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Protein

C-type lectin domain family 3 member A

Gene

CLEC3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Promotes cell adhesion to laminin-332 and fibronectin.

GO - Molecular functioni

  • carbohydrate binding Source: ProtInc

GO - Biological processi

  • skeletal system development Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 3 member A
Alternative name(s):
C-type lectin superfamily member 1
Cartilage-derived C-type lectin
Gene namesi
Name:CLEC3A
Synonyms:CLECSF1
ORF Names:UNQ700/PRO1345
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:2052. CLEC3A.

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26578.

Polymorphism and mutation databases

BioMutaiCLEC3A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22221 PublicationAdd
BLAST
Chaini23 – 197175C-type lectin domain family 3 member APRO_0000017374Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi68 ↔ 78PROSITE-ProRule annotation
Disulfide bondi95 ↔ 191PROSITE-ProRule annotation
Disulfide bondi167 ↔ 183PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO75596.
PRIDEiO75596.

PTM databases

iPTMnetiO75596.

Expressioni

Tissue specificityi

Restricted to cartilage and breast. Also expressed in breast cancers.1 Publication

Gene expression databases

BgeeiO75596.
CleanExiHS_CLEC3A.

Organism-specific databases

HPAiHPA051511.

Interactioni

Protein-protein interaction databases

BioGridi115446. 42 interactions.
STRINGi9606.ENSP00000460682.

Structurei

3D structure databases

ProteinModelPortaliO75596.
SMRiO75596. Positions 37-195.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini74 – 192119C-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
HOGENOMiHOG000060248.
HOVERGENiHBG108270.
InParanoidiO75596.
KOiK17519.
PhylomeDBiO75596.
TreeFamiTF330481.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75596-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKNGLVICI LVITLLLDQT TSHTSRLKAR KHSKRRVRDK DGDLKTQIEK
60 70 80 90 100
LWTEVNALKE IQALQTVCLR GTKVHKKCYL ASEGLKHFHE ANEDCISKGG
110 120 130 140 150
ILVIPRNSDE INALQDYGKR SLPGVNDFWL GINDMVTEGK FVDVNGIAIS
160 170 180 190
FLNWDRAQPN GGKRENCVLF SQSAQGKWSD EACRSSKRYI CEFTIPQ
Length:197
Mass (Da):22,233
Last modified:November 1, 1998 - v1
Checksum:iBB924DBDDB7729A4
GO

Sequence cautioni

The sequence AAQ88742.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti197 – 1971Q → K.1 Publication
Corresponds to variant rs2072663 [ dbSNP | Ensembl ].
VAR_021259

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077345, AF077344 Genomic DNA. Translation: AAD12542.1.
AY358376 mRNA. Translation: AAQ88742.1. Different initiation.
AK313316 mRNA. Translation: BAG36121.1.
BC104415 mRNA. Translation: AAI04416.1.
RefSeqiNP_005743.4. NM_005752.4.
UniGeneiHs.177936.
Hs.735656.

Genome annotation databases

EnsembliENST00000575655; ENSP00000460682; ENSG00000166509.
GeneIDi10143.
KEGGihsa:10143.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Cartilage C-Type lectin

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077345, AF077344 Genomic DNA. Translation: AAD12542.1.
AY358376 mRNA. Translation: AAQ88742.1. Different initiation.
AK313316 mRNA. Translation: BAG36121.1.
BC104415 mRNA. Translation: AAI04416.1.
RefSeqiNP_005743.4. NM_005752.4.
UniGeneiHs.177936.
Hs.735656.

3D structure databases

ProteinModelPortaliO75596.
SMRiO75596. Positions 37-195.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115446. 42 interactions.
STRINGi9606.ENSP00000460682.

PTM databases

iPTMnetiO75596.

Polymorphism and mutation databases

BioMutaiCLEC3A.

Proteomic databases

PaxDbiO75596.
PRIDEiO75596.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000575655; ENSP00000460682; ENSG00000166509.
GeneIDi10143.
KEGGihsa:10143.

Organism-specific databases

CTDi10143.
GeneCardsiCLEC3A.
HGNCiHGNC:2052. CLEC3A.
HPAiHPA051511.
MIMi613588. gene.
neXtProtiNX_O75596.
PharmGKBiPA26578.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
HOGENOMiHOG000060248.
HOVERGENiHBG108270.
InParanoidiO75596.
KOiK17519.
PhylomeDBiO75596.
TreeFamiTF330481.

Miscellaneous databases

GenomeRNAii10143.
PROiO75596.
SOURCEiSearch...

Gene expression databases

BgeeiO75596.
CleanExiHS_CLEC3A.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The cartilage-derived, C-type lectin (CLECSF1): structure of the gene and chromosomal location."
    Neame P.J., Tapp H., Grimm D.R.
    Biochim. Biophys. Acta 1446:193-202(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Cartilage.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-197.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Matrilysin (MMP-7) cleaves C-type lectin domain family 3 member A (CLEC3A) on tumor cell surface and modulates its cell adhesion activity."
    Tsunezumi J., Higashi S., Miyazaki K.
    J. Cell. Biochem. 106:693-702(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 23-48; 58-77 AND 152-163, CLEAVAGE OF INITIATOR METHIONINE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiCLC3A_HUMAN
AccessioniPrimary (citable) accession number: O75596
Secondary accession number(s): B2R8C4, Q3SX91, Q6UXF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: November 1, 1998
Last modified: June 8, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.