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Protein

Peptidoglycan recognition protein 1

Gene

PGLYRP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.2 Publications

GO - Molecular functioni

  • N-acetylmuramoyl-L-alanine amidase activity Source: InterPro
  • peptidoglycan binding Source: UniProtKB
  • peptidoglycan receptor activity Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Keywords - Biological processi

Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidoglycan recognition protein 1
Alternative name(s):
Peptidoglycan recognition protein short
Short name:
PGRP-S
Gene namesi
Name:PGLYRP1
Synonyms:PGLYRP, PGRP, TNFSF3L
ORF Names:SBBI68, UNQ639/PRO1269
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:8904. PGLYRP1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33241.

Polymorphism and mutation databases

BioMutaiPGLYRP1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 196175Peptidoglycan recognition protein 1PRO_0000023901Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei22 – 221Pyrrolidone carboxylic acidBy similarity
Disulfide bondi30 ↔ 1541 Publication
Disulfide bondi46 ↔ 911 Publication
Disulfide bondi67 ↔ 731 Publication
Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated. N-glycosylation is required for bactericidal activity.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiO75594.
PeptideAtlasiO75594.
PRIDEiO75594.

PTM databases

iPTMnetiO75594.
PhosphoSiteiO75594.

Expressioni

Tissue specificityi

Highly expressed in bone marrow. Weak expression found in kidney, liver, small intestine, spleen, thymus, peripheral leukocyte, lung, fetal spleen and neutrophils.2 Publications

Gene expression databases

BgeeiENSG00000008438.
CleanExiHS_PGLYRP1.
GenevisibleiO75594. HS.

Organism-specific databases

HPAiHPA045702.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.2 Publications

Protein-protein interaction databases

BioGridi114474. 3 interactions.
IntActiO75594. 1 interaction.
MINTiMINT-3306405.
STRINGi9606.ENSP00000008938.

Structurei

Secondary structure

1
196
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi36 – 394Combined sources
Beta strandi52 – 6110Combined sources
Helixi70 – 8617Combined sources
Beta strandi96 – 994Combined sources
Beta strandi105 – 1095Combined sources
Turni110 – 1123Combined sources
Beta strandi116 – 1183Combined sources
Turni120 – 1223Combined sources
Helixi123 – 1253Combined sources
Beta strandi126 – 1338Combined sources
Beta strandi136 – 1383Combined sources
Helixi142 – 15716Combined sources
Beta strandi160 – 16910Combined sources
Helixi170 – 1723Combined sources
Beta strandi174 – 1763Combined sources
Helixi181 – 1877Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YCKX-ray1.70A22-196[»]
ProteinModelPortaliO75594.
SMRiO75594. Positions 30-196.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75594.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYTD. Eukaryota.
ENOG4111PQD. LUCA.
GeneTreeiENSGT00390000016833.
HOGENOMiHOG000267017.
HOVERGENiHBG007406.
InParanoidiO75594.
KOiK01446.
OMAiLWNPMSI.
OrthoDBiEOG091G0O6Z.
PhylomeDBiO75594.
TreeFamiTF323898.

Family and domain databases

CDDicd06583. PGRP. 1 hit.
Gene3Di3.40.80.10. 1 hit.
InterProiIPR002502. Amidase_domain.
IPR017331. Peptidoglycan_recognition.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view]
PANTHERiPTHR11022. PTHR11022. 1 hit.
PfamiPF01510. Amidase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF037945. PGRPs. 1 hit.
SMARTiSM00644. Ami_2. 1 hit.
SM00701. PGRP. 1 hit.
[Graphical view]
SUPFAMiSSF55846. SSF55846. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75594-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRRSMLLAW ALPSLLRLGA AQETEDPACC SPIVPRNEWK ALASECAQHL
60 70 80 90 100
SLPLRYVVVS HTAGSSCNTP ASCQQQARNV QHYHMKTLGW CDVGYNFLIG
110 120 130 140 150
EDGLVYEGRG WNFTGAHSGH LWNPMSIGIS FMGNYMDRVP TPQAIRAAQG
160 170 180 190
LLACGVAQGA LRSNYVLKGH RDVQRTLSPG NQLYHLIQNW PHYRSP
Length:196
Mass (Da):21,731
Last modified:November 1, 1998 - v1
Checksum:iD954C51440DC27DC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti34 – 341V → G.
Corresponds to variant rs34180629 [ dbSNP | Ensembl ].
VAR_050497

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076483 mRNA. Translation: AAC31822.1.
AF242517 mRNA. Translation: AAF99598.1.
AY358936 mRNA. Translation: AAQ89295.1.
AC007785 Genomic DNA. Translation: AAD38243.1.
BC096154 mRNA. Translation: AAH96154.1.
BC096155 mRNA. Translation: AAH96155.1.
BC096156 mRNA. Translation: AAH96156.1.
BC096157 mRNA. Translation: AAH96157.1.
BC101845 mRNA. Translation: AAI01846.1.
BC101847 mRNA. Translation: AAI01848.1.
CCDSiCCDS12680.1.
RefSeqiNP_005082.1. NM_005091.2.
UniGeneiHs.137583.

Genome annotation databases

EnsembliENST00000008938; ENSP00000008938; ENSG00000008438.
GeneIDi8993.
KEGGihsa:8993.
UCSCiuc002pdx.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076483 mRNA. Translation: AAC31822.1.
AF242517 mRNA. Translation: AAF99598.1.
AY358936 mRNA. Translation: AAQ89295.1.
AC007785 Genomic DNA. Translation: AAD38243.1.
BC096154 mRNA. Translation: AAH96154.1.
BC096155 mRNA. Translation: AAH96155.1.
BC096156 mRNA. Translation: AAH96156.1.
BC096157 mRNA. Translation: AAH96157.1.
BC101845 mRNA. Translation: AAI01846.1.
BC101847 mRNA. Translation: AAI01848.1.
CCDSiCCDS12680.1.
RefSeqiNP_005082.1. NM_005091.2.
UniGeneiHs.137583.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YCKX-ray1.70A22-196[»]
ProteinModelPortaliO75594.
SMRiO75594. Positions 30-196.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114474. 3 interactions.
IntActiO75594. 1 interaction.
MINTiMINT-3306405.
STRINGi9606.ENSP00000008938.

PTM databases

iPTMnetiO75594.
PhosphoSiteiO75594.

Polymorphism and mutation databases

BioMutaiPGLYRP1.

Proteomic databases

PaxDbiO75594.
PeptideAtlasiO75594.
PRIDEiO75594.

Protocols and materials databases

DNASUi8993.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000008938; ENSP00000008938; ENSG00000008438.
GeneIDi8993.
KEGGihsa:8993.
UCSCiuc002pdx.4. human.

Organism-specific databases

CTDi8993.
GeneCardsiPGLYRP1.
HGNCiHGNC:8904. PGLYRP1.
HPAiHPA045702.
MIMi604963. gene.
neXtProtiNX_O75594.
PharmGKBiPA33241.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYTD. Eukaryota.
ENOG4111PQD. LUCA.
GeneTreeiENSGT00390000016833.
HOGENOMiHOG000267017.
HOVERGENiHBG007406.
InParanoidiO75594.
KOiK01446.
OMAiLWNPMSI.
OrthoDBiEOG091G0O6Z.
PhylomeDBiO75594.
TreeFamiTF323898.

Miscellaneous databases

EvolutionaryTraceiO75594.
GeneWikiiPGLYRP1.
GenomeRNAii8993.
PROiO75594.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000008438.
CleanExiHS_PGLYRP1.
GenevisibleiO75594. HS.

Family and domain databases

CDDicd06583. PGRP. 1 hit.
Gene3Di3.40.80.10. 1 hit.
InterProiIPR002502. Amidase_domain.
IPR017331. Peptidoglycan_recognition.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view]
PANTHERiPTHR11022. PTHR11022. 1 hit.
PfamiPF01510. Amidase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF037945. PGRPs. 1 hit.
SMARTiSM00644. Ami_2. 1 hit.
SM00701. PGRP. 1 hit.
[Graphical view]
SUPFAMiSSF55846. SSF55846. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPGRP1_HUMAN
AccessioniPrimary (citable) accession number: O75594
Secondary accession number(s): Q4VB36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.