O75594 (PGRP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidoglycan recognition protein 1

Alternative name(s):
Peptidoglycan recognition protein short
Short name=PGRP-S

Gene names

Name:	PGLYRP1
Synonyms:	PGLYRP, PGRP, TNFSF3L
ORF Names:	SBBI68, UNQ639/PRO1269

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	196 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity. Ref.6 Ref.7
Subunit structure	Homodimer; disulfide-linked. Ref.7 Ref.8
Subcellular location	Secreted. Cytoplasmic granule By similarity Ref.7.
Tissue specificity	Highly expressed in bone marrow. Weak expression found in kidney, liver, small intestine, spleen, thymus, peripheral leukocyte, lung, fetal spleen and neutrophils. Ref.1 Ref.6
Post-translational modification	N-glycosylated. N-glycosylation is required for bactericidal activity. Ref.7
Sequence similarities	Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

Ontologies

Keywords
Biological process	Immunity Innate immunity
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Antibiotic Antimicrobial
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	defense response to Gram-positive bacterium Inferred from direct assay Ref.6. Source: UniProtKB detection of bacterium Inferred from direct assay Ref.6. Source: UniProtKB innate immune response Non-traceable author statement Ref.6. Source: UniProtKB peptidoglycan catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Non-traceable author statement Ref.6. Source: UniProtKB
Molecular function	N-acetylmuramoyl-L-alanine amidase activity Inferred from electronic annotation. Source: InterPro bacterial cell surface binding Traceable author statement. Source: ProtInc peptidoglycan binding Inferred from direct assay Ref.6. Source: UniProtKB peptidoglycan receptor activity Inferred from direct assay Ref.6. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 21

21

Potential

Chain

22 – 196

175

Peptidoglycan recognition protein 1

PRO_0000023901

Amino acid modifications

Glycosylation

112

1

N-linked (GlcNAc...) Potential

Disulfide bond

30 ↔ 154

Ref.8

Disulfide bond

46 ↔ 91

Ref.8

Disulfide bond

67 ↔ 73

Ref.8

Natural variations

Natural variant

34

1

V → G.
Corresponds to variant rs34180629 [ dbSNP | Ensembl ].

VAR_050497

Secondary structure

1

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196

Helix Strand Turn

Details...

Helix

36 – 39

4

Beta strand

52 – 61

10

Helix

70 – 86

17

Beta strand

96 – 99

4

Beta strand

105 – 109

5

Turn

110 – 112

3

Beta strand

116 – 118

3

Turn

120 – 122

3

Helix

123 – 125

3

Beta strand

126 – 133

8

Beta strand

136 – 138

3

Helix

142 – 157

16

Beta strand

160 – 169

10

Helix

170 – 172

3

Beta strand

174 – 176

3

Helix

181 – 187

7

Sequences

	Sequence		Length	Mass (Da)
	O75594 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: D954C51440DC27DC	FASTA	196	21,731
	10 20 30 40 50 60 MSRRSMLLAW ALPSLLRLGA AQETEDPACC SPIVPRNEWK ALASECAQHL SLPLRYVVVS 70 80 90 100 110 120 HTAGSSCNTP ASCQQQARNV QHYHMKTLGW CDVGYNFLIG EDGLVYEGRG WNFTGAHSGH 130 140 150 160 170 180 LWNPMSIGIS FMGNYMDRVP TPQAIRAAQG LLACGVAQGA LRSNYVLKGH RDVQRTLSPG 190 NQLYHLIQNW PHYRSP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A peptidoglycan recognition protein in innate immunity conserved from insects to humans." Kang D., Liu G., Lundstroem A., Gelius E., Steiner H. Proc. Natl. Acad. Sci. U.S.A. 95:10078-10082(1998) [PubMed: 9707603] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Bone marrow.
[2]	Wan T., Zhang W., Cao X. Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules." Liu C., Xu Z., Gupta D., Dziarski R. J. Biol. Chem. 276:34686-34694(2001) [PubMed: 11461926] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
[7]	"Peptidoglycan recognition proteins are a new class of human bactericidal proteins." Lu X., Wang M., Qi J., Wang H., Li X., Gupta D., Dziarski R. J. Biol. Chem. 281:5895-5907(2006) [PubMed: 16354652] [Abstract] Cited for: FUNCTION, SUBUNIT, GLYCOSYLATION, SUBCELLULAR LOCATION.
[8]	"Crystal structure of human peptidoglycan recognition protein S (PGRP-S) at 1.70 A resolution." Guan R., Wang Q., Sundberg E.J., Mariuzza R.A. J. Mol. Biol. 347:683-691(2005) [PubMed: 15769462] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 22-196, DISULFIDE BONDS.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF076483 mRNA. Translation: AAC31822.1.
AF242517 mRNA. Translation: AAF99598.1.
AY358936 mRNA. Translation: AAQ89295.1.
AC007785 Genomic DNA. Translation: AAD38243.1.
BC096154 mRNA. Translation: AAH96154.1.
BC096155 mRNA. Translation: AAH96155.1.
BC096156 mRNA. Translation: AAH96156.1.
BC096157 mRNA. Translation: AAH96157.1.
BC101845 mRNA. Translation: AAI01846.1.
BC101847 mRNA. Translation: AAI01848.1.

IPI

IPI00021085.

RefSeq

NP_005082.1. NM_005091.2.

UniGene

Hs.137583.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1YCK	X-ray	1.70	A	22-196	[»]

ProteinModelPortal

O75594.

SMR

O75594. Positions 30-196.

ModBase

Search...

Protein-protein interaction databases

MINT

MINT-3306405.

STRING

O75594.

PTM databases

PhosphoSite

O75594.

Proteomic databases

PeptideAtlas

O75594.

PRIDE

O75594.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000008938; ENSP00000008938; ENSG00000008438.

GeneID

8993.

KEGG

hsa:8993.

UCSC

uc002pdx.1. human.

Organism-specific databases

CTD

8993.

GeneCards

GC19M046522.

H-InvDB

HIX0039958.

HGNC

HGNC:8904. PGLYRP1.

HPA

HPA045702.

MIM

604963. gene.

neXtProt

NX_O75594.

PharmGKB

PA33241.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG11911.

GeneTree

ENSGT00390000016833.

HOGENOM

HBG268368.

HOVERGEN

HBG007406.

InParanoid

O75594.

OMA

RNVQHYH.

OrthoDB

EOG4DFPPK.

PhylomeDB

O75594.

Gene expression databases

ArrayExpress

O75594.

Bgee

O75594.

CleanEx

HS_PGLYRP1.

Genevestigator

O75594.

GermOnline

ENSG00000008438. Homo sapiens.

Family and domain databases

InterPro

IPR002502. Amidase_domain.
IPR017331. Peptidoglycan_recognition.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view]

Gene3D

G3DSA:3.40.80.10. Amidase_2. 1 hit.

KO

K01446.

PANTHER

PTHR11022. PGRPs. 1 hit.

Pfam

PF01510. Amidase_2. 1 hit.
[Graphical view]

PIRSF

PIRSF037945. PGRPs. 1 hit.

SMART

SM00644. Ami_2. 1 hit.
SM00701. PGRP. 1 hit.
[Graphical view]

SUPFAM

SSF55846. Amidase_2. 1 hit.

ProtoNet

Search...

Other

NextBio

33723.

SOURCE

Search...

Entry information

Entry name

PGRP1_HUMAN

Accession

Primary (citable) accession number: O75594
Secondary accession number(s): Q4VB36

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 18, 2001
Last sequence update:	November 1, 1998
Last modified:	January 25, 2012
This is version 103 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.