVNGIAIS
160 170 180 190
FLNWDRAQPN GGKRENCVLF SQSAQGKWSD EACRSSKRYI CEFTIPQ
Length:197
Mass (Da):22,233
Last modified:November 1, 1998 - v1
Checksum:iBB924DBDDB7729A4
GO

Sequence cautioni

The sequence AAQ88742 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_021259197Q → K1 PublicationCorresponds to variant dbSNP:rs2072663Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077345, AF077344 Genomic DNA. Translation: AAD12542.1.
AY358376 mRNA. Translation: AAQ88742.1. Different initiation.
AK313316 mRNA. Translation: BAG36121.1.
BC104415 mRNA. Translation: AAI04416.1.
RefSeqiNP_005743.4. NM_005752.4.
UniGeneiHs.177936.
Hs.735656.

Genome annotation databases

EnsembliENST00000575655; ENSP00000460682; ENSG00000166509.
GeneIDi10143.
KEGGihsa:10143.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCLC3A_HUMAN
AccessioniPrimary (citable) accession number: O75596
Secondary accession number(s): B2R8C4, Q3SX91, Q6UXF5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: November 1, 1998
Last modified: August 30, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot